{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:40:06Z","timestamp":1789008006676,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Food allergy (FA) is an emerging problem in pediatrics, with tree nuts and peanuts being frequent causes of severe reactions. Oral food challenge (OFC) remains the gold standard for diagnosing FA. However, it is a stressful treatment and not always risk-free. Objectives: To identify potential biomarkers, using component-resolved diagnosis (CRD) associated with OFC outcome in children with tree nut (hazelnut, walnut, almond, and pistachio) and peanut allergy, who live in central and southern Italy. Methods: Eighty-eight (1\u201318 years) children followed at the Pediatric Allergy Clinic of Policlinico Umberto I in Rome were included in this study. All patients underwent skin prick tests (SPTs), prick-by-prick (PbP) tests, and serum-specific Immunoglobulin E (sIgE) measurement to allergenic components using CRDs. Results: In hazelnut allergy (n = 60 OFCs), OFC failure occurred in 41 children. Higher sIgE levels to Cor a 8 (OR 2.04, 95% CI 1.17\u20133.55), Cor a 9 (OR 2.61, 95% CI 1.37\u20135.00), and Cor a 14 (OR 1.65, 95% CI 1.14\u20132.38) were all significantly associated with an increased probability of a positive OFC outcome. In peanut allergy (n = 30 OFCs), OFC failure occurred in 16 children. Ara h 9 was the only statistically significant predictor of OFC failure, showing a very wide confidence interval (OR, 95% CI: 1.116\u2013484). For walnut, almond, and pistachio, sample sizes were insufficient to support inferential modeling. Conclusions: CRD biomarkers can stratify the likelihood of OFC reactions in pediatric FA, enhancing clinical decision-making and reducing unnecessary challenges.<\/jats:p>","DOI":"10.3390\/nu18030450","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:08:17Z","timestamp":1769702897000},"page":"450","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Value of Molecular Biomarkers for Oral Food Challenge Outcomes in Children with Hazelnut and Peanut Allergies"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-6082","authenticated-orcid":false,"given":"Giulia","family":"Brindisi","sequence":"first","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gravina","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-3411","authenticated-orcid":false,"given":"Daniela","family":"De Canditiis","sequence":"additional","affiliation":[{"name":"Institute of Applied Calculus, National Research Council, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1880-0995","authenticated-orcid":false,"given":"Filippo","family":"Mond\u00ec","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9211-6829","authenticated-orcid":false,"given":"Alessandra","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-455X","authenticated-orcid":false,"given":"Francesca","family":"Olivero","sequence":"additional","affiliation":[{"name":"Independent Researcher, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzio","family":"Masini","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Cela","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Semeraro","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Zicari","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Spalice","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Piccioni","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-8632","authenticated-orcid":false,"given":"Caterina","family":"Anania","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jaci.2014.05.013","article-title":"Food Allergy: A Practice Parameter Update\u20142014","volume":"134","author":"Sampson","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"NIAID-Sponsored Expert Panel, Boyce, J.A., Assa\u2019ad, A., Burks, A.W., Jones, S.M., Sampson, H.A., Wood, R.A., Plaut, M., Cooper, S.F., and Fenton, M.J. (2010). Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel. J. Allergy Clin. Immunol., 126, S1\u2013S58.","DOI":"10.1016\/j.jaci.2010.10.007"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0167-5699(92)90117-P","article-title":"Histamine: An Early Messenger in Inflammatory and Immune Reactions","volume":"13","author":"Falus","year":"1992","journal-title":"Immunol. Today"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e13856","DOI":"10.1111\/pai.13856","article-title":"Diagnosis and Management of Food Allergy-Associated Gastroesophageal Reflux Disease in Young Children-EAACI Position Paper","volume":"33","author":"Meyer","year":"2022","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1111\/all.15902","article-title":"EAACI Guidelines on the Diagnosis of IgE-Mediated Food Allergy","volume":"78","author":"Santos","year":"2023","journal-title":"Allergy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12016-018-8710-3","article-title":"IgE-Mediated Food Allergy","volume":"57","author":"Anvari","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.18176\/jiaci.0415","article-title":"Subcutaneous Immunotherapy with High-Dose Cat and Dog Extracts: A Real-Life Study","volume":"30","author":"Uriarte","year":"2020","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-7022-3-3","article-title":"The Skin Prick Test\u2014European Standards","volume":"3","author":"Heinzerling","year":"2013","journal-title":"Clin. Transl. Allergy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/pai.13389","article-title":"Biomarkers of Diagnosis and Resolution of Food Allergy","volume":"32","author":"Foong","year":"2021","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaci.2010.03.014","article-title":"Specific IgE Testing Task Force of the American Academy of Allergy; Asthma & Immunology; American College of Allergy, Asthma and Immunology. Human IgE Antibody Serology: A Primer for the Practicing North American Allergist\/Immunologist","volume":"126","author":"Hamilton","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Cela, L., Gravina, A., Semeraro, A., Pastore, F., Morelli, R., Marchetti, L., Brindisi, G., Olivero, F., Piccioni, M.G., and Zicari, A.M. (2024). Oral Food Challenge in Children with Tree Nut and Peanut Allergy: The Predictive Value of Diagnostic Tests. Diagnostics, 14.","DOI":"10.3390\/diagnostics14182069"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Calvani, M., Bianchi, A., Reginelli, C., Peresso, M., and Testa, A. (2019). Oral Food Challenge. Medicina, 55.","DOI":"10.3390\/medicina55100651"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jaip.2020.09.037","article-title":"Improving Diagnostic Accuracy in Food Allergy","volume":"9","author":"Foong","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1365-2222.2005.02150.x","article-title":"The Predictive Value of Specific Immunoglobulin E Levels in Serum for the Outcome of Oral Food Challenges","volume":"35","author":"Mehl","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0091-6749(03)02026-8","article-title":"Prevalence of Peanut and Tree Nut Allergy in the United States Determined by Means of a Random Digit Dial Telephone Survey: A 5-Year Follow-up Study","volume":"112","author":"Sicherer","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.jaci.2003.09.026","article-title":"Prevalence of Peanut Allergy in Primary-School Children in Montreal, Canada","volume":"112","author":"Kagan","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1067\/mai.2002.128802","article-title":"Rising Prevalence of Allergy to Peanut in Children: Data from 2 Sequential Cohorts","volume":"110","author":"Grundy","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1440-1754.2008.01436.x","article-title":"The Parent-Reported Prevalence and Management of Peanut and Nut Allergy in School Children in the Australian Capital Territory","volume":"45","author":"Kljakovic","year":"2009","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.jaci.2010.03.029","article-title":"US Prevalence of Self-Reported Peanut, Tree Nut, and Sesame Allergy: 11-Year Follow-Up","volume":"125","author":"Sicherer","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cela, L., Brindisi, G., Gravina, A., Pastore, F., Semeraro, A., Bringheli, I., Marchetti, L., Morelli, R., Cinicola, B., and Capponi, M. (2023). Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow\u2019s Milk Protein Allergy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24129781"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e70098","DOI":"10.1111\/1541-4337.70098","article-title":"Update on Hazelnut Allergy: Allergen Characterization, Epidemiology, Food Processing Technique and Detecting Strategy","volume":"24","author":"Wang","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11882-015-0555-8","article-title":"The Prevalence of Tree Nut Allergy: A Systematic Review","volume":"15","author":"McWilliam","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1111\/all.15801","article-title":"Prevalence Estimates of Eight Big Food Allergies in Europe: Updated Systematic Review and Meta-Analysis","volume":"78","author":"Spolidoro","year":"2023","journal-title":"Allergy"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/all.12423","article-title":"EAACI Food Allergy and Anaphylaxis Guidelines Group. Prevalence of Common Food Allergies in Europe: A Systematic Review and Meta-Analysis","volume":"69","author":"Nwaru","year":"2014","journal-title":"Allergy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jacig.2022.02.001","article-title":"Peanut Allergy in Italy: A Unique Italian Perspective","volume":"1","author":"Asero","year":"2022","journal-title":"J. Allergy Clin. Immunol. Glob."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tagliati, S., Barni, S., Giovannini, M., Liccioli, G., Sarti, L., Alicandro, T., Paladini, E., Perferi, G., Azzari, C., and Novembre, E. (2021). Nut Allergy: Clinical and Allergological Features in Italian Children. Nutrients, 13.","DOI":"10.3390\/nu13114076"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.anai.2020.01.024","article-title":"Prevalence and Natural History of Tree Nut Allergy","volume":"124","author":"McWilliam","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2005.09.002","article-title":"The Natural History of Tree Nut Allergy","volume":"116","author":"Fleischer","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/all.15166","article-title":"Measurement of IgE to Hazelnut Allergen Components Cannot Replace Hazelnut Challenge in Dutch Adults","volume":"77","author":"Lyons","year":"2022","journal-title":"Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/pai.13110","article-title":"Allergen Components in Diagnosing Childhood Hazelnut Allergy: Systematic Literature Review and Meta-Analysis","volume":"31","author":"Nilsson","year":"2020","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40521-016-0080-6","article-title":"Using Component-Resolved Diagnostics in the Management of Peanut-Allergic Patients","volume":"3","author":"Klemans","year":"2016","journal-title":"Curr. Treat. Options Allergy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1021\/jf050091p","article-title":"Influence of Thermal Processing on the Allergenicity of Peanut Proteins","volume":"53","author":"Mondoulet","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","first-page":"190","article-title":"Component Resolved Diagnosis of Walnut Allergy in Young Children: Jug r 1 as a Major Walnut Allergen","volume":"39","author":"Lee","year":"2021","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/pai.12610","article-title":"A Retrospect Study into the Utility of Allergen Components in Walnut Allergy","volume":"27","author":"Mew","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.imlet.2014.06.001","article-title":"Walnut Anaphylaxis: The Usefulness of Molecular-Based Allergy Diagnostics","volume":"161","author":"Ciprandi","year":"2014","journal-title":"Immunol. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/cea.12267","article-title":"Walnut Allergens: Molecular Characterization, Detection and Clinical Relevance","volume":"44","author":"Costa","year":"2014","journal-title":"Clin. Exp. Allergy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1002\/jsfa.10417","article-title":"Almond Allergens: Update and Perspective on Identification and Characterization","volume":"100","author":"Zhang","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-2222.2009.03259.x","article-title":"Identification of Two Pistachio Allergens, Pis v 1 and Pis v 2, Belonging to the 2S Albumin and 11S Globulin Family","volume":"39","author":"Ahn","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jaci.2014.12.1949","article-title":"Hazelnut Allergy across Europe Dissected Molecularly: A EuroPrevall Outpatient Clinic Survey","volume":"136","author":"Datema","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11882-015-0534-0","article-title":"Utility of Component-Resolved Diagnostics in Food Allergy","volume":"15","author":"Tuano","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/all.12429","article-title":"EAACI Food Allergy and Anaphylaxis Guidelines: Diagnosis and Management of Food Allergy","volume":"69","author":"Muraro","year":"2014","journal-title":"Allergy"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e14276","DOI":"10.1111\/pai.14276","article-title":"AAAAI-EAACI PRACTALL: Standardizing Oral Food Challenges\u20142024 Update","volume":"35","author":"Sampson","year":"2024","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000533313","article-title":"The Severity and Frequency of Systemic Reactions to Hazelnut Are Significantly Higher in Hazelnut Allergic Patients Monosensitized to Cor a 8 than in Patients Polysensitized to Cor a 1, Cor a 8, and Cor a 9","volume":"185","author":"Pastorello","year":"2024","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000321819","article-title":"Detection of Bet v1, Bet v2 and Bet v4 Specific IgE Antibodies in the Sera of Children and Adult Patients Allergic to Birch Pollen: Evaluation of Different IgE Reactivity Profiles Depending on Age and Local Sensitization","volume":"154","year":"2011","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaci.2017.06.038","article-title":"Food Challenges","volume":"141","author":"Beyer","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Valbuena, T., Reche, M., Marco, G., Toboso, I., Ringauf, A., Thuissard-Vasallo, I.J., Lozano-Ojalvo, D., Mart\u00ednez-Blanco, M., and Molina, E. (2021). Storage Proteins Are Driving Pediatric Hazelnut Allergy in a Lipid Transfer Protein-Rich Area. Foods, 10.","DOI":"10.3390\/foods10102463"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaip.2019.09.029","article-title":"Conducting an Oral Food Challenge: An Update to the 2009 Adverse Reactions to Foods Committee Work Group Report","volume":"8","author":"Bird","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_48","first-page":"56","article-title":"Practical Protocol of the Food Allergy Committee of the Seicap on Open Oral Food Challenges to Nuts","volume":"49","author":"Valero","year":"2021","journal-title":"Allergol. Immunopathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/ACI.0000000000000977","article-title":"Precision Allergy Molecular Diagnosis Applications in Food Allergy","volume":"24","author":"Sato","year":"2024","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/all.13328","article-title":"Component-Resolved Diagnosis and beyond: Multivariable Regression Models to Predict Severity of Hazelnut Allergy","volume":"73","author":"Datema","year":"2018","journal-title":"Allergy"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/all.12820","article-title":"Cor a 14 Is the Superior Serological Marker for Hazelnut Allergy in Children, Independent of Concomitant Peanut Allergy","volume":"71","author":"Eller","year":"2016","journal-title":"Allergy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.alit.2019.10.001","article-title":"Component-Resolved Diagnostics Can Be Useful for Identifying Hazelnut Allergy in Japanese Children","volume":"69","author":"Inoue","year":"2020","journal-title":"Allergol. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jaip.2015.12.012","article-title":"Cor a 14, Hazelnut-Specific IgE, and SPT as a Reliable Tool in Hazelnut Allergy Diagnosis in Eastern Mediterranean Children","volume":"4","author":"Buyuktiryaki","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jaci.2013.02.024","article-title":"Sensitization to Cor a 9 and Cor a 14 Is Highly Specific for a Hazelnut Allergy with Objective Symptoms in Dutch Children and Adults","volume":"132","author":"Masthoff","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Caffarelli, C., Mastrorilli, C., Santoro, A., Criscione, M., and Procaccianti, M. (2021). Component-Resolved Diagnosis of Hazelnut Allergy in Children. Nutrients, 13.","DOI":"10.3390\/nu13020640"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/pai.12299","article-title":"Ara h 2 and Ara h 6 Sensitization Predicts Peanut Allergy in Mediterranean Pediatric Patients","volume":"25","author":"Agabriel","year":"2014","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jaip.2020.08.060","article-title":"Added Diagnostic Value of Peanut Component Testing: A Cross-Sectional Study in Australian Children","volume":"9","author":"Kaur","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jaip.2021.12.040","article-title":"The Indirect Basophil Activation Test Is a Safe, Reliable, and Accessible Tool to Diagnose a Peanut Allergy in Children","volume":"10","author":"Brouwer","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"170452","DOI":"10.1155\/2013\/170452","article-title":"Peanut Sensitization Profiles in Italian Children and Adolescents with Specific IgE to Peanuts","volume":"2013","author":"Calamelli","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/all.12530","article-title":"Predictive Values of Component-Specific IgE for the Outcome of Peanut and Hazelnut Food Challenges in Children","volume":"70","author":"Beyer","year":"2015","journal-title":"Allergy"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.jaci.2016.01.043","article-title":"The Component-Specific to Total IgE Ratios Do Not Improve Peanut and Hazelnut Allergy Diagnoses","volume":"137","author":"Grabenhenrich","year":"2016","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/3\/450\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:25:38Z","timestamp":1769761538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/3\/450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["nu18030450"],"URL":"https:\/\/doi.org\/10.3390\/nu18030450","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}