{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:33:37Z","timestamp":1788150817625,"version":"build-2803163510"},"reference-count":75,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: With the emerging global popularity of botulinum neurotoxin (BoNT), both for aesthetical and medical purposes, there is a rising need for achieving better outcomes. The aim of this narrative review was to comprehensively cover the effect of BoNT, as well as its possible interactions with everyday mineral and vitamin supplementation. Results: It is well established that BoNT exerts its paralytic effects through zinc-dependent cleavage of SNARE proteins, blocking acetylcholine release at the neuromuscular junctions. However, after meticulous research of the available literature regarding the effect of oral supplementation on BoNT, there is very scarce data. The effect of zinc supplementation on the duration and effectiveness of BoNT in some facial applications was studied in a couple of clinical studies; however, systematic reviews indicate inconsistent results. Copper acts as a noncompetitive inhibitor, potentially antagonizing BoNT in animal models. Magnesium and calcium exhibit theoretical synergistic or compensatory roles via neuromuscular transmission modulation but lack clinical validation. Vitamin B complex shows no interference in rat studies and vitamin D influences baseline muscle strength and dosing needs, while vitamin E increases bruising risk but not efficacy. Conclusions: Even though zinc supplementation holds promise for potentiating BoNT effects, evidence for both zinc and other supplements remains speculative or contradictory, underscoring the need for randomized controlled trials to develop evidence-based guidelines. Clinicians should assess patient supplementation status pre-treatment to optimize outcomes and minimize complications, particularly advising against high-dose vitamin E peri-procedurally.<\/jats:p>","DOI":"10.3390\/nu18030491","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:38:12Z","timestamp":1770046692000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Botulinum Toxin Effects and Its Association with Vitamin and Mineral Supplementation: A Narrative Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-9415","authenticated-orcid":false,"given":"Ema","family":"Puizina","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia"},{"name":"Department of Maxillofacial Surgery, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-5130","authenticated-orcid":false,"given":"Dinko","family":"Martinovic","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia"},{"name":"Department of Maxillofacial Surgery, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-7625","authenticated-orcid":false,"given":"Slaven","family":"Lasic","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Dubrava, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovre","family":"Martinovic","sequence":"additional","affiliation":[{"name":"Medical Studies, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-7261","authenticated-orcid":false,"given":"Jasna","family":"Puizina","sequence":"additional","affiliation":[{"name":"Faculty of Science, University of Split, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Dediol","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital Dubrava, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slaven","family":"Lupi-Ferandin","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia"},{"name":"Department of Maxillofacial Surgery, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-0635","authenticated-orcid":false,"given":"Josko","family":"Bozic","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kumar, R., and Singh, B.R. (2025). Botulinum Toxin: A Comprehensive Review of Its Molecular Architecture and Mechanistic Action. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020777"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Martin, M.U., Frevert, J., and Tay, C.M. (2024). Complexing Protein-Free Botulinum Neurotoxin A Formulations: Implications of Excipients for Immunogenicity. Toxins, 16.","DOI":"10.3390\/toxins16020101"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jnnp.2003.034702","article-title":"Botulinum toxin in clinical practice","volume":"75","author":"Jankovic","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Field, M., Splevins, A., Picaut, P., van der Schans, M., Langenberg, J., Noort, D., Snyder, D., and Foster, K. (2018). AbobotulinumtoxinA (Dysport(\u00ae)), OnabotulinumtoxinA (Botox(\u00ae)), and IncobotulinumtoxinA (Xeomin(\u00ae)) Neurotoxin Content and Potential Implications for Duration of Response in Patients. Toxins, 10.","DOI":"10.3390\/toxins10120535"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1097\/00002508-200211001-00002","article-title":"Therapeutic use of botulinum toxins: Background and history","volume":"18","author":"Setler","year":"2002","journal-title":"Clin. J. Pain."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Choudhury, S., Baker, M.R., Chatterjee, S., and Kumar, H. (2021). Botulinum Toxin: An Update on Pharmacology and Newer Products in Development. Toxins, 13.","DOI":"10.3390\/toxins13010058"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Jost, W.H., and Kreisler, A. (2025). Botulinum Toxin: Previous Developments, Current Status, and Perspectives. Toxins, 17.","DOI":"10.3390\/toxins17100480"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.sbi.2015.03.013","article-title":"Architecture of the botulinum neurotoxin complex: A molecular machine for protection and delivery","volume":"31","author":"Lam","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/IAI.00063-15","article-title":"The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions","volume":"83","author":"Ayyar","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e00089-18","DOI":"10.1128\/mBio.00089-18","article-title":"The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes","volume":"9","author":"Pellett","year":"2018","journal-title":"mBio"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF03033927","article-title":"Neurophysiological effects of botulinum toxin type A","volume":"9","author":"Abbruzzese","year":"2006","journal-title":"Neurotox. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7181\/acfs.2021.00003","article-title":"Scientific review of the aesthetic uses of botulinum toxin type A","volume":"22","author":"Park","year":"2021","journal-title":"Arch. Craniofac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e4228","DOI":"10.1097\/GOX.0000000000004228","article-title":"The Multispecialty Toxin: A Literature Review of Botulinum Toxin","volume":"10","author":"Bach","year":"2022","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0928-4257(01)00086-9","article-title":"Botulinum neurotoxins: From paralysis to recovery of functional neuromuscular transmission","volume":"96","author":"Meunier","year":"2002","journal-title":"J. Physiol. Paris."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5999\/aps.2021.00766","article-title":"Immunogenicity of botulinum toxin","volume":"49","author":"Wee","year":"2022","journal-title":"Arch. Plast. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/mds.27072","article-title":"Botulinum toxin: State of the art","volume":"32","author":"Jankovic","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_17","first-page":"S13","article-title":"Guidelines on the use of botulinum toxin type A","volume":"74","author":"Shetty","year":"2008","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1212\/WNL.45.9.1743","article-title":"Response and immunoresistance to botulinum toxin injections","volume":"45","author":"Jankovic","year":"1995","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajodo.2019.07.014","article-title":"Efficacy of botulinum toxin for treating a gummy smile","volume":"158","author":"Cengiz","year":"2020","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_20","first-page":"e75549","article-title":"Exploring New and Potential Indications for Botulinum Toxin Treatment: An Updated Literature Review","volume":"16","author":"Wen","year":"2024","journal-title":"Cureus"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Anandan, C., and Jankovic, J. (2021). Botulinum Toxin in Movement Disorders: An Update. Toxins, 13.","DOI":"10.3390\/toxins13010042"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Becker, W.J. (2020). Botulinum Toxin in the Treatment of Headache. Toxins, 12.","DOI":"10.3390\/toxins12120803"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bouloux, G.F. (2021). Botulinum toxin (Botox). Front. Oral Maxillofac. Med., 4.","DOI":"10.21037\/fomm-20-42"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1524-4725.1992.tb03295.x","article-title":"Treatment of glabellar frown lines with C. botulinum-A exotoxin","volume":"18","author":"Carruthers","year":"1992","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.det.2013.09.009","article-title":"Aesthetic uses of the botulinum toxin","volume":"32","author":"Dorizas","year":"2014","journal-title":"Dermatol. Clin."},{"key":"ref_26","first-page":"e67961","article-title":"A Systematic Review and Comparative Analysis of Botox Treatment in Aesthetic and Therapeutic Applications: Advantages, Disadvantages, and Patient Outcomes","volume":"16","author":"Meretsky","year":"2024","journal-title":"Cureus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.5005\/jp-journals-10024-2068","article-title":"Botulinum Toxin for the Treatment of Gummv Smile","volume":"18","author":"Mokeem","year":"2017","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5115\/acb.22.258","article-title":"Novel anatomical proposal for botulinum neurotoxin injection targeting depressor anguli oris for treating drooping mouth corner","volume":"56","author":"Yi","year":"2023","journal-title":"Anat. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00006534-200002000-00050","article-title":"Botulinum toxin A for the treatment of facial hyperkinetic wrinkle lines in Koreans","volume":"105","author":"Ahn","year":"2000","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/PRS.0000000000009444","article-title":"Guidelines for Botulinum Neurotoxin Injection for Facial Contouring","volume":"150","author":"Yi","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00266-007-0081-8","article-title":"Botulinum toxin a for lower facial contouring: A prospective study","volume":"31","author":"Yu","year":"2007","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_32","first-page":"2950","article-title":"The use of botulinum toxin in keloid scar management: A literature review","volume":"6","author":"Sohrabi","year":"2020","journal-title":"Scars Burn. Heal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.12659\/MSM.916305","article-title":"Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis","volume":"25","author":"Bi","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Marinelli, G., Inchingolo, A.D., Trilli, I., Pezzolla, C., Sardano, R., Inchingolo, F., Palermo, A., Maspero, C.M.N., Dipalma, G., and Inchingolo, A.M. (2025). Proactive Aesthetic Strategies: Evaluating the Preventive Role of Botulinum Toxin in Facial Aging. Muscles, 4.","DOI":"10.3390\/muscles4030031"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e6084","DOI":"10.1097\/GOX.0000000000006084","article-title":"Intradermal Botulinum Toxin A on Skin Quality and Facial Rejuvenation: A Systematic Review and Meta-analysis","volume":"12","author":"Rahman","year":"2024","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/JCAS.JCAS_162_21","article-title":"Microdroplet Botulinum Toxin: A Review","volume":"15","author":"Kandhari","year":"2022","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3109\/14764172.2014.948882","article-title":"Scientific skepticism and new discoveries: An analysis of a report of zinc\/phytase supplementation and the efficacy of botulinum toxins in treating cosmetic facial rhytides, hemifacial spasm and benign essential blepharospasm","volume":"16","author":"Cohen","year":"2014","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_38","first-page":"507","article-title":"Effect of dietary zinc and phytase supplementation on botulinum toxin treatments","volume":"11","author":"Koshy","year":"2012","journal-title":"J. Drugs Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1007\/s00784-021-03944-2","article-title":"The effect of botulinum toxin A in patients with excessive gingival display with and without zinc supplementation: Randomized clinical trial","volume":"25","author":"Shemais","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_40","first-page":"100080","article-title":"Effects of zinc supplementation on duration and action of botulinum toxin applied to face muscles: A systematic review of randomized clinical trials","volume":"5","author":"Trindade","year":"2025","journal-title":"J. Trace Elem. Min."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Souza, A.C.R., Vasconcelos, A.R., Dias, D.D., Komoni, G., and Name, J.J. (2023). The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review. Nutrients, 15.","DOI":"10.3390\/nu15245127"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1113\/jphysiol.1954.sp005114","article-title":"The nature of the neuromuscular block produced by magnesium","volume":"124","author":"Engbaek","year":"1954","journal-title":"J. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ceca.2016.02.005","article-title":"Calcium signaling in skeletal muscle development, maintenance and regeneration","volume":"59","author":"Tu","year":"2016","journal-title":"Cell Calcium"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000356667","article-title":"Calcium\u2019s role in mechanotransduction during muscle development","volume":"33","author":"Egli","year":"2014","journal-title":"Cell Physiol. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/pro.670","article-title":"The role of calcium ions in the stability and instability of a thermolysin-like protease","volume":"20","author":"Eijsink","year":"2011","journal-title":"Protein Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2147\/DDDT.S256814","article-title":"Botulinum Toxin Type A Possibly Affects Ca(v)3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity","volume":"14","author":"Ma","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1021\/jacs.7b01084","article-title":"Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A","volume":"139","author":"Bremer","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e1065","DOI":"10.7717\/peerj.1065","article-title":"The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion","volume":"30","author":"Lu","year":"2015","journal-title":"PeerJ"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.13207","article-title":"B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin","volume":"26","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1016\/j.febslet.2005.08.072","article-title":"Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A","volume":"579","author":"Eubanks","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s00266-012-9873-6","article-title":"Does vitamin B alter the efficacy of botulinum toxin?","volume":"36","author":"Tatlidede","year":"2012","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Alberts, A., Moldoveanu, E.T., Niculescu, A.G., and Grumezescu, A.M. (2025). Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential. Molecules, 30.","DOI":"10.3390\/molecules30030748"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/odi.12446","article-title":"Vitamin C: The known and the unknown and Goldilocks","volume":"22","author":"Padayatty","year":"2016","journal-title":"Oral Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/2040622310381934","article-title":"Effects of vitamin d on muscle function and performance: A review of evidence from randomized controlled trials","volume":"2","author":"Rejnmark","year":"2011","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e396824","DOI":"10.1590\/acb396824","article-title":"Influence of vitamin D on muscle strength and botulinum toxin dosage through surface electromyography","volume":"7","author":"Coelho","year":"2024","journal-title":"Acta Cir. Bras."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.18295\/2075-0528.1566","article-title":"The role of vitamin e in human health and some diseases","volume":"14","author":"Rizvi","year":"2014","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_57","first-page":"809","article-title":"Multifunctional role of zinc in human health: An update","volume":"22","author":"Kiouri","year":"2023","journal-title":"Excli J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s10238-024-01302-6","article-title":"Role of zinc in health and disease","volume":"24","author":"Stiles","year":"2024","journal-title":"Clin. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tox.2015.07.003","article-title":"Botulinum neurotoxin type A: Actions beyond SNAP-25?","volume":"335","author":"Matak","year":"2015","journal-title":"Toxicology"},{"key":"ref_60","first-page":"220079","article-title":"Biomarkers of Nutrition for Development (BOND)-Zinc Review","volume":"146","author":"King","year":"2015","journal-title":"J. Nutr."},{"key":"ref_61","first-page":"9041694","article-title":"Magnesium and Human Health: Perspectives and Research Directions","volume":"16","author":"Majoni","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ndtplus\/sfr163","article-title":"Magnesium basics","volume":"5","author":"Ketteler","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"102156","DOI":"10.1016\/j.jormas.2024.102156","article-title":"Effect of zinc or copper supplementation on the efficacy and sustainability of botulinum toxin A \u201cBotox\u201d injection in masseter muscle of albino rats","volume":"126","author":"Elgendy","year":"2025","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7812\/TPP\/21.204","article-title":"Vitamins: Functions and Uses in Medicine","volume":"26","author":"Hanna","year":"2022","journal-title":"Perm. J."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kennedy, D.O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy\u2014A Review. Nutrients, 8.","DOI":"10.3390\/nu8020068"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4103\/ijmr.IJMR_1467_19","article-title":"Prescribing vitamin B complex: Need for reassessment","volume":"154","author":"Rana","year":"2021","journal-title":"Indian J. Med. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41538-025-00460-5","article-title":"Vitamin D: Recent advances, associated factors, and its role in combating non-communicable diseases","volume":"9","author":"Deepika","year":"2025","journal-title":"NPJ Sci. Food"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.1093\/pubmed\/fdaf080","article-title":"A systematic review and meta-analysis of circulating 25-hydroxyvitamin D concentration and vitamin D status worldwide","volume":"47","author":"Dunlop","year":"2025","journal-title":"J. Public Health"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1024\/0300-9831\/a000281","article-title":"A Systematic Review of Global Alpha-Tocopherol Status as Assessed by Nutritional Intake Levels and Blood Serum Concentrations","volume":"85","author":"Friedel","year":"2015","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.freeradbiomed.2024.01.024","article-title":"Human Vitamin E deficiency, and what is and is not Vitamin E?","volume":"213","author":"Traber","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10571-008-9340-8","article-title":"Is vitamin E toxic to neuron cells?","volume":"29","author":"Then","year":"2009","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_72","first-page":"16","article-title":"Minimizing bruising following fillers and other cosmetic injectables","volume":"6","author":"Hamman","year":"2013","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lykkesfeldt, J., and Tveden-Nyborg, P. (2019). The Pharmacokinetics of Vitamin C. Nutrients, 11.","DOI":"10.3390\/nu11102412"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Rowe, S., and Carr, A.C. (2020). Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?. Nutrients, 12.","DOI":"10.3390\/nu12072008"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Dhotre, T., Thanawala, S., and Shah, R. (2025). Optimizing Oral Vitamin C Supplementation: Addressing Pharmacokinetic Challenges with Nutraceutical Formulation Approaches-A Mini Review. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17111458"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/3\/491\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:44:50Z","timestamp":1770047090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/3\/491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":75,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["nu18030491"],"URL":"https:\/\/doi.org\/10.3390\/nu18030491","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}