{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:00:22Z","timestamp":1789740022643,"version":"4.0.1"},"reference-count":70,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"TUBITAK 1002-A Short-term Support Program","doi-asserted-by":"publisher","award":["323S263"],"award-info":[{"award-number":["323S263"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009706","name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University Scientific Research Projects Coordination Unit","doi-asserted-by":"publisher","award":["TSA-2024-978"],"award-info":[{"award-number":["TSA-2024-978"]}],"id":[{"id":"10.13039\/501100009706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: This study investigated the effects of different doses and timing of sulforaphane (SFN) supplementation on reducing obesity induced by a high-glycemic-index diet (HGID) and on correcting poor glycemic control and dyslipidemia in C57BL\/6 mice. Method: For 15 weeks, mice were administered a control diet (control), HGID, HGID + oral 5 mg\/kg\/day SFN (HGID + LSFN), or HGID + 20 mg\/kg\/day SFN (HGID + HSFN), and following 15 weeks of HGID, mice were treated with 5 mg\/kg\/day SFN (PO-HGID + LSFN) or 20 mg\/kg\/day SFN (PO-HGID + HSFN) for 5 weeks. Results: SFN reduced body weight gain and serum glucose. The lowest levels of HbA1c were observed in the control and HGID + LSFN groups. Mice in the HGID group exhibited impaired glucose clearance and were less sensitive to insulin compared to the control. A remarkable improvement in glucose and insulin tolerance was observed in both PO-HGID + SFN and HGID + SFN groups. Lipid profile parameters and serum insulin levels were found to be lower in the control and HGID + SFN groups compared to the HGID group. SFN increased serum adiponectin levels when administered concurrently with HGID. IRS1 and IRS2 levels were highest in the control and HGID + LSFN groups, and high-dose SFN supplementation suppressed IRS1 independently of timing. Exposure to HGID downregulated the expression of PGC-1\u03b1 and sirtuins. SIRT1 and SIRT3 gene expressions showed a significant increase at both doses, whereas SIRT2 gene expression increased significantly only at 5 mg\/kg\/day SFN. FASN expression was upregulated in all HGID-fed groups with or without SFN intervention. Conclusions: SFN may reverse the adverse effects of HGID in a time- and dose-dependent manner by regulating postprandial insulin, inhibiting gluconeogenesis, and enhancing fatty acid oxidation through the activation of sirtuins and PGC-1\u03b1.<\/jats:p>","DOI":"10.3390\/nu18040574","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T16:13:32Z","timestamp":1770653612000},"page":"574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sulforaphane Against the Metabolic Consequences of a High-Glycemic-Index Diet: Protective and Therapeutic Mechanisms Associated with Obesity and Insulin Resistance"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-2029","authenticated-orcid":false,"given":"Mihrican","family":"\u00c7ubuk","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Hacettepe University, 06100 Ankara, Turkey"},{"name":"Department of Nutrition and Dietetics, Erzincan Binali Y\u0131ld\u0131r\u0131m University, 24100 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin A\u00e7\u0131kg\u00f6z","family":"P\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Hacettepe University, 06100 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahad\u0131r","family":"S\u00fcleyman","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Erzincan Binali Y\u0131ld\u0131r\u0131m University, 24100 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necip G\u00f6khan","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Erzincan Binali Y\u0131ld\u0131r\u0131m University, 24100 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ajcn\/84.2.289","article-title":"Global nutrition dynamics: The world is shifting rapidly toward a diet linked with noncommunicable diseases","volume":"84","author":"Popkin","year":"2006","journal-title":"Am. 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