{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:28:39Z","timestamp":1789079319776,"version":"build-2803163510"},"reference-count":69,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Alcohol-associated liver disease (ALD) is a major cause of chronic liver injury, in which disruption of the gut\u2013liver axis plays a key pathogenic role. Probiotics have been proposed as a potential therapeutic strategy to mitigate alcohol-induced liver damage; however, the preclinical evidence has not been systematically synthesised. This systematic review aimed to evaluate and summarise the hepatoprotective effects of probiotic supplementation in experimental animal models of ALD. Methods: The review protocol was pre-registered in PROSPERO (CRD420250653666) and followed PRISMA guidelines. A systematic search was conducted across PubMed, EMBASE and AGRICOLA databases using relevant keywords from inception to 30 April 2025. We included preclinical randomised controlled trials evaluating single-strain probiotic interventions against placebo or untreated controls in animal models of ALD. Risk of bias was assessed using SYRCLE\u2019s tool, and the certainty of evidence for critical outcomes was evaluated using the GRADE framework. A narrative synthesis was performed, as a quantitative meta-analysis was precluded by incomplete numerical outcome reporting. Results: From initial 628 records, 36 studies were included in the final synthesis. Probiotic supplementation consistently attenuated alcohol-induced liver injury, as evidenced by marked reductions in serum ALT and AST levels and improved liver histology. Mechanistically, probiotics restored gut barrier integrity, reduced systemic endotoxemia, and suppressed pro-inflammatory pathways. Furthermore, probiotic treatment effectively counteracted alcohol-induced gut dysbiosis by increasing microbial diversity and restoring taxonomic balance, notably by reversing the alcohol-induced expansion of Proteobacteria. Despite these consistent directional effects, the overall certainty of evidence for the critical outcomes was rated as very low. Conclusions: Although the preclinical literature suggests hepatoprotective effects of probiotics in experimental ALD, these findings should be interpreted with caution due to the very low certainty of evidence. The observed benefits are limited by methodological shortcomings, indirectness inherent to animal models, and incomplete outcome reporting. This review provides a structured preclinical framework to inform the design of future translational studies and well-controlled clinical trials evaluating probiotics as potential adjunctive therapies in human ALD.<\/jats:p>","DOI":"10.3390\/nu18040608","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:28:11Z","timestamp":1770910091000},"page":"608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Probiotic Treatment in Alcoholic Liver Disease: A Systematic Review of Animal Studies"],"prefix":"10.3390","volume":"18","author":[{"given":"Konrad","family":"Sosnowski","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine, Medical University of Warsaw Banacha 1A, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-4700","authenticated-orcid":false,"given":"Robert","family":"Kucharski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine, Medical University of Warsaw Banacha 1A, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-2856","authenticated-orcid":false,"given":"Adam","family":"Przyby\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine, Medical University of Warsaw Banacha 1A, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3350\/cmh.2024.0835","article-title":"Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000\u20132021","volume":"31","author":"Danpanichkul","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.3350\/cmh.2024.0709","article-title":"Alcohol-associated liver disease: Natural history, management and novel targeted therapies","volume":"31","author":"Pose","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.14309\/ajg.0000000000002572","article-title":"ACG Clinical Guideline: Alcohol-Associated Liver Disease","volume":"119","author":"Jophlin","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Milosevic, I., Vujovic, A., Barac, A., Djelic, M., Korac, M., Radovanovic Spurnic, A., Gmizic, I., Stevanovic, O., Djordjevic, V., and Lekic, N. (2019). Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020395"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/1574887111666160810100538","article-title":"Gut Microbiota and Alcoholic Liver Disease","volume":"11","author":"Scarpellini","year":"2016","journal-title":"Rev. Recent Clin. Trials"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sosnowski, K., and Przyby\u0142kowski, A. (2024). Ethanol-induced changes to the gut microbiome compromise the intestinal homeostasis: A review. Gut Microbes, 16.","DOI":"10.1080\/19490976.2024.2393272"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Li, F., Duan, K., Wang, C., Mcclain, C., and Feng, W. (2016). Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms. Gastroenterol. Res. Pract., 2016.","DOI":"10.1155\/2016\/5491465"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Liu, J., Yang, D., Wang, X., Asare, P.T., Zhang, Q., Na, L., and Shao, L. (2022). Gut Microbiota Targeted Approach in the Management of Chronic Liver Diseases. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.774335"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Xiong, S.-Y., Wu, G.-S., Li, C., Ma, W., and Luo, H.-R. (2024). Clinical efficacy of probiotics in the treatment of alcoholic liver disease: A systematic review and meta-analysis. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1358063"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Saadh, M.J., Sabah Ghnim, Z., Salih Mahdi, M., Arora, V., Rekha, M.M., Sharma, A., Juneja, B., Aminov, Z., Taher, W.M., and Alwan, M. (2025). Effects of probiotics on liver function, inflammation, and gut microbiota in alcoholic liver injury: A systematic review and meta-analysis. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1717393"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hooijmans, C.R., Rovers, M.M., de Vries, R.B.M., Leenaars, M., Ritskes-Hoitinga, M., and Langendam, M.W. (2014). SYRCLE\u2019s risk of bias tool for animal studies. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-43"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yang, Z., Lian, J., Yang, Y., Li, J., Guo, W., Lv, X., Ni, L., and Chen, Y. (2025). Selenium enrichment enhances the alleviating effect of Lactobacillus rhamnosus GG on alcoholic liver injury in mice. Curr. Res. Food Sci., 10.","DOI":"10.1016\/j.crfs.2024.100964"},{"key":"ref_15","first-page":"169","article-title":"Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice","volume":"18","author":"Yi","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/jmf.2024.k.0184","article-title":"Lactobacillus rhamnosus GG Combined with Metformin Alleviates Alcohol-Induced Liver Inflammation in Mice by Maintaining the Intestinal Barrier and Regulating Treg\/Th1 Cells","volume":"28","author":"Zhu","year":"2025","journal-title":"J. Med. Food"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ding, Q., Cao, F., Lai, S., Zhuge, H., Chang, K., Valencak, T.G., Liu, J., Li, S., and Ren, D. (2022). Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis. Food Res. Int., 157.","DOI":"10.1016\/j.foodres.2022.111259"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.3168\/jds.2021-21265","article-title":"Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease","volume":"105","author":"He","year":"2022","journal-title":"J. Dairy Sci."},{"key":"ref_19","first-page":"4733","article-title":"Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model","volume":"18","author":"Huang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hong, M., Kim, S.W., Han, S.H., Kim, D.J., Suk, K.T., Kim, Y.S., Kim, M.J., Kim, M.Y., Baik, S.K., and Ham, Y.L. (2015). Probiotics (Lactobacillus rhamnosus R0011 and acidophilus R0052) reduce the expression of toll-like receptor 4 in mice with alcoholic liver disease. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117451"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/acs.jafc.0c06346","article-title":"Lactobacillus plantarum KLDS1.0344 and Lactobacillus acidophilus KLDS1.0901 Mixture Prevents Chronic Alcoholic Liver Injury in Mice by Protecting the Intestinal Barrier and Regulating Gut Microbiota and Liver-Related Pathways","volume":"69","author":"Li","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Roychowdhury, S., Glueck, B., Han, Y., Mohammad, M.A., and Cresci, G.A.M. (2019). A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice. Nutrients, 11.","DOI":"10.3390\/nu11010097"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chang, B., Sang, L., Wang, Y., Tong, J., Zhang, D., and Wang, B. (2013). The protective effect of VSL#3 on intestinal permeability in a rat model of alcoholic intestinal injury. BMC Gastroenterol., 13.","DOI":"10.1186\/1471-230X-13-151"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Wang, X., Zhu, L., Tu, Y., Chen, W., Gong, L., Pan, T., Lin, H., Lin, J., and Sun, H. (2022). Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg\/Th1 cells. Toxicol. Appl. Pharmacol., 439.","DOI":"10.1016\/j.taap.2022.115923"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12602-022-10005-x","article-title":"Compound Probiotic Ameliorates Acute Alcoholic Liver Disease in Mice by Modulating Gut Microbiota and Maintaining Intestinal Barrier","volume":"15","author":"Liu","year":"2023","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lu, J., Zhu, X., Zhang, C., Lu, F., Lu, Z., and Lu, Y. (2020). Co-expression of alcohol dehydrogenase and aldehyde dehydrogenase in Bacillus subtilis for alcohol detoxification. Food Chem. Toxicol., 135.","DOI":"10.1016\/j.fct.2019.110890"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/07315724.2019.1627955","article-title":"Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish","volume":"39","author":"Pasqualotto","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/jcpe.13833","article-title":"Porphyromonas gingivalis exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice","volume":"50","author":"Gao","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/1751-7915.14303","article-title":"Acetobacter pasteurianus BP2201 alleviates alcohol-induced hepatic and neuro-toxicity and modulate gut microbiota in mice","volume":"16","author":"Wen","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fang, C., Cheng, J., Jia, W., and Xu, Y. (2023). Akkermansia muciniphila Ameliorates Alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis. Metabolites, 13.","DOI":"10.3390\/metabo13101057"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gan, Y., Chen, X., Yi, R., and Zhao, X. (2021). Antioxidative and Anti-Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol-Induced Subacute Hepatic Damage. Oxid. Med. Cell. Longev., 2021.","DOI":"10.1155\/2021\/7337988"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Liu, Z., Liu, T., Zhang, Z., and Fan, Y. (2024). Bacillus coagulans regulates gut microbiota and ameliorates the alcoholic-associated liver disease in mice. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1337185"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Tian, X., Li, R., Jiang, Y., Zhao, F., Yu, Z., Wang, Y., Dong, Z., Liu, P., and Li, X. (2020). Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake. J. Funct. Foods, 72.","DOI":"10.1016\/j.jff.2020.104045"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhao, M., Chen, C., Yuan, Z., Li, W., Zhang, M., Cui, N., Duan, Y., Zhang, X., and Zhang, P. (2021). Dietary Bacillus subtilis supplementation alleviates alcohol-induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Exp. Ther. Med., 22.","DOI":"10.3892\/etm.2021.10747"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Arora, S., Kaur, I.P., Chopra, K., and Rishi, P. (2014). Efficiency of double layered microencapsulated probiotic to modulate proinflammatory molecular markers for the management of alcoholic liver disease. Mediat. Inflamm., 2014.","DOI":"10.1155\/2014\/715130"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.3168\/jds.2019-16891","article-title":"Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease","volume":"102","author":"Nam","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1039\/C9FO02040C","article-title":"Komagataeibacter hansenii CGMCC 3917 alleviates alcohol-induced liver injury by regulating fatty acid metabolism and intestinal microbiota diversity in mice","volume":"11","author":"Lin","year":"2020","journal-title":"Food Funct."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lv, J., Lang, G., Wang, Q., Zhao, W., Shi, D., Zhou, Z., Shen, Y., Xia, H., Han, S., and Li, L. (2024). Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice. Microb. Biotechnol., 17.","DOI":"10.1111\/1751-7915.70016"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1163\/18762891-bja00022","article-title":"Lacticaseibacillus rhamnosus LRa05 alleviated liver injury in mice with alcoholic fatty liver disease by improving intestinal permeability and balancing gut microbiota","volume":"15","author":"Gu","year":"2024","journal-title":"Benef. Microbes"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Li, H., Cheng, S., Huo, J., Dong, K., Ding, Y., Man, C., Zhang, Y., and Jiang, Y. (2022). Lactobacillus plantarum J26 Alleviating Alcohol-Induced Liver Inflammation by Maintaining the Intestinal Barrier and Regulating MAPK Signaling Pathways. Nutrients, 15.","DOI":"10.3390\/nu15010190"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.26599\/FSHW.2022.9250172","article-title":"Lactobacillus plantarum J26 alleviates alcohol-induced oxidative liver injury by regulating the Nrf2 signaling pathway","volume":"13","author":"Li","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jff.2019.05.018","article-title":"Protective effects of probiotics on acute alcohol-induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-\u03b1 response reduction","volume":"59","author":"Zhang","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s12275-015-5239-5","article-title":"Lactobacillus rhamnosus CCFM1107 treatment ameliorates alcohol-induced liver injury in a mouse model of chronic alcohol feeding","volume":"53","author":"Tian","year":"2015","journal-title":"J. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.ajpath.2011.08.039","article-title":"Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury","volume":"179","author":"Wang","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/jmf.2018.4357","article-title":"Lactobacillus rhamnosus Granules Dose-Dependently Balance Intestinal Microbiome Disorders and Ameliorate Chronic Alcohol-Induced Liver Injury","volume":"23","author":"Gu","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Liu, H., Fan, D., Wang, J., Wang, Y., Li, A., Wu, S., Zhang, B., Liu, J., and Wang, S. (2024). Lactobacillus rhamnosus NKU FL1-8 Isolated from Infant Feces Ameliorates the Alcoholic Liver Damage by Regulating the Gut Microbiota and Intestinal Barrier in C57BL\/6J Mice. Nutrients, 16.","DOI":"10.3390\/nu16132139"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Jung, H., You, S., Choi, S.-I., Kang, C.-H., and Kim, G.-H. (2022). Levilactobacillus brevis MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL\/6 Mice. Microorganisms, 10.","DOI":"10.3390\/microorganisms10122488"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zheng, T.-X., Pu, S.-L., Tan, P., Du, Y.-C., Qian, B.-L., Chen, H., Fu, W.-G., and Huang, M.-Z. (2020). Liver Metabolomics Reveals the Effect of Lactobacillus reuteri on Alcoholic Liver Disease. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.595382"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bull-Otterson, L., Feng, W., Kirpich, I., Wang, Y., Qin, X., Liu, Y., Gobejishvili, L., Joshi-Barve, S., Ayvaz, T., and Petrosino, J. (2013). Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053028"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.3748\/wjg.v26.i40.6224","article-title":"New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism","volume":"26","author":"Jiang","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1007\/s00253-019-10122-8","article-title":"Protective effects of Lactobacillus plantarum against chronic alcohol-induced liver injury in the murine model","volume":"103","author":"Fang","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wei, L., Pan, Y., Guo, Y., Zhu, Y., Jin, H., Gu, Y., Li, C., Wang, Y., Lin, J., and Chen, Y. (2024). Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1355225"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1111\/acer.12456","article-title":"Pyrroloquinoline quinone-secreting probiotic Escherichia coli Nissle 1917 ameliorates ethanol-induced oxidative damage and hyperlipidemia in rats","volume":"38","author":"Singh","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sangineto, M., Grander, C., Grabherr, F., Mayr, L., Enrich, B., Schw\u00e4rzler, J., Dallio, M., Bukke, V.N., Moola, A., and Moschetta, A. (2022). Recovery of Bacteroides thetaiotaomicron ameliorates hepatic steatosis in experimental alcohol-related liver disease. Gut Microbes, 14.","DOI":"10.1080\/19490976.2022.2089006"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Liang, X., Shan, T., Zheng, X., Zhang, Z., Fan, Y., Zhang, H., Zhang, L., and Liang, H. (2024). Study on the Regulatory Mechanism of Niacin Combined with B. animalis F1-7 in Alleviating Alcoholic Fatty Liver Disease by Up-Regulating GPR109A. Nutrients, 16.","DOI":"10.3390\/nu16234170"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12650","DOI":"10.1080\/21655979.2022.2070998","article-title":"The amelioration of alcohol-induced liver and intestinal barrier injury by Lactobacillus rhamnosus Gorbach-Goldin (LGG) is dependent on Interleukin 22 (IL-22) expression","volume":"13","author":"Ge","year":"2022","journal-title":"Bioengineered"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, X., Wang, Y., Zhang, J., Lu, G., You, Y., Wang, Y., Sun, H., Nan, B., and Wang, Y. (2022). The effect of Lactobacillus rhamnosus B10on alcoholic liver injury and intestinal microbiota in alcohol-induced mice model. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14372"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.4014\/jmb.2407.07051","article-title":"Therapeutic Potential of Lactiplantibacillus plantarum FB091 in Alleviating Alcohol-Induced Liver Disease through Gut-Liver Axis","volume":"34","author":"Lee","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jnutbio.2013.02.001","article-title":"Lactobacillus rhamnosus GG reduces hepatic TNF\u03b1 production and inflammation in chronic alcohol-induced liver injury","volume":"24","author":"Wang","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/pr501121c","article-title":"Hepatic and fecal metabolomic analysis of the effects of Lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice","volume":"14","author":"Shi","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Barone, R., Rappa, F., Macaluso, F., Bavisotto, C.C., Sangiorgi, C., Di Paola, G., Tomasello, G., Di Felice, V., Marcian\u00f2, V., and Farina, F. (2016). Alcoholic Liver Disease: A Mouse Model Reveals Protection by Lactobacillus fermentum. Clin. Transl. Gastroenterol., 7.","DOI":"10.1038\/ctg.2015.66"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Zhang, X., Huang, W., Luo, M., Feng, X., Zhang, H., and Qi, Q. (2025). Protective Effect of Enterococcus faecium Against Alcohol-Induced Acute Liver Injury Via Extracellular Vesicles in Rats. Foodborne Pathog. Dis., Online ahead of print.","DOI":"10.1089\/fpd.2025.0005"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Niu, B., Huang, L., Cheng, X., Pei, Z., Wang, H., Tian, F., and Lu, W. (2024). Lacticaseibacillus rhamnosus CCFM1060 Modulates gut microbiota and intestinal barrier Function: Alcoholic liver disease Mitigation through Nrf2\/HO-1 and NF-\u03baB Pathways. J. Funct. Foods, 122.","DOI":"10.1016\/j.jff.2024.106516"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.alcohol.2008.12.009","article-title":"Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis","volume":"43","author":"Forsyth","year":"2009","journal-title":"Alcohol"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/00952990.2019.1669629","article-title":"Changes in the composition of the human intestinal microbiome in alcohol use disorder: A systematic review","volume":"46","author":"Litwinowicz","year":"2020","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11605-021-05188-7","article-title":"The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases","volume":"26","author":"An","year":"2022","journal-title":"J. Gastrointest. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kawaratani, H., Tsujimoto, T., Douhara, A., Takaya, H., Moriya, K., Namisaki, T., Noguchi, R., Yoshiji, H., Fujimoto, M., and Fukui, H. (2013). The effect of inflammatory cytokines in alcoholic liver disease. Mediat. Inflamm., 2013.","DOI":"10.1155\/2013\/495156"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: Pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1194\/jlr.R119000547","article-title":"Alcohol effects on hepatic lipid metabolism","volume":"61","author":"Jeon","year":"2020","journal-title":"J. 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