{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T01:42:04Z","timestamp":1779327724862,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007822","name":"Almond Board of California, USA","doi-asserted-by":"publisher","award":["SH-22-Udipi-NR-01"],"award-info":[{"award-number":["SH-22-Udipi-NR-01"]}],"id":[{"id":"10.13039\/100007822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objectives: This randomized, controlled, parallel-group study was conducted to evaluate the effectiveness of daily almond consumption on acne lesion counts, skin hydration, sebum production, and skin microflora composition in 18\u201335-year-old young adults with acne vulgaris in Mumbai, India. Methods: A defined amount of whole, unsalted almonds with skin (60 g) was provided to the experimental group (n = 36). The control group (n = 38) received isocaloric cereal-pulse-based snack varieties. The primary endpoints were changes in inflammatory, non-inflammatory, and total acne lesion counts after 20 weeks of supplementation. Secondary endpoints included changes in facial sebum, hydration levels, skin morphology and microflora, and selected biochemical parameters. Results: At week 20, the almond group showed greater reductions in total lesion counts (\u221222.2% vs. \u22129.8%), inflammatory lesion counts (\u22128.3% vs. +12%), and non-inflammatory lesion counts (\u221226.1% vs. \u221220.4%) than controls. Objective lesion volume, area, and height measures for both single and clustered acne decreased in the almond group (p \u2264 0.001). Microbial diversity increased, with the Shannon index (2.6 to 3.4 (p = 0.039) and the Chao1 richness index (266.9 \u2192 835.2; p &lt; 0.001) showing improvements at endline. Moreover, significant post-intervention changes in the psychosocial outcomes, such as the acne-related quality of life scores (p &lt; 0.001) and anxiety symptoms (p = 0.016), were observed in the almond group. Conclusions: Daily almond consumption reduced acne lesion count and improved skin microbial diversity and acne-specific quality of life, highlighting its potential to complement standard acne treatments and support skin health.<\/jats:p>","DOI":"10.3390\/nu18040625","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:51:32Z","timestamp":1771005092000},"page":"625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Almond Supplementation Improves Acne Lesions and Skin Microbial Diversity in Adults with Mild to Moderate Acne Vulgaris"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-2794","authenticated-orcid":false,"given":"Panchali","family":"Moitra","sequence":"first","affiliation":[{"name":"Department of Postgraduate Programs and Research, Sir Vithaldas Thackersey College of Home Science (Empowered Autonomous Status), Shreemathi Nathibai Damodar Thackersey Women\u2019s University, Mumbai 400049, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1472-0821","authenticated-orcid":false,"given":"Jagmeet","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Food, Nutrition and Dietetics, Sir Vithaldas Thackersey College of Home Science (Empowered Autonomous Status), Shreemathi Nathibai Damodar Thackersey Women\u2019s University, Mumbai 400049, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8287-5183","authenticated-orcid":false,"given":"Krisha","family":"Shah","sequence":"additional","affiliation":[{"name":"Research, Innovation, Consultancy & Collaboration Centre, Sir Vithaldas Thackersey College of Home Science (Empowered Autonomous Status), Shreemathi Nathibai Damodar Thackersey Women\u2019s University, Mumbai 400049, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradnya","family":"Mandavkar","sequence":"additional","affiliation":[{"name":"Research, Innovation, Consultancy & Collaboration Centre, Sir Vithaldas Thackersey College of Home Science (Empowered Autonomous Status), Shreemathi Nathibai Damodar Thackersey Women\u2019s University, Mumbai 400049, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Joshi","sequence":"additional","affiliation":[{"name":"Clinical Aesthetics and Investigative Management Services Pvt Ltd., Andheri East, Mumbai 400093, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumik","family":"Kalita","sequence":"additional","affiliation":[{"name":"FamPhy, Gurugram 122101, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-2795","authenticated-orcid":false,"given":"Shobha A.","family":"Udipi","sequence":"additional","affiliation":[{"name":"Kasturba Integrative Health Society\u2014Medical Research Foundation (KiHS-MRF), Vile Parle West, Mumbai 400056, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1111\/jocd.14040","article-title":"Prevalence of Acne Vulgaris and Its Clinico-Epidemiological Pattern in Adult Patients: Results of a Prospective, Observational Study","volume":"20","author":"Shah","year":"2021","journal-title":"J. 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