{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:03:50Z","timestamp":1771567430106,"version":"3.50.1"},"reference-count":143,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFF0710402"],"award-info":[{"award-number":["2022YFF0710402"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Functional food research has long emphasized isolated bioactive compounds, yet such single-target strategies often show limited efficacy against complex, multifactorial processes such as brain aging. In this review, we examine edible bird\u2019s nest (EBN) as a representative multi-component functional food and discuss how its complex food matrix may exert coordinated neuroprotective effects. We summarize the major bioactive constituents of EBN, including sialic acid, functional glycoproteins, and bioactive peptides, and organize their actions into functional modules related to oxidative stress, neuroinflammation, apoptosis, synaptic maintenance, and neurotrophic support. Emerging evidence on the prebiotic potential of EBN and its modulation of the gut\u2013brain axis is also integrated, highlighting interactions between peripheral metabolic regulation and central nervous system function. By comparing EBN with conventional functional ingredients such as vitamins C and E, coenzyme Q10, curcumin, and omega-3 fatty acids, we propose that EBN represents a distinctive \u201cnetwork-regulatory\u201d food system in which nutritional support and pathway modulation are intrinsically linked. Overall, this review provides a conceptual framework for understanding how complex food matrices can be rationally applied to support brain health and reduce age-related neurodegenerative risk.<\/jats:p>","DOI":"10.3390\/nu18040671","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:28:18Z","timestamp":1771428498000},"page":"671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Edible Bird\u2019s Nest as a Multi-Component Functional Food for Brain Aging: From Single-Bioactive Actions to Network-Regulatory Mechanisms"],"prefix":"10.3390","volume":"18","author":[{"given":"Wenjuan","family":"Gong","sequence":"first","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"},{"name":"College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Food Laboratory of Zhongyuan, Luohe 462000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-4067","authenticated-orcid":false,"given":"Pengcheng","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ekiz, E., Oz, E., Abd El-Aty, A.M., Proestos, C., Brennan, C., Zeng, M., Tomasevic, I., Elobeid, T., Cadirci, K., and Bayrak, M. 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