{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T05:59:46Z","timestamp":1771739986014,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["25gk0210046h0001"],"award-info":[{"award-number":["25gk0210046h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: The oxidative balance score (OBS) is an indicator for assessing total oxidant status. This cross-sectional study aimed to investigate the relationships between OBS and factors associated with well-being among middle-aged and elderly women. Methods: Dietary habits, lifestyle factors, and factors associated with well-being, including physical, mental, and social health, were assessed based on the first-visit medical records in 385 Japanese women. The OBS was calculated using pro-oxidant factors (fat, saturated fatty acids, n-6 polyunsaturated fatty acids, iron, alcohol, smoking, body mass index, and waist circumference) and antioxidant factors (zinc, vitamins C, E, A, n-3 polyunsaturated fatty acids, genistein, and exercise). Results: After adjusting for age, menopausal status, and background factors, social engagement and weight-adjusted appendicular skeletal muscle mass (ASM\/Wt) were found to be significantly associated with OBS (social involvement, odds ratio = 0.882, 95% confidence interval [CI] = 0.817\u20130.949, p = 0.001; ASM\/Wt, odds ratio = 0.983, 95% CI = 0.974\u20130.990, p &lt; 0.001). Conclusions: Higher oxidative stress was associated with a low level of social involvement and ASM\/Wt. These findings indicate that oxidative balance is linked to social and physical aspects of well-being among middle-aged and older women. However, because of the cross-sectional design, causal relationships cannot be inferred, and the possibility of reverse causation should be considered.<\/jats:p>","DOI":"10.3390\/nu18040688","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T15:57:11Z","timestamp":1771603031000},"page":"688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative Balance Score Is Associated with Social Involvement and Weight-Adjusted Appendicular Skeletal Muscle Mass in Middle-Aged and Older Japanese Women"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7007-2324","authenticated-orcid":false,"given":"Tamami","family":"Odai","sequence":"first","affiliation":[{"name":"Department of Women\u2019s Health, Institute of Science Tokyo, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-0094","authenticated-orcid":false,"given":"Masakazu","family":"Terauchi","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Institute of Science Tokyo, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Enokuchi","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Institute of Science Tokyo, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-8352","authenticated-orcid":false,"given":"Naoyuki","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Science Tokyo, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yoh, K., Ikeda, K., Horie, K., and Inoue, S. 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