{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:38:28Z","timestamp":1790033908738,"version":"4.0.1"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Smarter Food Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remain unknown. This study aimed to evaluate whether short-term supplementation with broccoli-derived glucoraphanin improves recovery from exercise-induced muscle damage. We hypothesized that short-term supplementation with broccoli-derived glucoraphanin would attenuate exercise-induced muscle damage and accelerate recovery. Methods: In a randomized, double-blind, placebo-controlled crossover design, fifteen participants consumed either high-glucoraphanin broccoli powder (320 \u03bcg) or placebo for two weeks, followed by elbow flexor eccentric exercise. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology were measured at baseline, immediately post-exercise, and at 48 and 96 h post-exercise. Results: Significant main effects of time were observed for isometric and isokinetic torque (p &lt; 0.05), CK (p &lt; 0.05), soreness (p &lt; 0.05), and structural swelling markers (p &lt; 0.05), confirming exercise-induced muscle damage. However, there were no significant Time \u00d7 Supplement interactions for any variable (p &gt; 0.05), indicating that glucoraphanin did not influence recovery dynamics. Conclusions: These findings suggest that short-term high-dose broccoli supplementation reconstituted with hot water does not modulate recovery following eccentric muscle damage under the conditions tested, including the chosen preparation method and experimental context.<\/jats:p>","DOI":"10.3390\/nu18040710","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T14:05:11Z","timestamp":1771855511000},"page":"710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-1836","authenticated-orcid":false,"given":"Leonardo","family":"Cesanelli","sequence":"first","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rono","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mantas","family":"Mickevi\u010dius","sequence":"additional","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrius","family":"Snie\u010dkus","sequence":"additional","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4327-6651","authenticated-orcid":false,"given":"Dalia","family":"Mickevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-6616","authenticated-orcid":false,"given":"Tomas","family":"Venck\u016bnas","sequence":"additional","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvydas","family":"Stasiulis","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Rehabilitation, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-1069","authenticated-orcid":false,"given":"Sigitas","family":"Kamandulis","sequence":"additional","affiliation":[{"name":"Institute of Sport Science and Innovations, Lithuanian Sports University, 44225 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00424-023-02794-z","article-title":"Eccentric Muscle Contractions: From Single Muscle Fibre to Whole Muscle Mechanics","volume":"475","author":"Tomalka","year":"2023","journal-title":"Pflugers Arch. 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