{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:28:37Z","timestamp":1789687717223,"version":"4.0.1"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004817","name":"Medical Faculty of Lund University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5ne University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Crafoord Foundation"},{"name":"the Kockska Foundation"},{"name":"the Research Funds of Region Sk\u00e5ne"},{"name":"the Swedish Heart and Lung Foundation","award":["2024-0979"],"award-info":[{"award-number":["2024-0979"]}]},{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","award":["2022-00973"],"award-info":[{"award-number":["2022-00973"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Wallenberg Center for Molecular Medicine, Lund University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Selenium (Se), an essential trace element, is linked to poor prognosis in heart failure (HF) and kidney disease. Se deficiency (serum Se &lt; 70 \u03bcg\/L) has been associated with increased cardiovascular mortality. Selenoprotein P (SELENOP), the main Se transporter, reflects bioavailable Se. Selective glomerular hypofiltration syndrome (SGHS), defined by a cystatin C-based eGFR &lt; 0.7 of creatinine-based eGFR, signals early kidney dysfunction and worsens HF outcomes. The prognostic role of SELENOP for SGHS and kidney-related hospitalization in HF remains unclear. Purpose: To assess whether SELENOP is associated with SGHS at baseline and future kidney disease hospitalization in acute HF patients. Methods: In 570 patients hospitalized for acute HF, creatinine and cystatin C were analyzed; SELENOP was measured in the first 320 using an immunoassay. Kidney hospitalizations (ICD-10 N17\u2013N19) were identified from regional registries. Logistic and Cox regression models evaluated SELENOP\u2019s association with SGHS and hospitalization risk, adjusting for age, sex, blood pressure, BMI, eGFR and NT-proBNP. Results: Among 320 patients (mean age 75 years, 69% male), 58% had Se deficiency, and 30% had SGHS. During a median 43-month follow-up, 28 patients were hospitalized for kidney disease. Higher SELENOP was linked to lower odds of SGHS (OR 0.69; p = 0.002) and reduced risk of hospitalization for AKI or CKD (HR 0.60; p = 0.010), particularly AKI (HR 0.42; p = 0.002). SELENOP-deficiency (&lt;3.23 mg\/L) predicted AKI hospitalization (HR 4.02; p = 0.035). Conclusions: Low SELENOP is associated with SGHS and increased risk of kidney disease hospitalization, especially AKI, suggesting Se status may influence HF and renal outcomes.<\/jats:p>","DOI":"10.3390\/nu18050721","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:05:27Z","timestamp":1771945527000},"page":"721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-1727","authenticated-orcid":false,"given":"Marcus Andr\u00e9as","family":"Ohlsson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Sk\u00e5ne University Hospital, 214 28 Malm\u00f6, Sweden"},{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Molvin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Lund University, 205 02 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Holm Isholth","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Lund University, 205 02 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-8418","authenticated-orcid":false,"given":"Anders","family":"Christensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Nephrology, Sk\u00e5ne University Hospital, 214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Nephrology, Sk\u00e5ne University Hospital, 214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4020-1467","authenticated-orcid":false,"given":"Agne","family":"Laucyte-Cibulskiene","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Nephrology, Sk\u00e5ne University Hospital, 214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Grubb","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sk\u00e5ne University Hospital, Lund University, 205 02 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-1555","authenticated-orcid":false,"given":"Lutz","family":"Schomburg","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Experimentelle Endokrinologie, Campus Charit\u00e9 Mitte, Charite-Universit\u00e4tsmedizin, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-0158","authenticated-orcid":false,"given":"Amra","family":"Jujic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-5936","authenticated-orcid":false,"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Cardiology, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Wallenberg Center for Molecular Medicine, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Hypertension in Africa Research Team (HART), North-West University Potchefstroom, Potchefstroom 2531, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e13662","DOI":"10.1111\/asj.13662","article-title":"Selenium and the health status, production results, and product quality in poultry","volume":"92","author":"Michalczuk","year":"2021","journal-title":"Anim. Sci. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Maia, L.B., Maiti, B.K., Moura, I., and Moura, J.J.G. (2023). Selenium-More than Just a Fortuitous Sulfur Substitute in Redox Biology. Molecules, 29.","DOI":"10.3390\/molecules29010120"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9258(19)68065-8","article-title":"Factor 3 activity of selenium compounds","volume":"233","author":"Schwarz","year":"1958","journal-title":"J. Biol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tibs.2013.12.007","article-title":"Selenium and selenocysteine: Roles in cancer, health, and development","volume":"39","author":"Hatfield","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Razzaque, M.S., and Wimalawansa, S.J. (2025). Minerals and Human Health: From Deficiency to Toxicity. Nutrients, 17.","DOI":"10.3390\/nu17030454"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.freeradbiomed.2024.06.027","article-title":"Selenoprotein P increases upon selenium and coenzyme Q(10) supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality","volume":"222","author":"Alehagen","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMoa1012985","article-title":"Selenium and the course of mild Graves\u2019 orbitopathy","volume":"364","author":"Marcocci","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_9","first-page":"320","article-title":"An original discovery: Selenium deficiency and Keshan disease (an endemic heart disease)","volume":"21","author":"Chen","year":"2012","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/ejhf.1644","article-title":"Selenium and outcome in heart failure","volume":"22","author":"Bomer","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/JCN.0000000000000322","article-title":"Dietary Micronutrient Intake and Micronutrient Status in Patients With Chronic Stable Heart Failure: An Observational Study","volume":"32","author":"McKeag","year":"2017","journal-title":"J. Cardiovasc. Nurs."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.numecd.2010.08.006","article-title":"Nutritional intake and oxidative stress in chronic heart failure","volume":"22","author":"Hughes","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11897-021-00511-4","article-title":"Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective","volume":"18","author":"Bomer","year":"2021","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000323538","article-title":"Serum selenium levels in hemodialysis patients are significantly lower than those in healthy controls","volume":"32","author":"Fujishima","year":"2011","journal-title":"Blood Purif."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2215\/CJN.11451017","article-title":"Concentrations of Trace Elements and Clinical Outcomes in Hemodialysis Patients: A Prospective Cohort Study","volume":"13","author":"Tonelli","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.5301\/jn.5000213","article-title":"Selenium and kidney disease","volume":"26","author":"Iglesias","year":"2013","journal-title":"J. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Azevedo, R., Gennaro, D., Duro, M., Pinto, E., and Almeida, A. (2023). Further Evidence on Trace Element Imbalances in Haemodialysis Patients-Paired Analysis of Blood and Serum Samples. Nutrients, 15.","DOI":"10.3390\/nu15081912"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2022.08.022","article-title":"Selenoprotein P\u2014Selenium transport protein, enzyme and biomarker of selenium status","volume":"191","author":"Schomburg","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-nutr-071714-034250","article-title":"Regulation of Selenium Metabolism and Transport","volume":"35","author":"Burk","year":"2015","journal-title":"Annu. Rev. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jtemb.2015.07.005","article-title":"Revised reference values for selenium intake","volume":"32","author":"Kipp","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Alexander, J., and Olsen, A.K. (2023). Selenium\u2014A scoping review for Nordic Nutrition Recommendations 2023. Food Nutr. Res., 67.","DOI":"10.29219\/fnr.v67.10320"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3945\/ajcn.2009.28169","article-title":"Establishing optimal selenium status: Results of a randomized, double-blind, placebo-controlled trial","volume":"91","author":"Hurst","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103755","DOI":"10.1016\/j.redox.2025.103755","article-title":"Associations of selenium status with all-cause and cause-specific mortality: A systematic review and meta-analysis of cohort studies","volume":"85","author":"Cui","year":"2025","journal-title":"Redox Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103701","DOI":"10.1016\/j.redox.2025.103701","article-title":"Colorectal cancer mortality is associated with low selenoprotein P status at diagnosis","volume":"84","author":"Brezina","year":"2025","journal-title":"Redox Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clnu.2025.08.024","article-title":"Proteomic signatures of grip strength and healthy aging among older adults: A prospective cohort study in the UK Biobank","volume":"53","author":"Liu","year":"2025","journal-title":"Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1074\/jbc.M709945200","article-title":"Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells","volume":"283","author":"Olson","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/00365513.2015.1025427","article-title":"Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: \u2018Shrunken pore syndrome\u2019","volume":"75","author":"Grubb","year":"2015","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/joim.13589","article-title":"The complexity of kidney disease and diagnosing it\u2014Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation","volume":"293","author":"Malmgren","year":"2023","journal-title":"J. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2177991","DOI":"10.1155\/2022\/2177991","article-title":"Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases","volume":"2022","author":"Wu","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1002\/ehf2.13485","article-title":"The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: The HARVEST-Malm\u00f6 study","volume":"8","author":"Xhakollari","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.trsl.2015.11.001","article-title":"The cystatin C\/creatinine ratio, a marker of glomerular filtration quality: Associated factors, reference intervals, and prediction of morbidity and mortality in healthy seniors","volume":"169","author":"Purde","year":"2016","journal-title":"Transl. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2215\/CJN.0000000000000523","article-title":"Large Discordance between Creatinine-Based and Cystatin C-Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults","volume":"19","author":"Thacker","year":"2024","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00365513.2016.1223338","article-title":"The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population\u2014The HARVEST study","volume":"76","author":"Christensson","year":"2016","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/00365513.2020.1759139","article-title":"Shrunken pore syndrome and mortality: A cohort study of patients with measured GFR and known comorbidities","volume":"80","author":"Nyman","year":"2020","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102823","DOI":"10.1016\/j.redox.2023.102823","article-title":"Sex-specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II","volume":"65","author":"Demircan","year":"2023","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3109\/00365513.2011.557086","article-title":"Revised equations for estimating glomerular filtration rate based on the Lund-Malm\u00f6 Study cohort","volume":"71","author":"Grubb","year":"2011","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1373\/clinchem.2013.220707","article-title":"Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator","volume":"60","author":"Grubb","year":"2014","journal-title":"Clin. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1515\/cclm-2013-0741","article-title":"The revised Lund-Malm\u00f6 GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population","volume":"52","author":"Nyman","year":"2014","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.redox.2016.12.025","article-title":"Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P","volume":"11","author":"Hybsier","year":"2017","journal-title":"Redox Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/00365513.2025.2546320","article-title":"Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome\u2014A new kidney disorder defining selective glomerular hypofiltration syndromes\u2014Calls for expansion of the international KDIGO guidelines","volume":"85","author":"Malmgren","year":"2025","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1053\/j.ajkd.2023.08.001","article-title":"Etiologic and Diagnostic Implications of Morbidity and Mortality Associations When Cystatin C-Based Estimated GFR Is Lower Than Creatinine-Based Estimated GFR","volume":"82","author":"Grubb","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1039\/D3FO03212D","article-title":"Association between adequate dietary protein and all-cause and cardiovascular mortality in patients with selective glomerular hypofiltration syndrome","volume":"15","author":"Shen","year":"2024","journal-title":"Food Funct."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Esquinas, E., Carballo-Casla, A., Ortol\u00e1, R., Sotos-Prieto, M., Olmedo, P., Gil, F., Plans-Beriso, E., Fern\u00e1ndez-Navarro, P., Pastor-Barriuso, R., and Rodr\u00edguez-Artalejo, F. (2023). Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults. Nutrients, 15.","DOI":"10.3390\/nu15224750"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/07315724.1986.10720128","article-title":"Selenium status of malnourished hospitalized patients","volume":"5","author":"Smith","year":"1986","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_45","first-page":"1208","article-title":"Cardiorenal Syndrome and Heart Failure-Challenges and Opportunities","volume":"35","author":"Yogasundaram","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e027980","DOI":"10.1161\/JAHA.122.027980","article-title":"Shrunken Pore Syndrome: A New and More Powerful Phenotype of Renal Dysfunction Than Chronic Kidney Disease for Predicting Contrast-Associated Acute Kidney Injury","volume":"12","author":"Zhang","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_47","first-page":"e14939","article-title":"Potential relationship between eGFR(cystatin C)\/eGFR(creatinine)-ratio and glomerular basement membrane thickness in diabetic kidney disease","volume":"9","author":"Grubb","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_48","first-page":"30129","article-title":"The effectiveness of antioxidant agents in delaying progression of diabetic nephropathy: A systematic review of randomized controlled trials","volume":"15","author":"Rahayu","year":"2025","journal-title":"Bioimpacts"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1093\/jn\/nxac211","article-title":"Inverse Association Between Baseline Plasma Selenium Concentrations and Risks of Renal Function Decline in Hypertensive Adults","volume":"152","author":"Li","year":"2023","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Alehagen, U., Aaseth, J., Alexander, J., Brismar, K., and Larsson, A. (2020). Selenium and Coenzyme Q10 Supplementation Improves Renal Function in Elderly Deficient in Selenium: Observational Results and Results from a Subgroup Analysis of a Prospective Randomised Double-Blind Placebo-Controlled Trial. Nutrients, 12.","DOI":"10.3390\/nu12123780"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and selenoproteins: It\u2019s role in regulation of inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant Mechanisms in Renal Injury and Disease","volume":"25","author":"Ratliff","year":"2016","journal-title":"Antioxid. Redox Signal."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/5\/721\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:12:34Z","timestamp":1772082754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/5\/721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["nu18050721"],"URL":"https:\/\/doi.org\/10.3390\/nu18050721","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]}}}