{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:38:28Z","timestamp":1785609508848,"version":"3.56.0"},"reference-count":108,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017529","name":"Major Scientific and Technological Project of Zhejiang Province","doi-asserted-by":"crossref","award":["2024C04029"],"award-info":[{"award-number":["2024C04029"]}],"id":[{"id":"10.13039\/501100017529","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017529","name":"Major Scientific and Technological Project of Zhejiang Province","doi-asserted-by":"crossref","award":["2023C04027"],"award-info":[{"award-number":["2023C04027"]}],"id":[{"id":"10.13039\/501100017529","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32302042"],"award-info":[{"award-number":["32302042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Cistanche deserticola Y. C. Ma (C. deserticola) is a widely recognized medicinal and edible homologous plant. Phenylethanoid glycosides (PhGs), as its dominant bioactive components, are characterized by diverse chemical structures and prominent multi-target synergistic pharmacological activities. This review aims to systematically outline the structural characteristics, structure\u2013activity relationships, and pharmacological mechanisms of typical PhGs from C. deserticola, so as to provide a scientific basis for their further development and application. Methods: A comprehensive literature review was performed. The structural features, structure\u2013activity relationships, and multi-dimensional pharmacological mechanisms of representative PhGs, including echinacoside, verbascoside, and cistanoside A, were systematically summarized and analyzed. Results: PhGs exert anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, antitumor, and hepatoprotective effects mainly by regulating multiple signaling pathways, such as NF-\u03baB, MAPK, PI3K\/Akt, and Nrf2\/HO-1. These compounds display promising application potential in the prevention and amelioration of chronic inflammatory diseases, aging-related disorders including Alzheimer\u2019s disease and osteoporosis, as well as oxidative stress-induced injury. Conclusions: PhGs from C. deserticola possess distinct pharmacological effects and broad application prospects. Future research should emphasize in-depth structure\u2013activity relationship investigations, multi-component synergistic mechanisms, safety evaluation, and formulation design to enhance bioavailability, thus promoting the industrial development and application of PhGs.<\/jats:p>","DOI":"10.3390\/nu18050725","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:58:18Z","timestamp":1771952298000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phenylethanoid Glycosides from Cistanche deserticola Y. C. Ma: Synergistic Effects, Multi-target Mechanisms and Translational Applications"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-7804","authenticated-orcid":false,"given":"Xiaofeng","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Han","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zherui","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory for Chem and Bio Processing Technology of Farm Produces, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfa","family":"Guan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e07368","DOI":"10.1016\/j.heliyon.2021.e07368","article-title":"Atriplex canescens: A new host for Cistanche deserticola","volume":"7","author":"Wang","year":"2021","journal-title":"Heliyon"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hou, L., Li, G., Chen, Q., Zhao, J., Pan, J., Lin, R., Zhu, X., Wang, P., and Wang, X. 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