{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:23:49Z","timestamp":1791689029107,"version":"4.3.4"},"reference-count":163,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P021220"],"award-info":[{"award-number":["MR\/P021220"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Type 2 diabetes (T2D) is a major global healthcare challenge and burden on the quality of life in affected individuals. While lifestyle management is the mainstay treatment for T2D, the advent of gut-incretin-based therapies with powerful effects on metabolic health, appetite and weight regulation has focussed attention on the role of the gut in the risk, progression and management of T2D. Beyond the tongue, intestinal sweet taste receptors (STRs) are increasingly being identified and functionally characterised. Growing evidence now supports a role for nutrient-activated (e.g., sugars) intestinal STRs in the release of gut hormones from enteroendocrine cells (EECs) and the control of blood glucose and body weight. However, the specific STR pathway and mechanisms linking STRs to these homeostatic controls are poorly understood, with a notable gap existing between evidence from preclinical studies and clinical validation. This review explores intestinal STR-EEC functions and the evidence on how these functions regulate glucose metabolism and energy homeostasis. We further discuss the impact of environmental and dietary factors on these signalling pathways. Full knowledge of the signalling and regulation of intestinal STR-EEC and integrated neural pathways will bridge the current knowledge gap, with a high potential to develop new novel strategies targeting STRs or EECs that preserve hedonic taste rewards and reduce cravings, as well as improve the management of individuals with metabolic diseases.<\/jats:p>","DOI":"10.3390\/nu18050759","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:58:03Z","timestamp":1772114283000},"page":"759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-3572","authenticated-orcid":false,"given":"Kyaw Linn","family":"Su Khin","sequence":"first","affiliation":[{"name":"Centre of Metabolism, Ageing & Physiology, School of Medicine, University of Nottingham, Royal Derby Hospital, Uttoxeter Road, Derby DE22 3DT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Youssefi","sequence":"additional","affiliation":[{"name":"Cancer Genetics & Stem Cell Group, The BioDiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1441-623X","authenticated-orcid":false,"given":"Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Food, Nutrition and Dietetics, School of Biosciences, Sutton Bonnington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK"},{"name":"Sensory Science Centre, Division of Food, Nutrition and Dietetics, Sutton Bonnington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-5865","authenticated-orcid":false,"given":"Amanda J.","family":"Page","sequence":"additional","affiliation":[{"name":"Lifelong Health, South Australia Health and Medical Research Institute (SAHMRI), Adelaide, SA 5000, Australia"},{"name":"Intestinal Nutrient Sensing Group, Adelaide Medical School and Centre Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-6813","authenticated-orcid":false,"given":"Abdolrahman S.","family":"Nateri","sequence":"additional","affiliation":[{"name":"Cancer Genetics & Stem Cell Group, The BioDiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"},{"name":"Academic Unit of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-1100","authenticated-orcid":false,"given":"Sally","family":"Eldeghaidy","sequence":"additional","affiliation":[{"name":"Intestinal Nutrient Sensing Group, Adelaide Medical School and Centre Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, SA 5005, Australia"},{"name":"Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-4951","authenticated-orcid":false,"given":"Richard L.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Food, Nutrition and Dietetics, School of Biosciences, Sutton Bonnington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK"},{"name":"Sensory Science Centre, Division of Food, Nutrition and Dietetics, Sutton Bonnington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-8288","authenticated-orcid":false,"given":"Iskandar","family":"Idris","sequence":"additional","affiliation":[{"name":"Centre of Metabolism, Ageing & Physiology, School of Medicine, University of Nottingham, Royal Derby Hospital, Uttoxeter Road, Derby DE22 3DT, UK"},{"name":"National Institute of Health Research (NIHR), Nottingham Biomedical Research Centre (BRC), Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref_1","unstructured":"(2026, February 20). 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