{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:46:41Z","timestamp":1788778001646,"version":"build-2803163510"},"reference-count":205,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}]},{"DOI":"10.13039\/501100012550","name":"National Research, Development and Innovation Fund","doi-asserted-by":"crossref","award":["RRF-2.3.1-21-2022-00003"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00003"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European University for Well-Being (EUniWell) program","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019-1"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019-1"]}]},{"name":"Cooperative Translational Research Program (KTKP) of the Faculty of Medicine, Semmelweis University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: The biological effects of dietary polyphenols have gained increasing attention due to their roles in regulating oxidative stress, inflammatory processes, and mitochondrial function. Human studies suggest that polyphenol intake may support aspects of post-exercise recovery, neuromuscular function, and selected aspects of physical performance. However, most investigations have been conducted in young or metabolically healthy populations, limiting direct clinical translation to older adults. Objective: This narrative review aims to synthesize current mechanistic and human evidence on the physiological and recovery-related effects of dietary polyphenols in the context of exercise adaptation and skeletal muscle function, and to examine their potential relevance to muscle aging and sarcopenia. Methods: A structured, non-systematic literature search was conducted to integrate findings from human intervention trials, preclinical studies, and mechanistic research addressing polyphenols, exercise adaptation, muscle recovery, and muscle aging. Evidence was synthesized narratively with emphasis on shared physiological pathways and functional outcomes. Results: Human intervention studies suggest that polyphenol intake may attenuate biomarkers of exercise-induced muscle damage, modulate inflammatory responses, and accelerate recovery of muscle strength and functional performance. Mechanistic evidence supports the involvement of redox homeostasis, mitochondrial regulation, and inflammatory signaling as central mediators of these effects. While clinical data in older populations remain limited, converging evidence suggests biological overlap between recovery-related pathways and mechanisms implicated in age-related muscle decline. Conclusions: Current evidence is consistent with a biologically plausible role for polyphenols in modulating exercise-related physiological and recovery processes. By aligning recovery-focused evidence with pathways central to muscle aging, this review proposes a translational framework that may inform the design of future targeted clinical trials in older and clinical populations.<\/jats:p>","DOI":"10.3390\/nu18050788","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:05:16Z","timestamp":1772211916000},"page":"788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Physiological and Recovery Responses to Dietary Polyphenols in the Context of Exercise: Relevance for Muscle Aging and Sarcopenia"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-4003","authenticated-orcid":false,"given":"Vince","family":"Fazekas-Pongor","sequence":"first","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-9745","authenticated-orcid":false,"given":"D\u00e1vid","family":"Major","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-1336","authenticated-orcid":false,"given":"J\u00e1nos Tam\u00e1s","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lehoczki","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Varga","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-5292","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Jarecsny","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke, Saint John\u2019s Central Hospital of North Buda, 1125 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7608-3041","authenticated-orcid":false,"given":"\u00c1gnes","family":"Lip\u00e9cz","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Cs\u00edp\u0151","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Szappanos","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-602X","authenticated-orcid":false,"given":"Attila","family":"Matiscs\u00e1k","sequence":"additional","affiliation":[{"name":"S-CAPE Cognitive and Health Prevention Research Group, Faculty of Health Sciences, Semmelweis University, 1088 Budapest, Hungary"},{"name":"Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-2120","authenticated-orcid":false,"given":"M\u00f3nika","family":"Fekete","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.cmet.2018.04.014","article-title":"Maximizing cellular 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