{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:18:50Z","timestamp":1787167130510,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: There is increasing interest in cosmeceuticals\u2014cosmetic regimes incorporating a specific probiotic or postbiotic strain, fully characterized genetically and phenotypically\u2014which, when topically applied, have the ability to modulate the skin microbiome, exhibit anti-inflammatory properties and improve the overall skin appearance by reducing signs of aging. In addition, claims have been made that emotional and psychological well-being can be improved by neuroactive substances released by the probiotics in cosmeceuticals, acting via the skin\u2013brain axis. However, claims are somewhat generalized and imprecise, and we deemed it important to look more precisely at published research relating to cosmeceuticals. There have been very few research publications on these products, identified as neurocosmetics, and they immediately provoked strong reactions from dermatologists and psychiatrists, mainly with regard to the ethical and safety aspects of their use. Objectives\/Method: The present strain-centered literature evaluation aimed to select from peer-reviewed publications referring to cosmeceuticals only those dealing with fully characterized, specific probiotic strains with documented beneficial skin properties. Eligible strains found were subsequently subjected to a secondary search to ascertain whether they also demonstrated clinical, or even experimental, evidence of strain-specific psychobiotic properties. Results: From 33 strain-specific cosmeceuticals identified, only three strains\u2014Lactococcus lactis subsp. cremoris H61, Limosilactobacillus reuteri DSM 17938, and Weizmannia coagulans MTCC 5856\u2014demonstrated reproducible evidence of psychobiotic potential. Conclusions: Current evidence does not support the notion that cosmeceuticals are likely to directly modulate emotional states through topical application, since the coexistence of cosmeceutical and psychobiotic properties within the same probiotic strain seems to be both uncommon and highly strain-specific and therefore of little practical, generalized use.<\/jats:p>","DOI":"10.3390\/nu18050817","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:18:45Z","timestamp":1772554725000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurocosmetics or Hype? Psychobiotic Potential of Strain-Specific Cosmeceuticals"],"prefix":"10.3390","volume":"18","author":[{"given":"Alexandra-Eleftheria","family":"Menni","sequence":"first","affiliation":[{"name":"Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Theodorou","sequence":"additional","affiliation":[{"name":"Department of Sociology, School of Social Sciences, University of Crete, 74100 Rethymno, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-8709","authenticated-orcid":false,"given":"Georgios","family":"Tzikos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-8037","authenticated-orcid":false,"given":"George","family":"Stavrou","sequence":"additional","affiliation":[{"name":"Department of Surgery, 417 NIMTS (Army Share Fund Hospital), 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3526-194X","authenticated-orcid":false,"given":"Ioannis M.","family":"Theodorou","sequence":"additional","affiliation":[{"name":"Hellenic Institute for the Study of Sepsis (HISS), 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Semertzidou","sequence":"additional","affiliation":[{"name":"Library of AHEPA University Hospital, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Venieri","sequence":"additional","affiliation":[{"name":"Scientific & Biomedical Information Centre, Storm Memorial Library, Windsor, IL 61957, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-6358","authenticated-orcid":false,"given":"Aristeidis","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne D.","family":"Shrewsbury","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-7216","authenticated-orcid":false,"given":"Katerina","family":"Kotzampassi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mafra, A.L., Silva, C.S.A., Varella, M.A.C., and Valentova, J.V. 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