{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:10:37Z","timestamp":1773389437599,"version":"3.50.1"},"reference-count":82,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R00-MH121355"],"award-info":[{"award-number":["R00-MH121355"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007165","name":"University of Missouri","doi-asserted-by":"publisher","award":["F8717"],"award-info":[{"award-number":["F8717"]}],"id":[{"id":"10.13039\/100007165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Pfeil Foundation, Inc.","award":["#30335"],"award-info":[{"award-number":["#30335"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Maternal immune activation (MIA) during pregnancy is a known risk factor for several neurodevelopmental and psychiatric disorders, including schizophrenia. In rodent models, MIA is commonly induced using polyinosinic\/polycytidylic acid (Poly(I\/C)), a viral mimetic that activates Toll-like receptor 3 (TLR3) signaling and elicits an inflammatory response in both the dam and the fetuses. MIA results in various behavioral abnormalities in offspring, including deficits in social interaction. Recent studies have shown that MIA decreases the ability to maintain mitochondrial membrane potential (\u0394\u03a8m), the electrical component of the electrochemical gradient required for ATP production and alters mitochondrial protein expression in brain tissue isolated from adult offspring. Methods: In the present study, we monitor \u0394\u03a8m non-invasively in vivo using a previously published bioluminescence probe in juvenile and adult MIA offspring. We then investigated gene expression in the medial prefrontal cortex of MIA offspring by analyzing a previously published RNA sequencing dataset in combination with MitoCarta3.0, a comprehensive inventory of genes involved in mitochondrial function. Finally, we tested the hypothesis that this mitochondrial dysfunction contributes to the behavioral deficits observed in MIA offspring. Results: We have observed impaired \u0394\u03a8m maintenance in juvenile MIA offspring that persists into adulthood. Also, we found that MIA alters the expression of many genes associated with mitochondrial energy production. We demonstrated that nicotinamide riboside, a precursor to NAD+ known to restore \u0394\u03a8m, significantly attenuates MIA-induced social interaction deficits. Conclusions: Together, these findings highlight mitochondrial function as a promising therapeutic target for symptoms associated with schizophrenia and support the potential for drug discovery aimed at enhancing mitochondrial health.<\/jats:p>","DOI":"10.3390\/nu18060889","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:43:18Z","timestamp":1773240198000},"page":"889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Immune Activation Leads to Mitochondrial Dysfunction and a Social Deficit in Offspring That Is Reversed by Nicotinamide Riboside"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-9302","authenticated-orcid":false,"given":"Arkadiy A.","family":"Bazhin","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2976-4311","authenticated-orcid":false,"given":"Ekaterina S.","family":"Solodnikova","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0348-5082","authenticated-orcid":false,"given":"Daniel A. San","family":"San Miguel","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-6107","authenticated-orcid":false,"given":"Robert","family":"Dantzer","sequence":"additional","affiliation":[{"name":"Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-1871","authenticated-orcid":false,"given":"Yezaz A.","family":"Ghouri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, St. Louis University, St. Louis, MO 63110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-2429","authenticated-orcid":false,"given":"Jennifer J.","family":"Donegan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-0656","authenticated-orcid":false,"given":"Elena","family":"Goun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jphs.12027","article-title":"Estimating the direct and indirect costs for community-dwelling patients with schizophrenia: Schizophrenia-related costs for community-dwellers","volume":"4","author":"Desai","year":"2013","journal-title":"J. Pharm. Health Serv. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Moreno-K\u00fcstner, B., Mart\u00edn, C., and Pastor, L. (2018). Prevalence of psychotic disorders and its association with methodological issues. A systematic review and meta-analyses. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195687"},{"key":"ref_3","unstructured":"(2017). GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Lond. Engl., 390, 1211\u20131259."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1017\/S0033291706008191","article-title":"Annual prevalence of diagnosed schizophrenia in the USA: A claims data analysis approach","volume":"36","author":"Wu","year":"2006","journal-title":"Psychol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Saha, S., Chant, D., Welham, J., and McGrath, J. (2005). A systematic review of the prevalence of schizophrenia. PLoS Med., 2.","DOI":"10.1371\/journal.pmed.0020141"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamapsychiatry.2015.1737","article-title":"Premature Mortality Among Adults With Schizophrenia in the United States","volume":"72","author":"Olfson","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/archpsyc.62.3.247","article-title":"The lifetime risk of suicide in schizophrenia: A reexamination","volume":"62","author":"Palmer","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.it.2022.01.007","article-title":"Maternal inflammation and its ramifications on fetal neurodevelopment","volume":"43","author":"Kwon","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies","volume":"167","author":"Brown","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.schres.2007.07.018","article-title":"Obstetric conditions and risk of first admission with schizophrenia: A Danish national register based study","volume":"97","author":"Byrne","year":"2007","journal-title":"Schizophr. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e13260","DOI":"10.1111\/aji.13260","article-title":"Maternal host responses to poly(I:C) during pregnancy leads to both dysfunctional immune profiles and altered behaviour in the offspring","volume":"84","author":"Diermen","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1038\/s41386-018-0021-0","article-title":"Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism","volume":"43","author":"Donegan","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1073858406296401","article-title":"The Neurodevelopmental Impact of Prenatal Infections at Different Times of Pregnancy: The Earlier the Worse?","volume":"13","author":"Meyer","year":"2007","journal-title":"Neuroscientist"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbi.2005.11.003","article-title":"Immunological stress at the maternal\u2013foetal interface: A link between neurodevelopment and adult psychopathology","volume":"20","author":"Meyer","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","article-title":"Immune Activation During Pregnancy in Mice Leads to Dopaminergic Hyperfunction and Cognitive Impairment in the Offspring: A Neurodevelopmental Animal Model of Schizophrenia","volume":"59","author":"Ozawa","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/sj.npp.1300248","article-title":"Immune Activation During Pregnancy in Rats Leads to a PostPubertal Emergence of Disrupted Latent Inhibition, Dopaminergic Hyperfunction, and Altered Limbic Morphology in the Offspring: A Novel Neurodevelopmental Model of Schizophrenia","volume":"28","author":"Zuckerman","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jpsychires.2004.08.008","article-title":"Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring","volume":"39","author":"Zuckerman","year":"2005","journal-title":"J. Psychiatr. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000441252","article-title":"Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia","volume":"1","author":"Hjelm","year":"2015","journal-title":"Complex Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1038\/s41380-022-01494-x","article-title":"Schizophrenia: A disorder of broken brain bioenergetics","volume":"27","author":"Henkel","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrn3229","article-title":"Impaired mitochondrial function in psychiatric disorders","volume":"13","author":"Manji","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.neubiorev.2021.11.047","article-title":"The role of mitochondria in the pathophysiology of schizophrenia: A critical review of the evidence focusing on mitochondrial complex one","volume":"132","author":"Whitehurst","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopsych.2005.03.031","article-title":"Deficient Hippocampal Neuron Expression of Proteasome, Ubiquitin, and Mitochondrial Genes in Multiple Schizophrenia Cohorts","volume":"58","author":"Altar","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0920-9964(00)00075-X","article-title":"Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia","volume":"48","author":"Maurer","year":"2001","journal-title":"Schizophr. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.schres.2015.07.016","article-title":"Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia","volume":"168","author":"Roberts","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.mp.4001511","article-title":"Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress","volume":"9","author":"Prabakaran","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41380-022-01865-4","article-title":"Mitochondria play an essential role in the trajectory of adolescent neurodevelopment and behavior in adulthood: Evidence from a schizophrenia rat model","volume":"28","author":"Ene","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/mp.2014.22","article-title":"Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia","volume":"20","author":"Brennand","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/schbul\/sbx077","article-title":"Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder","volume":"44","author":"Robicsek","year":"2018","journal-title":"Schizophr. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.euroneuro.2019.03.011","article-title":"Impaired heme metabolism in schizophrenia-derived cell lines and in a rat model of the disorder: Possible involvement of mitochondrial complex I","volume":"29","author":"Ifhar","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Herst, P.M., Rowe, M.R., Carson, G.M., and Berridge, M.V. (2017). Functional Mitochondria in Health and Disease. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00296"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.mam.2004.03.001","article-title":"Mitochondria in health and disease: Perspectives on a new mitochondrial biology","volume":"25","author":"Duchen","year":"2004","journal-title":"Mol. Asp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/cns.13116","article-title":"Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"eabn4705","DOI":"10.1126\/science.abn4705","article-title":"Mitochondria metabolism sets the species-specific tempo of neuronal development","volume":"379","author":"Iwata","year":"2023","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses","volume":"119","author":"Li","year":"2004","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Cie\u015blik, M., Gassowska-Dobrowolska, M., Zawadzka, A., Frontczak-Baniewicz, M., Gewartowska, M., Dominiak, A., Czapski, G.A., and Adamczyk, A. (2021). The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.555290"},{"key":"ref_39","first-page":"498","article-title":"Maternal Inflammation During Pregnancy and Offspring Brain Development: The Role of Mitochondria","volume":"7","author":"Gyllenhammer","year":"2022","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41398-024-03010-x","article-title":"Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function","volume":"14","author":"Schaer","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000368305","article-title":"Maternal Immune Activation Induces Changes in Myelin and Metabolic Proteins, Some of Which Can Be Prevented with Risperidone in Adolescence","volume":"37","author":"Farrelly","year":"2015","journal-title":"Dev. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.biopsych.2021.03.017","article-title":"Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study","volume":"90","author":"Guma","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41380-020-00952-8","article-title":"Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation","volume":"26","author":"Mueller","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Naviaux, R.K., Zolkipli, Z., Wang, L., Nakayama, T., Naviaux, J.C., Le, T.P., Schuchbauer, M.A., Rogac, M., Tang, Q., and Dugan, L.L. (2013). Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057380"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s41589-020-0602-1","article-title":"A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential","volume":"16","author":"Bazhin","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.neubiorev.2020.04.012","article-title":"Maternal Immune Activation by Poly I:C as a preclinical Model for Neurodevelopmental Disorders: A focus on Autism and Schizophrenia","volume":"113","author":"Haddad","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/npp.2017.7","article-title":"Maternal Immune Activation Causes Behavioral Impairments and Altered Cerebellar Cytokine and Synaptic Protein Expression","volume":"42","author":"Pendyala","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_48","unstructured":"(2020). nf-core\/rnaseq: Nf-core\/rnaseq v3.0-Silver Shark 2020, Zenodo."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Li, B., and Dewey, C.N. (2011). RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-323"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13059-016-0881-8","article-title":"A survey of best practices for RNA-seq data analysis","volume":"17","author":"Conesa","year":"2016","journal-title":"Genome Biol."},{"key":"ref_53","unstructured":"Blighe, K., Rana, S., and Lewis, M. (2026, January 21). EnhancedVolcano: Publication-Ready Volcano Plots with Enhanced Colouring and Labeling, 2018. Available online: https:\/\/github.com\/kevinblighe\/EnhancedVolcano."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: An updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_55","first-page":"8.26.1","article-title":"Automated Three-Chambered Social Approach Task for Mice","volume":"56","author":"Yang","year":"2011","journal-title":"Curr. Protoc. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1038\/s41596-020-0382-9","article-title":"A standardized social preference protocol for measuring social deficits in mouse models of autism","volume":"15","author":"Rein","year":"2020","journal-title":"Nat. Protoc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cell.2013.06.016","article-title":"The NAD+\/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling","volume":"154","author":"Mouchiroud","year":"2013","journal-title":"Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.stem.2019.02.012","article-title":"The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance","volume":"24","author":"Vannini","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrn2851","article-title":"Behavioural phenotyping assays for mouse models of autism","volume":"11","author":"Silverman","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Choudhury, Z., and Lennox, B. (2021). Maternal Immune Activation and Schizophrenia\u2013Evidence for an Immune Priming Disorder. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.585742"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2016.06.005","article-title":"Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis","volume":"58","author":"Jiang","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbi.2024.12.018","article-title":"ATP8A2 expression is reduced in the mPFC of offspring mice exposed to maternal immune activation and its upregulation ameliorates synapse-associated protein loss and behavioral abnormalities","volume":"124","author":"Liu","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pistis, M., Santoni, M., Mastio, A., Concas, L., Mostallino, R., Herres, A., Sagheddu, C., Castelli, M.P., Frau, R., and Muntoni, A.L. (2025). Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult Offspring. Transl. Psychiatry.","DOI":"10.21203\/rs.3.rs-7131610\/v1"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1000190","DOI":"10.4172\/2165-7890.1000190","article-title":"Mitochondrial Dysfunction in Autism Spectrum Disorders","volume":"6","author":"Siddiqui","year":"2016","journal-title":"Autism Open Access"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Demine, S., Renard, P., and Arnould, T. (2019). Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases. Cells, 8.","DOI":"10.3390\/cells8080795"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuron.2019.04.013","article-title":"Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment","volume":"102","author":"Fernandez","year":"2019","journal-title":"Neuron"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1242\/jcs.104.3.917","article-title":"The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth","volume":"104","author":"Morris","year":"1993","journal-title":"J. Cell Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.cell.2013.05.021","article-title":"Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture","volume":"153","author":"Courchet","year":"2013","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1523\/JNEUROSCI.5095-13.2014","article-title":"Evidence That Dendritic Mitochondria Negatively Regulate Dendritic Branching in Pyramidal Neurons in the Neocortex","volume":"34","author":"Kimura","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1093\/brain\/awt060","article-title":"OPA1 loss of function affects in vitro neuronal maturation","volume":"136","author":"Bertholet","year":"2013","journal-title":"Brain"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Campbell, J.M. (2022). Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts. Nutrients, 14.","DOI":"10.3390\/nu14153231"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10035","DOI":"10.1038\/s41598-019-57236-7","article-title":"Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder","volume":"10","author":"Gerasimenko","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-neuro-102320-102847","article-title":"Oxytocin, Neural Plasticity, and Social Behavior","volume":"44","author":"Froemke","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature10360","article-title":"Neocortical excitation\/inhibition balance in information processing and social dysfunction","volume":"477","author":"Yizhar","year":"2011","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/mp.2014.171","article-title":"Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder","volume":"20","author":"Arion","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamapsychiatry.2019.3360","article-title":"Schizophrenia\u2014An Overview","volume":"77","author":"McCutcheon","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(13)60733-3","article-title":"Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis","volume":"382","author":"Leucht","year":"2013","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4088\/JCP.13049su1c.04","article-title":"Unmet Needs in the Treatment of Schizophrenia: New Targets to Help Different Symptom Domains","volume":"75","author":"Citrome","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.schres.2015.03.033","article-title":"Determinants of different aspects of everyday outcome in schizophrenia: The roles of negative symptoms, cognition, and functional capacity","volume":"165","author":"Strassnig","year":"2015","journal-title":"Schizophr. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/6\/889\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:21:08Z","timestamp":1773379268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/6\/889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":82,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["nu18060889"],"URL":"https:\/\/doi.org\/10.3390\/nu18060889","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]}}}