{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:02:10Z","timestamp":1773468130187,"version":"3.50.1"},"reference-count":95,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Dextran sulfate sodium (DSS) is widely used to induce intestinal injury, reducing intestinal barrier integrity and thus contributing to systemic inflammation and oxidative stress, which may affect liver homeostasis and central nervous system function. In this context, the intake of phenolic compounds and anthocyanins from fruits such as jabuticaba has gained attention due to their antioxidant and anti-inflammatory properties. This study evaluated the effects of jabuticaba in the form of freeze-dried whole fruit, freeze-dried peel, and microencapsulated peel extract on DSS-induced damage to the gut\u2013liver\u2013brain axis in an in ovo model. Methods: Fertile eggs were assigned to five groups: water, DSS, DSS plus whole jabuticaba (WJ), DSS plus jabuticaba peel (JP), and DSS plus microencapsulated jabuticaba peel (JM). Duodenal, colon, and liver gene expressions; and histomorphometry, cecal microbiota, and brain gene expressions were evaluated at hatch. Results: DSS administration increased NF-\u03baB expression and reduced MUC-2 in the duodenum, induced colonic inflammation, altered cecal microbiota, and caused hepatic oxidative stress, evidenced by elevated iNOS and enlarged fat globules, while reducing brain BDNF levels. Jabuticaba treatments mitigated intestinal, hepatic, and neural damage by reducing inflammatory markers; enhancing MUC-2, ZO-2, JAM-2, and claudin-1 expression; increasing villus area and goblet cell numbers; normalizing CAT and SOD activities in the liver; decreasing COX-2; increasing dopamine; and restoring BDNF in the brain. Conclusions: This study demonstrates that jabuticaba exerts protective effects along the gut\u2013liver\u2013brain axis, highlighting its potential as a functional food to support intestinal, hepatic, and brain health.<\/jats:p>","DOI":"10.3390\/nu18060903","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:46:31Z","timestamp":1773326791000},"page":"903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Jabuticaba (Myrciaria cauliflora) Modulates Intestinal Inflammation, Liver Homeostasis, and Brain Gene Expression Along the Gut\u2013Liver\u2013Brain Axis in a DSS-Induced In Vivo Model"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-0806","authenticated-orcid":false,"given":"Stephanie Michelin Santana","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Parzanini Brilhante de S\u00e3o","family":"Jos\u00e9","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-633X","authenticated-orcid":false,"given":"L\u00edvya Alves","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-0348","authenticated-orcid":false,"given":"Kelly Aparecida","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia D\u2019Almeida","family":"Francisquini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo Tuler","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-5694","authenticated-orcid":false,"given":"Ceres Mattos","family":"Della Lucia","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Tako","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/17474124.2025.2464037","article-title":"Gut Microbiota: The Pathogenetic Bridge between Inflammatory Bowel Disease and Metabolic-Associated Steatotic Liver Disease","volume":"19","author":"Scarlata","year":"2025","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41575-023-00771-6","article-title":"Gut\u2013Liver Axis: Barriers and Functional Circuits","volume":"20","author":"Pabst","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The Gut\u2013Liver Axis and Gut Microbiota in Health and Liver Disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10500","DOI":"10.1021\/acsnano.5c00325","article-title":"Probiotic Delivery for Editing of the Gut Microbiota to Mitigate Colitis and Maintain Hepatic Homeostasis Via Gut\u2013Liver Axis","volume":"19","author":"Deng","year":"2025","journal-title":"ACS Nano"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbi.2022.02.002","article-title":"Stress and the Gut-Brain Axis: Cognitive Performance, Mood State, and Biomarkers of Blood-Brain Barrier and Intestinal Permeability Following Severe Physical and Psychological Stress","volume":"101","author":"Varanoske","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s10571-024-01496-z","article-title":"Gut\u2013Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders","volume":"44","author":"Kearns","year":"2024","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S2468-1253(22)00241-2","article-title":"The Intestinal Barrier in Disorders of the Central Nervous System","volume":"8","author":"Pellegrini","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Iordache, M.M., Tocia, C., Aschie, M., Dumitru, A., Manea, M., Cozaru, G.C., Petcu, L., Vlad, S.E., Dumitru, E., and Chisoi, A. (2022). Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175121"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Vitali, R., Prioreschi, C., Lorenzo Rebenaque, L., Colantoni, E., Giovannini, D., Frusciante, S., Diretto, G., Marco-Jim\u00e9nez, F., Mancuso, M., and Casciati, A. (2022). Gut\u2013Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911495"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41380-020-0651-6","article-title":"Hippocampal Neural Stem Cells and Microglia Response to Experimental Inflammatory Bowel Disease (IBD)","volume":"26","author":"Gampierakis","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhao, L.P., Wu, J., Quan, W., Zhou, Y., Hong, H., Niu, G.Y., Li, T., Huang, S.B., Qiao, C.M., and Zhao, W.J. (2023). DSS-Induced Colitis Activates the Kynurenine Pathway in Serum and Brain by Affecting IDO-1 and Gut Microbiota. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1089200"},{"key":"ref_12","first-page":"15.25.1","article-title":"Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kolba, N., Cheng, J., Jackson, C.D., and Tako, E. (2022). Intra-Amniotic Administration\u2014An Emerging Method to Investigate Necrotizing Enterocolitis, In Vivo (Gallus gallus). Nutrients, 14.","DOI":"10.3390\/nu14224795"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shen, B., Wang, J., Guo, Y., Gu, T., Shen, Z., Zhou, C., Li, B., Xu, X., Li, F., and Zhang, Q. (2021). Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-Alcoholic Steatohepatitis. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.756299"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pereira, M.T.M., Charret, T.S., Pascoal, V.D.A.B., Machado, R.L.D., Rocha, L.M., and Pascoal, A.C.R.F. (2022). Myrciaria Genus: Bioactive Compounds and Biological Activities. Chem. Biodivers., 19.","DOI":"10.1002\/cbdv.202200864"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"125735","DOI":"10.1016\/j.foodchem.2019.125735","article-title":"Jabuticaba Residues (Myrciaria jaboticaba (Vell.) Berg) Are Rich Sources of Valuable Compounds with Bioactive Properties","volume":"309","author":"Albuquerque","year":"2020","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"112287","DOI":"10.1016\/j.fct.2021.112287","article-title":"Ellagitannins from Jabuticaba (Myrciaria jaboticaba) Seeds Attenuated Inflammation, Oxidative Stress, Aberrant Crypt Foci, and Modulated Gut Microbiota in Rats with 1,2 Dimethyl Hydrazine-Induced Colon Carcinogenesis","volume":"154","author":"Fidelis","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"112314","DOI":"10.1016\/j.biopha.2021.112314","article-title":"Jaboticaba (Myrciaria jaboticaba) Powder Consumption Improves the Metabolic Profile and Regulates Gut Microbiome Composition in High-Fat Diet-Fed Mice","volume":"144","author":"Soares","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102578","DOI":"10.1016\/j.fbio.2023.102578","article-title":"Freeze-Dried Jaboticaba (Myrciaria jaboticaba) Peel Powder, a Rich Source of Anthocyanins and Phenolic Acids, Mitigates Inflammation-Driven Colorectal Cancer in Mice","volume":"53","author":"Nascimento","year":"2023","journal-title":"Food Biosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s44403-025-00015-2","article-title":"From Peel to Health: Jaboticaba\u2019s Phenolics Counteract Oxidative Stress and Liver Fat Buildup","volume":"2","author":"Viana","year":"2025","journal-title":"Food Nutr. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1089\/jmf.2020.0141","article-title":"Jaboticaba (Myrciaria cauliflora) Peel Supplementation Prevents Hepatic Steatosis Through Hypolipidemic Effects and Cholesterol Metabolism Modulation in Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model","volume":"24","author":"Lage","year":"2021","journal-title":"J. Med. Food"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Calloni, C., Mart\u00ednez, L.S., Gil, D.F., da Silva, D.M., Jahn, M.P., and Salvador, M. (2021). Jabuticaba [Plinia trunciflora (O. Berg) Kausel] Protects Liver of Diabetic Rats Against Mitochondrial Dysfunction and Oxidative Stress Through the Modulation of SIRT3 Expression. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.665747"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Grabska-Koby\u0142ecka, I., Szpakowski, P., Kr\u00f3l, A., Ksi\u0105\u017cek-Winiarek, D., Koby\u0142ecki, A., G\u0142\u0105bi\u0144ski, A., and Nowak, D. (2023). Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development. Nutrients, 15.","DOI":"10.3390\/nu15153454"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Reguengo, L.M., Berilli, P., and Marostica Junior, M.R. (2025). The Benefits of Jaboticaba-Based Interventions on Disease: Metabolic, Cardiovascular, and Neurological Diseases. Jaboticaba Berry: A Brazilian Superfruit, Springer.","DOI":"10.1007\/978-3-031-81489-1_8"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kandasamy, S., and Naveen, R. (2022). A Review on the Encapsulation of Bioactive Components Using Spray-Drying and Freeze-Drying Techniques. J. Food Process Eng., 45.","DOI":"10.1111\/jfpe.14059"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126969","DOI":"10.1016\/j.ijbiomac.2023.126969","article-title":"Microencapsulation of Bioactive Compound Extracts Using Maltodextrin and Gum Arabic by Spray and Freeze-Drying Techniques","volume":"253","author":"Laureanti","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1080\/07373937.2022.2068028","article-title":"Effects of Different Drying Techniques on the Quality and Bioactive Compounds of Plant-Based Products: A Critical Review on Current Trends","volume":"40","author":"Belwal","year":"2022","journal-title":"Dry. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Huang, M.Y., Smieska, L.M., and Tako, E. (2025). Intestinal Effects of Brewers\u2019 Spent Grain Extract In Ovo (Gallus gallus)\u2014A Pilot Study. Animals, 15.","DOI":"10.3390\/ani15030303"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106840","DOI":"10.1016\/j.jff.2025.106840","article-title":"Concord Grape (Vitis labrusca \u2018Concord\u2019) Pomace Extract Impacts Dextran Sulfate Sodium-Induced Inflammation in Ovo (Gallus gallus)","volume":"129","author":"Huang","year":"2025","journal-title":"J. Funct. Foods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"107005","DOI":"10.1016\/j.jff.2025.107005","article-title":"Evaluating the Bioactive Capacity of Concord Grape (Vitis labrusca) Pomace Extract on Skeletal Muscle in a Healthy and Intestinally Inflamed in-Vivo Model (Gallus gallus): A Preliminary Study","volume":"133","author":"Dugan","year":"2025","journal-title":"J. Funct. Foods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.foodres.2019.04.060","article-title":"Soluble Extracts from Carioca Beans (Phaseolus vulgaris L.) Affect the Gut Microbiota and Iron Related Brush Border Membrane Protein Expression in Vivo (Gallus gallus)","volume":"123","author":"Dias","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109705","DOI":"10.1016\/j.foodres.2020.109705","article-title":"Yacon (Smallanthus sonchifolius) Flour Soluble Extract Improve Intestinal Bacterial Populations, Brush Border Membrane Functionality and Morphology in Vivo (Gallus gallus)","volume":"137","author":"Martino","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111227","DOI":"10.1016\/j.foodres.2022.111227","article-title":"Black Corn (Zea mays L.) Soluble Extract Showed Anti-Inflammatory Effects and Improved the Intestinal Barrier Integrity in Vivo (Gallus gallus)","volume":"157","author":"Kolba","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"126364","DOI":"10.1016\/j.foodchem.2020.126364","article-title":"Anthocyanin-Rich Extract of Jabuticaba Epicarp as a Natural Colorant: Optimization of Heat- and Ultrasound-Assisted Extractions and Application in a Bakery Product","volume":"316","author":"Albuquerque","year":"2020","journal-title":"Food Chem."},{"key":"ref_35","first-page":"5","article-title":"Influence of Pilot Spray Dryer Settings on Moisture and Water Activity of Whole Milk Powder","volume":"68","author":"Perrone","year":"2013","journal-title":"J. Candido Tostes Dairy Inst."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-Ciocalteu Reagent","volume":"299","author":"Singleton","year":"1999","journal-title":"Methods Enzymol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1369-703X(02)00221-8","article-title":"Acylated Anthocyanins from Edible Sources and Their Applications in Food Systems","volume":"14","author":"Giusti","year":"2003","journal-title":"Biochem. Eng. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(01)35227-8","article-title":"Overview of Methods for Analysis and Identification of Flavonoids","volume":"335","author":"Bloor","year":"2001","journal-title":"Methods Enzymol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.lwt.2014.05.040","article-title":"The Effect of in Vitro Digestion on the Antioxidant Activity of Fruit Extracts (Carica papaya, Artocarpus heterophillus and Annona marcgravii)","volume":"59","author":"Pavan","year":"2014","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5264\/eiyogakuzashi.44.307","article-title":"Studies on Products of Browning Reaction Antioxidative Activities of Products of Browning Reaction Prepared from Glucosamine","volume":"44","author":"Oyaizu","year":"1986","journal-title":"Jpn. J. Nutr. Diet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_42","unstructured":"Suvarna, K.S., Layton, C., and Bancroft, J.D. (2018). Bancroft\u2019s Theory and Practice of Histological Techniques, Elsevier. [8th ed.]."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Moreira, L.D.P.D., Enes, B.N., Jos\u00e9, V.P.B.D.S., Toledo, R.C.L., Ladeira, L.C.M., Cardoso, R.R., Duarte, V.d.S., Hermsdorff, H.H.M., de Barros, F.A.R., and Martino, H.S.D. (2022). Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet. Foods, 11.","DOI":"10.3390\/foods11030285"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"104744","DOI":"10.1016\/j.tifs.2024.104744","article-title":"Anthocyanin-Rich Jaboticaba Fruit: Natural Source of Bioactive and Coloring Ingredients for Nutraceutical Food Applications","volume":"153","author":"Bocker","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/13510002.2017.1375709","article-title":"Antioxidant, Antihyperglycemic, and Antidyslipidemic Effects of Brazilian-Native Fruit Extracts in an Animal Model of Insulin Resistance","volume":"23","author":"Oliveira","year":"2018","journal-title":"Redox Rep."},{"key":"ref_46","first-page":"1140","article-title":"Effect of Consumption of Brazilian Berries on Intestinal Health: A Systematic Review of in Vivo Studies","volume":"66","author":"Oliveira","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"115001","DOI":"10.1016\/j.jep.2022.115001","article-title":"Ganluyin Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting the Enteric-Origin LPS\/TLR4\/NF-\u039aB Pathway","volume":"289","author":"Xiong","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"114136","DOI":"10.1016\/j.biopha.2022.114136","article-title":"Tea (Camellia sinensis) Ameliorates DSS-Induced Colitis and Liver Injury by Inhibiting TLR4\/NF-\u039aB\/NLRP3 Inflammasome in Mice","volume":"158","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kaminsky, L.W., Al-Sadi, R., and Ma, T.Y. (2021). IL-1\u03b2 and the Intestinal Epithelial Tight Junction Barrier. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.767456"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.tcb.2020.08.004","article-title":"Tight Junction Structure and Function Revisited","volume":"30","author":"Otani","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrm.2016.80","article-title":"Tight Junctions: From Simple Barriers to Multifunctional Molecular Gates","volume":"17","author":"Zihni","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41575-023-00766-3","article-title":"Paracellular Permeability and Tight Junction Regulation in Gut Health and Disease","volume":"20","author":"Horowitz","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/s12276-021-00617-8","article-title":"Slimy Partners: The Mucus Barrier and Gut Microbiome in Ulcerative Colitis","volume":"53","author":"Fang","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9475","DOI":"10.3748\/wjg.v20.i28.9468","article-title":"Ulcerative Colitis as a Polymicrobial Infection Characterized by Sustained Broken Mucus Barrier","volume":"20","author":"Chen","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2499752","DOI":"10.1080\/21688370.2025.2499752","article-title":"Mucus and Mucin: Changes in the Mucus Barrier in Disease States","volume":"13","author":"Fan","year":"2025","journal-title":"Tissue Barriers"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Nascimento, R.D.P.D., Machado, A.P.D.F., Batista, \u00c2.G., and Marostica Junior, M.R. (2025). The Benefits of Jaboticaba-Based Interventions on Disease: Gastrointestinal, Renal, and Pulmonary Diseases. Jaboticaba Berry: A Brazilian Superfruit, Springer.","DOI":"10.1007\/978-3-031-81489-1"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"110139","DOI":"10.1016\/j.foodres.2021.110139","article-title":"Phenolic Compounds from Jaboticaba (Plinia jaboticaba (Vell.) Berg) Ameliorate Intestinal Inflammation and Associated Endotoxemia in Obesity","volume":"141","author":"Rodrigues","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Castangia, I., Manca, M.L., Allaw, M., Hellstr\u00f6m, J., Granato, D., and Manconi, M. (2021). Jabuticaba (Myrciaria jaboticaba) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes. Molecules, 26.","DOI":"10.3390\/molecules26216697"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nascimento, R.D.P.D., Rizzato, J.S., Polezi, G., Boughanem, H., Williams, N.G., Borguini, R.G., Santiago, M.C.P.D.A., Marostica Junior, M.R., and Parry, L. (2024). Myrciaria jaboticaba Fruit Peel: Bioactive Composition as Determined by Distinct Harvest Seasons and In Vitro Anti-Cancer Activity. Plants, 13.","DOI":"10.3390\/plants13202907"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"de Muros Amaral Barcellos, T., Volino-Souza, M., Lelis, C.A., Conte Junior, C.A., and da Silveira Alvares, T. (2025). Microencapsulated Jaboticaba Berry (M. cauliflora) Juice Improves Storage Stability and In Vitro Bioaccessibility of Polyphenols. Appl. Biosci., 4.","DOI":"10.3390\/applbiosci4030031"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s11947-021-02749-1","article-title":"Blueberry Phenolic Composition and Improved Stability by Microencapsulation","volume":"15","author":"Neuenfeldt","year":"2022","journal-title":"Food Bioproc. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Bi\u0144kowska, W., Szpicer, A., Stelmasiak, A., Wojtasik-Kalinowska, I., and P\u00f3\u0142torak, A. (2024). Microencapsulation of Polyphenols and Their Application in Food Technology. Appl. Sci., 14.","DOI":"10.3390\/app142411954"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"\u0218tef\u0103nescu, B.E., Nemes, S.A., Teleky, B.E., C\u0103linoiu, L.F., Mitrea, L., Mart\u0103u, G.A., Szabo, K., Mihai, M., Vodnar, D.C., and Cri\u0219an, G. (2022). Microencapsulation and Bioaccessibility of Phenolic Compounds of Vaccinium Leaf Extracts. Antioxidants, 11.","DOI":"10.3390\/antiox11040674"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"44","DOI":"10.20517\/mrr.2025.81","article-title":"Immunomodulatory Properties of Dietary Polyphenols: A Role for Combating Infections at Mucosal Surfaces?","volume":"4","author":"Sharma","year":"2025","journal-title":"Microbiome Res. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/10408398.2020.1744512","article-title":"Dietary Polyphenol Impact on Gut Health and Microbiota","volume":"61","author":"Wan","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"110189","DOI":"10.1016\/j.foodres.2021.110189","article-title":"Role of Dietary Polyphenols on Gut Microbiota, Their Metabolites and Health Benefits","volume":"142","author":"Aravind","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Makarewicz, M., Dro\u017cd\u017c, I., Tarko, T., and Duda-Chodak, A. (2021). The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota. Antioxidants, 10.","DOI":"10.3390\/antiox10020188"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"154979","DOI":"10.1016\/j.phymed.2023.154979","article-title":"Interactions between Gut Microbiota and Polyphenols: A Mechanistic and Metabolomic Review","volume":"119","author":"Cheng","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/advances\/nmaa104","article-title":"Roles of the Polyphenol\u2013Gut Microbiota Interaction in Alleviating Colitis and Preventing Colitis-Associated Colorectal Cancer","volume":"12","author":"Zhao","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_70","first-page":"322","article-title":"(Poly)Phenol-Gut Microbiota Interactions and Their Impact on Human Health","volume":"28","author":"Liu","year":"2025","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ray, S.K., and Mukherjee, S. (2021). Evolving Interplay Between Dietary Polyphenols and Gut Microbiota\u2014An Emerging Importance in Healthcare. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.634944"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Zhu, M., Xie, R., Xu, L., Yang, Y., Luo, H., and Lan, X. (2024). The Gut-Liver Axis in Fatty Liver Disease: Role Played by Natural Products. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1365294"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s12264-018-0288-5","article-title":"Cortical Inflammation Is Increased in a DSS-Induced Colitis Mouse Model","volume":"34","author":"Han","year":"2018","journal-title":"Neurosci. Bull."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"154702","DOI":"10.1016\/j.phymed.2023.154702","article-title":"Improved Colonic Inflammation by Nervonic Acid via Inhibition of NF-\u039aB Signaling Pathway of DSS-Induced Colitis Mice","volume":"112","author":"Yuan","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Agista, A.Z., Rusbana, T.B., Islam, J., Ohsaki, Y., Sultana, H., Hirakawa, R., Watanabe, K., Nochi, T., and Budijanto, S. (2021). Fermented Rice Bran Supplementation Prevents the Development of Intestinal Fibrosis Due to Dss-Induced Inflammation in Mice. Nutrients, 13.","DOI":"10.3390\/nu13061869"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41420-024-01891-x","article-title":"Targeting Cell Death Pathways in Intestinal Ischemia-Reperfusion Injury: A Comprehensive Review","volume":"10","author":"Wang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., and Mao, Z. (2024). The Emerging Role of Oxidative Stress in Inflammatory Bowel Disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1390351"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"101214","DOI":"10.1016\/j.omtm.2024.101214","article-title":"Glutaredoxin-1 Modulates the NF-\u039aB Signaling Pathway to Activate Inducible Nitric Oxide Synthase in Experimental Necrotizing Enterocolitis","volume":"32","author":"Zhang","year":"2024","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jff.2018.06.005","article-title":"Jaboticaba Extract Prevents Prediabetes and Liver Steatosis in High-Fat-Fed Aging Mice","volume":"47","author":"Lamas","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109964","DOI":"10.1016\/j.foodres.2020.109964","article-title":"Beneficial Effects of Anthocyanin-Rich Peels of Myrtaceae Fruits on Chemically-Induced Liver Fibrosis and Carcinogenesis in Mice","volume":"139","author":"Romualdo","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1126\/science.abi6087","article-title":"Signaling Inflammation across the Gut-Brain Axis","volume":"374","author":"Agirman","year":"2021","journal-title":"Science"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","article-title":"Gastrointestinal and Brain Barriers: Unlocking Gates of Communication across the Microbiota\u2013Gut\u2013Brain Axis","volume":"21","author":"Aburto","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s44337-025-00495-3","article-title":"A Comprehensive Review on Immunological Mechanisms and Gut-Brain Pathways Linking Gut Health and Neurological Disorders","volume":"2","author":"Oyovwi","year":"2025","journal-title":"Discov. Med."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Paucar, M., Laffita-Mesa, J.M., Beltran-Velasco, A.I., and Clemente-Su\u00e1rez, V.J. (2025). Impact of Peripheral Inflammation on Blood\u2013Brain Barrier Dysfunction and Its Role in Neurodegenerative Diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26062440"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"117207","DOI":"10.1016\/j.biopha.2024.117207","article-title":"The Communication Mechanism of the Gut-Brain Axis and Its Effect on Central Nervous System Diseases: A Systematic Review","volume":"178","author":"Lu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12943-025-02412-9","article-title":"Integrating Neuroscience and Oncology: Neuroimmune Crosstalk in the Initiation and Progression of Digestive System Tumors","volume":"24","author":"Sun","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41575-022-00669-9","article-title":"Nerves in Gastrointestinal Cancer: From Mechanism to Modulations","volume":"19","author":"Vaes","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Sochal, M., Ditmer, M., Gabryelska, A., and Bia\u0142asiewicz, P. (2022). The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206023"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Fiore, M., Terracina, S., and Ferraguti, G. (2025). Brain Neurotrophins and Plant Polyphenols: A Powerful Connection. Molecules, 30.","DOI":"10.3390\/molecules30122657"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1007\/s00210-025-04298-2","article-title":"Phytochemicals Encouraging Neurotrophic Pathways: Brain-Derived Neurotrophic Factors as Molecular Targets in Depression","volume":"398","author":"Karad","year":"2025","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1038\/s41598-017-11512-6","article-title":"Polyphenols Journey through Blood-Brain Barrier towards Neuronal Protection","volume":"7","author":"Figueira","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e533","DOI":"10.1093\/nutrit\/nuae034","article-title":"From the Gut to the Brain: The Long Journey of Phenolic Compounds with Neurocognitive Effects","volume":"83","year":"2025","journal-title":"Nutr. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"103041","DOI":"10.1016\/j.autneu.2022.103041","article-title":"The Multiple Roles of Dopamine Receptor Activation in the Modulation of Gastrointestinal Motility and Mucosal Function","volume":"244","author":"Serio","year":"2023","journal-title":"Auton. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Kurnik-\u0142ucka, M., Pasieka, P., \u0141\u0105czak, P., Wojnarski, M., Jurczyk, M., and Gil, K. (2021). Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312932"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41575-025-01112-5","article-title":"Dopaminergic Signalling in Gastrointestinal Health and Disease","volume":"22","author":"Pasricha","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/6\/903\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:12:29Z","timestamp":1773465149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/6\/903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["nu18060903"],"URL":"https:\/\/doi.org\/10.3390\/nu18060903","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]}}}