{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:20:48Z","timestamp":1782858048359,"version":"3.54.5"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Malnutrition and suboptimal diet quality are common, yet under-recognized, in inflammatory bowel disease (IBD) and are associated with worse clinical outcomes and lower quality of life. Digital tools may facilitate continuous, personalized nutritional support, but evidence in IBD remains limited. The aim of this study was to evaluate the impact of a nutritional intervention based on a mobile application (Nootric\u00ae) on nutritional status, diet quality, and malnutrition risk in patients with IBD undergoing stable follow-up. Methods: We conducted a prospective longitudinal cohort study without a control group including 151 adult patients with Crohn\u2019s disease or ulcerative colitis under stable follow-up in a tertiary IBD unit. Participants used a structured digital nutritional support program through the Nootric\u00ae app for 24 weeks, supervised by dietitians and the IBD team. Clinical activity, biochemical markers (C-reactive protein, fecal calprotectin), nutritional biomarkers (albumin, prealbumin, micronutrients), body mass index (BMI), malnutrition risk (self-administered Malnutrition Universal Screening Tool, MUST), and diet quality (PREDIMED and an expanded \u201cNootric score\u201d) were assessed at baseline, 12 weeks, and 24 weeks. Analyses focused on patients with adequate adherence. Results: Of the 151 included IBD patients, 110 maintained stable app use. Mean albumin increased from 4.38 to 4.49 g\/dL at 24 weeks (p = 0.003), and prealbumin from 24.9 to 26.1 mg\/dL (p = 0.047), despite the absence of overt protein\u2013calorie malnutrition at baseline. Patients with obesity achieved a mean weight loss of approximately 6% of baseline body weight. Diet quality improved significantly, with higher Nootric score and a positive correlation between app use intensity and increased score. Malnutrition risk according to the MUST scale improved in more adherent patients, while clinical and biochemical disease activity remained stable overall. Conclusions: A mobile app-based nutritional program supervised by dietitians was feasible, well accepted, and associated with improved nutritional markers, diet quality, and malnutrition risk, supporting its role as a complementary component of IBD care.<\/jats:p>","DOI":"10.3390\/nu18060910","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:26:19Z","timestamp":1773390379000},"page":"910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of Nutritional Intervention Through New Digital Technologies in Patients with Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-3784","authenticated-orcid":false,"given":"Cristina","family":"Su\u00e1rez Ferrer","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Martorell Marin\u00e9","sequence":"additional","affiliation":[{"name":"Nutrition Department, Nootric Inc., 08940 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-452X","authenticated-orcid":false,"given":"J. L.","family":"Rueda Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cubillo Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"},{"name":"Nutrition Department, Nootric Inc., 08940 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Garc\u00eda Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-010X","authenticated-orcid":false,"given":"C.","family":"Amiama Roig","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"S\u00e1nchez Azofra","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0501-0107","authenticated-orcid":false,"given":"J.","family":"Poza Cordon","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martin Arranz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garc\u00eda-Rojas Pleite","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Noci Belda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-0917","authenticated-orcid":false,"given":"Maria Dolores","family":"Martin-Arranz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Health Research Institute (IdiPAZ), La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S2468-1253(23)00011-0","article-title":"Inflammation and malnutrition in inflammatory bowel disease","volume":"8","author":"Massironi","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3748\/wjg.v22.i3.895","article-title":"Diet and nutritional factors in inflammatory bowel diseases","volume":"22","author":"Owczarek","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Roncoroni, L., Gori, R., Elli, L., Tontini, G.E., Doneda, L., Norsa, L., Cuomo, M., Lombardo, V., Scricciolo, A., and Caprioli, F. (2022). Nutrition in Patients with Inflammatory Bowel Diseases: A Narrative Review. Nutrients, 14.","DOI":"10.3390\/nu14040751"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Valvano, M., Capannolo, A., Cesaro, N., Stefanelli, G., Fabiani, S., Frassino, S., Monaco, S., Magistroni, M., Viscido, A., and Latella, G. (2023). Nutrition, Nutritional Status, Micronutrients Deficiency, and Disease Course of Inflammatory Bowel Disease. Nutrients, 15.","DOI":"10.3390\/nu15173824"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/ncp.10628","article-title":"Nutrition Considerations in Inflammatory Bowel Disease","volume":"36","author":"Lin","year":"2021","journal-title":"Nutr. Clin. Pract."},{"key":"ref_6","first-page":"2","article-title":"Nutricional habits in patients with inflammatory bowel disease: Perception of patients and health professionals","volume":"45","year":"2022","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7762\/cnr.2018.7.1.48","article-title":"Food Elimination Diet and Nutritional Deficiency in Patients with Inflammatory Bowel Disease","volume":"7","author":"Lim","year":"2018","journal-title":"Clin. Nutr. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.clnu.2019.11.002","article-title":"ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease","volume":"39","author":"Bischoff","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.clnu.2022.12.004","article-title":"ESPEN guideline on Clinical Nutrition in inflammatory bowel disease","volume":"42","author":"Bischoff","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.clnu.2016.12.027","article-title":"ESPEN guideline: Clinical nutrition in inflammatory bowel disease","volume":"36","author":"Forbes","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bezzio, C., Brinch, D., Ribaldone, D.G., Cappello, M., Ruzzon, N., Vernero, M., Scalvini, D., Loy, L., Donghi, S., and Ciminnisi, S. (2024). Prevalence, Risk Factors and Association with Clinical Outcomes of Malnutrition and Sarcopenia in Inflammatory Bowel Disease: A Prospective Study. Nutrients, 16.","DOI":"10.3390\/nu16233983"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/0148607114566656","article-title":"Self-Screening for Malnutrition Risk in Outpatient Inflammatory Bowel Disease Patients Using the Malnutrition Universal Screening Tool (MUST)","volume":"40","author":"Sandhu","year":"2016","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Gonz\u00e1lez, M.A., Garc\u00eda-Arellano, A., Toledo, E., Salas-Salvad\u00f3, J., Buil-Cosiales, P., Corella, D., Covas, M.I., Schr\u00f6der, H., Ar\u00f3s, F., and G\u00f3mez-Gracia, E. (2012). A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: The PREDIMED trial. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043134"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cgh.2024.05.049","article-title":"Diet and Microbiome-Directed Therapy 2.0 for IBD","volume":"23","author":"Ananthakrishnan","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2023.11.303","article-title":"AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients with Inflammatory Bowel Disease: Expert Review","volume":"166","author":"Hashash","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ska, B., and Mrowiec, S. (2023). Nutritional Status and Its Detection in Patients with Inflammatory Bowel Diseases. Nutrients, 15.","DOI":"10.3390\/nu15081991"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ibd\/izaa097","article-title":"Multidimensional Impact of Mediterranean Diet on IBD Patients","volume":"27","author":"Chicco","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11894-022-00851-8","article-title":"Incorporating Nutrition-Based Strategies into IBD Treatment","volume":"24","author":"Magavi","year":"2022","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00394-012-0450-1","article-title":"Effects of 5% weight loss through diet or diet plus exercise on cardiovascular parameters of obese: A randomized clinical trial","volume":"52","author":"Fayh","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_21","first-page":"576","article-title":"Micronutrient deficiencies in inflammatory bowel disease","volume":"18","author":"Weisshof","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wall, C.L., Wilson, B., and Lomer, M.C.E. (2023). Development and validation of an inflammatory bowel disease nutrition self-screening tool (IBD-NST) for digital use. Front Nutr., 10.","DOI":"10.3389\/fnut.2023.1065592"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1053\/j.gastro.2021.05.047","article-title":"A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn\u2019s Disease","volume":"161","author":"Lewis","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.3748\/wjg.v30.i34.3868","article-title":"Examining dietary interventions in Crohn\u2019s disease","volume":"30","author":"Chen","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.14309\/ajg.0000000000002973","article-title":"Using Diet to Treat Inflammatory Bowel Disease: A Systematic Review","volume":"120","author":"Gleave","year":"2025","journal-title":"Am. J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100219","DOI":"10.1016\/j.advnut.2024.100219","article-title":"Diet, Food, and Nutritional Exposures and Inflammatory Bowel Disease or Progression of Disease: An Umbrella Review","volume":"15","author":"Christensen","year":"2024","journal-title":"Adv. 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