{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:07:34Z","timestamp":1791288454077,"version":"4.3.0"},"reference-count":150,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>As a novel form of cell death, the discovery of cuproptosis presents significant opportunities and challenges for the field of cancer therapy. Notably, polyphenolic compounds have attracted considerable research attention for their ability to induce cuproptosis. These natural compounds not only exhibit marked anti-inflammatory and antioxidant properties, but their polyhydroxy structures also enable effective chelation and transport of copper ions. This provides novel insights into cuproptosis-mediated cancer therapy. Therefore, in this review, we systematically outline copper metabolism, the mechanisms of cuproptosis, and its association with cancer, while providing an in-depth discussion of the effects and mechanisms by which polyphenolic compounds act as copper ionophores to inhibit tumor growth and progression through the induction of cuproptosis. This review indicates the promising potential of polyphenolic compounds in the field of cancer therapy and provides a theoretical basis for therapeutic strategies based on cuproptosis.<\/jats:p>","DOI":"10.3390\/nu18060917","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:32:07Z","timestamp":1773667927000},"page":"917","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel Strategy for Cancer Therapy Proposal Based on Effects and Mechanisms of Targeting Cuproptosis by Polyphenols\u2014A Narrative Review"],"prefix":"10.3390","volume":"18","author":[{"given":"Xilong","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2299-6588","authenticated-orcid":false,"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41571-021-00514-z","article-title":"Planning for tomorrow: Global cancer incidence and the role of prevention 2020\u20132070","volume":"18","author":"Soerjomataram","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104844","DOI":"10.1016\/j.critrevonc.2025.104844","article-title":"Novel insight into the Warburg effect: Sweet temptation","volume":"214","author":"Zhang","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40170-024-00343-5","article-title":"Disrupting Na(+) ion homeostasis and Na(+)\/K(+) ATPase activity in breast cancer cells directly modulates glycolysis In Vitro and In Vivo","volume":"12","author":"Michaels","year":"2024","journal-title":"Cancer Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/BJ20121248","article-title":"The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function","volume":"450","author":"Coothankandaswamy","year":"2013","journal-title":"Biochem. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semcancer.2024.08.002","article-title":"AMPK: The energy sensor at the crossroads of aging and cancer","volume":"106-107","author":"Penugurti","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","article-title":"Oxidative cell death in cancer: Mechanisms and therapeutic opportunities","volume":"15","author":"An","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e70947","DOI":"10.1002\/cam4.70947","article-title":"Reactive oxygen species: From tumorigenesis to therapeutic strategies in cancer","volume":"14","author":"Attique","year":"2025","journal-title":"Cancer Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/iub.2341","article-title":"Copper homeostasis: Emerging target for cancer treatment","volume":"72","author":"Li","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R421","DOI":"10.1016\/j.cub.2021.03.054","article-title":"Copper biology","volume":"31","author":"Tsang","year":"2021","journal-title":"Curr. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1158\/0008-5472.CAN-20-0471","article-title":"Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion","volume":"80","author":"Voli","year":"2020","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"123201","DOI":"10.1016\/j.biomaterials.2025.123201","article-title":"Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system","volume":"319","author":"Li","year":"2025","journal-title":"Biomaterials"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1021\/ja9618715","article-title":"The electronic structure of CuA: A novel mixed-valence dinuclear copper electron-transfer center","volume":"118","author":"Farrar","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Boyd, S.D., Ullrich, M.S., Skopp, A., and Winkler, D.D. (2020). Copper sources for Sod1 activation. Antioxidants, 9.","DOI":"10.3390\/antiox9060500"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12011-008-8110-2","article-title":"Ceruloplasmin, an indicator of copper status","volume":"123","author":"Arredondo","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.59566\/IJBS.2009.5395","article-title":"Dopamine-\u03b2-hydroxylase (DBH), its cofactors and other biochemical parameters in the serum of neurological patients in Bangladesh","volume":"5","author":"Rahman","year":"2009","journal-title":"Int. J. Biomed. Sci. IJBS"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.bmc.2014.02.048","article-title":"Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation","volume":"22","author":"Ramsden","year":"2014","journal-title":"Bioorganic Med. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(01)70012-8","article-title":"Lysyl oxidases: A novel multifunctional amine oxidase family","volume":"70","author":"Csiszar","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Deshpande, C.N., Xin, V., Lu, Y., Savage, T., Anderson, G.J., and Jormakka, M. (2017). Large scale expression and purification of secreted mouse hephaestin. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184366"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1021\/ja046888z","article-title":"Investigation of the pathway for inter-copper electron transfer in peptidylglycine \u03b1-amidating monooxygenase","volume":"126","author":"Francisco","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/geno.1994.1357","article-title":"Extracellular superoxide dismutase (SOD3): Tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene","volume":"22","author":"Folz","year":"1994","journal-title":"Genomics"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Dini, I., and Grumetto, L. (2022). Recent advances in natural polyphenol research. Molecules, 27.","DOI":"10.3390\/molecules27248777"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.1021\/acsnano.2c00642","article-title":"A polyphenol-network-mediated coating modulates inflammation and vascular healing on vascular stents","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Farhan, M., and Rizvi, A. (2022). Understanding the prooxidant action of plant polyphenols in the cellular microenvironment of malignant cells: Role of copper and therapeutic implications. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.929853"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101145","DOI":"10.1016\/j.pmatsci.2023.101145","article-title":"The copper age in cancer treatment: From copper metabolism to cuproptosis","volume":"138","author":"Xie","year":"2023","journal-title":"Prog. Mater. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00424-020-02412-2","article-title":"The molecular mechanisms of copper metabolism and its roles in human diseases","volume":"472","author":"Chen","year":"2020","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/jn\/109.11.1979","article-title":"A conspectus of research on copper metabolism and requirements of man","volume":"109","author":"Mason","year":"1979","journal-title":"J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110173","DOI":"10.1016\/j.cbi.2022.110173","article-title":"Essential metals in health and disease","volume":"367","author":"Jomova","year":"2022","journal-title":"Chem. -Biol. Interact."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1039\/c5mt00097a","article-title":"Copper uptake by DMT1: A compensatory mechanism for CTR1 deficiency in human umbilical vein endothelial cells\u2020","volume":"7","author":"Lin","year":"2015","journal-title":"Metallomics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1073\/pnas.89.9.3869","article-title":"Ferric reductase of Saccharomyces cerevisiae: Molecular characterization, role in iron uptake, and transcriptional control by iron","volume":"89","author":"Dancis","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1182\/blood-2006-02-003681","article-title":"The Steap proteins are metalloreductases","volume":"108","author":"Ohgami","year":"2006","journal-title":"Blood"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.nutr.20.1.291","article-title":"Cellular copper transport and metabolism","volume":"20","author":"Harris","year":"2000","journal-title":"Annu. Rev. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ramos, D., Mar, D., Ishida, M., Vargas, R., Gaite, M., Montgomery, A., and Linder, M.C. (2016). Mechanism of copper uptake from blood plasma ceruloplasmin by mammalian cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149516"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"812s","DOI":"10.1093\/ajcn\/63.5.812","article-title":"Liver copper storage and transport during development: Implications for cytotoxicity","volume":"63","author":"Luza","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.biocel.2009.11.007","article-title":"Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: Emerging roles","volume":"42","author":"Ackland","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1079\/PNS2003316","article-title":"Molecular regulation of copper excretion in the liver","volume":"63","author":"Wijmenga","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"ref_38","first-page":"214","article-title":"An overview of the metabolism of copper","volume":"4","author":"Aggett","year":"1999","journal-title":"Eur. J. Med. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jn\/136.1.21","article-title":"Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status","volume":"136","author":"Kuo","year":"2006","journal-title":"J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1039\/C4MT00020J","article-title":"Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG\/2GSH and the availability of Cu (I)","volume":"6","author":"Brose","year":"2014","journal-title":"Metallomics"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1073\/pnas.040461197","article-title":"Copper chaperone for superoxide dismutase is essential to activate mammalian Cu\/Zn superoxide dismutase","volume":"97","author":"Wong","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1038\/s41467-022-31413-1","article-title":"Coordination of metal center biogenesis in human cytochrome c oxidase","volume":"13","author":"Dietz","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhang, M., Liao, X., Ji, G., Fan, X., and Wu, Q. (2023). High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065705"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1074\/jbc.275.1.619","article-title":"Cox11p is required for stable formation of the CuBand magnesium centers of cytochrome c oxidase","volume":"275","author":"Hiser","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ferguson, N., Zhang, Y., Perez, A.M., Mezzell, A.T., Shanbhag, V.C., Petris, M.J., and Vest, K.E. (2025). The copper chaperone ATOX1 exhibits differential protein-protein interactions and contributes to skeletal myoblast differentiation. bioRxiv.","DOI":"10.1101\/2025.07.08.663731"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"117182","DOI":"10.1016\/j.biopha.2024.117182","article-title":"Focus on cuproptosis: Exploring new mechanisms and therapeutic application prospects of cuproptosis regulation","volume":"178","author":"Hao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"215156","DOI":"10.1016\/j.ccr.2023.215156","article-title":"Cu-related agents for cancer therapies","volume":"487","author":"Wang","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41589-019-0291-9","article-title":"Mitochondrial metabolism promotes adaptation to proteotoxic stress","volume":"15","author":"Tsvetkov","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plipres.2016.05.002","article-title":"Fatty acylation of proteins: The long and the short of it","volume":"63","author":"Resh","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbamcr.2011.11.002","article-title":"Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis","volume":"1823","author":"Shi","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1021\/acs.biochem.6b00447","article-title":"Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis","volume":"56","author":"Cai","year":"2017","journal-title":"Biochemistry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41568-023-00594-2","article-title":"Bacteria in cancer initiation, promotion and progression","volume":"23","author":"Garrett","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"121335","DOI":"10.1016\/j.biomaterials.2021.121335","article-title":"Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens","volume":"281","author":"Lu","year":"2022","journal-title":"Biomaterials"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-023-01732-y","article-title":"Cuproptosis: Mechanisms and links with cancers","volume":"22","author":"Xie","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12964-024-01625-7","article-title":"Cuproptosis: Unveiling a new frontier in cancer biology and therapeutics","volume":"22","author":"Feng","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12935-025-03683-4","article-title":"Cuproplasia and cuproptosis in hepatocellular carcinoma: Mechanisms, relationship and potential role in tumor microenvironment and treatment","volume":"25","author":"Zhang","year":"2025","journal-title":"Cancer Cell Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41392-025-02192-0","article-title":"The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer","volume":"10","author":"Guo","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"34158","DOI":"10.18632\/oncotarget.5779","article-title":"Copper activates HIF-1\u03b1\/GPER\/VEGF signalling in cancer cells","volume":"6","author":"Rigiracciolo","year":"2015","journal-title":"Oncotarget"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"110496","DOI":"10.1016\/j.isci.2024.110496","article-title":"Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis","volume":"27","author":"Huang","year":"2024","journal-title":"iScience"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s11658-024-00623-4","article-title":"Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer","volume":"29","author":"Xiao","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108218","DOI":"10.1016\/j.isci.2023.108218","article-title":"Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10060","DOI":"10.1038\/s41467-024-54469-7","article-title":"Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy","volume":"15","author":"Guan","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2212267","DOI":"10.1002\/adma.202212267","article-title":"Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2304522","DOI":"10.1002\/adhm.202304522","article-title":"Mitochondrial-targeted copper delivery for cuproptosis-based synergistic cancer therapy","volume":"13","author":"Deng","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e202311549","DOI":"10.1002\/anie.202311549","article-title":"Cu2+-Anchored Carbon Nano-Photocatalysts for Visible Water Splitting to Boost Hydrogen Cuproptosis","volume":"62","author":"Ding","year":"2023","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1021\/acsnano.4c13753","article-title":"Cuproptosis-Inducing Functional Nanocomposites for Enhanced and Synergistic Cancer Radiotherapy","volume":"19","author":"Jiang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2310309","DOI":"10.1002\/advs.202310309","article-title":"Nanoparticles synergize ferroptosis and cuproptosis to potentiate cancer immunotherapy","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1038\/s41467-023-42025-8","article-title":"Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s42114-024-01153-5","article-title":"Engineered Cu-VT composite nanoparticles induce copper-dependent cell death in bladder cancer: Insights from single-cell spatial transcriptomics","volume":"8","author":"Ye","year":"2024","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bel\u0161\u010dak-Cvitanovi\u0107, A., Durgo, K., Hu\u0111ek, A., Ba\u010dun-Dru\u017eina, V., and Komes, D. (2018). Overview of polyphenols and their properties. Polyphenols: Properties, Recovery, and Applications, Elsevier.","DOI":"10.1016\/B978-0-12-813572-3.00001-4"},{"key":"ref_71","first-page":"12","article-title":"Bioactive flavonoids in medicinal plants: Structure, activity and biological fate","volume":"13","author":"Wang","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S335","DOI":"10.3233\/JAD-200185","article-title":"Polyphenols as potential metal chelation compounds against Alzheimer\u2019s disease","volume":"82","author":"Burillo","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wang, Z., and An, P. (2017). Characterization of copper complex nanoparticles synthesized by plant polyphenols. BioRxiv.","DOI":"10.1101\/134940"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"14750","DOI":"10.1021\/acs.jpcb.5b08020","article-title":"Keto-Enol Tautomeric Equilibrium of Acetylacetone Solution Confined in Extended Nanospaces","volume":"119","author":"Tsukahara","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12263-009-0143-4","article-title":"Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: A reflective outcome of its antioxidant, iron chelating and neuritogenic properties","volume":"4","author":"Weinreb","year":"2009","journal-title":"Genes Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0162-0134(02)00511-1","article-title":"Iron and copper chelation by flavonoids: An electrospray mass spectrometry study","volume":"92","author":"Fernandez","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2301346","DOI":"10.1002\/adhm.202301346","article-title":"Redox Homeostasis Disruptors Based on Metal-Phenolic Network Nanoparticles for Chemo\/Chemodynamic Synergistic Tumor Therapy through Activating Apoptosis and Cuproptosis","volume":"12","author":"Zhao","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"21001","DOI":"10.1021\/acsami.5c05104","article-title":"Atovaquone-Coordinated Copper-Polyphenol Nanoplatform Orchestrates Dual Metabolic Interference for Synergistic Cuproptosis and Apoptosis","volume":"17","author":"Qin","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13046-026-03642-5","article-title":"A mitochondrion-targeted natural polyphenolic copper carrier overcomes tumor resistance to cisplatin by potentiating cuproptosis","volume":"45","author":"Yang","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"100055","DOI":"10.1016\/j.preme.2026.100055","article-title":"Ion Overload-Induced Pyroptosis in Nanoscale Systems: A Novel Strategy for Tumor Immunotherapy","volume":"3","author":"Wang","year":"2026","journal-title":"Precis. Med. Eng."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"He, G., Zhu, H., Kang, P., Feng, L., Yu, C., Zhu, Y., Liu, B., Guo, Z., and Yang, P. (2025). Bimetallic Peroxide Nanocomposites-Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy. Adv. Sci., e12470.","DOI":"10.1002\/advs.202512470"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.actbio.2024.05.035","article-title":"Dendrimer\/metal-phenolic nanocomplexes encapsulating CuO2 for targeted magnetic resonance imaging and enhanced ferroptosis\/cuproptosis\/chemodynamic therapy by regulating the tumor microenvironment","volume":"183","author":"Huang","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"163577","DOI":"10.1016\/j.cej.2025.163577","article-title":"Copper deposited metal-phenolic networks enabled crosstalk between cuproptosis and ferroptosis for triple-negative breast cancer immunotherapy","volume":"515","author":"Yin","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1186\/s12951-025-03722-2","article-title":"Cascade-targeting copper homeostasis nano-regulators for mild-photothermal boosted cuproptosis\/ferroptosis mediated breast cancer therapy","volume":"23","author":"Liang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"113941","DOI":"10.1016\/j.jconrel.2025.113941","article-title":"Self-assembled copper chlorogenic acid nanoparticles: Inducing pyroptosis and cuproptosis to activate antitumor immunity","volume":"384","author":"Zhou","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wang, X., Jiang, P., Wang, P., Yang, C.S., Wang, X., and Feng, Q. (2015). EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125402"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"43337","DOI":"10.18632\/oncotarget.9712","article-title":"NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/mol.108.046771","article-title":"Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells","volume":"74","author":"Song","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phymed.2018.04.058","article-title":"Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop","volume":"48","author":"Zhang","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Hedayati, N., Yaghoobi, A., Salami, M., Gholinezhad, Y., Aghadavood, F., Eshraghi, R., Aarabi, M.H., Homayoonfal, M., Asemi, Z., and Mirzaei, H. (2023). Impact of polyphenols on heart failure and cardiac hypertrophy: Clinical effects and molecular mechanisms. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1174816"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Qin, X., Wang, P., Liang, H., and Si, W. (2024). Curcumin suppresses copper accumulation in non-small cell lung cancer by binding ATOX1. BMC Pharmacol. Toxicol., 25.","DOI":"10.1186\/s40360-024-00784-0"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Farhan, M. (2022). Naringin\u2019s Prooxidant Effect on Tumor Cells: Copper\u2019s Role and Therapeutic Implications. Pharmaceuticals, 15.","DOI":"10.3390\/ph15111431"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Farhan, M., El Oirdi, M., Aatif, M., Nahvi, I., Muteeb, G., and Alam, M.W. (2023). Soy isoflavones induce cell death by copper-mediated mechanism: Understanding its anticancer properties. Molecules, 28.","DOI":"10.3390\/molecules28072925"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Fu, Y., Hou, L., Han, K., Zhao, C., Hu, H., and Yin, S. (2025). Epigallocatechin Gallate Promotes Cuproptosis via the MTF1\/ATP7B Axis in Hepatocellular Carcinoma. Cells, 14.","DOI":"10.3390\/cells14060391"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"19581","DOI":"10.1021\/acsnano.3c07775","article-title":"Cuproptosis: Harnessing Transition Metal for Cancer Therapy","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"29579","DOI":"10.1038\/s41598-024-81317-x","article-title":"NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism","volume":"14","author":"Liu","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"173424","DOI":"10.1016\/j.ejphar.2020.173424","article-title":"Curcumin reduces methionine adenosyltransferase 2B expression by interrupting phosphorylation of p38 MAPK in hepatic stellate cells","volume":"886","author":"Hu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000516892","article-title":"Curcumin affects leptin-induced expression of methionine adenosyltransferase 2A in hepatic stellate cells by inhibition of JNK signaling","volume":"106","author":"Lu","year":"2021","journal-title":"Pharmacology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"23161","DOI":"10.1074\/jbc.M113.487157","article-title":"Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells","volume":"288","author":"Yang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1039\/C7MD00484B","article-title":"Antitumor effect of sikokianin C, a selective cystathionine \u03b2-synthase inhibitor, against human colon cancer In Vitro and In Vivo","volume":"9","author":"Niu","year":"2018","journal-title":"MedChemComm"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.niox.2022.07.007","article-title":"Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action","volume":"128","author":"Zuhra","year":"2022","journal-title":"Nitric Oxide"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1124\/dmd.31.1.11","article-title":"Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)","volume":"31","author":"Leslie","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7150\/thno.37472","article-title":"ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells","volume":"10","author":"Pan","year":"2020","journal-title":"Theranostics"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Chard Dunmall, L.S., Cheng, Z., Wang, Y., and Si, L. (2022). Natural products targeting glycolysis in cancer. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1036502"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s11658-024-00608-3","article-title":"Cuproptosis in cancer: Biological implications and therapeutic opportunities","volume":"29","author":"Li","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.lfs.2018.07.027","article-title":"Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction","volume":"208","author":"Jia","year":"2018","journal-title":"Life Sci."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Wu, H., Pan, L., Gao, C., Xu, H., Li, Y., Zhang, L., Ma, L., Meng, L., Sun, X., and Qin, H. (2019). Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway. Molecules, 24.","DOI":"10.3390\/molecules24101993"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3892\/ijo.2022.5309","article-title":"Epigallocatechin-3-gallate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancer-associated fibroblasts","volume":"60","author":"Chen","year":"2022","journal-title":"Int. J. Oncol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1038\/s41598-018-25524-3","article-title":"Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1\u03b1 inhibition","volume":"8","author":"Siddiqui","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Bianchini, S., Bovio, F., Negri, S., Guzzo, F., Forcella, M., and Fusi, P. (2025). Gratiola officinalis Alcoholic Extract Targets Warburg Effect, Apoptosis and Cell Cycle Progression in Colorectal Cancer Cell Lines. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052220"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1038\/s41598-017-07006-0","article-title":"Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells","volume":"7","author":"Saunier","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Iqbal, M.A., and Bamezai, R.N. (2012). Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036764"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Karpova, N., Fefilova, E., Daks, A., Parfenyev, S., Nazarov, A., Barlev, N.A., and Shuvalov, O. (2025). Dietary Polyphenol Combinations Have a Multifaceted Inhibitory Effect on Metabolic Rewiring and Signaling Pathways in Neuroblastoma. Pharmaceuticals, 18.","DOI":"10.3390\/ph18111717"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.freeradbiomed.2022.11.023","article-title":"Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore","volume":"193","author":"Yang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/biof.2052","article-title":"SP1\/CTR1-mediated oxidative stress-induced cuproptosis in intervertebral disc degeneration","volume":"50","author":"Chen","year":"2024","journal-title":"Biofactors"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2017.03.061","article-title":"Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases","volume":"133","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/bs.afnr.2021.02.010","article-title":"Antioxidant\/pro-oxidant and antiproliferative activities of phenolic-rich foods and extracts: A cell-based point of view","volume":"Volume 98","author":"Granato","year":"2021","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s41021-024-00307-7","article-title":"Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage","volume":"46","author":"Kobayashi","year":"2024","journal-title":"Genes Environ."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1042\/BST0351156","article-title":"Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications","volume":"35","author":"Villegas","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Xu, Y., Tang, G., Zhang, C., Wang, N., and Feng, Y. (2021). Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress. Molecules, 26.","DOI":"10.3390\/molecules26237115"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Fu, M., Zhang, L., Killeen, R., Onugwu, K.E., McCarrick, R.M., and Hagerman, A.E. (2025). Green Tea Polyphenol Epigallocatechin Gallate Interactions with Copper-Serum Albumin. Molecules, 30.","DOI":"10.3390\/molecules30020320"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"116326","DOI":"10.1016\/j.watres.2020.116326","article-title":"Natural polyphenols enhanced the Cu (II)\/peroxymonosulfate (PMS) oxidation: The contribution of Cu (III) and HO\u2022","volume":"186","author":"Wang","year":"2020","journal-title":"Water Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s42003-024-05903-5","article-title":"Phenolic compounds induce ferroptosis-like death by promoting hydroxyl radical generation in the Fenton reaction","volume":"7","author":"Sui","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"104744","DOI":"10.1016\/j.bioorg.2021.104744","article-title":"Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway","volume":"109","author":"Xie","year":"2021","journal-title":"Bioorg Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.bbrc.2019.06.070","article-title":"Typhaneoside prevents acute myeloid leukemia (AML) through suppressing proliferation and inducing ferroptosis associated with autophagy","volume":"516","author":"Zhu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"101040","DOI":"10.1016\/j.mtbio.2024.101040","article-title":"Self-assembled metal-phenolic nanocomplexes comprised of green tea catechin for tumor-specific ferroptosis","volume":"26","author":"Wang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"116115","DOI":"10.1016\/j.biopha.2023.116115","article-title":"Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application","volume":"171","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Wang, H., Luo, Y., Ran, R., Li, X., Ling, H., Wen, F., and Yu, T. (2022). IDO1 Modulates the Sensitivity of Epithelial Ovarian Cancer Cells to Cisplatin through ROS\/p53-Dependent Apoptosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231912002"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Ch\u00e1irez-Ram\u00edrez, M.H., de la Cruz-L\u00f3pez, K.G., and Garc\u00eda-Carranc\u00e1, A. (2021). Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.710304"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41420-025-02553-2","article-title":"Cuproptosis and cuproptosis-related cell death and genes: Mechanistic links to spermatogenic cell death","volume":"11","author":"Li","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e1509","DOI":"10.1038\/cddis.2014.467","article-title":"Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer","volume":"5","author":"Hasima","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Musial, C., Siedlecka-Kroplewska, K., Kmiec, Z., and Gorska-Ponikowska, M. (2021). Modulation of Autophagy in Cancer Cells by Dietary Polyphenols. Antioxidants, 10.","DOI":"10.3390\/antiox10010123"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Liu, W., Hu, M., Cao, F., and Jin, S. (2025). Polyphenols and exercise in autophagy regulation: Potential benefits for cancer management and healthspan. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1618813"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e70039","DOI":"10.1111\/cns.70039","article-title":"Cuproptosis: Mechanisms, biological significance, and advances in disease treatment-A systematic review","volume":"30","author":"Pan","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"117725","DOI":"10.1016\/j.ecoenv.2025.117725","article-title":"Inducers of autophagy and cell death: Focus on copper metabolism","volume":"290","author":"Ling","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Capasso, L., De Masi, L., Sirignano, C., Maresca, V., Basile, A., Nebbioso, A., Rigano, D., and Bontempo, P. (2025). Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential. Molecules, 30.","DOI":"10.3390\/molecules30030654"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Ciupei, D., Coli\u015far, A., Leopold, L., St\u0103nil\u0103, A., and Diaconeasa, Z.M. (2024). Polyphenols: From Classification to Therapeutic Potential and Bioavailability. Foods, 13.","DOI":"10.3390\/foods13244131"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Scott, M.B., Styring, A.K., and McCullagh, J.S.O. (2022). Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals. Pathogens, 11.","DOI":"10.3390\/pathogens11070770"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"24515","DOI":"10.1038\/s41598-025-08665-0","article-title":"Pharmacokinetic evaluation of two oral Resveratrol formulations in a randomized, open-label, crossover study in healthy fasting subjects","volume":"15","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"26905","DOI":"10.1038\/srep26905","article-title":"Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study","volume":"6","author":"Achaintre","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Shaito, A., Posadino, A.M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W.M., Eid, A.H., and Nasrallah, G.K. (2020). Potential Adverse Effects of Resveratrol: A Literature Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062084"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Talib, W.H., Awajan, D., Alqudah, A., Alsawwaf, R., Althunibat, R., Abu AlRoos, M., Al Safadi, A.a., Abu Asab, S., Hadi, R.W., and Al Kury, L.T. (2024). Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets. Molecules, 29.","DOI":"10.3390\/molecules29061373"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"100099","DOI":"10.1016\/j.arres.2024.100099","article-title":"Anti- and pro-oxidant properties of polyphenols and their role in modulating glutathione synthesis, activity and cellular redox potential: Potential synergies for disease management","volume":"11","author":"Dzah","year":"2024","journal-title":"Adv. Redox Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"7974","DOI":"10.1021\/jacs.2c13515","article-title":"Dynamic Metal\u2013Phenolic Coordination Complexes for Versatile Surface Nanopatterning","volume":"145","author":"Chen","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s13105-025-01105-7","article-title":"Phenolic compounds and epigenetic mechanisms regulating gene expression: Effects on human health","volume":"81","author":"Costa","year":"2025","journal-title":"J. Physiol. Biochem."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Taldaev, A., Svotin, A.A., Obukhov, S.I., Terekhov, R.P., and Selivanova, I.A. (2025). Modification of biopharmaceutical parameters of flavonoids: A review. Front. Chem., 13.","DOI":"10.3389\/fchem.2025.1602967"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Jia, W., Zhou, L., Li, L., Zhou, P., and Shen, Z. (2023). Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges. Pharmaceuticals, 16.","DOI":"10.3390\/ph16010101"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e09519","DOI":"10.1016\/j.heliyon.2022.e09519","article-title":"Synergistic effects of natural compounds and conventional chemotherapeutic agents: Recent insights for the development of cancer treatment strategies","volume":"8","author":"Uribe","year":"2022","journal-title":"Heliyon"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41420-025-02328-9","article-title":"Insights on the crosstalk among different cell death mechanisms","volume":"11","author":"Eskander","year":"2025","journal-title":"Cell Death Discov."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/6\/917\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:38:21Z","timestamp":1773668301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/6\/917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,14]]},"references-count":150,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["nu18060917"],"URL":"https:\/\/doi.org\/10.3390\/nu18060917","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,14]]}}}