{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:56:22Z","timestamp":1791618982578,"version":"4.3.4"},"reference-count":61,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Disorders of Gut\u2013Brain Interaction (DGBIs), particularly irritable bowel syndrome (IBS), are frequently underdiagnosed in clinical practice, contributing to a substantial hidden burden of disease. This study aimed to quantify this \u201csymptomatic iceberg\u201d by comparing the prevalence of formal IBS diagnoses with a broader symptom-based case definition in a clinical cohort. Methods: We conducted a cross-sectional analysis of 194 adult subjects from a gastroenterology clinic in Western Romania. Data on demographics, clinical diagnoses, self-reported symptoms, and eating behaviors were collected. For the case\u2013control analysis, patients with confirmed organic gastrointestinal pathology or incomplete data were excluded. The final analytical sample consisted of 52 patients classified as having a functional DGBI phenotype and 84 asymptomatic controls without organic disease, while 58 were excluded from the analysis. Results: While only 4.4% (95% CI: 2.0\u20139.3%) of the cohort (N = 136) had a formal IBS diagnosis, 47.8% (95% CI: 39.6\u201356.1%) met criteria for an IBS-compatible symptom cluster, yielding an underdiagnosis ratio of 10.8. Neuro-vegetative symptoms such as sweating (19.1%) and dizziness (11.8%) were highly prevalent. In the case\u2013control analysis, patients with a functional DGBI phenotype had a significantly higher mean BMI compared to controls (28.15 \u00b1 6.49 vs. 24.47 \u00b1 4.60 kg\/m2; p = 0.001). DGBI cases were less likely to report regular snacking behavior (OR = 0.36; 95% CI: 0.18\u20130.74; p = 0.009), suggesting behavioral adaptation. A sensitivity analysis excluding participants with CRP &gt; 10 mg\/L (n = 98) confirmed the robustness of these associations, indicating that minor systemic inflammation did not bias the primary findings.<\/jats:p>","DOI":"10.3390\/nu18071023","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:58:59Z","timestamp":1774357139000},"page":"1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary Behaviors, Digestive Symptoms, and Neurovegetative Features in Disorders of Gut\u2013Brain Interaction: A Cross-Sectional Clinical Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-3786","authenticated-orcid":false,"given":"Lavinia Cristina","family":"Moleriu","sequence":"first","affiliation":[{"name":"Department III, Functional Science, Discipline of Medical Informatics and Biostatistics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"The Doctoral School of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-4779","authenticated-orcid":false,"given":"Raluca","family":"Lupusoru","sequence":"additional","affiliation":[{"name":"Department III, Functional Science, Discipline of Medical Informatics and Biostatistics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Center for Modeling Biological Systems and Data Analysis, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Gastroenterology and Hepatology Clinic, County Emergency Hospital \u201cPius Brinzeu\u201d, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-0405","authenticated-orcid":false,"given":"C\u0103lin","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department III, Functional Science, Discipline of Medical Informatics and Biostatistics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Piro\u0219","sequence":"additional","affiliation":[{"name":"Department III, Functional Science, Discipline of Medical Informatics and Biostatistics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Popescu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Clinic, County Emergency Hospital \u201cPius Brinzeu\u201d, 300723 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Internal Medicine II, Division of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Sirli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Clinic, County Emergency Hospital \u201cPius Brinzeu\u201d, 300723 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Internal Medicine II, Division of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia","family":"Nica","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Clinic, County Emergency Hospital \u201cPius Brinzeu\u201d, 300723 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Internal Medicine II, Division of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-1865","authenticated-orcid":false,"given":"Daliborca Cristina","family":"Vlad","sequence":"additional","affiliation":[{"name":"Department IV, Biochemistry and Pharmacology, Discipline of Pharmacology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0113-6748","authenticated-orcid":false,"given":"Dora Mihaela","family":"C\u00eempian","sequence":"additional","affiliation":[{"name":"Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u015f, 540139 T\u00e2rgu Mure\u015f, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Mihaela","family":"Corodan Comiati","sequence":"additional","affiliation":[{"name":"Psychiatry Clinic 1, County Clinical Hospital Mure\u0219, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei Luca","family":"Dumitra\u0219cu","sequence":"additional","affiliation":[{"name":"The Doctoral School of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Dumitra\u0219cu","sequence":"additional","affiliation":[{"name":"Department IV, Biochemistry and Pharmacology, Discipline of Pharmacology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1053\/j.gastro.2016.03.035","article-title":"Rome IV\u2014Functional GI Disorders: Disorders of Gut-Brain 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