{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:07:41Z","timestamp":1791479261426,"version":"4.3.4"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hae-Jeung Lee","award":["Ildong Foodis Co., Ltd. (Seoul, Republic of Korea)"],"award-info":[{"award-number":["Ildong Foodis Co., Ltd. (Seoul, Republic of Korea)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Osteoarthritis is a chronic joint disorder involving the progressive breakdown of articular cartilage, which leads to joint pain and impaired mobility. The present study investigated the effects of curcuminoids phospholipid (CP) on osteoarthritis progression, assessed its cartilage-protective effects, and elucidated the underlying mechanisms. Methods: Male Sprague\u2013Dawley rats were randomly allocated to six experimental groups. One group received an intra-articular saline injection as the normal control (NC), while the remaining five groups were injected with monosodium iodoacetate (MIA) and consisted of an MIA control group (MC), a positive control group treated with celecoxib (PC, 3 mg\/kg), and three groups treated with CP (31.25, 62.5, or 125 mg\/kg). Results: Compared with the MC group, CP administration significantly improved pain-related behavior, as assessed by weight-bearing measurements. Micro-computed tomography and histological analyses demonstrated that CP administration mitigated subchondral bone erosion and preserved cartilage integrity. Additionally, the CP treatment significantly reduced markers associated with cartilage degradation, including matrix metalloproteinases and cartilage oligomeric matrix proteins; downregulated the expression of matrix-degrading enzymes; and restored aggrecan expression. Serum levels of inflammatory mediators, including nitric oxide; prostaglandin E2; C-reactive protein; and pro-inflammatory cytokines, including interleukin (IL)-6, tumor necrosis factor (TNF)-\u03b1, and IL-1\u03b2, were reduced following CP administration. Furthermore, CP decreased the activation of nuclear factor kappa B (NF-\u03baB) signaling. Conclusions: These findings suggest that CP may be a promising functional agent for osteoarthritis, demonstrating beneficial effects on pain-related outcomes and cartilage integrity, potentially mediated by its anti-inflammatory activity.<\/jats:p>","DOI":"10.3390\/nu18071111","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:20:47Z","timestamp":1774884047000},"page":"1111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Curcuminoids Phospholipid Attenuates Osteoarthritis and Protects Cartilage in a Monosodium Iodoacetate-Induced Rat Model"],"prefix":"10.3390","volume":"18","author":[{"given":"Hae-Sun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"},{"name":"Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-1834","authenticated-orcid":false,"given":"Eun-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam 13120, Republic of Korea"},{"name":"Department of Food and Nutrition, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-3619","authenticated-orcid":false,"given":"Hae-Jeung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"},{"name":"Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam 13120, Republic of Korea"},{"name":"Department of Food and Nutrition, Gachon University, Seongnam 13120, Republic of Korea"},{"name":"Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Gachon University, Incheon 21999, Republic of Korea"},{"name":"Gachon Biomedical Convergence Institute, Gachon University Gil Medical Center, Incheon 21565, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109683","DOI":"10.1016\/j.intimp.2023.109683","article-title":"Stevioside targets the NF-kappaB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo","volume":"115","author":"Cai","year":"2023","journal-title":"Int. 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