{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:43:30Z","timestamp":1792806210743,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Argentine Society of Diabetes","award":["SAD-SIC-2021"],"award-info":[{"award-number":["SAD-SIC-2021"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica de Argentina\n              https:\/\/ror.org\/03stxzb56","award":["PICT 2021-0078"],"award-info":[{"award-number":["PICT 2021-0078"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Gestational diabetes mellitus (GDM) is a prevalent metabolic disease associated with maternal and neonatal complications. Diets enriched with extra virgin olive oil may benefit metabolism and provide antioxidant effects. We aimed to evaluate the effects of dietary supplementation with extra virgin olive oil on metabolic parameters and insulinization rate in women with GDM. Methods: This is a multicenter, parallel, randomized controlled trial in which 190 patients with GDM were enrolled before week 29 of gestation and randomized into the Control group and the Intervention group. Patients in the Intervention group received the indication to consume three tablespoons of extra virgin olive oil (EVOO) daily. At term, metabolic parameters, insulin requirement and maternal and neonatal outcomes were evaluated. Results: Control and Intervention groups showed no differences in maternal age (31.7 \u00b1 6.0 and 32.4 \u00b1 5.2 years, respectively) or gestational age (26.5 \u00b1 3.6 and 26.7 \u00b1 3.3 weeks, respectively) at enrollment. Primary outcomes showed that EVOO consumption was associated with a reduction in insulin requirement (RR 0.595, 95% CI 0.361\u20130.967, p &lt; 0.05). There was a significant reduction in triglyceridemia in the EVOO-supplemented group compared to controls (MD \u221243.3 mg\/dL, 95% CI \u221266.8\u2013\u221219.8, p &lt; 0.01). There were no effects of the intervention on gestational weight gain. As secondary outcomes, maternal BMI and gestational age at delivery showed no changes between the groups. Although maternal and neonatal composite outcomes were not significantly reduced, the rate of neonates with more than one complication (RR 0.340, 95% CI 0.133\u20130.870, p &lt; 0.05) and NICU requirement (RR 0.367, 95% CI 0.140\u20130.939, p &lt; 0.05) were significantly reduced in the Intervention group. Conclusions: In GDM, maternal dietary supplementation with extra virgin olive oil resulted in reduction in maternal triglyceridemia, need of insulinization and neonatal complications.<\/jats:p>","DOI":"10.3390\/nu18071120","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:23:17Z","timestamp":1774963397000},"page":"1120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["OLIDIAG Study: Extra Virgin Olive Oil Supplementation in the Diet of Women with Gestational Diabetes Mellitus\u2014A Randomized Clinical Trial"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-2398","authenticated-orcid":false,"given":"Alicia","family":"Jawerbaum","sequence":"first","affiliation":[{"name":"Laboratory of Reproduction and Metabolism, Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires 1121, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-2090","authenticated-orcid":false,"given":"Silvia","family":"Gorban de Lapertosa","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Farmacol\u00f3gicas, Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes 3400, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Rey","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Ciudad Aut\u00f3noma de Buenos Aires 1118, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Argerich","sequence":"additional","affiliation":[{"name":"Hospital Perrupato, Mendoza 5570, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4470-5686","authenticated-orcid":false,"given":"Mariano","family":"Reynoso","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Biolog\u00eda Celular y Molecular, Departamento de Ciencias Biol\u00f3gicas, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Celeste","family":"Muntaner","sequence":"additional","affiliation":[{"name":"Unidad Patag\u00f3nica de Medicina Materno Fetal y Embarazo de Alto Riesgo, Neuqu\u00e9n 8300, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Bertona","sequence":"additional","affiliation":[{"name":"Hospital Universitario, Universidad Nacional de Cuyo (UNCUYO), Mendoza 5502, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica Kojdamanian","family":"Favetto","sequence":"additional","affiliation":[{"name":"Center for Education, Prevention and Care for Patients with Diabetes (CEPA), Municipalidad de Pilar, Pilar 1629, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Dr. Ignacio Pirovano, Ciudad Aut\u00f3noma de Buenos Aires 1428, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Sucani","sequence":"additional","affiliation":[{"name":"Hospital Materno Provincial Dr. Felipe Lucini, C\u00f3rdoba 5006, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-1112","authenticated-orcid":false,"given":"Dalmiro","family":"Gomez Ribot","sequence":"additional","affiliation":[{"name":"Laboratory of Reproduction and Metabolism, Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires 1121, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"ref_1","unstructured":"IDF Diabetes Atlas (2026, January 26). 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