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Objective: To assess the therapeutic effect and mechanism of action of the xanthan-gum-based thickener Tsururinko Quickly in older patients with structural OD and those with mild OD (Penetration\u2013Aspiration Score &lt; 3). Patients and Methods: We included 25 participants in each group (81.8 \u00b1 7.1 vs. 77.4 \u00b1 7.2 yr, respectively). Participants underwent videofluoroscopy (VFS) while swallowing 10 mL boluses at &lt;50 mPa\u00b7s, 100, 200, 400, 800, and 1600 mPa\u00b7s to evaluate the safety and efficacy of swallowing and the biomechanics of the swallowing response at each viscosity level. After 30 s oral incubation, the effect of salivary \u03b1-amylase on shear viscosity was assessed using viscometer measurements. Results: (a) For the &lt;50 mPa\u00b7s liquid series, no aspirations occurred in either group; however, 44% of patients with structural OD and 30% of patients with mild OD showed PAS 2 penetrations. (b) Fluid thickening reduced prevalence of penetrations with a maximal effect at 800 mPa\u00b7s and without affecting oral or pharyngeal residue in either group. (c) Increasing shear viscosity did not affect timing of airway protection mechanisms nor bolus kinematics. (d) Oral incubation decreased viscosity by 1.7\u20131.8% at 800 mPa\u00b7s. Conclusions: Fluid thickening with TQ enhances swallowing safety in older patients with structural causes of OD and those with mild OD through compensatory mechanisms and without a consistent increase in pharyngeal residue across the tested viscosity range.<\/jats:p>","DOI":"10.3390\/nu18071138","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T14:59:01Z","timestamp":1775055541000},"page":"1138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Fluid Thickening with a Gum-Based Thickening Product in Older Patients with Structural or Mild Oropharyngeal Dysphagia"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-5144","authenticated-orcid":false,"given":"Johana","family":"Muchov\u00e1","sequence":"first","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital Universitari de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-1150","authenticated-orcid":false,"given":"Mireia","family":"Bol\u00edvar-Prados","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital Universitari de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"N\u00fa\u00f1ez-Lara","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital Universitari de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-7948","authenticated-orcid":false,"given":"Noem\u00ed","family":"Tomsen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital Universitari de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-8560","authenticated-orcid":false,"given":"Pere","family":"Clav\u00e9","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Laboratory, Hospital Universitari de Matar\u00f3, Universitat Aut\u00f2noma de Barcelona, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1055\/s-0039-1688837","article-title":"Presbyphagia to Dysphagia: Multiple Perspectives and Strategies for Quality Care of Older Adults","volume":"40","author":"Riquelme","year":"2019","journal-title":"Semin. 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