{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:59:32Z","timestamp":1788490772473,"version":"build-2803163510"},"reference-count":379,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Graft-versus-host disease (GVHD) is one of the principal complications seen in the recipients of allogenic hematopoietic stem cell transplantation (allo-HSCT), and persists as a leading cause of post-transplant morbidity and mortality. Increasing evidence highlights the crucial influence of the gut microbiome (GM) on transplant outcomes. Microbial dysbiosis, characterized by reduced bacterial diversity and pathogenic overgrowth, is strongly associated with higher rates of complications and mortality. Patients with lower microbial diversity exhibit poorer overall survival (OS) and an increased incidence of acute GVHD (aGVHD). Conversely, restoration of beneficial commensal communities has been shown to enhance immune homeostasis, mitigate GVHD severity, and decrease infection risk. Emerging therapeutic strategies now focus on modulating the intestinal microbiome through dietary interventions, probiotics, prebiotics, and fecal microbiota transplantation (FMT). It has been demonstrated that bacterial metabolites, such as short-chain fatty acids (SCFAs) from the diet, especially a diet rich in fibers, reduce the occurrence\/severity of GVHD by inducing regulatory T cells (Tregs), which release anti-inflammatory cytokines and regulate the host immune system. Hence, the implementation of dietary fibers (DFs) could increase beneficial commensals, Treg induction, and improve outcomes such as GVHD and OS in recipients of allo-HCT. Hereupon, this review addresses how a fiber-rich diet modulates GM composition, reinforces epithelial barrier integrity, and improves the efficacy of Treg-based immunotherapy by stabilizing their regulatory phenotype and increasing their functional persistence, ultimately leading to a reduction in GI complications associated with GVHD. Unlike prior reviews that primarily cover the microbiome\u2013GVHD axis or Treg therapies in isolation, this review emphasizes fermentable dietary fibers as a mechanistically grounded, clinically actionable strategy to support Treg stability and persistence via microbiota-derived metabolites. We integrate mechanistic evidence with emerging clinical feasibility data and ongoing trials of prebiotic supplementation in allogeneic HSCT.<\/jats:p>","DOI":"10.3390\/nu18081216","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:29:29Z","timestamp":1776065369000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of Gut Microbiota Through Dietary Fibers to Enhance Regulatory T Cell-Based Immunotherapy in GVHD Following Hematopoietic Stem Cell Transplantation"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1627-5773","authenticated-orcid":false,"given":"Melika","family":"Asayesh","sequence":"first","affiliation":[{"name":"Student Research Committee, Hamedan University of Medical Science, Hamadan 65319, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5968-9143","authenticated-orcid":false,"given":"Ata","family":"Nazarzadeh","sequence":"additional","affiliation":[{"name":"Department of Hematology, Mashhad University of Medical Sciences, Mashhad 9177948974, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 1411713116, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Keramat","sequence":"additional","affiliation":[{"name":"VAS-European Independent Foundation in Angiology\/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy"},{"name":"Support Association of Patients of Buerger\u2019s Disease, Buerger\u2019s Disease NGO, Mashhad 9183785195, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-6014","authenticated-orcid":false,"given":"Ireneusz","family":"Ryszkiel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Metabolic Diseases and Angiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Zio\u0142owa 45\/47, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-9898","authenticated-orcid":false,"given":"Agata","family":"Stanek","sequence":"additional","affiliation":[{"name":"VAS-European Independent Foundation in Angiology\/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy"},{"name":"Department of Internal Medicine, Metabolic Diseases and Angiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Zio\u0142owa 45\/47, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20406207241237602","DOI":"10.1177\/20406207241237602","article-title":"Research advances on short-chain fatty acids in gastrointestinal acute graft-versus-host disease","volume":"15","author":"Song","year":"2024","journal-title":"Ther. Adv. Hematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40164-021-00240-3","article-title":"Roles of the intestinal microbiota and microbial metabolites in acute GVHD","volume":"10","author":"Lin","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103405","DOI":"10.1016\/j.transci.2022.103405","article-title":"How does transfusion-associated graft-versus-host disease compare to hematopoietic cell transplantation-associated graft-versus-host disease?","volume":"61","author":"Aizawa","year":"2022","journal-title":"Transfus. Apher. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-cancerbio-062722-035210","article-title":"The Intestinal Microbiota and Therapeutic Responses to Immunotherapy","volume":"8","author":"Herrera","year":"2024","journal-title":"Annu. Rev. Cancer Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/bmt.2013.59","article-title":"Prognosis of grade 3-4 acute GVHD continues to be dismal","volume":"48","author":"Jamani","year":"2013","journal-title":"Bone Marrow Transpl. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100773","DOI":"10.1016\/j.medj.2025.100773","article-title":"Microbiota-derived metabolites: Key modulators of cancer immunotherapies","volume":"6","author":"Perl","year":"2025","journal-title":"Med"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hong, T., Wang, R., Wang, X., Yang, S., Wang, W., Gao, Q., and Zhang, X. (2021). Interplay Between the Intestinal Microbiota and Acute Graft-Versus-Host Disease: Experimental Evidence and Clinical Significance. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.644982"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101836","DOI":"10.1016\/j.trim.2023.101836","article-title":"Gut microbiota intervention by pre and probiotics can induce regulatory T cells and reduce the risk of severe acute GVHD following allogeneic hematopoietic stem cell transplantation","volume":"78","author":"Yazdandoust","year":"2023","journal-title":"Transpl. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1182\/blood-2014-02-554725","article-title":"The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation","volume":"124","author":"Taur","year":"2014","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1002\/imt2.156","article-title":"Gut microbiota reshapes cancer immunotherapy efficacy: Mechanisms and therapeutic strategies","volume":"3","author":"Xie","year":"2024","journal-title":"iMeta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41577-024-01102-9","article-title":"The danger theory of immunity revisited","volume":"24","author":"Kroemer","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.immuni.2024.07.020","article-title":"Long-distance microbial mechanisms impacting cancer immunosurveillance","volume":"57","author":"Zitvogel","year":"2024","journal-title":"Immunity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2024-204399","article-title":"Increased Fiber Intake Results in Better Overall Survival and Lower GI-aGVHD in Allo-HCT Recipients and Pre-Clinical Gvhd Models","volume":"144","author":"Paredes","year":"2024","journal-title":"Blood"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tan, J., Taitz, J., Sun, S.M., Langford, L., Ni, D., and Macia, L. (2022). Your Regulatory T Cells Are What You Eat: How Diet and Gut Microbiota Affect Regulatory T Cell Development. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.878382"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.jaci.2018.10.015","article-title":"Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier","volume":"142","author":"Esensten","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e70092","DOI":"10.1111\/1541-4337.70092","article-title":"Advances in understanding dietary fiber: Classification, structural characterization, modification, and gut microbiome interactions","volume":"24","author":"Feng","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1017\/S0029665121002834","article-title":"Interactions between dietary fibre and the gut microbiota","volume":"80","author":"Thomson","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2891-13-34","article-title":"CODEX-aligned dietary fiber definitions help to bridge the \u2018fiber gap\u2019","volume":"13","author":"Jones","year":"2014","journal-title":"Nutr. J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hu, R., Li, S., Diao, H., Huang, C., Yan, J., Wei, X., Zhou, M., He, P., Wang, T., and Fu, H. (2023). The interaction between dietary fiber and gut microbiota, and its effect on pig intestinal health. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1095740"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13765-021-00605-6","article-title":"Effects of dietary fibers, micronutrients, and phytonutrients on gut microbiome: A review","volume":"64","author":"Beane","year":"2021","journal-title":"Appl. Biol. Chem."},{"key":"ref_24","unstructured":"Preedy, V.R., Watson, R.R., and Patel, V.B. (2011). Chapter 16-Dietary Fiber from Brewer\u2019s Spent Grain as a Functional Ingredient in Bread Making Technology. Flour and Breads and their Fortification in Health and Disease Prevention, Academic Press."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Alahmari, L.A. (2024). Dietary fiber influence on overall health, with an emphasis on CVD, diabetes, obesity, colon cancer, and inflammation. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1510564"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106181","DOI":"10.1016\/j.jff.2024.106181","article-title":"Effect of soluble dietary fiber on gut microbiota and derived metabolites in stage 3 to 5 chronic kidney disease patients: A randomized controlled trial","volume":"116","author":"Cui","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Salvi, P.S., and Cowles, R.A. (2021). Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease. Cells, 10.","DOI":"10.3390\/cells10071775"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Fakhar, F., Mohammadian, K., Keramat, S., and Stanek, A. (2024). The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia. Nutrients, 16.","DOI":"10.3390\/nu16234100"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Merra, G., Noce, A., Marrone, G., Cintoni, M., Tarsitano, M.G., Capacci, A., and De Lorenzo, A. (2020). Influence of Mediterranean Diet on Human Gut Microbiota. Nutrients, 13.","DOI":"10.3390\/nu13010007"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Jafarnezhad, F., Nazarzadeh, A., Bazavar, H., Keramat, S., Ryszkiel, I., and Stanek, A. (2025). Vegan and Plant-Based Diets in the Management of Metabolic Syndrome: A Narrative Review from Anti-Inflammatory and Antithrombotic Perspectives. Nutrients, 17.","DOI":"10.3390\/nu17162656"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/19490976.2016.1270811","article-title":"Western diets, gut dysbiosis, and metabolic diseases: Are they linked?","volume":"8","author":"Martinez","year":"2017","journal-title":"Gut Microbes"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Montero, C., Fraile-Mart\u00ednez, O., G\u00f3mez-Lahoz, A.M., Pekarek, L., Castellanos, A.J., Noguerales-Fraguas, F., Coca, S., Guijarro, L.G., Garc\u00eda-Honduvilla, N., and As\u00fansolo, A. (2021). Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease. Nutrients, 13.","DOI":"10.3390\/nu13020699"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/advances\/nmaa181","article-title":"Diet and the Microbiota-Gut-Brain Axis: Sowing the Seeds of Good Mental Health","volume":"12","author":"Berding","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/1541-4337.12489","article-title":"Dietary Fibers from Fruits and Vegetables and Their Health Benefits via Modulation of Gut Microbiota","volume":"18","author":"Cui","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/imm.12930","article-title":"Immune regulation by microbiome metabolites","volume":"154","author":"Kim","year":"2018","journal-title":"Immunology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.molcel.2012.08.033","article-title":"The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation","volume":"48","author":"Donohoe","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1467-3010.2008.00706.x","article-title":"Dietary fibre and the gut microbiota","volume":"33","author":"Scott","year":"2008","journal-title":"Nutr. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1136\/gutjnl-2016-313271","article-title":"Prebiotic inulin-type fructans induce specific changes in the human gut microbiota","volume":"66","author":"Vandeputte","year":"2017","journal-title":"Gut"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.carbpol.2018.07.041","article-title":"In vitro fermentation properties of pectins and enzymatic-modified pectins obtained from different renewable bioresources","volume":"199","author":"Kachrimanidou","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1079\/BJN20041358","article-title":"Inulin, oligofructose and bone health: Experimental approaches and mechanisms","volume":"93","author":"Weaver","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10100","DOI":"10.1038\/s41598-018-28521-8","article-title":"Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet","volume":"8","author":"Tan","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1128\/AEM.69.2.1136-1142.2003","article-title":"Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system","volume":"69","author":"Duncan","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s12276-020-0449-2","article-title":"The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: Impact via gut microbiota and direct effects on immune cells","volume":"52","author":"Beukema","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Heinritz, S.N., Weiss, E., Eklund, M., Aumiller, T., Louis, S., Rings, A., Messner, S., Camarinha-Silva, A., Seifert, J., and Bischoff, S.C. (2016). Intestinal Microbiota and Microbial Metabolites Are Changed in a Pig Model Fed a High-Fat\/Low-Fiber or a Low-Fat\/High-Fiber Diet. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154329"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Shin, Y., Han, S., Kwon, J., Ju, S., Choi, T.G., Kang, I., and Kim, S.S. (2023). Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease. Nutrients, 15.","DOI":"10.3390\/nu15204466"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wu, G., Tang, X., Fan, C., Wang, L., Shen, W., Ren, S., Zhang, L., and Zhang, Y. (2022). Gastrointestinal Tract and Dietary Fiber Driven Alterations of Gut Microbiota and Metabolites in Durco \u00d7 Bamei Crossbred Pigs. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.806646"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Fu, J., Zheng, Y., Gao, Y., and Xu, W. (2022). Dietary Fiber Intake and Gut Microbiota in Human Health. Microorganisms, 10.","DOI":"10.3390\/microorganisms10122507"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"skaa338","DOI":"10.1093\/jas\/skaa338","article-title":"Canola meal in nursery pig diets: Growth performance and gut health","volume":"98","author":"Hong","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10096-019-03721-w","article-title":"The effects of inulin on gut microbial composition: A systematic review of evidence from human studies","volume":"39","author":"Chapelet","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2017.1290756","article-title":"Dietary fiber and prebiotics and the gastrointestinal microbiota","volume":"8","author":"Holscher","year":"2017","journal-title":"Gut Microbes"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"nzy005","DOI":"10.1093\/cdn\/nzy005","article-title":"Health Effects and Sources of Prebiotic Dietary Fiber","volume":"2","author":"Carlson","year":"2018","journal-title":"Curr. Dev. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Carlson, J.L., Erickson, J.M., Hess, J.M., Gould, T.J., and Slavin, J.L. (2017). Prebiotic Dietary Fiber and Gut Health: Comparing the in Vitro Fermentations of Beta-Glucan, Inulin and Xylooligosaccharide. Nutrients, 9.","DOI":"10.20944\/preprints201710.0171.v1"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11882-021-01020-z","article-title":"The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota","volume":"21","author":"Steigerwald","year":"2021","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13568-018-0629-9","article-title":"The influence of in vitro pectin fermentation on the human fecal microbiome","volume":"8","author":"Bang","year":"2018","journal-title":"AMB Express"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1128\/AEM.02507-15","article-title":"Effect of Whole-Grain Barley on the Human Fecal Microbiota and Metabolome","volume":"81","author":"Montemurno","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.BAD-0019-2017","article-title":"Modulation of the Gastrointestinal Microbiome with Nondigestible Fermentable Carbohydrates To Improve Human Health","volume":"5","author":"Deehan","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3920\/BM2019.0082","article-title":"Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: A review","volume":"11","author":"Swanson","year":"2020","journal-title":"Benef. Microbes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1407S","DOI":"10.1093\/jn\/129.7.1407S","article-title":"Presence of inulin and oligofructose in the diets of Americans","volume":"129","author":"Moshfegh","year":"1999","journal-title":"J. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1080\/19490976.2020.1730149","article-title":"Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota","volume":"11","author":"Kim","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Jana, U.K., Kango, N., and Pletschke, B. (2021). Hemicellulose-Derived Oligosaccharides: Emerging Prebiotics in Disease Alleviation. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.670817"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"130008","DOI":"10.1016\/j.ijbiomac.2024.130008","article-title":"Nanochitosan from crustacean and mollusk byproduct: Extraction, characterization, and applications in the food industry","volume":"262","author":"Koirala","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.32604\/jrm.2022.018142","article-title":"A Review of Various Sources of Chitin and Chitosan in Nature","volume":"10","author":"Iber","year":"2022","journal-title":"J. Renew. Mater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jff.2016.01.009","article-title":"Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling","volume":"22","author":"Xiao","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_66","unstructured":"Yadav, M.K., Babu, P.J., Song, J.J., and Kharat, A.S. (2023). Chapter 11-The role of chitosan-based nanoparticles to reduce obesity: A glimpse. Nanotechnology and Human Health, Elsevier."},{"key":"ref_67","unstructured":"McGuckin, M., Thornton, D., and Whitsett, J. (2015). Mucosal Immunology, Academic Press. [4th ed.]."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Yap, Y.A., and Mari\u00f1o, E. (2018). An Insight Into the Intestinal Web of Mucosal Immunity, Microbiota, and Diet in Inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02617"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Sunkara, L.T., Achanta, M., Schreiber, N.B., Bommineni, Y.R., Dai, G., Jiang, W., Lamont, S., Lillehoj, H.S., Beker, A., and Teeter, R.G. (2011). Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027225"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.celrep.2019.03.054","article-title":"Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism","volume":"27","author":"Fachi","year":"2019","journal-title":"Cell Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.4049\/jimmunol.1700105","article-title":"Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2","volume":"199","author":"Zheng","year":"2017","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1002\/1521-4141(200209)32:9<2635::AID-IMMU2635>3.0.CO;2-N","article-title":"Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region","volume":"32","author":"Kalina","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/mi.2015.13","article-title":"Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine","volume":"8","author":"Harrison","year":"2015","journal-title":"Mucosal Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","article-title":"The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages","volume":"50","author":"Schulthess","year":"2019","journal-title":"Immunity"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Bagheri, S., Zolghadri, S., and Stanek, A. (2022). Beneficial Effects of Anti-Inflammatory Diet in Modulating Gut Microbiota and Controlling Obesity. Nutrients, 14.","DOI":"10.3390\/nu14193985"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"230014","DOI":"10.1098\/rsob.230014","article-title":"Short chain fatty acids: Key regulators of the local and systemic immune response in inflammatory diseases and infections","volume":"13","author":"Ney","year":"2023","journal-title":"Open Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mi.2014.44","article-title":"Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway","volume":"8","author":"Park","year":"2015","journal-title":"Mucosal Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41467-019-08711-2","article-title":"The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes","volume":"10","author":"Luu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.4110\/in.2022.22.e46","article-title":"Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier","volume":"22","author":"Akuzum","year":"2022","journal-title":"Immune Netw."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ni.3400","article-title":"Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease","volume":"17","author":"Mathewson","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.chom.2016.07.001","article-title":"Gut Microbial Metabolites Fuel Host Antibody Responses","volume":"20","author":"Kim","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"jem.20190489","DOI":"10.1084\/jem.20190489","article-title":"Acetate coordinates neutrophil ILC3 responses against, C. difficile through FFAR2","volume":"217","author":"Fachi","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jnutbio.2010.07.009","article-title":"Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils","volume":"22","author":"Vinolo","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2220\/biomedres.30.149","article-title":"Expression of short-chain fatty acid receptor GPR41 in the human colon","volume":"30","author":"Tazoe","year":"2009","journal-title":"Biomed. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2362.2010.02407.x","article-title":"Impaired anti-inflammatory efficacy of n-butyrate in patients with IBD","volume":"41","author":"Kovarik","year":"2011","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.clnu.2010.04.002","article-title":"Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission","volume":"29","author":"Hamer","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2013.03.002","article-title":"Development and maintenance of regulatory T cells","volume":"38","author":"Ohkura","year":"2013","journal-title":"Immunity"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.immuni.2004.07.009","article-title":"Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors","volume":"21","author":"Hsieh","year":"2004","journal-title":"Immunity"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Omenetti, S., and Pizarro, T.T. (2015). The Treg\/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00639"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/eji.201746960","article-title":"Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells","volume":"47","author":"Pasztoi","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1084\/jem.20081359","article-title":"Antigen-specific peripheral shaping of the natural regulatory T cell population","volume":"205","author":"Lathrop","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature10434","article-title":"Peripheral education of the immune system by colonic commensal microbiota","volume":"478","author":"Lathrop","year":"2011","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Pandiyan, P., Bhaskaran, N., Zou, M., Schneider, E., Jayaraman, S., and Huehn, J. (2019). Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00426"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e03335-20","DOI":"10.1128\/mBio.03335-20","article-title":"An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses","volume":"12","author":"Zhang","year":"2021","journal-title":"mBio"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.immuni.2011.03.021","article-title":"Intestinal bacterial colonization induces mutualistic regulatory T cell responses","volume":"34","author":"Geuking","year":"2011","journal-title":"Immunity"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Bhaskaran, N., Quigley, C., Paw, C., Butala, S., Schneider, E., and Pandiyan, P. (2018). Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01995"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.immuni.2009.08.020","article-title":"The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses","volume":"31","author":"Rakotobe","year":"2009","journal-title":"Immunity"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1007\/s13346-022-01284-6","article-title":"Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro","volume":"13","author":"McBride","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/ecco-jcc\/jjaa065","article-title":"Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice","volume":"14","author":"Bajic","year":"2020","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2516702","DOI":"10.1080\/19490976.2025.2516702","article-title":"Gut microbiota in regulatory T cell generation and function: Mechanisms and health implications","volume":"17","author":"Sharma","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"eaat6975","DOI":"10.1126\/sciimmunol.aat6975","article-title":"Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells","volume":"3","author":"Verma","year":"2018","journal-title":"Sci. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri3089","article-title":"Peptidoglycan recognition proteins: Modulators of the microbiome and inflammation","volume":"11","author":"Royet","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nature07008","article-title":"A microbial symbiosis factor prevents intestinal inflammatory disease","volume":"453","author":"Mazmanian","year":"2008","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota","volume":"332","author":"Round","year":"2011","journal-title":"Science"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Hoeppli, R.E., Wu, D., Cook, L., and Levings, M.K. (2015). The environment of regulatory T cell biology: Cytokines, metabolites, and the microbiome. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00061"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/19490976.2015.1056973","article-title":"A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function","volume":"6","author":"Telesford","year":"2015","journal-title":"Gut Microbes"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/19490976.2018.1560755","article-title":"Promoter orientation of the immunomodulatory Bacteroides fragilis capsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD)","volume":"10","author":"Blandford","year":"2019","journal-title":"Gut Microbes"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1128\/AEM.02216-08","article-title":"Exploring the diversity of the bifidobacterial population in the human intestinal tract","volume":"75","author":"Turroni","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.cell.2021.01.016","article-title":"Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies","volume":"184","author":"Doron","year":"2021","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13099-024-00651-7","article-title":"Unveiling the overlooked fungi: The vital of gut fungi in inflammatory bowel disease and colorectal cancer","volume":"16","author":"Huang","year":"2024","journal-title":"Gut Pathog."},{"key":"ref_116","first-page":"29","article-title":"Survival of Saccharomyces boulardii in the Rat Gastrointestinal Tract and Effects of Dietary Fiber","volume":"11","author":"Elmer","year":"1999","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e01250-16","DOI":"10.1128\/mBio.01250-16","article-title":"Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn\u2019s Disease","volume":"7","author":"Hoarau","year":"2016","journal-title":"mBio"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/gutjnl-2015-310746","article-title":"Fungal microbiota dysbiosis in IBD","volume":"66","author":"Sokol","year":"2017","journal-title":"Gut"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1038\/s41467-021-23929-9","article-title":"Structural specificities of cell surface \u03b2-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities","volume":"12","author":"Lee","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2560019","DOI":"10.1080\/19490976.2025.2560019","article-title":"Regulatory roles of intestinal CD4+ T cells in inflammation and their modulation by the intestinal microbiota","volume":"17","author":"Ma","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41586-023-06749-3","article-title":"Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity","volume":"623","author":"Fan","year":"2023","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cell.2020.02.035","article-title":"Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism","volume":"180","author":"Duscha","year":"2020","journal-title":"Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mi.2009.100","article-title":"Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa","volume":"2","author":"Khader","year":"2009","journal-title":"Mucosal Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"20662","DOI":"10.1002\/jcp.28671","article-title":"Exosomal microRNA-155-5p from PDLSCs regulated Th17\/Treg balance by targeting sirtuin-1 in chronic periodontitis","volume":"234","author":"Zheng","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_127","first-page":"65","article-title":"Th17\/Treg Ratio and Disease Activity in Systemic Lupus Erythematosus","volume":"10","author":"Yuliasih","year":"2019","journal-title":"Casp. J. Intern. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2019.07.001","article-title":"The connection between the Th17 cell related cytokines and cancer stem cells in cancer: Novel therapeutic targets","volume":"213","author":"Shahid","year":"2019","journal-title":"Immunol. Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nature13279","article-title":"Focused specificity of intestinal TH17 cells towards commensal bacterial antigens","volume":"510","author":"Yang","year":"2014","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.1000082107","article-title":"Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.immuni.2014.03.005","article-title":"Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation","volume":"40","author":"Goto","year":"2014","journal-title":"Immunity"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1111\/j.1365-2672.2009.04431.x","article-title":"16S rRNA gene sequence-based analysis of clostridia related to conversion of germfree mice to the normal state","volume":"107","author":"Momose","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Cheng, H., Guan, X., Chen, D., and Ma, W. (2019). The Th17\/Treg Cell Balance: A Gut Microbiota-Modulated Story. Microorganisms, 7.","DOI":"10.3390\/microorganisms7120583"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1574-6968.2002.tb11467.x","article-title":"The microbiology of butyrate formation in the human colon","volume":"217","author":"Pryde","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e125986","DOI":"10.1172\/JCI125986","article-title":"IFN-\u03b3R\/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease","volume":"133","author":"Lu","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1182\/blood.V124.21.842.842","article-title":"Tregs Suppress GvHD at the Periphery and Unleash the Gvl Effect in the Bone Marrow","volume":"124","author":"Ruggeri","year":"2014","journal-title":"Blood"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1182\/blood-2016-09-740431","article-title":"Tissue tolerance: A distinct concept to control acute GVHD severity","volume":"129","author":"Wu","year":"2017","journal-title":"Blood"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood-2016-02-700849","article-title":"Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells","volume":"128","author":"Leclerc","year":"2016","journal-title":"Blood"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood-2009-12-255810","article-title":"Th17\/Treg ratio in human graft-versus-host disease","volume":"116","author":"Ratajczak","year":"2010","journal-title":"Blood"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1182\/blood-2013-08-453126","article-title":"Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation","volume":"122","author":"Schneidawind","year":"2013","journal-title":"Blood"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2006-12-022038","article-title":"The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia","volume":"110","author":"Chakraverty","year":"2007","journal-title":"Blood"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1182\/blood-2010-10-311894","article-title":"Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation","volume":"117","author":"Falzetti","year":"2011","journal-title":"Blood"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1182\/blood-2006-02-003996","article-title":"High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT","volume":"108","author":"Rezvani","year":"2006","journal-title":"Blood"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1182\/blood-2010-11-317305","article-title":"Can Treg therapy prevent GVHD?","volume":"117","author":"Komanduri","year":"2011","journal-title":"Blood"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1182\/blood.2019000952","article-title":"Cytokines and costimulation in acute graft-versus-host disease","volume":"136","author":"Hill","year":"2020","journal-title":"Blood"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"101977","DOI":"10.1016\/j.trim.2023.101977","article-title":"Effect of GVHD on the gut and intestinal microflora","volume":"82","author":"Ji","year":"2024","journal-title":"Transpl. Transplant. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.bbmt.2015.12.016","article-title":"Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients","volume":"22","author":"Khandelwal","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/bloodadvances.2023011625","article-title":"Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD","volume":"8","author":"Bader","year":"2024","journal-title":"Blood Adv."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1038\/bmt.2008.56","article-title":"Acute GvHD: Pathogenesis and classification","volume":"41","author":"Ball","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e6799","DOI":"10.1002\/cam4.6799","article-title":"Gut microbiota, microbiota-derived metabolites, and graft-versus-host disease","volume":"13","author":"Yue","year":"2024","journal-title":"Cancer Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nm1089","article-title":"Donor APCs are required for maximal GVHD but not for GVL","volume":"10","author":"Matte","year":"2004","journal-title":"Nat. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1002\/eji.200939432","article-title":"Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD","volume":"39","author":"Koenecke","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/eji.202149530","article-title":"GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity","volume":"52","author":"Zeiser","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12026-012-8267-9","article-title":"Immune modulation of inflammatory conditions: Regulatory T cells for treatment of GvHD","volume":"53","author":"Haase","year":"2012","journal-title":"Immunol. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-065X.1997.tb00976.x","article-title":"Recent advances in graft-versus-host disease (GVHD) prevention","volume":"157","author":"Blazar","year":"1997","journal-title":"Immunol. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/bmt.2013.215","article-title":"Increased Th17\/Treg ratio in chronic liver GVHD","volume":"49","author":"Malard","year":"2014","journal-title":"Bone Marrow Transplant."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1172\/JCI90593","article-title":"Cytokine mediators of chronic graft-versus-host disease","volume":"127","author":"MacDonald","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2124627","DOI":"10.1155\/2022\/2124627","article-title":"A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood-2016-08-686659","article-title":"Mechanistic approaches for the prevention and treatment of chronic GVHD","volume":"129","author":"Cutler","year":"2017","journal-title":"Blood"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1182\/blood.2022019396","article-title":"New mechanisms of GVHD suppression by Tregs","volume":"141","author":"Lederer","year":"2023","journal-title":"Blood"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Ghimire, S., Weber, D., Mavin, E., Wang, X.N., Dickinson, A.M., and Holler, E. (2017). Pathophysiology of GvHD and Other HSCT-Related Major Complications. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00079"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"K\u00f6hler, N., and Zeiser, R. (2019). Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03179"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Piper, C., and Drobyski, W.R. (2019). Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00163"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Bastian, D., Wu, Y., Betts, B.C., and Yu, X.Z. (2019). The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00988"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Bertaina, A., and Roncarolo, M.G. (2019). Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01342"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jtos.2019.12.005","article-title":"Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD)","volume":"18","author":"Hu","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autrev.2005.02.006","article-title":"T cell immunity and graft-versus-host disease (GVHD)","volume":"5","author":"Ichiki","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Pinzon, P., Gutierrez Barbosa, H., Medina-Moreno, S., and Zapata, J. (2025). The Microbiome, Inflammation, and GVHD Axis: The Balance Between the \u201cGut\u201d and the Bad. Immuno, 5.","DOI":"10.3390\/immuno5010010"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1084\/jem.20151563","article-title":"Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion","volume":"213","author":"Chopra","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_171","first-page":"S21","article-title":"Diagnosis and differential diagnosis of hepatic graft versus host disease (GVHD)","volume":"7","author":"Matsukuma","year":"2016","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"eaay7713","DOI":"10.1126\/scitranslmed.aay7713","article-title":"Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation","volume":"12","author":"Khuat","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2141.2007.06510.x","article-title":"Advances in the understanding of acute graft-versus-host disease","volume":"137","author":"Morris","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/bmt.2014.69","article-title":"Prognostic factors and outcomes of severe gastrointestinal GVHD after allogeneic hematopoietic cell transplantation","volume":"49","author":"Martin","year":"2014","journal-title":"Bone Marrow Transplant."},{"key":"ref_175","first-page":"90","article-title":"Targeting Cytokines in GVHD Therapy","volume":"2","author":"Kumar","year":"2017","journal-title":"J. Immunol. Res. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/tri.12909","article-title":"Treg therapy in transplantation: A general overview","volume":"30","author":"Romano","year":"2017","journal-title":"Transpl. Transplant. Int."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/intimm\/dxm153","article-title":"Predominant donor CD103+CD8+ T cell infiltration into the gut epithelium during acute GvHD: A role of gut lymph nodes","volume":"20","author":"Zhou","year":"2008","journal-title":"Int. Immunol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Guo, W.W., Su, X.H., Wang, M.Y., Han, M.Z., Feng, X.M., and Jiang, E.L. (2021). Regulatory T Cells in GVHD Therapy. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.697854"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMoa1108188","article-title":"Interleukin-2 and regulatory T cells in graft-versus-host disease","volume":"365","author":"Koreth","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1182\/blood-2016-04-711275","article-title":"TNF-\u03b1 priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment","volume":"128","author":"Pierini","year":"2016","journal-title":"Blood"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1182\/blood-2014-10-605238","article-title":"Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans","volume":"125","author":"Choi","year":"2015","journal-title":"Blood"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Gooptu, M., and Antin, J.H. (2021). GVHD Prophylaxis 2020. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.605726"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Campe, J., and Ullrich, E. (2022). T Helper Cell Lineage-Defining Transcription Factors: Potent Targets for Specific GVHD Therapy?. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.806529"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Hess, N.J., Kink, J.A., and Hematti, P. (2023). Exosomes, MDSCs and Tregs: A new frontier for GVHD prevention and treatment. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1143381"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Carreras, E., Dufour, C., Mohty, M., and Kr\u00f6ger, N. (2019). The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies, Springer.","DOI":"10.1007\/978-3-030-02278-5"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.leukres.2010.03.017","article-title":"Decrease of CD4(+)CD25(+) regulatory T cells and TGF-beta at early immune reconstitution is associated to the onset and severity of graft-versus-host disease following allogeneic haematogenesis stem cell transplantation","volume":"34","author":"Li","year":"2010","journal-title":"Leuk. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1182\/blood.2022017982","article-title":"Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHD","volume":"141","author":"Lohmeyer","year":"2023","journal-title":"Blood"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13045-018-0680-7","article-title":"A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD","volume":"11","author":"Lai","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/s10875-021-00991-y","article-title":"Thymopoiesis, Alterations in Dendritic Cells and Tregs, and Reduced T Cell Activation in Successful Extracorporeal Photopheresis Treatment of GVHD","volume":"41","author":"Flinn","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"ref_190","first-page":"4","article-title":"Isolation and Expansion of Clinical Grade T Regulatory Cells for GvHD Prophylaxis","volume":"1","author":"Kumaresan","year":"2025","journal-title":"Int. J. Clin. Transl. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.bbmt.2015.08.038","article-title":"Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-\u03b27 during Acute Graft-versus-Host Disease of the Liver","volume":"21","author":"Schreder","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Gail, L.M., Schell, K.J., \u0141acina, P., Strobl, J., Bolton, S.J., Steinbakk Ulriksen, E., Bogunia-Kubik, K., Greinix, H., Crossland, R.E., and Inngjerdingen, M. (2023). Complex interactions of cellular players in chronic Graft-versus-Host Disease. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1199422"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41423-023-00987-1","article-title":"Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity","volume":"20","author":"Kim","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.celrep.2016.05.047","article-title":"Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways","volume":"15","author":"Tan","year":"2016","journal-title":"Cell Rep."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2022.11.007","article-title":"Dietary fiber and SCFAs in the regulation of mucosal immunity","volume":"151","author":"Tan","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_196","first-page":"8529578","article-title":"Gut Microbiota Promotes Immune Tolerance by Regulating ROR\u03b3t+ Treg Cells in Food Allergy","volume":"2022","author":"Ning","year":"2021","journal-title":"Adv. Gut Microbiome Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1111\/jgh.15970","article-title":"Short-chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: A promising therapy?","volume":"37","author":"Peng","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Du, H.X., Yue, S.Y., Niu, D., Liu, C., Zhang, L.G., Chen, J., Chen, Y., Guan, Y., Hua, X.-L., and Li, C. (2022). Gut Microflora Modulates Th17\/Treg Cell Differentiation in Experimental Autoimmune Prostatitis via the Short-Chain Fatty Acid Propionate. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.915218"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"100163","DOI":"10.1016\/j.jacig.2023.100163","article-title":"Short-chain fatty acids ameliorate allergic airway inflammation via sequential induction of PMN-MDSCs and Treg cells","volume":"2","author":"Huang","year":"2023","journal-title":"J. Allergy Clin. Immunol. Glob."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Ghimire, S., Weber, D., Hippe, K., Meedt, E., Hoepting, M., Kattner, A.S., Hiergeist, A., Gessner, A., Matos, C., and Ghimire, S. (2021). GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.753287"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Han, L., Jin, H., Zhou, L., Zhang, X., Fan, Z., Dai, M., Lin, Q., Huang, F., Xuan, L., and Zhang, H. (2018). Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg\/Th17 Balance in Allo-HSCT Recipients. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00669"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"101125","DOI":"10.1016\/j.xcrm.2023.101125","article-title":"Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD","volume":"4","author":"Jarosch","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"S332","DOI":"10.1097\/01.tp.0000543062.07035.1b","article-title":"Allogenic Endothelial Cells Differentially Modulate the Expansion of Anti-Inflammatory FoxP3 High Regulatory T Lymphocytes According to Their State of Activation","volume":"102","author":"Cross","year":"2018","journal-title":"Transplantation"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/intimm\/dxz022","article-title":"Faecalibacterium prausnitzii produces butyrate to decrease c-Myc-related metabolism and Th17 differentiation by inhibiting histone deacetylase 3","volume":"31","author":"Zhang","year":"2019","journal-title":"Int. Immunol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12026-010-8193-7","article-title":"Prevention of GVHD without losing GVL effect: Windows of opportunity","volume":"49","author":"Zhang","year":"2011","journal-title":"Immunol. Res."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Adair, P.R., Kim, Y.C., Zhang, A.H., Yoon, J., and Scott, D.W. (2017). Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01117"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Fujiwara, H. (2021). Crosstalk Between Intestinal Microbiota Derived Metabolites and Tissues in Allogeneic Hematopoietic Cell Transplantation. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.703298"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2217\/imt.09.32","article-title":"Separating graft-versus-leukemia from graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"1","author":"Li","year":"2009","journal-title":"Immunotherapy"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/bbmt.2003.50027","article-title":"Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response","volume":"9","author":"Jones","year":"2003","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1182\/blood.2025028617","article-title":"Challenges in GVHD and GVL after hematopoietic stem cell transplantation for myeloid malignancies","volume":"146","author":"Socie","year":"2025","journal-title":"Blood"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Teshima, T., and Hashimoto, D. (2023). Separation of GVL from GVHD -location, location, location. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1296663"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/BS9.0000000000000061","article-title":"High-choline diets ameliorate acute graft-versus-host disease","volume":"2","author":"Hu","year":"2020","journal-title":"Blood Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41375-019-0625-3","article-title":"Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells","volume":"34","author":"Riegel","year":"2020","journal-title":"Leukemia"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Bolivar-Wagers, S., Larson, J.H., Jin, S., and Blazar, B.R. (2022). Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.864748"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1182\/blood-2007-07-103895","article-title":"The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation","volume":"111","author":"Nguyen","year":"2008","journal-title":"Blood"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"e1146842","DOI":"10.1080\/2162402X.2016.1146842","article-title":"CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice","volume":"5","author":"Heinrichs","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/10428190009087014","article-title":"Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: Considerations for the allogeneic transplantation therapy of leukemia and lymphoma","volume":"38","author":"Fowler","year":"2000","journal-title":"Leuk. Lymphoma"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"e121717","DOI":"10.1172\/jci.insight.121717","article-title":"Superior immune reconstitution using Treg-expanded donor cells versus PTCy treatment in preclinical HSCT models","volume":"3","author":"Wolf","year":"2018","journal-title":"JCI Insight"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1182\/blood-2011-03-340315","article-title":"Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR\u03b3t in mice","volume":"118","author":"Yu","year":"2011","journal-title":"Blood"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s12185-017-2292-3","article-title":"Treg-protected donor lymphocyte infusions: A new tool to address the graft-versus-leukemia effect in the absence of graft-versus-host disease in patients relapsed after HSCT","volume":"106","author":"Olioso","year":"2017","journal-title":"Int. J. Hematol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1182\/blood-2014-03-564401","article-title":"HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse","volume":"124","author":"Martelli","year":"2014","journal-title":"Blood"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Pacella, I., and Piconese, S. (2019). Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01889"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1172\/JCI82587","article-title":"Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation","volume":"126","author":"Nguyen","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.it.2019.11.005","article-title":"Distinct Regulatory and Effector T Cell Metabolic Demands during Graft-Versus-Host Disease","volume":"41","author":"Hippen","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Mohamed, F.A., Thangavelu, G., Rhee, S.Y., Sage, P.T., O\u2019Connor, R.S., Rathmell, J.C., and Blazar, B.R. (2021). Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.757836"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Schirrmacher, V. (2020). Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism. Biomedicines, 8.","DOI":"10.3390\/biomedicines8110526"},{"key":"ref_227","unstructured":"Theocharidis, S. (2024). Characterising the Metabolic Reprogramming of Human Alloreactive T Cells. [Ph.D. Thesis, Queen Mary University of London]."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"109235","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1158\/2326-6066.CIR-18-0066","article-title":"Treg Fragility: A Prerequisite for Effective Antitumor Immunity?","volume":"6","author":"Vignali","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/jid.2013.75","article-title":"Tumor-specific T cells in human Merkel cell carcinomas: A possible role for Tregs and T-cell exhaustion in reducing T-cell responses","volume":"133","author":"Dowlatshahi","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Cassady, K., Martin, P.J., and Zeng, D. (2018). Regulation of GVHD and GVL Activity via PD-L1 Interaction with PD-1 and CD80. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03061"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI94196","article-title":"PD-L1 serves as a double agent in separating GVL from GVHD","volume":"127","author":"Brennan","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Mhandire, K., Saggu, K., and Buxbaum, N.P. (2021). Immunometabolic Therapeutic Targets of Graft-versus-Host Disease (GvHD). Metabolites, 11.","DOI":"10.3390\/metabo11110736"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.bbmt.2017.02.013","article-title":"Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation","volume":"23","author":"Wolf","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s40472-020-00285-z","article-title":"CAR-Tregs as a Strategy for Inducing Graft Tolerance","volume":"7","author":"Wagner","year":"2020","journal-title":"Curr. Transplant. Rep."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"13125","DOI":"10.1038\/s41598-021-92526-z","article-title":"Reduced dose of PTCy followed by adjuvant \u03b1-galactosylceramide enhances GVL effect without sacrificing GVHD suppression","volume":"11","author":"Nakamura","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"e136437","DOI":"10.1172\/jci.insight.136437","article-title":"Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity","volume":"5","author":"Walton","year":"2020","journal-title":"JCI Insight"},{"key":"ref_238","unstructured":"Leuschner, U. (2021). Modulation of T-Regulatory Cells by Small Molecules: Potential Therapy for GvHD. [Ph.D. Thesis, University of Oxford]."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Copsel, S.N., Lightbourn, C.O., Barreras, H., Lohse, I., Wolf, D., Bader, C.S., Manov, J., Kale, B.J., Shah, D., and Brothers, S.P. (2019). BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03104"},{"key":"ref_240","first-page":"302","article-title":"Effects of donor T cell stat3 deficiency on acute intestinal graft-versus-host disease in mice","volume":"46","author":"Xu","year":"2025","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Yu, X., Chen, Y., Lei, L., Li, P., Lin, D., Shen, Y., Hou, C., Chen, J., Fan, Y., and Jin, Y. (2025). Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse. BMC Med., 23.","DOI":"10.1186\/s12916-025-04026-w"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s11033-025-10714-w","article-title":"Role of the intestinal flora-immunity axis in the pathogenesis of rheumatoid arthritis-mechanisms regulating short-chain fatty acids and Th17\/Treg homeostasis","volume":"52","author":"Lv","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2533244","DOI":"10.1080\/09540105.2025.2533244","article-title":"Nutritional supplement Youtianli regulates Treg function and gut immunity via SCFA-producing microbiota modulation","volume":"36","author":"Yuan","year":"2025","journal-title":"Food Agric. Immunol."},{"key":"ref_244","first-page":"e123672","article-title":"Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells","volume":"4","author":"Dawson","year":"2019","journal-title":"JCI Insight"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"e160674","DOI":"10.1172\/jci.insight.160674","article-title":"Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses","volume":"7","author":"Loschi","year":"2022","journal-title":"JCI Insight"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"e136185","DOI":"10.1172\/jci.insight.136185","article-title":"CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD","volume":"5","author":"Imura","year":"2020","journal-title":"JCI Insight"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1182\/bloodadvances.2019000411","article-title":"Human CD8+ Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice","volume":"3","author":"Charreau","year":"2019","journal-title":"Blood Adv."},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Zhao, J., Wang, M., Huang, F., Li, J., Liu, R., Wan, J., and Hao, S. (2023). Mesenchymal stem cell-derived exosomes can alleviate GVHD and preserve the GVL effect in allogeneic stem cell transplantation animal models. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1284936"},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Amini, L., Kaeda, J., Fritsche, E., Roemhild, A., Kaiser, D., and Reinke, P. (2023). Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1081644"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1097\/TP.0000000000003149","article-title":"A Clinical Trial with Adoptive Transfer of Ex Vivo-induced, Donor-specific Immune-regulatory Cells in Kidney Transplantation-A Second Report","volume":"104","author":"Koyama","year":"2020","journal-title":"Transplantation"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Pilat, N., Steiner, R., and Sprent, J. (2023). Treg Therapy for the Induction of Immune Tolerance in Transplantation-Not Lost in Translation?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021752"},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Pikor, L.A., Arivazhagan, S., Mendicino, M., and Sathiamoorthy, S. (2025). Navigating the manufacturing, testing and regulatory complexities of regulatory T cells for adoptive cell therapy. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1626085"},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Schmidt, A., Eriksson, M., Shang, M.M., Weyd, H., and Tegn\u00e9r, J. (2016). Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148474"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/cei.12887","article-title":"T cell receptor repertoires after adoptive transfer of expanded allogeneic regulatory T cells","volume":"187","author":"Theil","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.it.2016.08.012","article-title":"Induced Regulatory T Cells: Their Development, Stability, and Applications","volume":"37","author":"Kanamori","year":"2016","journal-title":"Trends Immunol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood-2016-05-715896","article-title":"Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner","volume":"128","author":"Flynn","year":"2016","journal-title":"Blood"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1093\/ibd\/izy182","article-title":"Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17\/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1","volume":"24","author":"Zhou","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"e004147","DOI":"10.1136\/jitc-2021-004147","article-title":"Microbial short-chain fatty acids: A strategy to tune adoptive T cell therapy","volume":"10","author":"Rangan","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1681\/ASN.2019080852","article-title":"Gut Microbial Metabolites Induce Donor-Specific Tolerance of Kidney Allografts through Induction of T Regulatory Cells by Short-Chain Fatty Acids","volume":"31","author":"Wu","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12172","article-title":"Treg functional stability and its responsiveness to the microenvironment","volume":"259","author":"Barbi","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Shi, H., and Chi, H. (2019). Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02716"},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Arroyo Hornero, R., Hamad, I., C\u00f4rte-Real, B., and Kleinewietfeld, M. (2020). The Impact of Dietary Components on Regulatory T Cells and Disease. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00253"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Hu, M., Alashkar Alhamwe, B., Santner-Nanan, B., Miethe, S., Harb, H., Renz, H., Potaczek, D.P., and Nanan, R.K. (2022). Short-Chain Fatty Acids Augment Differentiation and Function of Human Induced Regulatory T Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105740"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1111\/ajt.15845","article-title":"Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics","volume":"20","author":"Chen","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cellimm.2018.03.003","article-title":"High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier","volume":"328","author":"Hu","year":"2018","journal-title":"Cell. Immunol."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Hippen, K.L., Hefazi, M., Larson, J.H., and Blazar, B.R. (2022). Emerging translational strategies and challenges for enhancing regulatory T cell therapy for graft-versus-host disease. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.926550"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"156723","DOI":"10.1016\/j.cyto.2024.156723","article-title":"The role of interleukin-2 in graft-versus-host disease pathogenesis, prevention and therapy","volume":"183","author":"Razi","year":"2024","journal-title":"Cytokine"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Zeiser, R., Ringden, O., Sadeghi, B., Gonen-Yaacovi, G., and Segurado, O.G. (2023). Novel therapies for graft versus host disease with a focus on cell therapies. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1241068"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.seminhematol.2020.06.001","article-title":"Short chain fatty acids: Postbiotics\/metabolites and graft versus host disease colitis","volume":"57","author":"Riwes","year":"2020","journal-title":"Semin. Hematol."},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Muratore, E., Leardini, D., Baccelli, F., Venturelli, F., Prete, A., and Masetti, R. (2022). Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.993668"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/TP.0000000000001951","article-title":"Navigating T-Cell Immunometabolism in Transplantation","volume":"102","author":"Tanimine","year":"2018","journal-title":"Transplantation"},{"key":"ref_272","doi-asserted-by":"crossref","unstructured":"Amini, L., Greig, J., Schmueck-Henneresse, M., Volk, H.D., B\u00e9zie, S., Reinke, P., Guillonneau, C., Wagner, D.L., and Anegon, I. (2021). Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.611638"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"e89278","DOI":"10.1172\/jci.insight.89278","article-title":"Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells","volume":"1","author":"Hirakawa","year":"2016","journal-title":"JCI Insight"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41392-017-0002-5","article-title":"Targeting IL-2: An unexpected effect in treating immunological diseases","volume":"3","author":"Ye","year":"2018","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"179ra43","DOI":"10.1126\/scitranslmed.3005265","article-title":"Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease","volume":"5","author":"Matsuoka","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Gra\u00dfhoff, H., Comd\u00fchr, S., Monne, L.R., M\u00fcller, A., Lamprecht, P., Riemekasten, G., and Humrich, J.Y. (2021). Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.648408"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1182\/blood-2016-02-702852","article-title":"Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease","volume":"128","author":"Koreth","year":"2016","journal-title":"Blood"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1182\/bloodadvances.2019000631","article-title":"Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children","volume":"3","author":"Whangbo","year":"2019","journal-title":"Blood Adv."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1182\/bloodadvances.2023009729","article-title":"Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease","volume":"7","author":"Wobma","year":"2023","journal-title":"Blood Adv."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1182\/bloodadvances.2023010756","article-title":"More evidence for low-dose IL-2 for chronic GVHD in children","volume":"7","author":"Levine","year":"2023","journal-title":"Blood Adv."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1182\/bloodadvances.2022007773","article-title":"Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease","volume":"6","author":"Kim","year":"2022","journal-title":"Blood Adv."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1182\/bloodadvances.2018027474","article-title":"Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease","volume":"3","author":"Whangbo","year":"2019","journal-title":"Blood Adv."},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Donato, V., Kim, H.T., Stowe, P., Reynolds, C.G., Ritz, J., Koreth, J., and Whangbo, J.S. (2022). Durability of clinical and immunologic responses to extended low-dose interleukin-2 therapy in patients with refractory chronic graft-versus-host disease. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.954966"},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"Meguri, Y., Asano, T., Yoshioka, T., Iwamoto, M., Ikegawa, S., Sugiura, H., Kishi, Y., Nakamura, M., Sando, Y., and Kondo, T. (2022). Responses of regulatory and effector T-cells to low-dose interleukin-2 differ depending on the immune environment after allogeneic stem cell transplantation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.891925"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1182\/blood-2016-09-741629","article-title":"PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy","volume":"129","author":"Asano","year":"2017","journal-title":"Blood"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3324\/haematol.2016.153072","article-title":"IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation","volume":"102","author":"Betts","year":"2017","journal-title":"Haematologica"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"e159406","DOI":"10.1172\/jci.insight.159406","article-title":"Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation","volume":"7","author":"Tchitchek","year":"2022","journal-title":"JCI Insight"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2147\/JIR.S344393","article-title":"Low-Dose Interleukin-2 Altered Gut Microbiota and Ameliorated Collagen-Induced Arthritis","volume":"15","author":"Li","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/ajt.14443","article-title":"Microbial metabolites and graft versus host disease","volume":"18","author":"Riwes","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_290","first-page":"1","article-title":"Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)","volume":"66","author":"Ratajczak","year":"2019","journal-title":"Acta Biochim. Pol."},{"key":"ref_291","first-page":"8","article-title":"Create a healthy diet after transplant!","volume":"136","author":"Teshima","year":"2020","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbmt.2008.12.494","article-title":"Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation","volume":"15","author":"Zorn","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1158\/1078-0432.CCR-13-3205","article-title":"Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity","volume":"20","author":"Ku","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"e1250992","DOI":"10.1080\/2162402X.2016.1250992","article-title":"Prophylactic use of low-dose interleukin-2 and the clinical outcomes of hematopoietic stem cell transplantation: A randomized study","volume":"5","author":"Zhao","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.1182\/bloodadvances.2021006625","article-title":"A phase 1 study of donor regulatory T-cell infusion plus low-dose interleukin-2 for steroid-refractory chronic graft-vs-host disease","volume":"6","author":"Whangbo","year":"2022","journal-title":"Blood Adv."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1182\/blood-2010-10-313684","article-title":"Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells","volume":"118","author":"Shin","year":"2011","journal-title":"Blood"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.2337\/db19-0525","article-title":"Low-Dose Interleukin-2 Combined with Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet allograft Survival in Humanized Mice","volume":"69","author":"Hu","year":"2020","journal-title":"Diabetes"},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Tini, S., Baima, J., Pigni, S., Antoniotti, V., Caputo, M., De Palma, E., Cerbone, L., Grosso, F., La Vecchia, M., and Bona, E. (2025). The Microbiota-Diet-Immunity Axis in Cancer Care: From Prevention to Treatment Modulation and Survivorship. Nutrients, 17.","DOI":"10.3390\/nu17172898"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.tibtech.2019.12.009","article-title":"Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy","volume":"38","author":"Fritsche","year":"2020","journal-title":"Trends Biotechnol."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Lu, W., Liang, C.L., Chen, Y., Liu, H., Qiu, F., and Dai, Z. (2018). Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02359"},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Chan, A.M.L., Sakthiswary, R., and Lokanathan, Y. (2025). Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells. Biomedicines, 13.","DOI":"10.3390\/biomedicines13071757"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1182\/blood.2022016052","article-title":"Engineering T cells to suppress acute GVHD and leukemia relapse after allogeneic hematopoietic stem cell transplantation","volume":"141","author":"Mo","year":"2023","journal-title":"Blood"},{"key":"ref_303","doi-asserted-by":"crossref","unstructured":"Hefazi, M., Bolivar-Wagers, S., and Blazar, B.R. (2021). Regulatory T Cell Therapy of Graft-versus-Host Disease: Advances and Challenges. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189676"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"e2219086120","DOI":"10.1073\/pnas.2219086120","article-title":"Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion","volume":"120","author":"Lamarche","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_305","first-page":"3153","article-title":"Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction","volume":"141","author":"Selli","year":"2023","journal-title":"Blood"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"152126","DOI":"10.1016\/j.imbio.2021.152126","article-title":"Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling","volume":"226","author":"Kibbie","year":"2021","journal-title":"Immunobiology"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ymthe.2025.02.007","article-title":"Expanding the engineered Treg multiverse","volume":"33","author":"Cochrane","year":"2025","journal-title":"Mol. Ther."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"6446","DOI":"10.1038\/s41467-021-26844-1","article-title":"Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction","volume":"12","author":"Marchal","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"101561","DOI":"10.1016\/j.omtm.2025.101561","article-title":"HLA-A2 CAR\/IL-2-CISC engineered Treg display robust in vitro and in vivo antigen-specific regulatory function","volume":"33","author":"Tripathi","year":"2025","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/imr.13254","article-title":"Eras of designer Tregs: Harnessing synthetic biology for immune suppression","volume":"320","author":"Tuomela","year":"2023","journal-title":"Immunol. Rev."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1038\/s41591-023-02587-y","article-title":"Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation","volume":"29","author":"Riwes","year":"2023","journal-title":"Nat. Med."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"2178805","DOI":"10.1080\/19490976.2023.2178805","article-title":"Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease","volume":"15","author":"Vos","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Christofi, P., Pantazi, C., Psatha, N., Sakellari, I., Yannaki, E., and Papadopoulou, A. (2023). Promises and Pitfalls of Next-Generation Treg Adoptive Immunotherapy. Cancers, 15.","DOI":"10.3390\/cancers15245877"},{"key":"ref_314","doi-asserted-by":"crossref","unstructured":"Introna, M., and Golay, J. (2020). Tolerance to Bone Marrow Transplantation: Do Mesenchymal Stromal Cells Still Have a Future for Acute or Chronic GvHD?. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.609063"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/advances\/nmab047","article-title":"A Systematic Review of Dietary Influences on Fecal Microbiota Composition and Function among Healthy Humans 1-20 Years of Age","volume":"12","author":"Dinsmoor","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Gibiino, G., De Siena, M., Sbrancia, M., Binda, C., Sambri, V., Gasbarrini, A., and Fabbri, C. (2021). Dietary Habits and Gut Microbiota in Healthy Adults: Focusing on the Right Diet. A Systematic Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136728"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature25973","article-title":"Environment dominates over host genetics in shaping human gut microbiota","volume":"555","author":"Rothschild","year":"2018","journal-title":"Nature"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"110716","DOI":"10.1016\/j.foodres.2021.110716","article-title":"Fostering next-generation probiotics in human gut by targeted dietary modulation: An emerging perspective","volume":"150","author":"Kumari","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cmet.2021.05.005","article-title":"Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?","volume":"33","author":"Hanssen","year":"2021","journal-title":"Cell Metab."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"eaaz8926","DOI":"10.1126\/scitranslmed.aaz8926","article-title":"Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients","volume":"12","author":"Davids","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_322","doi-asserted-by":"crossref","unstructured":"Bili\u0144ski, J., Jasi\u0144ski, M., and Basak, G.W. (2022). The Role of Fecal Microbiota Transplantation in the Treatment of Acute Graft-versus-Host Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10040837"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2971-8","article-title":"The gut microbiota is associated with immune cell dynamics in humans","volume":"588","author":"Schluter","year":"2020","journal-title":"Nature"},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Li, X., Zhou, Y., Gao, J., Jiao, Y., Zhu, B., Wu, D., and Qi, X. (2021). Safety and Efficacy of Fecal Microbiota Transplantation for Grade IV Steroid Refractory GI-GvHD Patients: Interim Results From FMT2017002 Trial. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.678476"},{"key":"ref_325","first-page":"e23873","article-title":"Restoration of the Original Inhabitants: A Systematic Review on Fecal Microbiota Transplantation for Graft-Versus-Host Disease","volume":"14","author":"Alabdaljabar","year":"2022","journal-title":"Cureus"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"55","DOI":"10.6002\/ect.2011.0082","article-title":"Pretransplant nutritional habits and clinical outcome in children undergoing hematopoietic stem cell transplant","volume":"10","author":"Tavil","year":"2012","journal-title":"Exp. Clin. Transplant."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1159\/000368714","article-title":"Efficacy of Enteral Supplementation Enriched with Glutamine, Fiber, and Oligosaccharide on Mucosal Injury following Hematopoietic Stem Cell Transplantation","volume":"7","author":"Iyama","year":"2014","journal-title":"Case Rep. Oncol."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/bmj.327.7407.117","article-title":"Immunonutrition","volume":"327","author":"Calder","year":"2003","journal-title":"BMJ"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"137S","DOI":"10.1177\/0148607190014004201","article-title":"Safety and metabolic effects of L-glutamine administration in humans","volume":"14","author":"Ziegler","year":"1990","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3390\/nu6062148","article-title":"Is omega-3 fatty acids enriched nutrition support safe for critical ill patients? A systematic review and meta-analysis","volume":"6","author":"Chen","year":"2014","journal-title":"Nutrients"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07315724.2001.10719007","article-title":"Nutritional selenium supplements: Product types, quality, and safety","volume":"20","author":"Schrauzer","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"51S","DOI":"10.1177\/0148607113493326","article-title":"Pharmaconutrition review: Physiological mechanisms","volume":"37","author":"Pierre","year":"2013","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/cc11316","article-title":"Antioxidant micronutrients in the critically ill: A systematic review and meta-analysis","volume":"16","author":"Manzanares","year":"2012","journal-title":"Crit. Care"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"R184","DOI":"10.1186\/cc11668","article-title":"n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: A meta-analysis","volume":"16","author":"Pradelli","year":"2012","journal-title":"Crit. Care"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_336","doi-asserted-by":"crossref","unstructured":"Portincasa, P., Bonfrate, L., Vacca, M., De Angelis, M., Farella, I., Lanza, E., Khalil, M., Wang, D.Q.-H., Sperandio, M., and Di Ciaula, A. (2022). Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031105"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"102913","DOI":"10.1016\/j.ebiom.2020.102913","article-title":"Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells","volume":"58","author":"Takahashi","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"25168657231199893","DOI":"10.1177\/25168657231199893","article-title":"DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors","volume":"16","author":"Maleknia","year":"2023","journal-title":"Epigenetics Insights"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.anaerobe.2013.09.012","article-title":"Starch structure modulates metabolic activity and gut microbiota profile","volume":"24","author":"Zhou","year":"2013","journal-title":"Anaerobe"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1182\/bloodadvances.2020002604","article-title":"Prebiotics protect against acute graft-versus-host disease and preserve the gut microbiota in stem cell transplantation","volume":"4","author":"Yoshifuji","year":"2020","journal-title":"Blood Adv."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1186\/s12967-025-06797-5","article-title":"The microbiome in graft-versus-host disease: A tale of two ecosystems","volume":"23","author":"Nouri","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/PPO.0000000000000645","article-title":"The microbiome and its impact on allogeneic hematopoietic cell transplantation","volume":"29","author":"Malard","year":"2023","journal-title":"Cancer J."},{"key":"ref_346","doi-asserted-by":"crossref","unstructured":"Hajjar, C., Kuijper, E.J., Butel, M.J., Khoury, G., Mallah, M., Karam Sarkis, D., Lesnik, P., Le Goff, W., Bazarbachi, A., and Abifadel, M. (2026). Microbiota-derived short-chain fatty acids in hematopoietic stem cell transplantation: Immunomodulation at the host-microbiota interface. Front. Microbiol., 17.","DOI":"10.3389\/fmicb.2026.1754099"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-\/- mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cmet.2018.05.006","article-title":"Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota","volume":"27","author":"Cignarella","year":"2018","journal-title":"Cell Metab."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/cis580","article-title":"Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation","volume":"55","author":"Taur","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1182\/bloodadvances.2021006783","article-title":"Lasting shift in the gut microbiota in patients with acute myeloid leukemia","volume":"6","author":"Rashidi","year":"2022","journal-title":"Blood Adv."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/cncr.32641","article-title":"Gut dysbiosis during antileukemia chemotherapy versus allogeneic hematopoietic cell transplantation","volume":"126","author":"Rashidi","year":"2020","journal-title":"Cancer"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrc.2018.10","article-title":"Gut microbiota injury in allogeneic haematopoietic stem cell transplantation","volume":"18","author":"Shono","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrgastro.2017.126","article-title":"Acute graft-versus-host disease of the gut: Considerations for the gastroenterologist","volume":"14","author":"Naymagon","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/1078-0432.CCR-22-1254","article-title":"Conditioning Regimens are Associated with Distinct Patterns of Microbiota Injury in Allogeneic Hematopoietic Cell Transplantation","volume":"29","author":"Shouval","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.bbmt.2018.07.030","article-title":"Antibiotic Exposure and Reduced Short Chain Fatty Acid Production after Hematopoietic Stem Cell Transplant","volume":"24","author":"Haslam","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.aax3760","article-title":"Lactose drives Enterococcus expansion to promote graft-versus-host disease","volume":"366","author":"Nichols","year":"2019","journal-title":"Science"},{"key":"ref_357","doi-asserted-by":"crossref","unstructured":"Gavriilaki, E., Christoforidi, M., Ouranos, K., Minti, F., Mallouri, D., Varelas, C., Lazaridou, A., Baldoumi, E., Panteliadou, A., and Bousiou, Z. (2024). Alteration of Gut Microbiota Composition and Diversity in Acute and\/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115789"},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbmt.2017.02.006","article-title":"Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation","volume":"23","author":"Weber","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bbmt.2017.02.004","article-title":"Antibiotic-Induced Depletion of Anti-inflammatory Clostridia Is Associated with the Development of Graft-versus-Host Disease in Pediatric Stem Cell Transplantation Patients","volume":"23","author":"Sunkersett","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"e70334","DOI":"10.1002\/mco2.70334","article-title":"Gut Microbiome and Metabolome Dynamics as Predictors of Clinical Outcomes in Hematopoietic Stem Cell Transplantation","volume":"6","author":"Kim","year":"2025","journal-title":"MedComm"},{"key":"ref_361","doi-asserted-by":"crossref","unstructured":"Nie, K., Ma, K., Luo, W., Shen, Z., Yang, Z., Xiao, M., Tong, T., Yang, Y., and Wang, X. (2021). Roseburia intestinalis: A Beneficial Gut Organism from the Discoveries in Genus and Species. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.757718"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1875796","article-title":"Blautia-a new functional genus with potential probiotic properties?","volume":"13","author":"Liu","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.aad3503","article-title":"Population-level analysis of gut microbiome variation","volume":"352","author":"Falony","year":"2016","journal-title":"Science"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.aad3369","article-title":"Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity","volume":"352","author":"Zhernakova","year":"2016","journal-title":"Science"},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/ajcn\/75.2.183","article-title":"Nutritional and metabolic support in patients undergoing bone marrow transplantation","volume":"75","author":"Muscaritoli","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/adc.75.3.208","article-title":"Gastrointestinal and nutritional sequelae of bone marrow transplantation","volume":"75","author":"Papadopoulou","year":"1996","journal-title":"Arch. Dis. Child."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1056\/NEJMoa1900623","article-title":"Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation","volume":"382","author":"Peled","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1182\/bloodadvances.2021005129","article-title":"Gut microbiome in pediatric acute leukemia: From predisposition to cure","volume":"5","author":"Masetti","year":"2021","journal-title":"Blood Adv."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s40168-022-01270-7","article-title":"Linking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in paediatric haematopoietic stem cell transplantation","volume":"10","author":"Vaitkute","year":"2022","journal-title":"Microbiome"},{"key":"ref_370","doi-asserted-by":"crossref","unstructured":"Andermann, T.M., Fouladi, F., Tamburini, F.B., Sahaf, B., Tkachenko, E., Greene, C., Buckley, M.T., Brooks, E.F., Hedlin, H., and Arai, S. (2021). A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant. Cell. Ther., 27.","DOI":"10.1101\/2021.04.26.21256127"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbmt.2015.04.016","article-title":"Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease","volume":"21","author":"Jenq","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/cid\/ciz777","article-title":"Gut Microbiome Signatures Are Predictive of Infectious Risk Following Induction Therapy for Acute Myeloid Leukemia","volume":"71","author":"Shi","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/cncr.30039","article-title":"The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia","volume":"122","author":"Smith","year":"2016","journal-title":"Cancer"},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/apt.13302","article-title":"Chemotherapy-driven dysbiosis in the intestinal microbiome","volume":"42","author":"Montassier","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"609","DOI":"10.7326\/M16-0271","article-title":"Effect of Fecal Microbiota Transplantation on Recurrence in Multiply Recurrent Clostridium difficile Infection: A Randomized Trial","volume":"165","author":"Kelly","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_376","doi-asserted-by":"crossref","unstructured":"Qi, X., Li, X., Zhao, Y., Wu, X., Chen, F., Ma, X., Zhang, F., and Wu, D. (2018). Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease with Fecal Microbiota Transplantation: A Pilot Study. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02195"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/j.cell.2021.06.019","article-title":"Gut-microbiota-targeted diets modulate human immune status","volume":"184","author":"Wastyk","year":"2021","journal-title":"Cell"},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/bjh.16218","article-title":"Pilot study investigating the effect of enteral and parenteral nutrition on the gastrointestinal microbiome post-allogeneic transplantation","volume":"188","author":"Andersen","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.chom.2020.12.012","article-title":"Role of dietary fiber in the recovery of the human gut microbiome and its metabolome","volume":"29","author":"Tanes","year":"2021","journal-title":"Cell Host Microbe"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/8\/1216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:01:36Z","timestamp":1776067296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/8\/1216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,12]]},"references-count":379,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["nu18081216"],"URL":"https:\/\/doi.org\/10.3390\/nu18081216","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,12]]}}}