{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:50:43Z","timestamp":1776941443748,"version":"3.51.4"},"reference-count":63,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Division of the Medical School-UNAM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Dietary antioxidants are frequently utilized by breast cancer (BC) patients to mitigate treatment-related toxicities and enhance quality of life. However, their clinical efficacy remains highly controversial due to conflicting epidemiological and clinical data. This review aims to critically evaluate the molecular mechanisms, clinical outcomes, and translational challenges of antioxidant supplementation in BC management. Methods: A comprehensive evaluation of current literature\u2014encompassing observational cohorts, randomized controlled trials, and mechanistic in vitro\/in vivo models\u2014was conducted. The analysis focused on the pharmacological interactions of diverse bioactive compounds (polyphenols, vitamins, carotenoids) with BC progression and standard antineoplastic regimens. Results: Current evidence demonstrates a paradoxical, double-edged role of antioxidants in oncology. While specific interventions (e.g., Coenzyme Q10, melatonin) effectively ameliorate treatment-induced toxicities without compromising therapeutic efficacy, the concurrent administration of antioxidants during cytotoxic chemotherapy can inadvertently neutralize essential reactive oxygen species (ROS), correlating with increased disease recurrence and mortality. Furthermore, clinical translation is severely hindered by the intrinsic hydrophobicity of natural compounds, the lack of whole-food matrix standardization, and dose-dependent hepatotoxicity. Emerging targeted delivery systems, such as lipid nanoformulations, show significant potential in overcoming these pharmacokinetic barriers. Conclusions: The therapeutic viability of antioxidant supplementation in BC is not universal; it is heavily dictated by intrinsic tumor biology, specific treatment modalities, and chronopharmacology. These findings underscore a critical biological imperative to transition from generalized dietary guidelines toward a rigorous paradigm of precision nutritional oncology, strictly avoiding concurrent antioxidant supplementation during active oxidative therapies.<\/jats:p>","DOI":"10.3390\/nu18091328","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:10:17Z","timestamp":1776939017000},"page":"1328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Nutritional Supplements and Antioxidants in the Treatment of Breast Cancer: A Systematic Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-6976","authenticated-orcid":false,"given":"Daniel","family":"Uribe-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-739X","authenticated-orcid":false,"given":"Kevin David","family":"Laguna-Maldonado","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5388-6752","authenticated-orcid":false,"given":"Melissa","family":"V\u00e1zquez-Carrada","sequence":"additional","affiliation":[{"name":"Cluster of Excellence on Plant Sciences, Institute for Microbiology, Heinrich Heine University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4818-1154","authenticated-orcid":false,"given":"Luis Fernando","family":"Cort\u00e9s-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-7646","authenticated-orcid":false,"given":"Mar\u00eda Magdalena","family":"Vilchis-Landeros","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-3115","authenticated-orcid":false,"given":"H\u00e9ctor","family":"V\u00e1zquez-Meza","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-9832","authenticated-orcid":false,"given":"Deyamira","family":"Matuz-Mares","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.21873\/anticanres.17036","article-title":"Harnessing Micronutrient Power: Vitamins, Antioxidants and Probiotics in Breast Cancer Prevention","volume":"44","author":"Mokbel","year":"2024","journal-title":"Anticancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s10654-025-01277-y","article-title":"Plant-Based Dietary Patterns and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study","volume":"40","author":"Shah","year":"2025","journal-title":"Eur. J. Epidemiol."},{"key":"ref_3","first-page":"155","article-title":"Selenium and Triple Negative Breast Cancer","volume":"53","author":"Sidira","year":"2024","journal-title":"Acta Medica Acad."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wendlocha, D., Krzykawski, K., Mielczarek-Palacz, A., and Kubina, R. (2023). Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review. Nutrients, 15.","DOI":"10.3390\/nu15132938"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Braakhuis, A., Campion, P., and Bishop, K. (2016). Reducing Breast Cancer Recurrence: The Role of Dietary Polyphenolics. Nutrients, 8.","DOI":"10.3390\/nu8090547"},{"key":"ref_6","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_7","unstructured":"(2026, March 26). Cancer (IARC), T.I.A. for R. on Global Cancer Observatory. Available online: https:\/\/gco.iarc.fr\/."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Vilchis-Landeros, M.M., V\u00e1zquez-Meza, H., V\u00e1zquez-Carrada, M., Uribe-Ram\u00edrez, D., and Matuz-Mares, D. (2024). Antioxidant Enzymes and Their Potential Use in Breast Cancer Treatment. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115675"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"114262","DOI":"10.1016\/j.biopha.2023.114262","article-title":"Fighting Secondary Triple-Negative Breast Cancer in Cerebellum: A Powerful Aid from a Medicinal Mushrooms Blend","volume":"159","author":"Roda","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12032-024-02454-x","article-title":"Exploring the Potential of Tocopherols: Mechanisms of Action and Perspectives in the Prevention and Treatment of Breast Cancer","volume":"41","year":"2024","journal-title":"Med. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26444\/aaem\/94299","article-title":"Environmental Risk Factors for Cancer\u2014Review Paper","volume":"26","author":"Lewandowska","year":"2019","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biochi.2022.03.005","article-title":"Molecular and Cellular Mechanisms of Melatonin in Breast Cancer","volume":"202","author":"Sadoughi","year":"2022","journal-title":"Biochimie"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.tjnut.2023.05.001","article-title":"Paternal Combined Botanicals Contribute to the Prevention of Estrogen Receptor\u2013Negative Mammary Cancer in Transgenic Mice","volume":"153","author":"Li","year":"2023","journal-title":"J. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.2007.14.4147","article-title":"Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer","volume":"26","author":"Liedtke","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1172\/JCI45014","article-title":"Identification of Human Triple-Negative Breast Cancer Subtypes and Preclinical Models for Selection of Targeted Therapies","volume":"121","author":"Lehmann","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Newton, E.E., Mueller, L.E., Treadwell, S.M., Morris, C.A., and Machado, H.L. (2022). Molecular Targets of Triple-Negative Breast Cancer: Where Do We Stand?. Cancers, 14.","DOI":"10.3390\/cancers14030482"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.talanta.2011.08.034","article-title":"Analysis of Anticancer Drugs: A Review","volume":"85","author":"Nussbaumer","year":"2011","journal-title":"Talanta"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Majrashi, T.A., Alshehri, S.A., Alsayari, A., Muhsinah, A.B., Alrouji, M., Alshahrani, A.M., Shamsi, A., and Atiya, A. (2023). Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics. Nutrients, 15.","DOI":"10.3390\/nu15071704"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1007\/s13277-016-4873-9","article-title":"The Role of Oxidative Stress on Breast Cancer Development and Therapy","volume":"37","author":"Hecht","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.trecan.2020.03.004","article-title":"Tissue-Specific Carcinogens as Soil to Seed BRCA1\/2-Mutant Hereditary Cancers","volume":"6","author":"Singh","year":"2020","journal-title":"Trends Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12032-017-1044-9","article-title":"Kefir: A Powerful Probiotics with Anticancer Properties","volume":"34","author":"Sharifi","year":"2017","journal-title":"Med. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.3390\/cimb46070450","article-title":"Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?","volume":"46","author":"Roda","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/01635581.2017.1267777","article-title":"Oxidative Stress and Carcinogenesis: Potential of Phytochemicals in Breast Cancer Therapy","volume":"69","author":"Forcados","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Herdiana, Y., Sriwidodo, S., Sofian, F.F., Wilar, G., and Diantini, A. (2023). Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment. Molecules, 28.","DOI":"10.3390\/molecules28145305"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2217\/fon-2016-0547","article-title":"Coenzyme Q10 in Breast Cancer Care","volume":"13","author":"Tafazoli","year":"2017","journal-title":"Future Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.clbc.2021.09.001","article-title":"Post-Diagnosis Use of Antioxidant Vitamin Supplements and Breast Cancer Prognosis: A Systematic Review and Meta-Analysis","volume":"21","author":"Li","year":"2021","journal-title":"Clin. Breast Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Eren, E., Das, J., and Tollefsbol, T.O. (2024). Polyphenols as Immunomodulators and Epigenetic Modulators: An Analysis of Their Role in the Treatment and Prevention of Breast Cancer. Nutrients, 16.","DOI":"10.3390\/nu16234143"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sindhu, R.K., Verma, R., Salgotra, T., Rahman, M.H., Shah, M., Akter, R., Murad, W., Mubin, S., Bibi, P., and Qusti, S. (2021). Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment. Molecules, 26.","DOI":"10.3390\/molecules26175163"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117463","DOI":"10.1016\/j.lfs.2020.117463","article-title":"A Review on Anti-Cancer Properties of Quercetin in Breast Cancer","volume":"248","author":"Ezzati","year":"2020","journal-title":"Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/1389203718666170111115914","article-title":"Walking a Tightrope: A Perspective of Resveratrol Effects on Breast Cancer","volume":"19","author":"Bartolacci","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Scafuri, L., Buonerba, C., Strianese, O., De Azambuja, E., Palleschi, M., Riccio, V., Marotta, V., Scocca, C., Riccio, G., and Errico, C. (2025). Impact of Dietary Supplements on Clinical Outcomes and Quality of Life in Patients with Breast Cancer: A Systematic Review. Nutrients, 17.","DOI":"10.3390\/nu17060981"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1158\/1940-6207.CAPR-17-0187","article-title":"A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer","volume":"10","author":"Samavat","year":"2017","journal-title":"Cancer Prev. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Xiang, L.-P., Wang, A., Ye, J.-H., Zheng, X.-Q., Polito, C., Lu, J.-L., Li, Q.-S., and Liang, Y.-R. (2016). Suppressive Effects of Tea Catechins on Breast Cancer. Nutrients, 8.","DOI":"10.3390\/nu8080458"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20150665","DOI":"10.1259\/bjr.20150665","article-title":"Phase I Study of Topical Epigallocatechin-3-Gallate (EGCG) in Patients with Breast Cancer Receiving Adjuvant Radiotherapy","volume":"89","author":"Zhao","year":"2016","journal-title":"Br. J. Radiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1158\/1940-6207.CAPR-17-0160","article-title":"Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States","volume":"10","author":"Yu","year":"2017","journal-title":"Cancer Prev. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Markowska, A., Antoszczak, M., Markowska, J., and Huczy\u0144ski, A. (2025). Role of Epigallocatechin Gallate in Selected Malignant Neoplasms in Women. Nutrients, 17.","DOI":"10.3390\/nu17020212"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"79008","DOI":"10.18632\/oncotarget.12592","article-title":"Dietary Iron Intake and Breast Cancer Risk: Modulation by an Antioxidant Supplementation","volume":"7","author":"Diallo","year":"2016","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00394-017-1489-9","article-title":"Serum Antioxidant Capacity, Biochemical Profile and Body Composition of Breast Cancer Survivors in a Randomized Mediterranean Dietary Intervention Study","volume":"57","author":"Skouroliakou","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10549-016-4070-y","article-title":"Fatigue Reduction Diet in Breast Cancer Survivors: A Pilot Randomized Clinical Trial","volume":"161","author":"Zick","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"122557","DOI":"10.1016\/j.lfs.2024.122557","article-title":"Melatonin: Current Evidence on Protective and Therapeutic Roles in Gynecological Diseases","volume":"344","author":"Hosseinzadeh","year":"2024","journal-title":"Life Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Stephenson, E., Mclaughlin, M., Bray, J.W., Saxton, J.M., and Vince, R.V. (2024). Nutrition Modulation of Cardiotoxicity in Breast Cancer: A Scoping Review. Nutrients, 16.","DOI":"10.3390\/nu16213777"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.31557\/APJCP.2019.20.7.2065","article-title":"Genetic Variations in VDR Could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial","volume":"20","author":"Mohseni","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1177\/10781552241268778","article-title":"Evaluation of Oral Silymarin Formulation Efficacy in Prevention of Doxorubicin Induced Hepatotoxicity in Patients with Non-Metastatic Breast Cancer","volume":"31","author":"Karimi","year":"2025","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2217\/pme-2020-0003","article-title":"Polymorphisms in Genes Involved in Breast Cancer Among Iranian Patients","volume":"18","author":"Farnoosh","year":"2021","journal-title":"Pers. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00203-024-03868-x","article-title":"Exploring the Underlying Correlation between Microbiota, Immune System, Hormones, and Inflammation with Breast Cancer and the Role of Probiotics, Prebiotics and Postbiotics","volume":"206","author":"Summer","year":"2024","journal-title":"Arch. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13058-023-01677-6","article-title":"Exploring Breast Tissue Microbial Composition and the Association with Breast Cancer Risk Factors","volume":"25","author":"German","year":"2023","journal-title":"Breast Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Thu, M.S., Ondee, T., Nopsopon, T., Farzana, I.A.K., Fothergill, J.L., Hirankarn, N., Campbell, B.J., and Pongpirul, K. (2025). Correction: Thu et al. Effect of Probiotics in Breast Cancer: A Systematic Review and Meta-Analysis. Biology 2023, 12, 280. Biology, 14.","DOI":"10.3390\/biology14080991"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1200\/JCO.19.01203","article-title":"Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients with Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)","volume":"38","author":"Ambrosone","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Reitz, L.K., Baptista, S.D.L., Santos, E.D.S., Hinnig, P.F., Rockenbach, G., Vieira, F.G.K., De Assis, M.A.A., Da Silva, E.L., Boaventura, B.C.B., and Pietro, P.F.D. (2020). Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study. Nutrients, 13.","DOI":"10.3390\/nu13010115"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"108504","DOI":"10.1016\/j.jnutbio.2020.108504","article-title":"Nutritional Supplements in Combination with Chemotherapy or Targeted Therapy Reduces Tumor Progression in Mice Bearing Triple-Negative Breast Cancer","volume":"87","author":"Guo","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/cncr.26526","article-title":"Antioxidant Supplement Use after Breast Cancer Diagnosis and Mortality in the Life After Cancer Epidemiology (LACE) Cohort","volume":"118","author":"Greenlee","year":"2012","journal-title":"Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Hu, W., Lyu, X., Xu, H., Guo, X., Zhu, H., Pan, H., Wang, L., Yang, H., and Gong, F. (2023). Intragastric Safflower Yellow Alleviates HFD Induced Metabolic Dysfunction-Associated Fatty Liver Disease in Mice through Regulating Gut Microbiota and Liver Endoplasmic Reticulum Stress. Nutrients, 15.","DOI":"10.3390\/nu15132954"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11864-021-00865-w","article-title":"The Promise of Nutrient-Derived Bioactive Compounds and Dietary Components to Ameliorate Symptoms of Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors","volume":"22","author":"Kumar","year":"2021","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.nbd.2018.03.006","article-title":"Resveratrol, a Natural Polyphenol, Prevents Chemotherapy-Induced Cognitive Impairment: Involvement of Cytokine Modulation and Neuroprotection","volume":"114","author":"Shi","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.25122\/jml-2023-0098","article-title":"Coq10 for Preventing Cardiotoxicity in Breast Cancer Patients Treated with Trastuzumab","volume":"16","author":"AlSabri","year":"2023","journal-title":"J. Med. Life"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3923\/pjn.2003.54.59","article-title":"Kefir: A Probiotic Dairy-Composition, Nutritional and Therapeutic Aspects","volume":"2","author":"Otles","year":"2003","journal-title":"Pak. J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5468\/ogs.2019.62.4.242","article-title":"Effect of Quercetin on the Anti-Tumor Activity of Cisplatin in EMT6 Breast Tumor-Bearing Mice","volume":"62","author":"Liu","year":"2019","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering Precision Nanoparticles for Drug Delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Yang, B., Dong, Y., Wang, F., and Zhang, Y. (2020). Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols. Molecules, 25.","DOI":"10.3390\/molecules25204613"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Khalil, I., Yehye, W.A., Etxeberria, A.E., Alhadi, A.A., Dezfooli, S.M., Julkapli, N.B.M., Basirun, W.J., and Seyfoddin, A. (2019). Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications. Antioxidants, 9.","DOI":"10.3390\/antiox9010024"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/acsomega.2c05976","article-title":"Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery","volume":"8","author":"Priya","year":"2023","journal-title":"ACS Omega"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e2016024","DOI":"10.4178\/epih.e2016024","article-title":"Reinterpretation of the Results of a Pooled Analysis of Dietary Carotenoid Intake and Breast Cancer Risk by Using the Interval Collapsing Method","volume":"38","author":"Bae","year":"2016","journal-title":"Epidemiol. Health"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/9\/1328\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:17:45Z","timestamp":1776939465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/9\/1328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":63,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["nu18091328"],"URL":"https:\/\/doi.org\/10.3390\/nu18091328","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}