{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:29:27Z","timestamp":1777757367658,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Proper nutrition is a fundamental determinant of human health and is structured through the intake of various nutritional components: (i) macronutrients, including carbohydrates, lipids, and proteins, which provide energy and essential structural materials for metabolic and physiological processes; (ii) micronutrients, such as vitamins and minerals, although required in smaller quantities, play crucial roles as enzymatic cofactors and regulators of numerous biochemical pathways; (iii) natural bioactive compounds (NBCs), substances found in plant-based foods (including polyphenols, carotenoids, phytosterols, and sulfur compounds) that exert protective effects thanks to their antioxidant and anti-inflammatory properties, contributing to the prevention of numerous chronic non-communicable diseases (CNCDs) [...]<\/jats:p>","DOI":"10.3390\/nu18091401","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:31:56Z","timestamp":1777465916000},"page":"1401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutrients: 15th Anniversary"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-3730","authenticated-orcid":false,"given":"Annalisa","family":"Noce","sequence":"first","affiliation":[{"name":"UOSD Nephrology and Dialysis, Policlinico Tor Vergata, 00133 Rome, Italy"},{"name":"Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-6603","authenticated-orcid":false,"given":"Jay R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Ariel University, Ariel 40700, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-8636","authenticated-orcid":false,"given":"Ines","family":"Gonzalez-Casanova","sequence":"additional","affiliation":[{"name":"Department of Applied Health Science, School of Public Heath, Indiana University, Bloomington, IN 47405, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cena, H., and Calder, P.C. (2020). Defining a Healthy Diet: Evidence for the Role of Contemporary Dietary Patterns in Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12020334"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/joim.13728","article-title":"Diet strategies for promoting healthy aging and longevity: An epidemiological perspective","volume":"295","author":"Hu","year":"2024","journal-title":"J. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kussmann, M., Abe Cunha, D.H., and Berciano, S. (2023). Bioactive compounds for human and planetary health. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1193848"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2174\/1871530322666220903143820","article-title":"Micronutrients and Plant Food Bioactive Compounds Against Obesity Related Diseases","volume":"23","author":"Azzini","year":"2023","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Benameur, T., Porro, C., Twfieg, M.E., Benameur, N., Panaro, M.A., Filannino, F.M., and Hasan, A. (2023). Emerging Paradigms in Inflammatory Disease Management: Exploring Bioactive Compounds and the Gut Microbiota. Brain Sci., 13.","DOI":"10.3390\/brainsci13081226"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/10408398.2020.1744512","article-title":"Dietary polyphenol impact on gut health and microbiota","volume":"61","author":"Wan","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106570","DOI":"10.1016\/j.fitote.2025.106570","article-title":"Gut microbiota: A potential enhancing factor for the therapeutic efficacy of bioactive compounds in herbal medicines","volume":"183","author":"Chen","year":"2025","journal-title":"Fitoterapia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3390\/cimb46030119","article-title":"Microbial-Based Bioactive Compounds to Alleviate Inflammation in Obesity","volume":"46","author":"Apalowo","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41579-025-01183-w","article-title":"Gut microbiota-derived short-chain fatty acids and their role in human health and disease","volume":"23","author":"Mukhopadhya","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12918","DOI":"10.1038\/s41598-019-49452-y","article-title":"Defining Dysbiosis for a Cluster of Chronic Diseases","volume":"9","author":"Wilkins","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S1080","DOI":"10.4103\/jpbs.jpbs_309_25","article-title":"Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review","volume":"17","author":"Patel","year":"2025","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Marrone, G., Di Lauro, M., Cornali, K., Masci, C., Vanni, G., Vita, C., and Noce, A. (2025). Sustainability and role of plant-based diets in chronic kidney disease prevention and treatment. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1562409"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/s41591-024-03165-6","article-title":"Western diets and chronic diseases","volume":"30","author":"Adolph","year":"2024","journal-title":"Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Canale, M.P., Noce, A., Di Lauro, M., Marrone, G., Cantelmo, M., Cardillo, C., Federici, M., Di Daniele, N., and Tesauro, M. (2021). Gut Dysbiosis and Western Diet in the Pathogenesis of Essential Arterial Hypertension: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13041162"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jurcevic Zidar, B., Knezovic, Z., Pribisalic, A., Luetic, S., Jurcic, K., Knezovic, N., and Sutlovic, D. (2025). Consumer Perceptions of Artificial Sweeteners in Food Products, Consumption Frequency, and Body Mass Index: A Multivariate Analysis. Nutrients, 17.","DOI":"10.3390\/nu17050814"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41579-024-01068-4","article-title":"The interplay between diet and the gut microbiome: Implications for health and disease","volume":"22","author":"Ross","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Martinez-Vazquez, S.E., Kammar-Garc\u00eda, A., Moctezuma-Vel\u00e1zquez, C., Mancilla-Galindo, J., Garc\u00eda-Ju\u00e1rez, I., and Uscanga-Dom\u00ednguez, L.F. (2025). The Impact of Dietary Sugars and Saturated Fats on Body and Liver Fat in a Healthcare Worker Population. Nutrients, 17.","DOI":"10.20944\/preprints202503.0588.v1"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Knezovic, Z., Jurcevic Zidar, B., Pribisalic, A., Luetic, S., Jurcic, K., Knezovic, N., and Sutlovic, D. (2025). Artificial Sweeteners in Food Products: Concentration Analysis, Label Practices, and Cumulative Intake Assessment in Croatia. Nutrients, 17.","DOI":"10.3390\/nu17071110"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Barber, T.M., Kabisch, S., Pfeiffer, A.F.H., and Weickert, M.O. (2023). The Effects of the Mediterranean Diet on Health and Gut Microbiota. Nutrients, 15.","DOI":"10.3390\/nu15092150"},{"key":"ref_20","first-page":"415","article-title":"The anti-inflammatory effects of a Mediterranean diet: A review","volume":"25","author":"Itsiopoulos","year":"2022","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113026","DOI":"10.1016\/j.nut.2025.113026","article-title":"Effects of the Mediterranean diet on inflammation, quality of life, and mortality in autoimmune diseases: A systematic review featured in the Italian National Guidelines \u201cLa Dieta Mediterranea\u201d","volume":"143","author":"Gianfredi","year":"2026","journal-title":"Nutrition"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mahdi, L., Graziani, A., Baffy, G., Mitten, E.K., Portincasa, P., and Khalil, M. (2025). Unlocking Polyphenol Efficacy: The Role of Gut Microbiota in Modulating Bioavailability and Health Effects. Nutrients, 17.","DOI":"10.3390\/nu17172793"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Knudsen, D.C., Babb, A.M., Conway, M.R., and Beck, D.L. (2025). An Analysis of the Affordability of Harvard, Mediterranean and DASH Eating Patterns for Individuals Enrolled in the Supplementary Nutrition Assistance Program (SNAP). Nutrients, 17.","DOI":"10.3390\/nu17213480"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101596","DOI":"10.1016\/j.arr.2022.101596","article-title":"The role of nutrition in inflammaging","volume":"77","author":"Stamerra","year":"2022","journal-title":"Ageing Res. Rev."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/9\/1401\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:45:55Z","timestamp":1777466755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/9\/1401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":24,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["nu18091401"],"URL":"https:\/\/doi.org\/10.3390\/nu18091401","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}