{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:51:38Z","timestamp":1787784698279,"version":"build-2784847793"},"reference-count":94,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Muscle vulnerability occurs at both extremes of the human lifespan, although its biological significance differs substantially between developmental growth and late-life decline. During childhood and adolescence, insufficient muscle accretion reflects disruption of physiological anabolic trajectories driven by inadequate energy availability, inflammatory burden, endocrine imbalance, or disease-associated catabolism. In older adults, muscle deterioration is characterized by anabolic resistance, neuromuscular remodeling, chronic low-grade inflammation, and hormonal decline, culminating in sarcopenia and loss of functional independence. The absence of harmonized diagnostic frameworks across age groups limits direct translational extrapolation. A lifespan-informed perspective distinguishing growth-supportive from function-preserving nutritional approaches is, therefore, required. This narrative review examines how major classes of nutritional bioactive interact with molecular pathways regulating skeletal muscle homeostasis in fragile populations across the lifespan. The analysis encompasses energy adequacy, protein quantity and quality, amino acid-dependent anabolic signaling, vitamin D status, lipid-derived mediators, redox-modulating phytochemicals, and micronutrients supporting mitochondrial bioenergetics. In pediatric contexts, nutritional interventions primarily aim to restore anabolic permissiveness within a structurally intact growth environment. In aging individuals, strategies focus on mitigating anabolic resistance through optimized protein intake, correction of micronutrient insufficiencies, and integration with resistance exercise to preserve functional capacity. This narrative review emphasizes the need to distinguish mechanistic rationale from clinically validated interventions, as improvements in molecular pathways do not consistently translate into meaningful functional outcomes.<\/jats:p>","DOI":"10.3390\/nu18091437","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:32:21Z","timestamp":1777555941000},"page":"1437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Growth Trajectory to Functional Decline: Age-Contextualized Nutritional Strategies for Muscle Vulnerability. A Narrative Review"],"prefix":"10.3390","volume":"18","author":[{"given":"Luisa","family":"Malaguarnera","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-8430","authenticated-orcid":false,"given":"Vincenzo","family":"Sortino","sequence":"additional","affiliation":[{"name":"PhD Program in Innovative Technologies in Biomedical Sciences, University Kore of Enna, 94100 Enna, Italy"},{"name":"National Council of Research, Institute for Research and Biomedical Innovation (IRIB), Unit of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Surdo","sequence":"additional","affiliation":[{"name":"Assotiations ABC OdV Catania, 95027 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1781-0902","authenticated-orcid":false,"given":"Salvatore","family":"Piro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Iglesias, P. (2025). Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine-Metabolic Diseases. J. Clin. Med., 14.","DOI":"10.3390\/jcm14134490"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bone.2019.05.021","article-title":"The clinical impact and biological mechanisms of skeletal muscle aging","volume":"127","author":"Aversa","year":"2019","journal-title":"Bone"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/s42255-025-01349-z","article-title":"The insulin signalling network","volume":"7","author":"Burchfield","year":"2025","journal-title":"Nat. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Faienza, M.F., Urbano, F., Chiarito, M., Lassandro, G., and Giordano, P. (2023). Musculoskeletal health in children and adolescents. Front. Pediatr., 11.","DOI":"10.3389\/fped.2023.1226524"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/nutrit\/nuac062","article-title":"Age-related muscle anabolic resistance: Inevitable or preventable?","volume":"81","author":"Aragon","year":"2023","journal-title":"Nutr. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.clnu.2025.06.007","article-title":"Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine","volume":"51","author":"Liu","year":"2025","journal-title":"Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/nutrit\/nuaf154","article-title":"Feed Modification for Improved Energy and Protein Provision for Infants and Young Children in the Pediatric Critical Care Setting: A Scoping Review","volume":"83","author":"Winderlich","year":"2025","journal-title":"Nutr. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Serrano, J.C.E., Cassanye, A., Mart\u00edn-Gari, M., Granado-Serrano, A.B., and Portero-Ot\u00edn, M. (2016). Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility. Diseases, 4.","DOI":"10.3390\/diseases4010014"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fernandes, S.A., and Demetriades, C. (2021). The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging. Front. Aging, 2.","DOI":"10.3389\/fragi.2021.707372"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Ma\u00f1as, L., Murray, R., Glencorse, C., and Sulo, S. (2023). Good nutrition across the lifespan is foundational for healthy aging and sustainable development. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1113060"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Flores-Opazo, M., Monsalves-\u00c1lvarez, M., Sep\u00falveda-Guzm\u00e1n, C., Jannas-Vela, S., Fern\u00e1ndez Valero, P., Burrows, R., Correa-Burrows, P., and Troncoso, R. (2025). Perspective Review: Advancing toward the diagnosis of sarcopenia in the pediatric population. Pediatr. Res., ahead of print.","DOI":"10.1038\/s41390-025-04716-4"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.molcel.2013.01.019","article-title":"Nutrient sensing, metabolism, and cell growth control","volume":"49","author":"Yuan","year":"2013","journal-title":"Mol. Cell."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ferrara, I.R., and Sadowsky, C.L. (2024). Muscle Mass as a Biomarker for Health Status and Function in Pediatric Individuals with Neuromuscular Disabilities: A Systematic Review. Children, 11.","DOI":"10.3390\/children11070815"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s43587-024-00613-3","article-title":"Human skeletal muscle aging atlas","volume":"4","author":"Kedlian","year":"2024","journal-title":"Nat. Aging"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Horlem, T., Carvalhal, S.R.S., Bonatto, S.J.R., and Fernandes, L.C. (2025). Molecular Framework of the Onset and Progression of Skeletal Muscle Aging. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262010145"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.mayocp.2020.07.033","article-title":"Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications","volume":"96","author":"Pataky","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Solsona, R., Pavlin, L., Bernardi, H., and Sanchez, A.M. (2021). Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052741"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Perrotta, C., Cattaneo, M.G., Molteni, R., and De Palma, C. (2020). Autophagy in the Regulation of Tissue Differentiation and Homeostasis. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.602901"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102589","DOI":"10.1016\/j.arr.2024.102589","article-title":"Mechanisms of muscle cells alterations and regeneration decline during aging","volume":"102","author":"Chinvattanachot","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Zhang, M., Jin, H., Lv, S., Li, Y., and Li, Y. (2025). Mitochondrial Quality Control and Cell Death. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262211084"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12986-024-00820-0","article-title":"Amino acids regulating skeletal muscle metabolism: Mechanisms of action, physical training dosage recommendations and adverse effects","volume":"21","author":"Li","year":"2024","journal-title":"Nutr. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12929-020-00679-2","article-title":"Amino acid-dependent control of mTORC1 signaling: A variety of regulatory modes","volume":"27","author":"Takahara","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/s41556-024-01523-7","article-title":"Spatial and functional separation of mTORC1 signalling in response to different amino acid sources","volume":"26","author":"Fernandes","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.clnu.2023.08.010","article-title":"A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states","volume":"42","author":"Ely","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00005-012-0210-1","article-title":"Inflammation, cytokines and insulin resistance: A clinical perspective","volume":"61","author":"Wieser","year":"2013","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3390\/nu4070740","article-title":"Exercise and amino acid anabolic cell signaling and the regulation of skeletal muscle mass","volume":"4","author":"Pasiakos","year":"2012","journal-title":"Nutrients"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2044-5040-1-11","article-title":"Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis","volume":"1","author":"Fry","year":"2011","journal-title":"Skelet. Muscle"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Salucci, S. (2023). Nutrition and Regulation of Muscle Protein Synthesis. Nutrients, 15.","DOI":"10.3390\/nu15184017"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102008","DOI":"10.1016\/j.eclinm.2023.102008","article-title":"Physical activity in young children across developmental and health states: The ActiveCHILD study","volume":"60","author":"Kolehmainen","year":"2023","journal-title":"EClinicalMedicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41514-025-00239-8","article-title":"The role of physical activity in mitigating age-related changes in the neuromuscular control of gait","volume":"11","author":"Dewolf","year":"2025","journal-title":"NPJ Aging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41580-023-00606-x","article-title":"Exercise metabolism and adaptation in skeletal muscle","volume":"24","author":"Smith","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gladyshev, M.I., and Sushchik, N.N. (2019). Long-chain Omega-3 Polyunsaturated Fatty Acids in Natural Ecosystems and the Human Diet: Assumptions and Challenges. Biomolecules, 9.","DOI":"10.3390\/biom9090485"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sethi, P., Mishra, A.K., Ghosh, S., Singh, K.K., Sharma, S., Stojchevski, R., Avtanski, D., and Sinha, J.K. (2025). Lipid Metabolism-Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets. Nutrients, 17.","DOI":"10.3390\/nu17233699"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3233\/NHA-220184","article-title":"Omega-3 long-chain polyunsaturated fatty acids and their bioactive lipids: A strategy to improve resistance to respiratory tract infectious diseases in the elderly?","volume":"9","author":"Korpak","year":"2024","journal-title":"Nutr. Healthy Aging"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tomczyk, M. (2024). Omega-3 Fatty Acids and Muscle Strength-Current State of Knowledge and Future Perspectives. Nutrients, 16.","DOI":"10.3390\/nu16234075"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s40272-014-0084-2","article-title":"Long-term safety of immunomodulators in pediatric inflammatory diseases","volume":"16","author":"Nuti","year":"2014","journal-title":"Paediatr. Drugs"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.18632\/aging.101210","article-title":"Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults","volume":"9","author":"Lalia","year":"2017","journal-title":"Aging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1152\/physiol.00031.2023","article-title":"Emerging Pathophysiological Roles of Ketone Bodies","volume":"39","author":"Tsuruta","year":"2024","journal-title":"Physiology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cheng, S., Cheng, C., Zhou, J., Ji, Y., Liu, Y., Jiang, W., Liu, C., and Wang, H. (2025). Metabolism Meets Epigenetics: \u03b2-Hydroxybutyrate-Driven Lysine \u03b2-Hydroxybutyrylation Bridging Energy Metabolism With Transcription and Protein Functional Remodeling. Nutr. Rev., nuaf258. ahead of print.","DOI":"10.1093\/nutrit\/nuaf258"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-nutr-111120-111518","article-title":"Metabolic and Signaling Roles of Ketone Bodies in Health and Disease","volume":"41","author":"Puchalska","year":"2021","journal-title":"Annu. Rev. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/MED.0000000000000659","article-title":"Effect of low carbohydrate diets on insulin resistance and the metabolic syndrome","volume":"28","author":"Foley","year":"2021","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s41043-025-01090-z","article-title":"Effects of ketogenic diet on muscle mass, strength, aerobic metabolic capacity, and endurance in adults: A systematic review and meta-analysis","volume":"44","author":"Wang","year":"2025","journal-title":"J. Health Popul. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Carbone, J.W., and Pasiakos, S.M. (2019). Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit. Nutrients, 11.","DOI":"10.3390\/nu11051136"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Vargas-Molina, S., Murri, M., Gonzalez-Jimenez, A., G\u00f3mez-Urquiza, J.L., and Ben\u00edtez-Porres, J. (2024). Effects of the Ketogenic Diet on Strength Performance in Trained Men and Women: A Systematic Review and Meta-Analysis. Nutrients, 16.","DOI":"10.3390\/nu16142200"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106780","DOI":"10.1016\/j.phrs.2023.106780","article-title":"Ketogenic diet in children and adolescents: The effects on growth and nutritional status","volume":"191","author":"Corsello","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ferraris, C., Guglielmetti, M., Pasca, L., De Giorgis, V., Ferraro, O.E., Brambilla, I., Leone, A., De Amicis, R., Bertoli, S., and Veggiotti, P. (2019). Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases. Nutrients, 11.","DOI":"10.3390\/nu11071442"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejpn.2026.03.007","article-title":"Efficacy, safety, and growth outcomes of ketogenic diet therapy in children under two years of age","volume":"61","author":"Yavuz","year":"2026","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cbf.3595","article-title":"Myogenic, genomic and non-genomic influences of the vitamin D axis in skeletal muscle","volume":"39","author":"Bollen","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e230013","DOI":"10.1530\/REM-23-0013","article-title":"Antioxidative effects of vitamin D in muscle dysfunction","volume":"2023","author":"Russo","year":"2023","journal-title":"Redox Exp. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"109271","DOI":"10.1016\/j.steroids.2023.109271","article-title":"Genomic signaling of vitamin, D","volume":"198","author":"Carlberg","year":"2023","journal-title":"Steroids"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Russo, C., Valle, M.S., D\u2019Angeli, F., Surdo, S., and Malaguarnera, L. (2024). Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147503"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101059","DOI":"10.1016\/j.molmet.2020.101059","article-title":"Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy","volume":"42","author":"Bass","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Pratic\u00f2, A.D., Lo Bianco, M., Leonardi, R., Polizzi, A., and Ruggieri, M. (2024). The Impact of Vitamin D Supplementation Duration on Early Childhood Developmental Milestones: A Retrospective Study. Nutrients, 16.","DOI":"10.3390\/nu16244395"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/children1020208","article-title":"Vitamin D in Children\u2019s Health","volume":"1","author":"Weydert","year":"2014","journal-title":"Children"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2024). Physiology of Vitamin D-Focusing on Disease Prevention. Nutrients, 16.","DOI":"10.3390\/nu16111666"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e210596","DOI":"10.1530\/EC-21-0596","article-title":"Vitamin D and musculoskeletal health: Outstanding aspects to be considered in the light of current evidence","volume":"11","author":"Mendes","year":"2022","journal-title":"Endocr. Connect."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"D\u2019Amelio, P., and Quacquarelli, L. (2020). Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health?. Nutrients, 12.","DOI":"10.3390\/nu12030628"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Fuentes-Barr\u00eda, H., Aguilera-Egu\u00eda, R., Angarita-Davila, L., Rojas-G\u00f3mez, D., Alarc\u00f3n-Rivera, M., L\u00f3pez-Soto, O., Maureira-S\u00e1nchez, J., Berm\u00fadez, V., Rivera-Porras, D., and Contreras-Vel\u00e1zquez, J.C. (2025). Vitamin D and Sarcopenia: Implications for Muscle Health. Biomedicines, 13.","DOI":"10.3390\/biomedicines13081863"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"491S","DOI":"10.1093\/ajcn\/88.2.491S","article-title":"From vitamin D to hormone D: Fundamentals of the vitamin D endocrine system essential for good health","volume":"88","author":"Norman","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"102374","DOI":"10.1016\/j.redox.2022.102374","article-title":"Redox signaling regulates skeletal muscle remodeling in response to exercise and prolonged inactivity","volume":"54","author":"Powers","year":"2022","journal-title":"Redox Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e70101","DOI":"10.1002\/fsn3.70101","article-title":"Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications-A Comprehensive Review","volume":"13","author":"Hossain","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Saha, S., Buttari, B., Panieri, E., Profumo, E., and Saso, L. (2020). An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules, 25.","DOI":"10.3390\/molecules25225474"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41420-025-02491-z","article-title":"Targeting epigenetic and post-translational modifications of NRF2: Key regulatory factors in disease treatment","volume":"11","author":"Yang","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nutres.2019.11.004","article-title":"Polyphenols and their potential role in preventing skeletal muscle atrophy","volume":"74","author":"Salucci","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s44187-025-00637-7","article-title":"A review on exploring the health benefits and antioxidant properties of bioactive polyphenols","volume":"5","author":"Jain","year":"2025","journal-title":"Discov. Food"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jshs.2024.05.001","article-title":"Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles","volume":"13","author":"Powers","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s11332-024-01205-9","article-title":"Effects of antioxidant vitamin supplementation on sports performance, endurance and strength performance: A systematic review and meta-analysis","volume":"20","author":"Dadalt","year":"2024","journal-title":"Sport Sci. Health"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Micangeli, G., Menghi, M., Profeta, G., Tarani, F., Mariani, A., Petrella, C., Barbato, C., Ferraguti, G., Ceccanti, M., and Tarani, L. (2022). The Impact of Oxidative Stress on Pediatrics Syndromes. Antioxidants, 11.","DOI":"10.3390\/antiox11101983"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"23605","DOI":"10.1038\/s41598-025-05818-z","article-title":"Oxidative stress markers and inflammation in type 1 and 2 diabetes are affected by, B.M.I.; treatment type, and complications","volume":"15","author":"Engwert","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s13679-022-00490-0","article-title":"The Role of Nutrition on Meta-inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management","volume":"11","author":"Martinez","year":"2022","journal-title":"Curr. Obes. Rep."},{"key":"ref_74","first-page":"1","article-title":"The Aging Muscle: Sarcopenia, Mitochondrial Function, and Redox Biology","volume":"72","author":"Bellanti","year":"2024","journal-title":"J. Gerontol. Geriatr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: From mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"M\u0105dra-Gackowska, K., Szewczyk-Golec, K., Gackowski, M., Wo\u017aniak, A., and K\u0119dziora-Kornatowska, K. (2023). Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status. Antioxidants, 12.","DOI":"10.3390\/antiox12030569"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101163","DOI":"10.1016\/j.crfs.2025.101163","article-title":"Regulation of aging-related chronic diseases by dietary polyphenols: An updated overview","volume":"11","author":"Liu","year":"2025","journal-title":"Curr. Res. Food Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Jin, J.B., Robinson, A., Soukup, T., Black, E., Abit, A., Hammer, S.M., Han, A., Lucas, E., Kim, Y., and Bae, J. (2025). Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration. Front. Cell. Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1651553"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.freeradbiomed.2022.02.022","article-title":"Mineral requirements for mitochondrial function: A connection to redox balance and cellular differentiation","volume":"182","author":"Killilea","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0140-6736(21)01590-7","article-title":"Nutrition in adolescent growth and development","volume":"399","author":"Norris","year":"2022","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/17474086.2016.1268047","article-title":"Mitochondria and Iron: Current questions","volume":"10","author":"Paul","year":"2017","journal-title":"Expert Rev. Hematol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Fiorentini, D., Cappadone, C., Farruggia, G., and Prata, C. (2021). Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients, 13.","DOI":"10.3390\/nu13041136"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Costa, M.I., Sarmento-Ribeiro, A.B., and Gon\u00e7alves, A.C. (2023). Zinc: From Biological Functions to Therapeutic Potential. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054822"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Lee, J.G., Jang, J.Y., and Baik, S.M. (2025). Selenium as an Antioxidant: Roles and Clinical Applications in Critically Ill and Trauma Patients: A Narrative Review. Antioxidants, 14.","DOI":"10.3390\/antiox14030294"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(22)00367-9","article-title":"Micronutrient deficiencies among preschool-aged children and women of reproductive age worldwide: A pooled analysis of individual-level data from population-representative surveys","volume":"10","author":"Stevens","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_86","first-page":"266","article-title":"Micronutrient deficiency and supplements in schoolchildren and teenagers","volume":"27","author":"Berger","year":"2024","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/MOG.0000000000001000","article-title":"Micronutrient status and protein-energy malnutrition in free-living older adults: A current perspective","volume":"40","author":"Ziegler","year":"2024","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Valvano, M., Faenza, S., Cortellini, F., Vinci, A., Ingravalle, F., Calabr\u00f2, M., Scurti, L., Di Nezza, M., Valerio, S., and Viscido, A. (2025). The Relationship Between Nutritional Status, Micronutrient Deficiency, and Disease Activity in IBD Patients: A Multicenter Cross-Sectional Study. Nutrients, 17.","DOI":"10.3390\/nu17162690"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"skac035","DOI":"10.1093\/jas\/skac035","article-title":"Molecular and biochemical regulation of skeletal muscle metabolism","volume":"100","author":"Zumbaugh","year":"2022","journal-title":"J. Anim. Sci."},{"key":"ref_90","first-page":"3","article-title":"Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing","volume":"38","author":"Maggini","year":"2021","journal-title":"Nutr. Hosp."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Gustafsson, T., and Ulfhake, B. (2024). Aging Skeletal Muscles: What Are the Mechanisms of Age-Related Loss of Strength and Muscle Mass, and Can We Impede Its Development and Progression?. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202409.1049.v1"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41392-024-01749-9","article-title":"Protein translation: Biological processes and therapeutic strategies for human diseases","volume":"9","author":"Jia","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Abdullahi, L.H., Rithaa, G.K., Muthomi, B., Kyallo, F., Ngina, C., Hassan, M.A., and Farah, M.A. (2021). Best practices and opportunities for integrating nutrition specific into nutrition sensitive interventions in fragile contexts: A systematic review. BMC Nutr., 7.","DOI":"10.1186\/s40795-021-00443-1"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Castillo, \u00cd.M., Rueda, R., Pereira, S.L., Bouzamondo, H., L\u00f3pez-Chicharro, J., Segura-Ortiz, F., and Atherton, P.J. (2025). Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers. 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