{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:06:18Z","timestamp":1792242378723,"version":"4.4.0"},"reference-count":239,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has emerged as a promising dietary pattern associated with reduced Alzheimer\u2019s disease (AD) risk, supported by growing evidence that both diet and the gut microbiota are modifiable contributors to disease development and progression. Observational studies have linked higher MIND diet adherence to lower AD incidence and slower cognitive decline, with certain comparative analyses reporting stronger associations with cognitive outcomes than those observed for the parent Mediterranean or DASH diets. Developed specifically to support cognitive health, the MIND diet emphasizes leafy green vegetables, berries, and olive oil while restricting butter, cheese, fried foods, sweets, and red meat. While these features suggest a biologically plausible basis for neuroprotection, the underlying mechanisms remain incompletely defined. The microbiota\u2013gut\u2013brain axis offers a potential mechanistic framework, as diet is a major determinant of gut microbiota composition and microbiota-derived metabolites that may influence brain function and AD-related pathways. However, direct evidence characterizing MIND diet-specific effects on the gut microbiota remains limited, with most mechanistic insights derived from related dietary patterns or individual dietary components. Accordingly, this review synthesizes evidence from these related dietary patterns and key MIND components to propose a conceptual framework linking the MIND diet, the gut microbiota, and AD risk, while highlighting priorities for future research.<\/jats:p>","DOI":"10.3390\/nu18091445","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:35:53Z","timestamp":1777559753000},"page":"1445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Gut Microbiota as a Mediator Linking the MIND Diet to Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-8952","authenticated-orcid":false,"given":"Fatemeh","family":"Ramezani","sequence":"first","affiliation":[{"name":"Department of Food Service and Clinical Nutrition, Cedars-Sinai Medical Center, Los Angeles, CA 95136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina S.","family":"Herfeh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Azad University, Rasht 4147654919, Guilan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Food Service and Clinical Nutrition, Cedars-Sinai Medical Center, Los Angeles, CA 95136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","unstructured":"GBD 2016 Dementia Collaborators (2019). 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