{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:28Z","timestamp":1787029288894,"version":"build-2736575974"},"reference-count":125,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Traditional food systems have historically sustained nutrient adequacy under conditions of environmental variability and limited food diversity, yet their underlying nutritional mechanisms remain insufficiently integrated into contemporary nutrition science. This article attempts to provide a conceptual synthesis of how traditional dietary practices may function as informal nutrient optimization strategies. Drawing on evidence from nutrition science, food chemistry, and human physiology, it examines how food processing techniques (e.g., fermentation, soaking, germination, and thermal treatment), food pairing, and structural properties of foods influence nutrient bioavailability, absorption, and metabolic responses. Across diverse dietary contexts\u2014including Mediterranean, agrarian cereal\u2013legume, and East Asian-type patterns\u2014recurring mechanisms emerge that can boost mineral solubility, improve protein digestibility and amino acid balance, facilitate vitamin absorption, and modulate glycemic responses. These effects are mediated not only by nutrient content but by interactions within the food structure and at the meal level. The synthesis supports a reframing of traditional diets as functional nutritional architectures in which processing and dietary configuration may enhance nutrient utilization efficiency. From this perspective, nutrient adequacy arises from coordinated structural features rather than from maximal nutrient density alone. The findings can be influential in contemporary nutrition research and policy, highlighting the need to move beyond reductionist intake-based models toward integrated approaches that account for bioavailability, metabolic handling, and dietary context. Several transferable principles of nutrient optimization are proposed, offering a framework for designing nutritionally efficient and resilient diets in modern settings.<\/jats:p>","DOI":"10.3390\/nu18091448","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:35:53Z","timestamp":1777559753000},"page":"1448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Traditional Food Systems as Nutrient Optimization Architectures: Mechanisms of Bioavailability and Dietary Resilience"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-6987","authenticated-orcid":false,"given":"Corina-Aurelia","family":"Zugravu","sequence":"first","affiliation":[{"name":"Department of Hygiene and Nutrition, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050463 Bucharest, Romania"},{"name":"National Institute of Public Health, Dr. Leonte Street 1-3, 050463 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Petre","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, Dr. Leonte Street 1-3, 050463 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-5048","authenticated-orcid":false,"given":"Ciprian","family":"Constantin","sequence":"additional","affiliation":[{"name":"Research Metabolism Center, Faculty of Medicine, Titu Maiorescu University, 1, 76 Al I Cuza Blvd, 011053 Bucharest, Romania"},{"name":"\u201cCarol Davila\u201d Emergency Hospital, 1, 88 M. Vulcanescu Street, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(24)00276-6","article-title":"Global Estimation of Dietary Micronutrient Inadequacies: A Modelling Analysis","volume":"12","author":"Passarelli","year":"2024","journal-title":"Lancet Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(22)00367-9","article-title":"Micronutrient Deficiencies among Preschool-Aged Children and Women of Reproductive Age Worldwide: A Pooled Analysis of Individual-Level Data from Population-Representative Surveys","volume":"10","author":"Stevens","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"k2392","DOI":"10.1136\/bmj.k2392","article-title":"History of Modern Nutrition Science\u2014Implications for Current Research, Dietary Guidelines, and Food Policy","volume":"361","author":"Mozaffarian","year":"2018","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/03670244.2015.1017758","article-title":"Traditional Knowledge and Nutritive Value of Indigenous Foods in the Oraon Tribal Community of Jharkhand: An Exploratory Cross-Sectional Study","volume":"54","author":"Singh","year":"2015","journal-title":"Ecol. Food Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kuhnlein, H.V., and Chotiboriboon, S. (2022). Why and How to Strengthen Indigenous Peoples\u2019 Food Systems With Examples From Two Unique Indigenous Communities. Front. Sustain. 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Available online: https:\/\/ebooks.inflibnet.ac.in\/ftp1\/chapter\/historical-developments-in-food-processing\/?utm_source=copilot.com."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"G\u00e4nzle, M.G., Seifert, J., Weiss, J., and Zijlstra, R.T. (2025). Food Fermentation: An Essential Unit Operation towards Secure, Sustainable, Safe, and Sustaining Food Systems. Front. Sci., 3.","DOI":"10.3389\/fsci.2025.1693920"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Samtiya, M., Aluko, R.E., Puniya, A.K., and Dhewa, T. (2021). Enhancing Micronutrients Bioavailability through Fermentation of Plant-Based Foods: A Concise Review. Fermentation, 7.","DOI":"10.3390\/fermentation7020063"},{"key":"ref_12","first-page":"435","article-title":"The Impact of Food Processing Techniques on Nutrient Retention and Bioavailability","volume":"8","author":"Moyo","year":"2024","journal-title":"Iconic Res. Eng. J."},{"key":"ref_13","unstructured":"Katz, S.H., and Weaver, W.W. (2002). Encyclopedia of Food and Culture, Gale Group. Scribner library of daily life."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wuni, A., Alemawor, F., Mills-Robertson, F.C., Boateng, E.F., and Owusu-Kwarteng, J. (2025). Impact of Traditional Food Processing Techniques on Mineral Bioaccessibility in Ghanaian Fermented Millet-Based Koko and Zoomkoom. Foods, 14.","DOI":"10.3390\/foods14122126"},{"key":"ref_15","first-page":"30","article-title":"Traditional Food Processing Techniques and Micronutrients Bioavailability of Plant and Plant-Based Foods: A Review","volume":"20","author":"Akeem","year":"2019","journal-title":"Ann. Food Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Springfield-Trice, S., Joyce, C., Wu, Y.-H., Hsing, A.W., Cunanan, K., and Gardner, C. (2024). Diet Quality and Resilience through Adulthood: A Cross-Sectional Analysis of the WELL for Life Study. Nutrients, 16.","DOI":"10.3390\/nu16111724"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gustafson, D., Gutman, A., Leet, W., Drewnowski, A., Fanzo, J., and Ingram, J. (2016). Seven Food System Metrics of Sustainable Nutrition Security. Sustainability, 8.","DOI":"10.3390\/su8030196"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Fekete, M., Lehoczki, A., Kryczyk-Poprawa, A., Z\u00e1b\u00f3, V., Varga, J.T., B\u00e1lint, M., Fazekas-Pongor, V., Cs\u00edp\u0151, T., Rz\u0105sa-Duran, E., and Varga, P. (2025). Functional Foods in Modern Nutrition Science: Mechanisms, Evidence, and Public Health Implications. Nutrients, 17.","DOI":"10.3390\/nu17132153"},{"key":"ref_19","unstructured":"Fardet, A. (2025, September 08). Cereal Products and Global Health: Are Minimally-Processed Food Matrices the Key? 2021. Available online: https:\/\/www.researchgate.net\/publication\/355587429_Cereal_products_and_global_health_Are_minimally-processed_food_matrices_the_key."},{"key":"ref_20","first-page":"1","article-title":"Traditional Food Systems: Preserving Culture, Health, and Sustainability","volume":"15","author":"Emmanuel","year":"2024","journal-title":"Afr. J. Food Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ghosh, S., Meyer-Rochow, V.B., and Jung, C. (2023). Embracing Tradition: The Vital Role of Traditional Foods in Achieving Nutrition Security. Foods, 12.","DOI":"10.3390\/foods12234220"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"109392","DOI":"10.1016\/j.foodcont.2022.109392","article-title":"Revelation of the Sciences of Traditional Foods","volume":"145","author":"Jia","year":"2023","journal-title":"Food Control"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.22573\/spg.ijals.024.s122000121","article-title":"A Comprehensive Review of Traditional Food Processing Methods and Their Effects on Food Security","volume":"10","author":"David","year":"2024","journal-title":"Int. J. Agric. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/jn\/137.4.1097","article-title":"Traditional Food-Processing and Preparation Practices to Enhance the Bioavailability of Micronutrients in Plant-Based Diets","volume":"137","author":"Hotz","year":"2007","journal-title":"J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1111\/j.1750-3841.2007.00274.x","article-title":"Food Microstructure Affects the Bioavailability of Several Nutrients","volume":"72","author":"Parada","year":"2007","journal-title":"J. Food Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2125.2012.04425.x","article-title":"Bioavailability of Bioactive Food Compounds: A Challenging Journey to Bioefficacy","volume":"75","author":"Rein","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1177\/15648265100312S206","article-title":"A Review of Phytate, Iron, Zinc, and Calcium Concentrations in Plant-Based Complementary Foods Used in Low-Income Countries and Implications for Bioavailability","volume":"31","author":"Gibson","year":"2010","journal-title":"Food Nutr. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0029665118002732","article-title":"Nutrient\u2013Nutrient Interactions: Competition, Bioavailability, Mechanism and Function in Health and Diseases","volume":"78","author":"Combet","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_29","unstructured":"Kuhnlein, H.V., Erasmus, B., Spigelski, D. (2009). Indigenous Peoples\u2019 Food Systems: The Many Dimensions of Culture, Diversity and Environment for Nutrition and Health, Food and Agriculture Organization of the United Nations. Reprinted."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fabbri, L.P., Cavallero, A., Vidotto, F., and Gabriele, M. (2024). Bioactive Peptides from Fermented Foods: Production Approaches, Sources, and Potential Health Benefits. Foods, 13.","DOI":"10.3390\/foods13213369"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Department of Pharmaceutical Sciences, Gurugram University, Gurugram, Samaspur, Haryana 122003-India (2025). Bioactive Peptides from Fermented Foods as Natural Antimicrobials and Antioxidants. Acta Pharma Rep., 4, 20\u201325.","DOI":"10.51470\/APR.2025.04.01.20"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00203-025-04435-8","article-title":"Microbial Transformation: The Role of Fermentation in Advancing Nutritional Quality and Human Health","volume":"207","author":"Iqbal","year":"2025","journal-title":"Arch. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sawant, S.S., Park, H.-Y., Sim, E.-Y., Kim, H.-S., and Choi, H.-S. (2025). Microbial Fermentation in Food: Impact on Functional Properties and Nutritional Enhancement\u2014A Review of Recent Developments. Fermentation, 11.","DOI":"10.3390\/fermentation11010015"},{"key":"ref_34","unstructured":"Pollan, M. (2008). In Defense of Food: An Eater\u2019s Manifesto, Penguin Press."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1017\/S0029665112003011","article-title":"Food Synergy: The Key to a Healthy Diet","volume":"72","author":"Jacobs","year":"2013","journal-title":"Proc. Nutr. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Melini, F., Melini, V., Luziatelli, F., Ficca, A.G., and Ruzzi, M. (2019). Health-Promoting Components in Fermented Foods: An Up-to-Date Systematic Review. Nutrients, 11.","DOI":"10.3390\/nu11051189"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cuamatzin-Garc\u00eda, L., Rodr\u00edguez-Rugarc\u00eda, P., El-Kassis, E.G., Galicia, G., Meza-Jim\u00e9nez, M.d.L., Ba\u00f1os-Lara, M.d.R., Zaragoza-Maldonado, D.S., and P\u00e9rez-Armend\u00e1riz, B. (2022). Traditional Fermented Foods and Beverages from around the World and Their Health Benefits. Microorganisms, 10.","DOI":"10.3390\/microorganisms10061151"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.fm.2009.07.011","article-title":"Sourdough and Cereal Fermentation in a Nutritional Perspective","volume":"26","author":"Poutanen","year":"2009","journal-title":"Food Microbiol."},{"key":"ref_39","first-page":"553","article-title":"Food Fermentation: A Safety and Nutritional Assessment. Joint FAO\/WHO Workshop on Assessment of Fermentation as a Household Technology for Improving Food Safety","volume":"74","author":"Motarjemi","year":"1996","journal-title":"Bull. World Health Organ."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0963-9969(94)90096-5","article-title":"Reduction in Antinutritional and Toxic Components in Plant Foods by Fermentationa","volume":"27","author":"Reddy","year":"1994","journal-title":"Food Res. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s43016-025-01195-y","article-title":"Unrefined Plant Raw Materials Are Key to Nutritious Food","volume":"6","author":"Germerdonk","year":"2025","journal-title":"Nat. Food"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1365-2672.2011.05157.x","article-title":"B-Group Vitamin Production by Lactic Acid Bacteria\u2013Current Knowledge and Potential Applications","volume":"111","author":"LeBlanc","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s13197-013-0978-y","article-title":"Reduction of Phytic Acid and Enhancement of Bioavailable Micronutrients in Food Grains","volume":"52","author":"Gupta","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.crfs.2021.11.019","article-title":"Effect of Soaking and Germination Treatments on Nutritional, Anti-Nutritional, and Bioactive Properties of Amaranth (Amaranthus hypochondriacus L.), Quinoa (Chenopodium quinoa L.), and Buckwheat (Fagopyrum esculentum L.)","volume":"4","author":"Thakur","year":"2021","journal-title":"Curr. Res. Food Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tifs.2020.05.003","article-title":"Germination as a Bioprocess for Enhancing the Quality and Nutritional Prospects of Legume Proteins","volume":"101","author":"Ohanenye","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, X., Fan, B., Li, Y., Fei, C., Xiong, Y., Li, L., Liu, Y., Tong, L., Huang, Y., and Wang, F. (2024). Effect of Germination on the Digestion of Legume Proteins. Foods, 13.","DOI":"10.3390\/foods13172655"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.foodchem.2004.06.019","article-title":"Thermal Heat Processing Effects on Antinutrients, Protein and Starch Digestibility of Food Legumes","volume":"91","author":"Rehman","year":"2005","journal-title":"Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2200195","DOI":"10.1002\/star.202200195","article-title":"Impact of Starch Gelatinization on Digestibility and Human Health","volume":"75","author":"Qi","year":"2023","journal-title":"Starch\u2013St\u00e4rke"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Holland, C., Ryden, P., Edwards, C.H., and Grundy, M.M.-L. (2020). Plant Cell Walls: Impact on Nutrient Bioaccessibility and Digestibility. Foods, 9.","DOI":"10.3390\/foods9020201"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1024\/0300-9831\/a000717","article-title":"Partial Disintegration of Vegetable Cell Wall during Cooking Improves Vitamin K1 (Phylloquinone) Bioaccessibility in in Vitro Digestion","volume":"91","author":"Sriwichai","year":"2021","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, P., Peng, H., Chen, Q., Jiao, X., Jia, J., Pan, Z., Cheng, J., and Wang, L. (2023). Effects of Cooking Processes on Protein Nutritional Values and Volatile Flavor Substances of Silver Carp (Hypophthalmichthys molitrix). Foods, 12.","DOI":"10.3390\/foods12173169"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s43014-020-0020-5","article-title":"Plant Food Anti-Nutritional Factors and Their Reduction Strategies: An Overview","volume":"2","author":"Samtiya","year":"2020","journal-title":"Food Prod. Process. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Okaiyeto, S.A., Liu, D., Zhang, C., Bai, J.-W., Chen, C., Sharma, P., Venugopal, A.P., Asiamah, E., Ketemepi, H.K., and Imadegbor, F.A. (2025). Anti-Nutrients of Plant-Based Food: Physicochemical Properties, Effects on Health and Degradation Techniques\u2014A Comprehensive Review. J. Future Foods, in press.","DOI":"10.1016\/j.jfutfo.2025.06.022"},{"key":"ref_54","first-page":"7454376","article-title":"The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review","volume":"2017","author":"Pilz","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104059","DOI":"10.1016\/j.jff.2020.104059","article-title":"New Perspectives in Fermented Dairy Products and Their Health Relevance","volume":"72","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.tjnut.2024.07.011","article-title":"The Effect of Adding Protein to a Carbohydrate Meal on Postprandial Glucose and Insulin Responses: A Systematic Review and Meta-Analysis of Acute Controlled Feeding Trials","volume":"154","author":"Wolever","year":"2024","journal-title":"J. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cevallos-Fern\u00e1ndez, E., Beltr\u00e1n-Sinchiguano, E., J\u00e1come, B., Quintana, T., and Rivera, N. (2026). Fermented Plant-Based Foods and Postbiotics for Glycemic Control\u2014Microbial Biotransformation of Phytochemicals. Molecules, 31.","DOI":"10.3390\/molecules31020360"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tjnut.2024.07.033","article-title":"Protein Adequacy, Plant Protein Proportion, and Main Plant Protein Sources Consumed Across Vegan, Vegetarian, Pescovegetarian, and Semivegetarian Diets: A Systematic Review","volume":"155","author":"Rolands","year":"2025","journal-title":"J. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jsfa.13001","article-title":"Nutritional and Potential Health Benefits of Fermented Food Proteins","volume":"104","author":"Tachie","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/nutrit\/nuab097","article-title":"Dairy Bioactive Proteins and Peptides: A Narrative Review","volume":"79","author":"Auestad","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1080\/10408398.2025.2560680","article-title":"Structural Modifications of Plant Proteins through Fermentation: Unlocking Their Functional and Sensory Potential in Food Applications","volume":"66","author":"Cirunay","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10068-023-01401-2","article-title":"Germination and Probiotic Fermentation: A Way to Enhance Nutritional and Biochemical Properties of Cereals and Millets","volume":"33","author":"Kumari","year":"2024","journal-title":"Food Sci. Biotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1093\/cvr\/cvaf218","article-title":"The Mediterranean Diet and Cardiovascular Disease","volume":"121","year":"2025","journal-title":"Cardiovasc. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Scaglione, S., Di Chiara, T., Daidone, M., and Tuttolomondo, A. (2025). Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk. Nutrients, 17.","DOI":"10.3390\/nu17020358"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ahmad, S., Moorthy, M.V., Lee, I.-M., Ridker, P.M., Manson, J.E., Buring, J.E., Demler, O.V., and Mora, S. (2024). Mediterranean Diet Adherence and Risk of All-Cause Mortality in Women. JAMA Netw. Open, 7.","DOI":"10.1001\/jamanetworkopen.2024.14322"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Tokarczyk, J., and Koch, W. (2025). Dietary Zn\u2014Recent Advances in Studies on Its Bioaccessibility and Bioavailability. Molecules, 30.","DOI":"10.3390\/molecules30132742"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/fft2.244","article-title":"Food-Borne Polyphenols: A Biocompatible Anchor Recuperating Iron Homeostasis","volume":"4","author":"Li","year":"2023","journal-title":"Food Front."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Adebo, J.A., Njobeh, P.B., Gbashi, S., Oyedeji, A.B., Ogundele, O.M., Oyeyinka, S.A., and Adebo, O.A. (2022). Fermentation of Cereals and Legumes: Impact on Nutritional Constituents and Nutrient Bioavailability. Fermentation, 8.","DOI":"10.3390\/fermentation8020063"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Alkay, Z., Falah, F., Cankurt, H., and Dertli, E. (2024). Exploring the Nutritional Impact of Sourdough Fermentation: Its Mechanisms and Functional Potential. Foods, 13.","DOI":"10.3390\/foods13111732"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"114635","DOI":"10.1016\/j.foodres.2024.114635","article-title":"Effect of Fermentation on Nutrient Composition, Antinutrients, and Mineral Bioaccessibility of Finger Millet Based Injera: A Traditional Ethiopian Food","volume":"190","author":"Endalew","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.gaost.2024.03.001","article-title":"Impact of Sourdough Fermentation on Nutrient Transformations in Cereal-Based Foods: Mechanisms, Practical Applications, and Health Implications","volume":"7","author":"Wang","year":"2024","journal-title":"Grain Oil Sci. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Harahap, I.A., Suliburska, J., Karaca, A.C., Capanoglu, E., and Esatbeyoglu, T. (2025). Fermented Soy Products: A Review of Bioactives for Health from Fermentation to Functionality. Compr. Rev. Food Sci. Food Saf., 24.","DOI":"10.1111\/1541-4337.70080"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Sayyed, R.Z., and Khan, M. (2022). Production and Biofunctionality of Milk-Derived Bioactive Peptides. Microbiome-Gut-Brain Axis: Implications on Health, Springer Nature.","DOI":"10.1007\/978-981-16-1626-6"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Meleti, E., Koureas, M., Manouras, A., Giannouli, P., and Malissiova, E. (2025). Bioactive Peptides from Dairy Products: A Systematic Review of Advances, Mechanisms, Benefits, and Functional Potential. Dairy, 6.","DOI":"10.3390\/dairy6060065"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.copbio.2016.11.010","article-title":"Health Benefits of Fermented Foods: Microbiota and Beyond","volume":"44","author":"Marco","year":"2017","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Monteiro, S.S., Schnorr, C.E., and Pasquali, M.A.d.B. (2023). Paraprobiotics and Postbiotics\u2014Current State of Scientific Research and Future Trends toward the Development of Functional Foods. Foods, 12.","DOI":"10.3390\/foods12122394"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Rizvi, Q.U.E.H., Guin\u00e9, R.P.F., Ahmed, N., Sheikh, M.A., Sharma, P., Sheikh, I., Yadav, A.N., and Kumar, K. (2024). Effects of Soaking and Germination Treatments on the Nutritional, Anti-Nutritional, and Bioactive Characteristics of Adzuki Beans (Vigna angularis L.) and Lima Beans (Phaseolus lunatus L.). Foods, 13.","DOI":"10.3390\/foods13091422"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Ravoninjatovo, M., Ralison, C., Servent, A., Morel, G., Achir, N., Andriamazaoro, H., and Dornier, M. (2022). Effects of Soaking and Thermal Treatment on Nutritional Quality of Three Varieties of Common Beans (Phaseolus vulgaris L.) from Madagascar. Legume Sci., 4.","DOI":"10.1002\/leg3.143"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"106","DOI":"10.11648\/j.wjfst.20210504.17","article-title":"Effect of Heating on, Lactobacillus Fermentation and Enzyme Treatment on the Content of Phytic Acid in Kernels of Adansonia digitata and Sclerocarya birrea","volume":"5","author":"Magaia","year":"2021","journal-title":"World J. Food Sci. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"ElGamal, R., Song, C., Rayan, A.M., Liu, C., Al-Rejaie, S., and ElMasry, G. (2023). Thermal Degradation of Bioactive Compounds during Drying Process of Horticultural and Agronomic Products: A Comprehensive Overview. Agronomy, 13.","DOI":"10.3390\/agronomy13061580"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Mehta, B.M. (2015). Nutritional and Toxicological Aspects of the Chemical Changes of Food Components and Nutrients During Heating and Cooking. Handbook of Food Chemistry, Springer.","DOI":"10.1007\/978-3-642-36605-5_1"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-food-032519-051646","article-title":"Food Matrix and Macronutrient Digestion","volume":"12","author":"Capuano","year":"2021","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00394-015-0857-6","article-title":"Increased Iron Bioavailability from Lactic-Fermented Vegetables Is Likely an Effect of Promoting the Formation of Ferric Iron (Fe3+)","volume":"55","author":"Scheers","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.foodchem.2017.01.130","article-title":"Assessment of Iron Bioavailability from Different Bread Making Processes Using an in Vitro Intestinal Cell Model","volume":"228","author":"Brearley","year":"2017","journal-title":"Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Nsabimana, S., Ismail, T., and Lazarte, C.E. (2024). Enhancing Iron and Zinc Bioavailability in Maize (Zea mays) through Phytate Reduction: The Impact of Fermentation Alone and in Combination with Soaking and Germination. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1478155"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Varshanath, B., Robin, D.T., Meera, S., Dileep, A., Archana, S., Chandran, N., and Vandana Rani, M. (2026). Enhancement of Iron, Zinc, and Calcium Bioaccessibility and Bioavailability in Green Gram (Vigna radiata L.) Supplemented with Buttermilk through Phytate Reduction: An in Vitro Dietary Evaluation. Front. Nutr., 13.","DOI":"10.3389\/fnut.2026.1756171"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.3945\/jn.116.236307","article-title":"Egg Consumption Increases Vitamin E Absorption from Co-Consumed Raw Mixed Vegetables in Healthy Young Men","volume":"146","author":"Kim","year":"2016","journal-title":"J. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/nutrit\/nuab098","article-title":"Effects of Dietary Fats on the Bioaccessibility and Bioavailability of Carotenoids: A Systematic Review and Meta-Analysis of in Vitro Studies and Randomized Controlled Trials","volume":"80","author":"Yao","year":"2022","journal-title":"Nutr. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41522-024-00524-6","article-title":"Cross-Feeding of Bifidobacteria Promotes Intestinal Homeostasis: A Lifelong Perspective on the Host Health","volume":"10","author":"Xiao","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Meiners, F., Ortega-Matienzo, A., Fuellen, G., and Barrantes, I. (2025). Gut Microbiome-Mediated Health Effects of Fiber and Polyphenol-Rich Dietary Interventions. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1647740"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Park, I., and Mannaa, M. (2025). Fermented Foods as Functional Systems: Microbial Communities and Metabolites Influencing Gut Health and Systemic Outcomes. Foods, 14.","DOI":"10.3390\/foods14132292"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00394-017-1546-4","article-title":"Systematic Review of the Effects of the Intestinal Microbiota on Selected Nutrients and Non-Nutrients","volume":"57","author":"Shortt","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/ajcn\/71.5.1147","article-title":"Prediction of Dietary Iron Absorption: An Algorithm for Calculating Absorption and Bioavailability of Dietary Iron","volume":"71","author":"Hallberg","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1461S","DOI":"10.3945\/ajcn.2010.28674F","article-title":"Iron Bioavailability and Dietary Reference Values","volume":"91","author":"Hurrell","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/09637480903170641","article-title":"The Beneficial Effect of Mediterranean Dietary Patterns on Dietary Iron Utilization in Male Adolescents Aged 11\u201314 Years","volume":"60","author":"Seiquer","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"De Alvarenga, J.F.R., Quifer-Rada, P., Juliano, F.F., Hurtado-Barroso, S., Illan, M., Torrado-Prat, X., and Lamuela-Ravent\u00f3s, R.M. (2019). Using Extra Virgin Olive Oil to Cook Vegetables Enhances Polyphenol and Carotenoid Extractability: A Study Applying the Sofrito Technique. Molecules, 24.","DOI":"10.3390\/molecules24081555"},{"key":"ref_98","first-page":"131","article-title":"Increases in Plasma Lycopene Concentration after Consumption of Tomatoes Cooked with Olive Oil","volume":"14","author":"Fielding","year":"2005","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.foodchem.2014.07.053","article-title":"Influence of Olive Oil on Carotenoid Absorption from Tomato Juice and Effects on Postprandial Lipemia","volume":"168","author":"Arranz","year":"2015","journal-title":"Food Chem."},{"key":"ref_100","first-page":"34","article-title":"Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health","volume":"14","author":"Maresz","year":"2015","journal-title":"Integr. Med. Clin. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1080\/10408398.2020.1810624","article-title":"Dairy Intake and Bone Health across the Lifespan: A Systematic Review and Expert Narrative","volume":"61","author":"Wallace","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40520-024-02721-x","article-title":"Role of Fermented Dairy Products in the Health Benefits of a Mediterranean Diet","volume":"36","author":"Rizzoli","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Oniang\u2019o, R., Maingi, Z., Jaika, S., and Konyole, S. (2025). Africa\u2019s Contribution to Global Sustainable and Healthy Diets: A Scoping Review. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1519248"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Noort, M.W.J., Renzetti, S., Linderhof, V., du Rand, G.E., Marx-Pienaar, N.J.M.M., de Kock, H.L., Magano, N., and Taylor, J.R.N. (2022). Towards Sustainable Shifts to Healthy Diets and Food Security in Sub-Saharan Africa with Climate-Resilient Crops in Bread-Type Products: A Food System Analysis. Foods, 11.","DOI":"10.3390\/foods11020135"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13213-024-01763-w","article-title":"Review on Effect of Fermentation on Physicochemical Properties, Anti-Nutritional Factors and Sensory Properties of Cereal-Based Fermented Foods and Beverages","volume":"74","author":"Kitessa","year":"2024","journal-title":"Ann. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"622","DOI":"10.12944\/CRNFSJ.13.2.6","article-title":"Blue Zone Dietary Patterns, Telomere Length Maintenance, and Longevity: A Critical Review","volume":"13","author":"Mohol","year":"2010","journal-title":"Curr. Res. Nutr. Food Sci. J."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Fatima, G., Dalmadi, I., S\u00fcll\u0151s, G., Tak\u00e1cs, K., and Halmy, E. (2025). Dietary Patterns for Health-Span and Longevity: A Comprehensive Review of Nutritional Strategies Promoting Lifelong Wellness. Appl. Sci., 15.","DOI":"10.3390\/app152212013"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Dominguez, L.J., Veronese, N., Baiamonte, E., Guarrera, M., Parisi, A., Ruffolo, C., Tagliaferri, F., and Barbagallo, M. (2022). Healthy Aging and Dietary Patterns. Nutrients, 14.","DOI":"10.3390\/nu14040889"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"100221","DOI":"10.1016\/j.advnut.2024.100221","article-title":"Perspective: Beyond the Mediterranean Diet\u2014Exploring Latin American, Asian, and African Heritage Diets as Cultural Models of Healthy Eating","volume":"15","author":"LeBlanc","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_110","first-page":"53","article-title":"Dietary Habits and Lifestyle among Long-Lived Residents from the Nicoya peninsula of Costa Rica","volume":"3","author":"Campos","year":"2017","journal-title":"Rev. Hispanoam. Cienc. Salud RHCS"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Nieddu, A., Vindas, L., Errigo, A., Vindas, J., Pes, G.M., and Dore, M.P. (2020). Dietary Habits, Anthropometric Features and Daily Performance in Two Independent Long-Lived Populations from Nicoya peninsula (Costa Rica) and Ogliastra (Sardinia). Nutrients, 12.","DOI":"10.3390\/nu12061621"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"8065","DOI":"10.1021\/acs.jafc.1c01687","article-title":"Sodium Reduction in Traditional Fermented Foods: Challenges, Strategies, and Perspectives","volume":"69","author":"Lin","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Negrete-Romero, B., Valencia-Olivares, C., Ba\u00f1os-Dossetti, G.A., P\u00e9rez-Armend\u00e1riz, B., and Cardoso-Ugarte, G.A. (2021). Nutritional Contributions and Health Associations of Traditional Fermented Foods. Fermentation, 7.","DOI":"10.3390\/fermentation7040289"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Tan, X., Cui, F., Wang, D., Lv, X., Li, X., and Li, J. (2023). Fermented Vegetables: Health Benefits, Defects, and Current Technological Solutions. Foods, 13.","DOI":"10.3390\/foods13010038"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"104703","DOI":"10.1016\/j.tifs.2024.104703","article-title":"Benefits and Challenges of Food Processing in the Context of Food Systems, Value Chains and Sustainable Development Goals","volume":"153","author":"Michel","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Alharbi, F., Naumovski, N., and McFarlane, R.A. (2025). Traditional Place-Based Diets and Their Effects on Healthy and Sustainable Food Transitions: A Systematic Literature Review. Public Health Nutr., 28.","DOI":"10.1017\/S1368980025101274"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Gladyshev, M.I., and Sushchik, N.N. (2019). Long-Chain Omega-3 Polyunsaturated Fatty Acids in Natural Ecosystems and the Human Diet: Assumptions and Challenges. Biomolecules, 9.","DOI":"10.3390\/biom9090485"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/ajcn\/80.2.396","article-title":"Carotenoid Bioavailability Is Higher from Salads Ingested with Full-Fat than with Fat-Reduced Salad Dressings as Measured with Electrochemical Detection","volume":"80","author":"Brown","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/nutrit\/nux034","article-title":"Intestinal Absorption of Vitamin D: A Systematic Review","volume":"76","author":"Silva","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s13197-016-2466-7","article-title":"Dietary Fat Composition, Food Matrix and Relative Polarity Modulate the Micellarization and Intestinal Uptake of Carotenoids from Vegetables and Fruits","volume":"54","author":"Mashurabad","year":"2017","journal-title":"J. Food Sci. Technol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1271\/bbb.130025","article-title":"Effects of Fats and Oils on the Bioaccessibility of Carotenoids and Vitamin E in Vegetables","volume":"77","author":"Nagao","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.foodchem.2014.12.013","article-title":"Interactions of Polyphenols with Carbohydrates, Lipids and Proteins","volume":"175","author":"Jakobek","year":"2015","journal-title":"Food Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/ijfs.13323","article-title":"Digestion and Bioavailability of Bioactive Phytochemicals","volume":"52","author":"Jakubczyk","year":"2017","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cofs.2017.07.004","article-title":"Food: More than the Sum of Its Parts","volume":"16","author":"Mackie","year":"2017","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Russo, M.D., Formisano, A., Lauria, F., Ahrens, W., Bogl, L.H., Eiben, G., Henauw, S.D., Hebestreit, A., Intemann, T., and Hunsberger, M. (2023). Dietary Diversity and Its Association with Diet Quality and Health Status of European Children, Adolescents, and Adults: Results from the I.Family Study. 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