{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:11:21Z","timestamp":1788372681070,"version":"build-2803163510"},"reference-count":269,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Fund of Hungary","doi-asserted-by":"publisher","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Fund of Hungary","doi-asserted-by":"publisher","award":["RRF-2.3.1-21-2022-00003"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00003"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RRF-2.3.1-21-2022-00003"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00003"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"publisher"}]},{"name":"European University for Well-Being","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019-1"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019-1"]}]},{"name":"Cooperative Translational Research Program (KTKP) of the Faculty of Medicine, Semmelweis University"},{"id":[{"id":"https:\/\/ror.org\/01g9ty582","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Population aging is accompanied by a rapidly increasing burden of neurodegenerative disorders, particularly Alzheimer\u2019s and Parkinson\u2019s diseases. Within the geroscience framework, targeting fundamental mechanisms of aging may delay the onset or progression of multiple age-related conditions. Dietary factors, especially plant-derived polyphenols, have gained increasing attention due to their potential to modulate molecular pathways involved in brain aging. This narrative review aims to integrate current evidence on dietary polyphenols and their role in modulating the molecular mechanisms underlying brain aging and neurodegeneration. Methods: This narrative review synthesizes findings from molecular, experimental, epidemiological, and clinical studies to provide an integrated assessment of the effects of dietary polyphenols on key cellular pathways involved in brain aging. Results: Polyphenols are widely present in plant-based foods, and polyphenol-rich dietary patterns\u2014particularly the Mediterranean and MIND diets\u2014have been consistently associated in observational studies with a reduced risk of cognitive decline. Mechanistic evidence, derived predominantly from in vitro and animal studies with limited validation in humans, suggests that polyphenols may influence key hallmarks of aging, including oxidative stress, chronic inflammation, mitochondrial dysfunction, cellular senescence, and impaired proteostasis. These effects are mediated through pathways such as Nrf2, NF-\u03baB, AMPK, mTOR, and SIRT1, as well as via gut\u2013brain axis interactions. However, clinical evidence remains heterogeneous. Conclusions: Dietary polyphenols represent a biologically plausible and promising, yet not fully validated, nutritional strategy for promoting healthy brain aging. Their translation into clinical practice is limited by low bioavailability, substantial interindividual variability, and the lack of large-scale, long-term randomized controlled trials.<\/jats:p>","DOI":"10.3390\/nu18091470","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:01:30Z","timestamp":1777975290000},"page":"1470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dietary Polyphenols in Brain Aging: Molecular Mechanisms and Implications for Neurodegeneration"],"prefix":"10.3390","volume":"18","author":[{"given":"No\u00e9mi","family":"M\u00f3zes","sequence":"first","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-1336","authenticated-orcid":false,"given":"J\u00e1nos Tam\u00e1s","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-0669","authenticated-orcid":false,"given":"Dominik","family":"Szwajgier","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-250X","authenticated-orcid":false,"given":"Agata","family":"Kryczyk-Poprawa","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry and Pharmaceutical Analytics, Faculty of Pharmacy, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vir\u00e1g","family":"Z\u00e1b\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-7518","authenticated-orcid":false,"given":"Andrea","family":"Lehoczki","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7608-3041","authenticated-orcid":false,"given":"\u00c1gnes","family":"Lip\u00e9cz","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Cs\u00edp\u0151","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-4003","authenticated-orcid":false,"given":"Vince","family":"Fazekas-Pongor","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-9745","authenticated-orcid":false,"given":"D\u00e1vid","family":"Major","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Varga","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-602X","authenticated-orcid":false,"given":"Attila","family":"Matiscs\u00e1k","sequence":"additional","affiliation":[{"name":"S-CAPE Cognitive and Health Prevention Research Group, Faculty of Health Sciences, Semmelweis University, 1088 Budapest, Hungary"},{"name":"Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-2120","authenticated-orcid":false,"given":"M\u00f3nika","family":"Fekete","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"ref_1","first-page":"1726","article-title":"Neuroinflammaging: A tight line between normal aging and age-related neurodegenerative disorders","volume":"15","author":"Soraci","year":"2024","journal-title":"Aging Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.30574\/ijsra.2024.11.1.0067","article-title":"Demographic shifts and healthcare: A review of aging populations and systemic challenges","volume":"11","author":"Muonde","year":"2024","journal-title":"Int. J. Sci. Res. Arch."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Toader, C., Dobrin, N., Brehar, F.-M., Popa, C., Covache-Busuioc, R.-A., Glavan, L.A., Costin, H.P., Bratu, B.-G., Corlatescu, A.D., and Popa, A.A. (2023). From recognition to remedy: The significance of biomarkers in neurodegenerative disease pathology. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216119"},{"key":"ref_4","first-page":"2937","article-title":"The expanding burden of neurodegenerative diseases: An unmet medical and social need","volume":"16","author":"Wang","year":"2024","journal-title":"Aging Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1611623","DOI":"10.3389\/pore.2024.1611623","article-title":"Geroscience and pathology: A new frontier in understanding age-related diseases","volume":"30","author":"Fekete","year":"2024","journal-title":"Pathol. Oncol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11357-024-01364-0","article-title":"Inflammation and aging-related disease: A transdisciplinary inflammaging framework","volume":"47","author":"Andonian","year":"2025","journal-title":"Geroscience"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"156158","DOI":"10.1016\/j.metabol.2025.156158","article-title":"Metabolaging: A new geroscience perspective linking aging pathologies and metabolic dysfunction","volume":"166","author":"Khalaf","year":"2025","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1007\/s11064-010-0307-z","article-title":"Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: Role of hormesis and vitagenes","volume":"35","author":"Calabrese","year":"2010","journal-title":"Neurochem. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Azam, S., Haque, M.E., Balakrishnan, R., Kim, I.-S., and Choi, D.-K. (2021). The ageing brain: Molecular and cellular basis of neurodegeneration. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.683459"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jurcau, M.C., Jurcau, A., Cristian, A., Hogea, V.O., Diaconu, R.G., and Nunkoo, V.S. (2024). Inflammaging and brain aging. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910535"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., and Tarantini, S. (2022). Nutrition strategies promoting healthy aging: From improvement of cardiovascular and brain health to prevention of age-associated diseases. Nutrients, 15.","DOI":"10.3390\/nu15010047"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fekete, M., Lehoczki, A., Kryczyk-Poprawa, A., Z\u00e1b\u00f3, V., Varga, J.T., B\u00e1lint, M., Fazekas-Pongor, V., Cs\u00edp\u0151, T., Rz\u0105sa-Duran, E., and Varga, P. (2025). Functional Foods in Modern Nutrition Science: Mechanisms, Evidence, and Public Health Implications. Nutrients, 17.","DOI":"10.3390\/nu17132153"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Fekete, M., Lehoczki, A., Tarantini, S., Fazekas-Pongor, V., Cs\u00edp\u0151, T., Csizmadia, Z., and Varga, J.T. (2023). Improving cognitive function with nutritional supplements in aging: A comprehensive narrative review of clinical studies investigating the effects of vitamins, minerals, antioxidants, and other dietary supplements. Nutrients, 15.","DOI":"10.3390\/nu15245116"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1007\/s11357-024-01488-3","article-title":"The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer\u2019s disease: A meta-analysis","volume":"47","author":"Fekete","year":"2025","journal-title":"Geroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1007\/s11357-024-01165-5","article-title":"Mitochondrial dysfunction in long COVID: Mechanisms, consequences, and potential therapeutic approaches","volume":"46","author":"Molnar","year":"2024","journal-title":"Geroscience"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Jiang, S., Liu, H., and Li, C. (2021). Dietary regulation of oxidative stress in chronic metabolic diseases. Foods, 10.","DOI":"10.3390\/foods10081854"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1080\/10408398.2020.1805407","article-title":"Food-derived bioactive compounds with anti-aging potential for nutricosmetic and cosmeceutical products","volume":"61","author":"Hernandez","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lehoczki, A., Fekete, M., Jarecsny, T., Z\u00e1b\u00f3, V., Szappanos, \u00c1., Cs\u00edp\u0151, T., Lip\u00e9cz, \u00c1., Major, D., Fazekas-Pongor, V., and Varga, P. (2025). The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation\u2014A Narrative Review. Nutrients, 17.","DOI":"10.3390\/nu17172884"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Fekete, M., Lehoczki, A., Major, D., Fazekas-Pongor, V., Cs\u00edp\u0151, T., Tarantini, S., Csizmadia, Z., and Varga, J.T. (2024). Exploring the influence of gut\u2013brain axis modulation on cognitive health: A comprehensive review of prebiotics, probiotics, and symbiotics. Nutrients, 16.","DOI":"10.3390\/nu16060789"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fekete, M., Lehoczki, A., Szappanos, \u00c1., Z\u00e1b\u00f3, V., Kaposv\u00e1ri, C., Horv\u00e1th, A., Farkas, \u00c1., Fazekas-Pongor, V., Major, D., and Lip\u00e9cz, \u00c1. (2025). Vitamin D and colorectal cancer prevention: Immunological mechanisms, inflammatory pathways, and nutritional implications. Nutrients, 17.","DOI":"10.3390\/nu17081351"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Fekete, M., Jarecsny, T., Lehoczki, A., Major, D., Fazekas-Pongor, V., Cs\u00edp\u0151, T., Lip\u00e9cz, \u00c1., Szappanos, \u00c1., P\u00e1zm\u00e1ndi, E.M., and Varga, P. (2025). Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein. Nutrients, 17.","DOI":"10.3390\/nu17243929"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fazekas-Pongor, V., Major, D., Varga, J.T., Lehoczki, A., Varga, P., Jarecsny, T., Lip\u00e9cz, \u00c1., Cs\u00edp\u0151, T., Szappanos, \u00c1., and Matiscs\u00e1k, A. (2026). Physiological and Recovery Responses to Dietary Polyphenols in the Context of Exercise: Relevance for Muscle Aging and Sarcopenia. Nutrients, 18.","DOI":"10.3390\/nu18050788"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"C\u00e2mara, J.S., Albuquerque, B.R., Aguiar, J., Corr\u00eaa, R.C., Gon\u00e7alves, J.L., Granato, D., Pereira, J.A., Barros, L., and Ferreira, I.C. (2020). Food bioactive compounds and emerging techniques for their extraction: Polyphenols as a case study. Foods, 10.","DOI":"10.3390\/foods10010037"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Issaoui, M., Delgado, A.M., Iommi, C., and Chammem, N. (2020). Dietary intakes of polyphenols in selected vegetables and fruits. Polyphenols and the Mediterranean Diet, Springer.","DOI":"10.1007\/978-3-030-41134-3"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1111\/ijfs.15936","article-title":"Role of phenolic acid, tannins, stilbenes, lignans and flavonoids in human health\u2014A review","volume":"57","author":"Oluwole","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_26","first-page":"1934578X211069721","article-title":"A brief review of phenolic compounds identified from plants: Their extraction, analysis, and biological activity","volume":"17","author":"Zhang","year":"2022","journal-title":"Nat. Prod. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2300472","DOI":"10.1002\/mnfr.202300472","article-title":"Dietary (Poly) phenols and Cognitive Decline: A Systematic Review and Meta-Analysis of Observational Studies","volume":"68","author":"Godos","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Batarseh, N., and Abdulla, F.A. (2026). Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and brain health: A systematic review. Nutr. Neurosci., 1\u201326.","DOI":"10.1080\/1028415X.2025.2610643"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.14283\/jpad.2019.28","article-title":"Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) Diet Slows Cognitive Decline After Stroke","volume":"6","author":"Cherian","year":"2019","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Luo, J., Si, H., Jia, Z., and Liu, D. (2021). Dietary anti-aging polyphenols and potential mechanisms. Antioxidants, 10.","DOI":"10.3390\/antiox10020283"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e1900400","DOI":"10.1002\/cbdv.201900400","article-title":"Recent advances of natural polyphenols activators for Keap1-Nrf2 signaling pathway","volume":"16","author":"Zhou","year":"2019","journal-title":"Chem. Biodivers."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnmol.2015.00024","article-title":"Plant polyphenols as inhibitors of NF-\u03baB induced cytokine production\u2014A potential anti-inflammatory treatment for Alzheimer\u2019s disease?","volume":"8","author":"Karunaweera","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jalouli, M., Harrath, A.H., Al-Zharani, M., and Rahman, M.A. (2026). Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications for Human Aging and Longevity. Nutrients, 18.","DOI":"10.3390\/nu18050863"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/87559129.2021.1888973","article-title":"Ways to enhance the bioavailability of polyphenols in the brain: A journey through the blood-brain barrier","volume":"38","author":"Zhang","year":"2022","journal-title":"Food Rev. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.4103\/1673-5374.241429","article-title":"Polyphenols-gut microbiota interplay and brain neuromodulation","volume":"13","author":"Filosa","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Matsumura, Y., Kitabatake, M., Kayano, S.-I., and Ito, T. (2023). Dietary phenolic compounds: Their health benefits and association with the gut microbiota. Antioxidants, 12.","DOI":"10.3390\/antiox12040880"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Fried, L.P., and Ferrucci, L. (2016). Etiological role of aging in chronic diseases: From epidemiological evidence to the new Geroscience. Advances in Geroscience, Springer.","DOI":"10.1007\/978-3-319-23246-1_2"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bhatiya, M., Duttaroy, A.K., Pathak, S., and Banerjee, A. (2023). Cellular Aging: An Introduction, Principle, Hallmarks, and Aging-Associated Diseases. Evidence-Based Functional Foods for Prevention of Age-Related Diseases, Springer.","DOI":"10.1007\/978-981-99-0534-8_1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1007\/s11357-025-01621-w","article-title":"Cerebromicrovascular senescence in vascular cognitive impairment: Does accelerated microvascular aging accompany atherosclerosis?","volume":"47","author":"Ungvari","year":"2025","journal-title":"Geroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00581.2016","article-title":"Functional vascular contributions to cognitive impairment and dementia: Mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging","volume":"312","author":"Toth","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ungvari, A., K\u00e1llai, A., Stankovics, L., Lendvai-Emmert, D., Gulej, R., Pal, E., Patai, R., Csik, B., Fekete, M., and Lipecz, \u00c1. (2025). Age-Related Alterations of Cerebral Autoregulation. Life, 15.","DOI":"10.3390\/life15111669"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrn1886","article-title":"Ageing and neuronal vulnerability","volume":"7","author":"Mattson","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11357-025-01894-1","article-title":"Senescence-associated gene signatures predict survival in lung cancer: A multi-cohort analysis","volume":"48","author":"Menyhart","year":"2025","journal-title":"GeroScience"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acschemneuro.3c00531","article-title":"Aging hallmarks and progression and age-related diseases: A landscape view of research advancement","volume":"15","author":"Tenchov","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s11357-025-01654-1","article-title":"Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: Implications for vascular contributions to cognitive impairment and dementia (VCID)","volume":"47","author":"Kallai","year":"2025","journal-title":"GeroScience"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ungvari, A., Gulej, R., Csik, B., Mukli, P., Negri, S., Tarantini, S., Yabluchanskiy, A., Benyo, Z., Csiszar, A., and Ungvari, Z. (2023). The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment. Nutrients, 15.","DOI":"10.3390\/nu15214662"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Varga, P., Lehoczki, A., Fekete, M., Jarecsny, T., Kryczyk-Poprawa, A., Z\u00e1b\u00f3, V., Major, D., Fazekas-Pongor, V., Cs\u00edp\u0151, T., and Varga, J.T. (2025). The Role of Magnesium in Depression, Migraine, Alzheimer\u2019s Disease, and Cognitive Health: A Comprehensive Review. Nutrients, 17.","DOI":"10.3390\/nu17132216"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2024.12.014","article-title":"The pathobiology of neurovascular aging","volume":"113","author":"Santisteban","year":"2025","journal-title":"Neuron"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11357-024-01487-4","article-title":"Cerebromicrovascular mechanisms contributing to long COVID: Implications for neurocognitive health","volume":"47","author":"Fekete","year":"2025","journal-title":"Geroscience"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1556\/650.2024.32962","article-title":"A D-vitamin-hi\u00e1ny mint a cerebrovascularis betegs\u00e9gek kock\u00e1zati t\u00e9nyez\u0151je","volume":"165","author":"Bereczki","year":"2024","journal-title":"Orvosi Hetil."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Manful, C.F., Fordjour, E., Subramaniam, D., Sey, A.A., Abbey, L., and Thomas, R. (2025). Antioxidants and reactive oxygen species: Shaping human health and disease outcomes. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157520"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Friedman, J. (2010). Why is the nervous system vulnerable to oxidative stress?. Oxidative STRESS and Free Radical Damage in Neurology, Springer.","DOI":"10.1007\/978-1-60327-514-9_2"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3164\/jcbn.14-10","article-title":"The role of lipid peroxidation in neurological disorders","volume":"54","author":"Shichiri","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Kruchinin, A.A., Kamzeeva, P.N., Zharkov, D.O., Aralov, A.V., and Makarova, A.V. (2024). 8-Oxoadenine: A \u00abNew\u00bb player of the oxidative stress in mammals?. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021342"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3934\/Neuroscience.2025020","article-title":"Oxidative genomic or genotoxic stress in neurodegeneration: Mechanisms and therapeutic avenues","volume":"12","author":"Uddin","year":"2025","journal-title":"AIMS Neurosci."},{"key":"ref_59","first-page":"S4","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. Ser. A Biomed. Sci. Med. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12016-021-08909-7","article-title":"Immunosenescence, inflammaging, and frailty: Role of myeloid cells in age-related diseases","volume":"64","author":"Bleve","year":"2023","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"101755","DOI":"10.1016\/j.molmet.2023.101755","article-title":"Chronic inflammation and the hallmarks of aging","volume":"74","author":"Baechle","year":"2023","journal-title":"Mol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S1740925X12000063","article-title":"Functions of microglia in the central nervous system\u2013beyond the immune response","volume":"7","author":"Wake","year":"2011","journal-title":"Neuron Glia Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","article-title":"Microglia: Immune and non-immune functions","volume":"54","author":"Borst","year":"2021","journal-title":"Immunity"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wendimu, M.Y., and Hooks, S.B. (2022). Microglia phenotypes in aging and neurodegenerative diseases. Cells, 11.","DOI":"10.3390\/cells11132091"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Beltran-Velasco, A.I., and Clemente-Su\u00e1rez, V.J. (2025). Impact of peripheral inflammation on blood\u2013brain barrier dysfunction and its role in neurodegenerative diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26062440"},{"key":"ref_66","first-page":"383","article-title":"Energy nutrient metabolism: The inter-conversions and the chain reaction leading to oxidative-phosphorilation and production of adenosine tri-phosphate (ATP)","volume":"6","author":"Mahundi","year":"2015","journal-title":"J. Emerg. Trends Educ. Res. Policy Stud."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Haas, R.H. (2019). Mitochondrial dysfunction in aging and diseases of aging. Biology, 8.","DOI":"10.3390\/biology8020048"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/CIRCRESAHA.118.311378","article-title":"Mechanisms of Vascular Aging","volume":"123","author":"Ungvari","year":"2018","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s11357-023-00913-3","article-title":"Exposome and unhealthy aging: Environmental drivers from air pollution to occupational exposures","volume":"45","author":"Pandics","year":"2023","journal-title":"Geroscience"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.freeradbiomed.2015.05.005","article-title":"Mechanisms linking mtDNA damage and aging","volume":"85","author":"Pinto","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1089\/dna.2019.5347","article-title":"Mitochondrial and nuclear DNA oxidative damage in physiological and pathological aging","volume":"39","author":"Kowalska","year":"2020","journal-title":"DNA Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12964-025-02308-7","article-title":"Mitochondrial dysfunction in the regulation of aging and aging-related diseases","volume":"23","author":"Zhang","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.bbadis.2018.08.008","article-title":"Endothelial cell senescence in aging-related vascular dysfunction","volume":"1865","author":"Jia","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"168060","DOI":"10.1016\/j.bbadis.2025.168060","article-title":"The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases","volume":"1872","author":"Churov","year":"2026","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/1873-3468.14298","article-title":"Mitochondria, energy, and metabolism in neuronal health and disease","volume":"596","author":"Trigo","year":"2022","journal-title":"FEBS Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","article-title":"Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States","volume":"27","author":"Mattson","year":"2018","journal-title":"Cell Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbabio.2006.03.016","article-title":"Multiple pathways of cytochrome c release from mitochondria in apoptosis","volume":"1757","author":"Gogvadze","year":"2006","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3934\/molsci.2016.3.300","article-title":"Oxidative stress, cellular senescence and ageing","volume":"3","author":"Pole","year":"2016","journal-title":"AIMS Mol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Qin, Y., Liu, H., and Wu, H. (2025). Cellular senescence in health, disease, and lens aging. Pharmaceuticals, 18.","DOI":"10.20944\/preprints202501.1109.v1"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Cuollo, L., Antonangeli, F., Santoni, A., and Soriani, A. (2020). The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases. Biology, 9.","DOI":"10.3390\/biology9120485"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Giroud, J., Bouriez, I., Paulus, H., Pourtier, A., Debacq-Chainiaux, F., and Pluquet, O. (2023). Exploring the communication of the SASP: Dynamic, interactive, and adaptive effects on the microenvironment. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310788"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Mishra, R. (2025). Cellular Senescence in the Aging Brain. Cellular Senescence and Brain Aging: Mechanisms, Therapeutic Strategies, and Implications for Neurodegenerative Diseases, Springer.","DOI":"10.1007\/978-981-96-8873-9_4"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and aging","volume":"21","author":"Kaushik","year":"2015","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s12013-024-01581-6","article-title":"Proteostasis and its role in disease development","volume":"83","author":"Shukla","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, S., and Wu, H. (2022). Ubiquitination-proteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress. Cells, 11.","DOI":"10.3390\/cells11050851"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4172\/pharmaceutical-sciences.1000397","article-title":"Pathogenesis of Alzheimer\u2019s Disease: Role of Amyloid-\u03b2 and Hyperphosphorylated Tau Protein","volume":"80","author":"Sajjad","year":"2018","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Srinivasan, E., Chandrasekhar, G., Chandrasekar, P., Anbarasu, K., Vickram, A., Karunakaran, R., Rajasekaran, R., and Srikumar, P. (2021). Alpha-synuclein aggregation in Parkinson\u2019s disease. Front. Med., 8.","DOI":"10.3389\/fmed.2021.736978"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10522-017-9724-6","article-title":"Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing","volume":"18","author":"Bettedi","year":"2017","journal-title":"Biogerontology"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Fu, W., and Wu, G. (2023). Targeting mTOR for anti-aging and anti-cancer therapy. Molecules, 28.","DOI":"10.3390\/molecules28073157"},{"key":"ref_92","first-page":"992","article-title":"Exploring the role of mTOR pathway in aging and age-related disorders","volume":"24","author":"Raghuvanshi","year":"2025","journal-title":"EXCLI J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase\u2014An energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"He, Y., Liu, Y., and Zhang, M. (2025). The beneficial effects of curcumin on aging and age-related diseases: From oxidative stress to antioxidant mechanisms, brain health and apoptosis. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1533963"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4103\/0366-6999.158375","article-title":"Sirtuins function as the modulators in aging-related diseases in common or respectively","volume":"128","author":"Wang","year":"2015","journal-title":"Chin. Med. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40169-016-0104-7","article-title":"Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders","volume":"5","author":"Srivastava","year":"2016","journal-title":"Clin. Transl. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1172\/JCI64094","article-title":"The sirtuin family\u2019s role in aging and age-associated pathologies","volume":"123","author":"Hall","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aac4854","article-title":"NAD+ in aging, metabolism, and neurodegeneration","volume":"350","author":"Verdin","year":"2015","journal-title":"Science"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Samtiya, M., Aluko, R.E., Dhewa, T., and Moreno-Rojas, J.M. (2021). Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview. Foods, 10.","DOI":"10.3390\/foods10040839"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Rudrapal, M., Khairnar, S.J., Khan, J., Dukhyil, A.B., Ansari, M.A., Alomary, M.N., Alshabrmi, F.M., Palai, S., Deb, P.K., and Devi, R. (2022). Dietary polyphenols and their role in oxidative stress-induced human diseases: Insights into protective effects, antioxidant potentials and mechanism(s) of action. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.806470"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Maniglia, B.C., Rebelatto, E.A., Andrade, K.S., Zielinski, A., and de Andrade, C.J. (2021). Polyphenols. Food Bioactives and Health, Springer.","DOI":"10.1007\/978-3-030-57469-7_1"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Eseberri, I., Trepiana, J., L\u00e9niz, A., G\u00f3mez-Garc\u00eda, I., Carr-Ugarte, H., Gonz\u00e1lez, M., and Portillo, M.P. (2022). Variability in the beneficial effects of phenolic compounds: A review. Nutrients, 14.","DOI":"10.3390\/nu14091925"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Grabska-Koby\u0142ecka, I., Szpakowski, P., Kr\u00f3l, A., Ksi\u0105\u017cek-Winiarek, D., Koby\u0142ecki, A., G\u0142\u0105bi\u0144ski, A., and Nowak, D. (2023). Polyphenols and their impact on the prevention of neurodegenerative diseases and development. Nutrients, 15.","DOI":"10.3390\/nu15153454"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"293","DOI":"10.22271\/journalofsport.2021.v6.i1e.2236","article-title":"Classifications of polyphenols and their potential application in human health and diseases","volume":"6","author":"Prabhu","year":"2021","journal-title":"Int. J. Physiol. Nutr. Phys. Educ."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Sharma, A., Singh Tuli, H., and Sharma, A.K. (2019). Chemistry and synthetic overview of flavonoids. Curr. Asp. Flavonoids Their Role Cancer Treat., 23\u201338.","DOI":"10.1007\/978-981-13-5874-6_3"},{"key":"ref_106","first-page":"108","article-title":"Natural flavonoids: Classification, potential role, and application of flavonoid analogues","volume":"7","author":"Brodowska","year":"2017","journal-title":"Eur. J. Biol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1016\/j.cub.2012.01.021","article-title":"Anthocyanins","volume":"22","author":"Glover","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Bellavite, P. (2023). Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action. Antioxidants, 12.","DOI":"10.3390\/antiox12020280"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Santos-Buelga, C., Gonz\u00e1lez-Param\u00e1s, A.M., and Gonz\u00e1lez-Manzano, S. (2023). Phenolic acids and derivatives: Description, sources, properties, and applications. Natural Secondary Metabolites: From Nature, Through Science, to Industry, Springer.","DOI":"10.1007\/978-3-031-18587-8_3"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10408398.2012.708909","article-title":"Phenolic compounds of cereals and their antioxidant capacity","volume":"56","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Ciupei, D., Coli\u015far, A., Leopold, L., St\u0103nil\u0103, A., and Diaconeasa, Z.M. (2024). Polyphenols: From classification to therapeutic potential and bioavailability. Foods, 13.","DOI":"10.3390\/foods13244131"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wici\u0144ski, M., Domanowska, A., W\u00f3dkiewicz, E., and Malinowski, B. (2020). Neuroprotective properties of resveratrol and its derivatives\u2014Influence on potential mechanisms leading to the development of Alzheimer\u2019s disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082749"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fct.2013.03.038","article-title":"Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties","volume":"61","author":"Kasiotis","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_114","first-page":"155","article-title":"Biological functions of lignans in plants","volume":"67","year":"2021","journal-title":"Agriculture"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Burgberger, M., Mierziak, J., Augustyniak, B., Wojtasik, W., and Kulma, A. (2025). The Power of Lignans: Plant Compounds with Multifaceted Health-Promoting Effects. Metabolites, 15.","DOI":"10.3390\/metabo15090589"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Arfaoui, L. (2021). Dietary Plant Polyphenols: Effects of Food Processing on Their Content and Bioavailability. Molecules, 26.","DOI":"10.3390\/molecules26102959"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zagoskina, N.V., Zubova, M.Y., Nechaeva, T.L., Kazantseva, V.V., Goncharuk, E.A., Katanskaya, V.M., Baranova, E.N., and Aksenova, M.A. (2023). Polyphenols in Plants: Structure, Biosynthesis, Abiotic Stress Regulation, and Practical Applications (Review). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241813874"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e2259","DOI":"10.1212\/WNL.0000000000207176","article-title":"Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets with Alzheimer Disease Pathology","volume":"100","author":"Agarwal","year":"2023","journal-title":"Neurology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"112118","DOI":"10.1016\/j.nut.2023.112118","article-title":"The role of the Mediterranean diet in modulating the gut microbiome: A review of current evidence","volume":"114","author":"Gundogdu","year":"2023","journal-title":"Nutrition"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1007\/s11357-025-01625-6","article-title":"The role of purpose in life in healthy aging: Implications for the Semmelweis Study and the Semmelweis-EUniWell Workplace Health Promotion Model Program","volume":"47","author":"Lehoczki","year":"2025","journal-title":"Geroscience"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1007\/s11357-024-01491-8","article-title":"Impact of adherence to the Mediterranean diet on stroke risk","volume":"47","author":"Ungvari","year":"2025","journal-title":"GeroScience"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3945\/an.116.012138","article-title":"Mediterranean diet, cognitive function, and dementia: A systematic review of the evidence","volume":"7","author":"Petersson","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1056\/NEJMoa2302368","article-title":"Trial of the MIND diet for prevention of cognitive decline in older persons","volume":"389","author":"Barnes","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Lehoczki, A., Cs\u00edp\u0151, T., Lip\u00e9cz, \u00c1., Major, D., Fazekas-Pongor, V., Cs\u00edk, B., M\u00f3zes, N., Feh\u00e9r, \u00c1., D\u00f3sa, N., and \u00c1rva, D. (2025). Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study. Nutrients, 17.","DOI":"10.3390\/nu17152446"},{"key":"ref_125","first-page":"4","article-title":"T\u00e1pl\u00e1lkoz\u00e1si strat\u00e9gi\u00e1k az eg\u00e9szs\u00e9ges \u00f6reged\u00e9s\u00e9rt: Kr\u00f3nikus, \u00e9letkorral \u00f6sszef\u00fcgg\u0151 betegs\u00e9gek","volume":"9","author":"Vince","year":"2024","journal-title":"Sci. J. Hung. Assoc. Gerontol. Geriatr."},{"key":"ref_126","first-page":"3801","article-title":"Survival and longevity of European rulers: Geographical influences and exploring potential factors, including the Mediterranean diet\u2014A historical analysis from 1354 to the twentieth century","volume":"46","author":"Szarvas","year":"2024","journal-title":"GeroScience"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Scott, M.B., Styring, A.K., and McCullagh, J.S.O. (2022). Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals. Pathogens, 11.","DOI":"10.3390\/pathogens11070770"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1080\/10408398.2018.1437023","article-title":"Polyphenols and bioavailability: An update","volume":"59","author":"Teng","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Spencer","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"17429","DOI":"10.3390\/molecules200917429","article-title":"Metabolic and Microbial Modulation of the Large Intestine Ecosystem by Non-Absorbed Diet Phenolic Compounds: A Review","volume":"20","author":"Mosele","year":"2015","journal-title":"Molecules"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1021\/acs.jafc.1c00737","article-title":"Absorption, Distribution, Metabolism, and Excretion of the Main Olive Tree Phenols and Polyphenols: A Literature Review","volume":"69","author":"Palou","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1517\/17425255.3.3.389","article-title":"Natural polyphenol disposition via coupled metabolic pathways","volume":"3","author":"Liu","year":"2007","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1021\/acs.jafc.4c12596","article-title":"Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery","volume":"73","author":"Tsiara","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Kadayifci, F.Z., Zheng, S., and Pan, Y.X. (2018). Molecular Mechanisms Underlying the Link between Diet and DNA Methylation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19124055"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Lippolis, T., Cofano, M., Caponio, G.R., De Nunzio, V., and Notarnicola, M. (2023). Bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043813"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0029665114001463","article-title":"Links between diet, gut microbiota composition and gut metabolism","volume":"74","author":"Flint","year":"2015","journal-title":"Proc. Nutr. Soc."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Li, H., Gao, J., Peng, W., Sun, X., Qi, W., and Wang, Y. (2025). Dietary Polyphenols-Gut Microbiota Interactions: Intervention Strategies and Metabolic Regulation for Intestinal Diseases. Biology, 14.","DOI":"10.3390\/biology14121705"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: Structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Tanaka, M., Araujo, A.C., Valenti, V.E., Guiguer, E.L., Catharin, V.C.S., Gualhardi, C.M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R.S., and de Carvalho, A.C.A. (2026). From Polyphenols to Prodrugs: Bridging the Blood-Brain Barrier with Nanomedicine and Neurotherapeutics. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27052370"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/BPL-200099","article-title":"Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey","volume":"6","author":"Carecho","year":"2021","journal-title":"Brain Plast."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"914273","DOI":"10.1155\/2012\/914273","article-title":"Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Kaluza, M., Ksiazek-Winiarek, D., Szpakowski, P., Czpakowska, J., Fijalkowska, J., and Glabinski, A. (2025). Polyphenols in the Central Nervous System: Cellular Effects and Liposomal Delivery Approaches. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136477"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/nure.12114","article-title":"Dietary factors affecting polyphenol bioavailability","volume":"72","author":"Bohn","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00394-019-01987-6","article-title":"Factors affecting intake, metabolism and health benefits of phenolic acids: Do we understand individual variability?","volume":"59","author":"Koistinen","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.anaerobe.2013.07.009","article-title":"Fecal microbial metabolism of polyphenols and its effects on human gut microbiota","volume":"23","author":"Parkar","year":"2013","journal-title":"Anaerobe"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Bas, T.G. (2026). Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27031404"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Arias-S\u00e1nchez, R.A., Torner, L., and Fenton Navarro, B. (2023). Polyphenols and Neurodegenerative Diseases: Potential Effects and Mechanisms of Neuroprotection. Molecules, 28.","DOI":"10.3390\/molecules28145415"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Caruso, G., Godos, J., Privitera, A., Lanza, G., Castellano, S., Chillemi, A., Bruni, O., Ferri, R., Caraci, F., and Grosso, G. (2022). Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer\u2019s Disease. Nutrients, 14.","DOI":"10.3390\/nu14040819"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Hussain, G., Zhang, L., Rasul, A., Anwar, H., Sohail, M.U., Razzaq, A., Aziz, N., Shabbir, A., Ali, M., and Sun, T. (2018). Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer\u2019s and Parkinson\u2019s Diseases: An Update of Recent Data. Molecules, 23.","DOI":"10.3390\/molecules23040814"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., and Bonaduce, D. (2018). Oxidative stress, aging, and diseases. Clin. Interv. Aging, 757\u2013772.","DOI":"10.2147\/CIA.S158513"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"569146","DOI":"10.1155\/2014\/569146","article-title":"Oxidative stress and aging diseases","volume":"2014","author":"Shaw","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_152","first-page":"12","article-title":"A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders","volume":"690","author":"Kim","year":"2010","journal-title":"Mutat. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11033-024-09771-4","article-title":"Regulation of Keap1-Nrf2 signaling in health and diseases","volume":"51","author":"Xiao","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"33554","DOI":"10.1074\/jbc.M804597200","article-title":"Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes","volume":"283","author":"Ohtsuji","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Rodrigo, R., and Gil-Becerra, D. (2014). Implications of polyphenols on endogenous antioxidant defense systems in human diseases. Polyphenols in Human Health and Disease, Elsevier.","DOI":"10.1016\/B978-0-12-398456-2.00017-7"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Adamu, A., Li, S., Gao, F., and Xue, G. (2024). The role of neuroinflammation in neurodegenerative diseases: Current understanding and future therapeutic targets. Front Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1347987"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1080\/10408398.2019.1661827","article-title":"Targeting NF-\u03baB signaling pathway in cancer by dietary polyphenols","volume":"60","author":"Khan","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s11033-021-06896-8","article-title":"Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis","volume":"49","author":"Vishwakarma","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/cimb46030130","article-title":"Mitochondrial dysfunction: A key player in brain aging and diseases","volume":"46","author":"Bartman","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/cvr\/cvn098","article-title":"Transcriptional control of mitochondrial biogenesis: The central role of PGC-1\u03b1","volume":"79","author":"Garnier","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1039\/D2FO02688K","article-title":"Targeting AMPK signaling by polyphenols: A novel strategy for tackling aging","volume":"14","author":"Xu","year":"2023","journal-title":"Food Funct."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Zerdka, J., Brasse, P., Piszka, M., Kwapien, E., Kubicka, M., Bartkowski, J., Banach, J., Dacyl, H., and Owczarska, A. (2025). The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity. Cureus, 17.","DOI":"10.7759\/cureus.98514"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Fiore, M., Terracina, S., and Ferraguti, G. (2025). Brain neurotrophins and plant polyphenols: A powerful connection. Molecules, 30.","DOI":"10.3390\/molecules30122657"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Harun, Z.Z., Azhar, A.A., Kim, Y.-J., Ibrahim, F.W., Ng, M.-H., Tan, J.-K., and Lokanathan, Y. (2025). Modulation of BDNF\/TrkB Signalling Pathway in Alzheimer\u2019s Disease: Mechanistic Insights and the Role of Stem Cell Therapy. Biomedicines, 13.","DOI":"10.3390\/biomedicines13122931"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41392-024-02030-9","article-title":"Chromatin accessibility: Biological functions, molecular mechanisms and therapeutic application","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Faggi, L., Porrini, V., Lanzillotta, A., Benarese, M., Mota, M., Tsoukalas, D., Parrella, E., and Pizzi, M. (2019). A polyphenol-enriched supplement exerts potent epigenetic-protective activity in a cell-based model of brain ischemia. Nutrients, 11.","DOI":"10.3390\/nu11020345"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"223S","DOI":"10.1093\/jn\/137.1.223S","article-title":"Dietary polyphenols may affect DNA methylation","volume":"137","author":"Fang","year":"2007","journal-title":"J. Nutr."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s11101-019-09627-x","article-title":"Phytochemicals in cancer prevention: Modulating epigenetic alterations of DNA methylation","volume":"18","author":"Pop","year":"2019","journal-title":"Phytochem. Rev."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Di Meo, F., Valentino, A., Petillo, O., Peluso, G., Filosa, S., and Crispi, S. (2020). Bioactive polyphenols and neuromodulation: Molecular mechanisms in neurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072564"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"La Rosa, G., Lonardo, M.S., Cacciapuoti, N., Muscariello, E., Guida, B., Faraonio, R., Santillo, M., and Damiano, S. (2023). Dietary polyphenols, microbiome, and multiple sclerosis: From molecular anti-inflammatory and neuroprotective mechanisms to clinical evidence. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087247"},{"key":"ref_172","first-page":"1262","article-title":"Molecular mechanisms underlying the neuroprotective effects of polyphenols: Implications for cognitive function","volume":"24","author":"Godos","year":"2025","journal-title":"EXCLI J."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s40120-022-00338-8","article-title":"Alzheimer\u2019s disease: Epidemiology and clinical progression","volume":"11","author":"Byrnes","year":"2022","journal-title":"Neurol. Ther."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1021\/acschemneuro.4c00339","article-title":"Alzheimer\u2019s disease: Exploring the landscape of cognitive decline","volume":"15","author":"Tenchov","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Orobets, K.S., and Karamyshev, A.L. (2023). Amyloid precursor protein and Alzheimer\u2019s disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914794"},{"key":"ref_176","first-page":"2","article-title":"Interaction between polyphenols and amyloids: From the view of prevention of protein misfolding disorders related diseases","volume":"2","author":"Ruan","year":"2022","journal-title":"Food Mater. Res."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Pagano, K., Tomaselli, S., Molinari, H., and Ragona, L. (2020). Natural compounds as inhibitors of A\u03b2 peptide aggregation: Chemical requirements and molecular mechanisms. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.619667"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Chandrasekaran, V., Hediyal, T.A., Anand, N., Kendaganna, P.H., Gorantla, V.R., Mahalakshmi, A.M., Ghanekar, R.K., Yang, J., Sakharkar, M.K., and Chidambaram, S.B. (2023). Polyphenols, autophagy and neurodegenerative diseases: A review. Biomolecules, 13.","DOI":"10.3390\/biom13081196"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Rawat, P., Sehar, U., Bisht, J., Selman, A., Culberson, J., and Reddy, P.H. (2022). Phosphorylated tau in Alzheimer\u2019s disease and other tauopathies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112841"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1021\/acschemneuro.5c00207","article-title":"Alzheimer\u2019s disease: A review of molecular mechanisms and therapeutic implications by targeting sirtuins, caspases, and GSK-3","volume":"16","author":"Pandya","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Yadav, E., Yadav, P., Khan, M.M.U., Singh, H., and Verma, A. (2022). Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.922232"},{"key":"ref_182","first-page":"136","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Guo, S., Wang, H., and Yin, Y. (2022). Microglia polarization from M1 to M2 in neurodegenerative diseases. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.815347"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cca.2021.08.009","article-title":"Dopamine in Parkinson\u2019s disease","volume":"522","author":"Latif","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s disease: Clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00018-022-04240-2","article-title":"Initiation and progression of \u03b1-synuclein pathology in Parkinson\u2019s disease","volume":"79","author":"Tofaris","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1021\/acschemneuro.3c00162","article-title":"Mechanistic insights into polyphenols\u2019 aggregation inhibition of \u03b1-synuclein and related peptides","volume":"14","author":"Martins","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Caradonna, E., Nemni, R., Bifone, A., Gandolfo, P., Costantino, L., Giordano, L., Mormone, E., Macula, A., Cuomo, M., and Difruscolo, R. (2024). The brain\u2013gut axis, an important player in Alzheimer and Parkinson disease: A narrative review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13144130"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s11064-007-9482-y","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson\u2019s disease","volume":"33","author":"Onyango","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Kim, T.Y., Leem, E., Lee, J.M., and Kim, S.R. (2020). Control of reactive oxygen species for the prevention of Parkinson\u2019s disease: The possible application of flavonoids. Antioxidants, 9.","DOI":"10.3390\/antiox9070583"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Sharma, N., Saini, D., Kesharwani, R.K., Gupta, P.C., and Keservani, R.K. (2024). Advances in Flavonoids for Human Health and Prevention of Diseases, CRC Press.","DOI":"10.1201\/9781003369813"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1111\/bph.14898","article-title":"Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing","volume":"177","author":"Howes","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2174\/1567205015666180119092427","article-title":"Estimating Alzheimer\u2019s disease progression rates from normal cognition through mild cognitive impairment and stages of dementia","volume":"15","author":"Davis","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Ammar, A., Trabelsi, K., Boukhris, O., Bouaziz, B., Mueller, P., M Glenn, J., Bott, N.T., Mueller, N., Chtourou, H., and Driss, T. (2020). Effects of polyphenol-rich interventions on cognition and brain health in healthy young and middle-aged adults: Systematic review and meta-analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051598"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Gardener, S.L., Rainey-Smith, S.R., Weinborn, M., Bondonno, C.P., and Martins, R.N. (2021). Intake of products containing anthocyanins, flavanols, and flavanones, and cognitive function: A narrative review. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.640381"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"de Vries, K., Medawar, E., Korosi, A., and Witte, A.V. (2022). The effect of polyphenols on working and episodic memory in non-pathological and pathological aging: A systematic review and meta-analysis. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.720756"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3945\/jn.113.184945","article-title":"Dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in European populations","volume":"144","author":"Forouhi","year":"2014","journal-title":"J. Nutr."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.03.005","article-title":"Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)","volume":"84","author":"Vogiatzoglou","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3945\/jn.113.177121","article-title":"High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults","volume":"143","author":"Rabassa","year":"2013","journal-title":"J. Nutr."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e2434136","DOI":"10.1001\/jamanetworkopen.2024.34136","article-title":"Flavonoid-rich foods, dementia risk, and interactions with genetic risk, hypertension, and depression","volume":"7","author":"Jennings","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1017\/S136898001900394X","article-title":"Long-term dietary flavonoid intake and change in cognitive function in the Framingham Offspring cohort","volume":"23","author":"Shishtar","year":"2020","journal-title":"Public Health Nutr."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.tjnut.2025.05.047","article-title":"Polyphenol intake and risk of dementia and cognitive decline in older adults: Principal component analysis approach","volume":"155","author":"Chatzispyrellis","year":"2025","journal-title":"J. Nutr."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S000711452000392X","article-title":"Polyphenol intake and cognitive decline in the Seguimiento Universidad de Navarra (SUN) Project","volume":"126","author":"Goni","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.14283\/jpad.2024.116","article-title":"Flavonoid-Rich fruit intake in midlife and Late-Life and associations with risk of dementia: The Framingham heart study","volume":"11","author":"Lyu","year":"2024","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/nqaa079","article-title":"Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort","volume":"112","author":"Shishtar","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s41043-023-00382-6","article-title":"Fruit and vegetable consumption across population segments: Evidence from a national household survey","volume":"42","author":"Urak","year":"2023","journal-title":"J. Health Popul. Nutr."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"41317","DOI":"10.1038\/srep41317","article-title":"Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s41983-023-00752-1","article-title":"Examining the efficacy of the Mediterranean-DASH diet intervention for neurodegenerative delay in mitigating cognitive decline","volume":"59","author":"Aderinto","year":"2023","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2174\/1871527321666220608085852","article-title":"The potential effect of blueberry on cognitive health and mood state based on human intervention studies: Systematic review and mini meta-analysis","volume":"22","author":"Soveid","year":"2023","journal-title":"CNS Neurol. Disord.-Drug Targets-CNS Neurol. Disord."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbi.2019.04.001","article-title":"The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials","volume":"85","author":"Travica","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Whyte, A.R., Cheng, N., Butler, L.T., Lamport, D.J., and Williams, C.M. (2019). Flavonoid-Rich Mixed Berries Maintain and Improve Cognitive Function Over a 6 h Period in Young Healthy Adults. Nutrients, 11.","DOI":"10.3390\/nu11112685"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3945\/ajcn.114.092189","article-title":"Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: The Cocoa, Cognition, and Aging (CoCoA) Study\u2014A randomized controlled trial","volume":"101","author":"Mastroiacovo","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/HYPERTENSIONAHA.112.193060","article-title":"Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: The Cocoa, Cognition, and Aging (CoCoA) study","volume":"60","author":"Desideri","year":"2012","journal-title":"Hypertension"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1038\/s41598-021-83370-2","article-title":"Insights into the role of diet and dietary flavanols in cognitive aging: Results of a randomized controlled trial","volume":"11","author":"Sloan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nn.3850","article-title":"Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults","volume":"17","author":"Brickman","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"112860","DOI":"10.1016\/j.nut.2025.112860","article-title":"Acute effects of cocoa flavanols on cognitive control and response inhibition","volume":"139","author":"Altinok","year":"2025","journal-title":"Nutrition"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/GME.0000000000000290","article-title":"Do soy isoflavones improve cognitive function in postmenopausal women? A meta-analysis","volume":"22","author":"Cheng","year":"2015","journal-title":"Menopause"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/1028415X.2015.1101304","article-title":"Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial","volume":"20","author":"Kennedy","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Carrillo, J.\u00c1., Arcusa, R., Xandri-Mart\u00ednez, R., Cerd\u00e1, B., Zafrilla, P., and Marhuenda, J. (2025). Impact of polyphenol-rich nutraceuticals on cognitive function and neuroprotective biomarkers: A randomized, double-blind, placebo-controlled clinical trial. Nutrients, 17.","DOI":"10.3390\/nu17040601"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Ammar, A., Trabelsi, K., Mueller, P., Bouaziz, B., Boukhris, O., Glenn, J.M., Bott, N., Driss, T., Chtourou, H., and M\u00fcller, N. (2020). The effect of (poly) phenol-rich interventions on cognitive functions and neuroprotective measures in healthy aging adults: A systematic review and meta-analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030835"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Micek, A., Godos, J., Giampieri, F., Battino, M., Quiles, J.L., Del Rio, D., Mena, P., Caruso, G., Frias-Toral, E., and Azp\u00edroz, I.D. (2025). The effect of anthocyanins and anthocyanin-rich foods on cognitive function: A meta-analysis of randomized controlled trials. GeroScience, 1\u201335.","DOI":"10.1007\/s11357-025-02008-7"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2100976","DOI":"10.1002\/mnfr.202100976","article-title":"Dietary flavonoids and human cognition: A meta-analysis","volume":"66","author":"Cheng","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Szulc, A., Wi\u015bniewska, K., \u017babi\u0144ska, M., Gaffke, L., Szota, M., Olendzka, Z., W\u0119grzyn, G., and Pierzynowska, K. (2024). Effectiveness of flavonoid-rich diet in alleviating symptoms of neurodegenerative diseases. Foods, 13.","DOI":"10.3390\/foods13121931"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Farag, S., Tsang, C., Al-Dujaili, E.A., and Murphy, P.N. (2024). Effect of polyphenol supplementation on memory functioning in overweight and obese adults: A systematic review and Meta-Analysis. Nutrients, 16.","DOI":"10.3390\/nu16040474"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Colletti, A., Cravotto, G., De Meo, A., Pellizzato, M., Riccardi, E.L., and Marchetti, M. (2025). Health benefits of (poly) phenols from cherries: A review of clinical trials. Nutraceuticals, 5.","DOI":"10.3390\/nutraceuticals5020012"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"S479","DOI":"10.3233\/JAD-231222","article-title":"Polyphenols and diets as current and potential nutrition senotherapeutics in alzheimer\u2019s disease: Findings from clinical trials","volume":"101","author":"Chen","year":"2024","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_227","first-page":"203","article-title":"The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. Gastroenterol. Q. Publ. Hell. Soc. Gastroenterol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tifs.2018.06.007","article-title":"Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis","volume":"78","author":"Serra","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s13098-024-01561-z","article-title":"Understanding the complex function of gut microbiota: Its impact on the pathogenesis of obesity and beyond: A comprehensive review","volume":"16","author":"Yarahmadi","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Rudrapal, M., de Oliveira, A.M., and Singh, R.P. (2025). Dietary polyphenols maintain human health through modulation of gut microbiota. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1710088"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Be\u0161lo, D., Golubi\u0107, N., Rastija, V., Agi\u0107, D., Karna\u0161, M., \u0160ubari\u0107, D., and Lu\u010di\u0107, B. (2023). Antioxidant activity, metabolism, and bioavailability of polyphenols in the diet of animals. Antioxidants, 12.","DOI":"10.3390\/antiox12061141"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Plamada, D., and Vodnar, D.C. (2021). Polyphenols\u2014Gut microbiota interrelationship: A transition to a new generation of prebiotics. Nutrients, 14.","DOI":"10.3390\/nu14010137"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Toderescu, C.D., Parveen, M., Trifunschi, S., Oancea, A., Cresneac, I.G., Munteanu, M.F., Ciopanoiu, I., Boru, C., Pogurschi, E.N., and Ionite, C. (2026). Dietary Polyphenols as Modulators of Bifidobacterium in the Human Gut Microbiota. Nutrients, 18.","DOI":"10.3390\/nu18050782"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Nazzaro, F., Coppola, F., Fratianni, F., Abdalrazeq, M., Ombra, M.N., De Giulio, B., Coppola, R., and Zengin, G. (2025). Polyphenols bioactive metabolites, and their anti-biofilm and neuroprotective potential. Foods, 14.","DOI":"10.3390\/foods14223976"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Wu, X., Mu, B., Li, G., Du, R., and Park, S. (2026). Gut Microbial Composition, Oxidative Stress, and Immunity in Metabolic Disease: Toward Personalized Interventions. Antioxidants, 15.","DOI":"10.3390\/antiox15020175"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Wojciechowska, O., and Kujawska, M. (2023). Urolithin a in health and diseases: Prospects for parkinson\u2019s disease management. Antioxidants, 12.","DOI":"10.3390\/antiox12071479"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Behl, T., Upadhyay, T., Singh, S., Chigurupati, S., Alsubayiel, A.M., Mani, V., Vargas-De-La-Cruz, C., Uivarosan, D., Bustea, C., and Sava, C. (2021). Polyphenols targeting MAPK mediated oxidative stress and inflammation in rheumatoid arthritis. Molecules, 26.","DOI":"10.3390\/molecules26216570"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Shakoor, H., Feehan, J., Apostolopoulos, V., Platat, C., Al Dhaheri, A.S., Ali, H.I., Ismail, L.C., Bosevski, M., and Stojanovska, L. (2021). Immunomodulatory effects of dietary polyphenols. Nutrients, 13.","DOI":"10.3390\/nu13030728"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S2468-1253(22)00241-2","article-title":"The intestinal barrier in disorders of the central nervous system","volume":"8","author":"Pellegrini","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chembiol.2024.08.014","article-title":"Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration","volume":"32","author":"Kern","year":"2025","journal-title":"Cell Chem. Biol."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Silva, Y.P., Bernardi, A., and Frozza, R.L. (2020). The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00025"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Al Noman, A., Alhudhaibi, A.M., Afroza, M., Tonni, S.D., Shehab, H.M., Jahan Iba, N., Taha, T.H., and Abdallah, E.M. (2025). Neuroplasticity and the microbiome: How microorganisms influence brain change. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1629349"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Tuigunov, D., Sinyavskiy, Y., Nurgozhin, T., Zholdassova, Z., Smagul, G., Omarov, Y., Dolmatova, O., Yeshmanova, A., and Omarova, I. (2025). Precision Nutrition and Gut\u2013Brain Axis Modulation in the Prevention of Neurodegenerative Diseases. Nutrients, 17.","DOI":"10.3390\/nu17193068"},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Stromsnes, K., Lagzdina, R., Olaso-Gonzalez, G., Gimeno-Mallench, L., and Gambini, J. (2021). Pharmacological properties of polyphenols: Bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081074"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1039\/C8FO01997E","article-title":"The effects of polyphenols and other bioactives on human health","volume":"10","author":"Fraga","year":"2019","journal-title":"Food Funct."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Del Bo, C., Bernardi, S., Marino, M., Porrini, M., Tucci, M., Guglielmetti, S., Cherubini, A., Carrieri, B., Kirkup, B., and Kroon, P. (2019). Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?. Nutrients, 11.","DOI":"10.3390\/nu11061355"},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Garza, S.L., Laveriano-Santos, E.P., Marhuenda-Mu\u00f1oz, M., Storniolo, C.E., Tresserra-Rimbau, A., Vallverd\u00fa-Queralt, A., and Lamuela-Ravent\u00f3s, R.M. (2018). Health effects of resveratrol: Results from human intervention trials. Nutrients, 10.","DOI":"10.3390\/nu10121892"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/met.2016.0035","article-title":"The effects of resveratrol supplementation in overweight and obese humans: A systematic review of randomized trials","volume":"14","author":"Christenson","year":"2016","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","article-title":"Dietary polyphenols and the prevention of diseases","volume":"45","author":"Scalbert","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s13105-024-01046-7","article-title":"Polyphenols and metabolism: From present knowledge to future challenges","volume":"80","author":"Eseberri","year":"2024","journal-title":"J. Physiol. Biochem."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1017\/S0007114510003946","article-title":"Colonic metabolites of berry polyphenols: The missing link to biological activity?","volume":"104","author":"Williamson","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/mnfr.201100143","article-title":"Resveratrol and health\u2014A comprehensive review of human clinical trials","volume":"55","author":"Smoliga","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/nbu.12278","article-title":"The role of polyphenols in modern nutrition","volume":"42","author":"Williamson","year":"2017","journal-title":"Nutr. Bull."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Cory, H., Passarelli, S., Szeto, J., Tamez, M., and Mattei, J. (2018). The role of polyphenols in human health and food systems: A mini-review. Front. Nutr., 5.","DOI":"10.3389\/fnut.2018.00087"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00217-016-2826-6","article-title":"Plant polyphenol content, soil fertilization and agricultural management: A review","volume":"243","author":"Heimler","year":"2017","journal-title":"Eur. Food Res. Technol."},{"key":"ref_258","doi-asserted-by":"crossref","unstructured":"ElGamal, R., Song, C., Rayan, A.M., Liu, C., Al-Rejaie, S., and ElMasry, G. (2023). Thermal degradation of bioactive compounds during drying process of horticultural and agronomic products: A comprehensive overview. Agronomy, 13.","DOI":"10.3390\/agronomy13061580"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"104578","DOI":"10.1016\/j.numecd.2026.104578","article-title":"Low polyphenol content is on the pathway between ultra-processed food consumption and low-grade inflammation: Cross-sectional analyses from the Moli-sani Study","volume":"36","author":"Ruggiero","year":"2026","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Naomi, R., Yazid, M.D., Teoh, S.H., Balan, S.S., Shariff, H., Kumar, J., Bahari, H., and Embong, H. (2023). Dietary polyphenols as a protection against cognitive decline: Evidence from animal experiments; mechanisms and limitations. Antioxidants, 12.","DOI":"10.3390\/antiox12051054"},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Papadopoulou, P., Polissidis, A., Kythreoti, G., Sagnou, M., Stefanatou, A., and Theoharides, T.C. (2024). Anti-inflammatory and neuroprotective polyphenols derived from the European olive tree, Olea europaea L., in long COVID and other conditions involving cognitive impairment. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011040"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2018.07.050","article-title":"Polyphenols, food and pharma. Current knowledge and directions for future research","volume":"156","author":"Moreno","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Morand, C. (2024). How to better consider and understand interindividual variability in response to polyphenols in clinical trials. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1522516"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/ajcn.2010.29924","article-title":"Urinary metabolites as biomarkers of polyphenol intake in humans: A systematic review","volume":"92","author":"Hubert","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/advances\/nmab017","article-title":"Dietary assessment methods to estimate (poly) phenol intake in epidemiological studies: A systematic review","volume":"12","author":"Xu","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"326S","DOI":"10.1093\/ajcn\/81.1.326S","article-title":"Risks and safety of polyphenol consumption","volume":"81","author":"Mennen","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Quetglas-Llabr\u00e9s, M.M., Monserrat-Mesquida, M., Bouzas, C., Garc\u00eda, S., Mateos, D., Ugarriza, L., G\u00f3mez, C., Sureda, A., and Tur, J.A. (2024). Long-Term Impact of Nutritional Intervention with Increased Polyphenol Intake and Physical Activity Promotion on Oxidative and Inflammatory Profiles in Patients with Metabolic Syndrome. Nutrients, 16.","DOI":"10.3390\/nu16132121"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/cdn.116.000042","article-title":"The Impact of Tannin Consumption on Iron Bioavailability and Status: A Narrative Review","volume":"1","author":"Delimont","year":"2017","journal-title":"Curr. Dev. Nutr."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"854015","DOI":"10.1155\/2015\/854015","article-title":"Interactions between CYP3A4 and Dietary Polyphenols","volume":"2015","author":"Basheer","year":"2015","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/9\/1470\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:13:09Z","timestamp":1777975989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/9\/1470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":269,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["nu18091470"],"URL":"https:\/\/doi.org\/10.3390\/nu18091470","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]}}}