{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:07:32Z","timestamp":1785424052192,"version":"3.56.0"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Uniwersytet WSB Merito we Wroc\u0142awiu ul"},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris de Recerca","award":["AGAUR-2021-SGR-0003"],"award-info":[{"award-number":["AGAUR-2021-SGR-0003"]}]},{"award":["AGAUR-2021-SGR-0003"],"award-info":[{"award-number":["AGAUR-2021-SGR-0003"]}],"id":[{"id":"https:\/\/ror.org\/01n4pqe45","id-type":"ROR","asserted-by":"publisher"}]},{"name":"INVESTIGO Program from the URV, AGAUR and Plan de Recuperaci\u00f3n, Transformaci\u00f3n y Resiliencia","award":["2023POST-INV-10"],"award-info":[{"award-number":["2023POST-INV-10"]}]},{"name":"Mart\u00ed Franqu\u00e9s d\u2019Ajuts a la Investigaci\u00f3 Program from the URV","award":["2023PMF-PIPF-17"],"award-info":[{"award-number":["2023PMF-PIPF-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Metabolically dysfunction-associated steatotic liver disease (MASLD) is a growing public health challenge linked to obesity and metabolic dysregulation. Since pharmacological options are limited, Mediterranean (MED) and DASH patterns are recommended. These diets include animal-derived foods, providing essential nutrients but also potential saturated fats. Objective: This updated systematic review aims to evaluate evidence from randomized controlled trials (RCTs) regarding the effects of specific animal-based foods on metabolic, hepatic, and anthropometric outcomes in adults with MASLD. Methods: A systematic search of nine databases (including PubMed, Scopus, and Embase) and trial registries (ClinicalTrials.gov) was conducted for RCTs published between January 2020 and 31 March 2026. Participants were adults (18\u201365 years) with MASLD. Interventions included animal-derived foods typical of MED\/DASH. Outcomes focused on hepatic function, lipid profiles, glycemic control, and anthropometry. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Results: A total of seven RCTs demonstrated food-specific and heterogeneous effects. Freshwater fish and vitamin D-fortified probiotic yogurt showed consistent benefits for glycemic control and lipid profiles. Fish oil and omega-3 supplementation led to modest improvements in lipids and hepatic markers. Ghee intake was linked with improved total cholesterol and liver enzyme (ALP). Red meat demonstrated heterogeneous effects depending on dose and background dietary pattern. Most studies exhibited limited concerns regarding risk of bias. Discussion: Animal-based foods within MED\/DASH patterns exert distinct effects in MASLD. Freshwater fish and fortified yogurt appear most beneficial. The evidence is limited by small sample sizes in specific food categories and variability in dietary assessment methods. These findings support nuanced, evidence-based recommendations for MASLD management.<\/jats:p>","DOI":"10.3390\/nu18101508","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:35:43Z","timestamp":1778528143000},"page":"1508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Animal-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities: A Systematic Review of Randomized Controlled Trials (2020\u20132026)"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-0672","authenticated-orcid":false,"given":"Joanna Michalina","family":"Jurek","sequence":"first","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"},{"name":"Department of Biostatistics and Translational Medicine, Medical University of Lodz, Mazowiecka 15, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Zablocka-Slowinska","sequence":"additional","affiliation":[{"name":"The Faculty of Finance and Management, WSB Merito University Wroclaw, Fabryczna 29\/31, 53-609 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-3523","authenticated-orcid":false,"given":"Joanna","family":"Pieczynska","sequence":"additional","affiliation":[{"name":"Department of Dietetics and Bromatology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-0901","authenticated-orcid":false,"given":"Anna","family":"Lipert","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Diseases Prevention Laboratory, Department of Preventive Medicine, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0001-1866","authenticated-orcid":false,"given":"Helena","family":"Clavero-Mestres","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-6428","authenticated-orcid":false,"given":"Teresa","family":"Auguet","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"},{"name":"Servei Medicina Interna, Hospital Universitari de Tarragona Joan XXIII, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2025","journal-title":"Clin. 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