{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:25:50Z","timestamp":1791822350526,"version":"4.3.4"},"reference-count":190,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Colorectal cancer (CRC) is a multifactorial disease arising from dynamic interactions between gut microbiota, inflammatory processes, metabolic reprogramming, and dysregulated host signaling pathways. Increasing evidence highlights the potential of synbiotics\u2014combinations of probiotics and prebiotics\u2014as promising modulators of these processes. This review explores the mechanisms by which synbiotics influence CRC development and progression, integrating data from preclinical and clinical studies. Synbiotics exert beneficial effects by restoring microbial balance, enhancing the production of short-chain fatty acids (SCFAs), strengthening intestinal barrier integrity, and reducing chronic inflammation and oxidative stress. These functional changes converge on key molecular pathways, including Wnt\/\u03b2-catenin, NF-\u03baB, and PI3K\/Akt\/mTOR, which regulate tumor cell proliferation, survival, and immune responses. Preclinical studies consistently demonstrate anti-tumor effects, including reduced tumor growth, increased apoptosis, and modulation of the tumor microenvironment. Clinical evidence suggests that synbiotics may improve postoperative outcomes, reduce chemotherapy-related toxicity, and positively influence microbiome composition, although results remain heterogeneous. Emerging approaches focusing on microbiome profiling and personalized synbiotic interventions offer new opportunities for precision medicine in CRC. Overall, synbiotics represent a promising adjunctive strategy in colorectal cancer management, with potential to enhance therapeutic efficacy and improve patient outcomes. Further large-scale clinical studies are needed to validate their long-term benefits and establish standardized treatment protocols.<\/jats:p>","DOI":"10.3390\/nu18101591","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:56:27Z","timestamp":1779094587000},"page":"1591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synbiotics as a Microbiome-Based Strategy in Colorectal Cancer"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-5775","authenticated-orcid":false,"given":"Lucia Maria","family":"Procopciuc","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-3161","authenticated-orcid":false,"given":"Adrina Corina","family":"Hangan","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-4760","authenticated-orcid":false,"given":"Roxana Liana","family":"Lucaciu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref_5","unstructured":"GBD 2019 Colorectal Cancer Collaborators (2022). Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol. Hepatol., 7, 627\u2013647."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101174","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Transl. Oncol."},{"key":"ref_7","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107785","DOI":"10.4240\/wjgs.v17.i8.107785","article-title":"Surgical treatment of colorectal cancer: A multidimensional review","volume":"17","author":"Mao","year":"2025","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ags3.12853","article-title":"Essential updates 2022-2023: Surgical and adjuvant therapies for locally advanced colorectal cancer","volume":"8","author":"Kajiwara","year":"2024","journal-title":"Ann. Gastroenterol. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Oh, J.M., Kim, S., Tsung, C., Kent, E., Jain, A., Ruff, S.M., and Zhang, H. (2025). Comprehensive review of the resistance mechanisms of colorectal cancer classified by therapy type. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1571731"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Adeleke, A., Adebayo, A.S., Agbaje, K., Olajubutu, O., and Adesina, S.K. (2025). Colorectal cancer: Therapeutic approaches and their complications. Biomedicines, 13.","DOI":"10.20944\/preprints202506.0111.v1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.14218\/ERHM.2023.00008","article-title":"Immunotherapy in colorectal cancer: A review","volume":"9","author":"Colombo","year":"2024","journal-title":"Explor. Res. Hypothesis Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12935-026-04177-7","article-title":"Advances in immunotherapy for colorectal cancer: Overcoming resistance in mismatch repair-proficient tumors","volume":"26","author":"Keivany","year":"2026","journal-title":"Cancer Cell Int."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ji, K., Jia, H., Liu, Z., Yu, G., Wen, R., Zhang, T., Peng, Z., Man, W., Tian, Y., and Wang, C. (2025). New insight in immunotherapy and combine therapy in colorectal cancer. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1453630"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.5306\/wjco.v15.i9.1136","article-title":"Colorectal cancer: Recent advances in management and treatment","volume":"15","author":"Fadlallah","year":"2024","journal-title":"World J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41575-019-0209-8","article-title":"Gut microbiota in colorectal cancer: Mechanisms of action and clinical applications","volume":"16","author":"Wong","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-020-2080-8","article-title":"Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli","volume":"580","author":"Puschhof","year":"2020","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41591-019-0377-7","article-title":"The microbiome, cancer, and cancer therapy","volume":"25","author":"Helmink","year":"2019","journal-title":"Nat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrgastro.2017.20","article-title":"Gut microbiota modulation of chemotherapy efficacy and toxicity","volume":"14","author":"Alexander","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","article-title":"The international scientific association for probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics","volume":"17","author":"Swanson","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41586-020-2729-3","article-title":"Host-microbiota maladaptation in colorectal cancer","volume":"585","author":"Janney","year":"2020","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/ajcn\/85.2.488","article-title":"Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients","volume":"85","author":"Rafter","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"k2179","DOI":"10.1136\/bmj.k2179","article-title":"Role of the gut microbiota in nutrition and health","volume":"361","author":"Valdes","year":"2018","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-016-0307-y","article-title":"The healthy human microbiome","volume":"8","author":"Huttenhower","year":"2016","journal-title":"Genome Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","article-title":"You are what you eat: Diet, health and the gut microbiota","volume":"16","author":"Zmora","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: Metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.micpath.2016.02.005","article-title":"Akkermansia muciniphila and its role in regulating host functions","volume":"106","author":"Derrien","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/ismej.2011.212","article-title":"The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates","volume":"6","author":"Zoetendal","year":"2012","journal-title":"ISME J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"16062","DOI":"10.3748\/wjg.v20.i43.16062","article-title":"Archaea and the human gut: New beginning of an old story","volume":"20","author":"Gaci","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2019.01.017","article-title":"Bacteriophages of the human gut: The \u201cknown unknown\u201d of the microbiome","volume":"25","author":"Shkoporov","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_36","first-page":"331","article-title":"The gut mycobiota: Insights into analysis, environmental interactions and role in gastrointestinal diseases","volume":"16","author":"Richard","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Human Microbiome Project Consortium (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207\u2013214.","DOI":"10.1038\/nature11234"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","article-title":"Human genetics shape the gut microbiome","volume":"159","author":"Goodrich","year":"2014","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1002329","DOI":"10.37349\/etat.2025.1002329","article-title":"Dysbiosis and colorectal cancer: Conducive factors, biological and molecular role, and therapeutic prospectives","volume":"6","author":"Singh","year":"2025","journal-title":"Explor. Target. Anti-Tumor Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s12013-025-01683-9","article-title":"The gut microbiome and colorectal cancer: An integrative review of the underlying mechanisms","volume":"83","author":"Karam","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101942","DOI":"10.1016\/j.bpg.2024.101942","article-title":"Gut microbiota in inflammation and colorectal cancer: A potential toolbox for clinicians","volume":"72","author":"Grellier","year":"2024","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41586-024-07182-w","article-title":"A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche","volume":"628","author":"Minot","year":"2024","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e13872","DOI":"10.1111\/obr.13872","article-title":"Systematic review: The gut microbiota as a link between colorectal cancer and obesity","volume":"26","author":"Redondo","year":"2025","journal-title":"Obes. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/\u03b2-catenin signaling","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm.2015","article-title":"A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses","volume":"15","author":"Wu","year":"2009","journal-title":"Nat. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.chom.2014.02.007","article-title":"Microbes, microbiota, and colon cancer","volume":"15","author":"Sears","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chom.2018.01.007","article-title":"Bacteroides fragilis toxin coordinates a pro-carcinogenic inflammatory cascade via targeting of colonic epithelial cells","volume":"23","author":"Chung","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Xia, S., Ma, L., Li, H., Li, Y., and Yu, L. (2025). Prevalence of enterotoxigenic Bacteroides fragilis in colorectal cancer: A systematic review and meta-analysis. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1525609"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sadeghi, M., Mestivier, D., and Sobhani, I. (2024). Contribution of pks+ Escherichia coli to colon carcinogenesis. Microorganisms, 12.","DOI":"10.3390\/microorganisms12061111"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"122462","DOI":"10.1016\/j.lfs.2024.122462","article-title":"Prevalence and implications of pKs-positive Escherichia coli in colorectal cancer","volume":"341","author":"Cavalcanti","year":"2024","journal-title":"Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhang, G., and Sun, D. (2024). The synthesis of the novel Escherichia coli toxin-colibactin and its mechanisms of tumorigenesis of colorectal cancer. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1501973"},{"key":"ref_53","first-page":"e96473","article-title":"A review of susceptibility factors for colibactin-associated colorectal cancer in african populations","volume":"17","author":"Badero","year":"2025","journal-title":"Cureus"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1038\/s41467-023-43329-5","article-title":"Contribution of pks+ E. coli mutations to colorectal carcinogenesis","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.tim.2025.04.010","article-title":"Physiological drivers of pks+ E. coli in colorectal cancer","volume":"33","author":"Jans","year":"2025","journal-title":"Trends Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s41564-019-0541-3","article-title":"Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity","volume":"4","author":"Long","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Bai, B., Ma, J., Xu, W., Chen, X., Chen, X., Lv, C., Su, W., Li, Y., Sun, H., and Zhang, B. (2025). Gut microbiota and colorectal cancer: Mechanistic insights, diagnostic advances, and microbiome-based therapeutic strategies. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1699893"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Dong, X., Yang, J., He, L., Fang, H., Wang, L., Zhu, J., Xu, J., Song, K., and Xuan, Z. (2026). The barrier\u2013microbiota\u2013inflammation axis in colorectal cancer: Mechanisms and emerging diagnostic & therapeutic strategies. Cancers, 18.","DOI":"10.3390\/cancers18040576"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1186\/s40001-024-02168-w","article-title":"NF-\u03baB pathway and angiogenesis: Insights into colorectal cancer development and therapeutic targets","volume":"29","author":"Bahrami","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/s40001-025-02734-w","article-title":"NF-\u03baB and apoptosis: Colorectal cancer progression and novel strategies for treatment","volume":"30","author":"Sadati","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00262-025-04118-9","article-title":"Gut modulation to regulate NF-\u03baB in colorectal and gastric cancer therapy and inflammation","volume":"74","author":"Kearns","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3892\/ol.2024.14390","article-title":"Advances in molecular mechanisms of inflammatory bowel disease-associated colorectal cancer (Review)","volume":"27","author":"Wang","year":"2024","journal-title":"Oncol. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Alhinai, E.A., Walton, G.E., and Commane, D.M. (2019). The role of the gut microbiota in colorectal cancer causation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215295"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pastorelli, L., De Salvo, C., Mercado, J.R., Vecchi, M., and Pizarro, T.T. (2013). Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00280"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature11465","article-title":"Adenoma-linked barrier defects and microbial products drive IL-23\/IL-17-mediated tumour growth","volume":"491","author":"Grivennikov","year":"2012","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"271ps1","DOI":"10.1126\/scitranslmed.3010473","article-title":"Cancer and the gut microbiota: An unexpected link","volume":"7","author":"Zitvogel","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Markowiak, P., and \u015ali\u017cewska, K. (2017). Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients, 9.","DOI":"10.3390\/nu9091021"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Smolinska, S., Popescu, F.D., and Zemelka-Wiacek, M. (2025). A review of the influence of prebiotics, probiotics, synbiotics, and postbiotics on the human gut microbiome and intestinal integrity. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113673"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: Metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"He, Y., Peng, K., Tan, J., Hao, Y., Zhang, S., Gao, C., and Li, L. (2025). Short-chain fatty acids and colorectal cancer: A systematic review and integrative bayesian meta-analysis of microbiome\u2013metabolome interactions and intervention efficacy. Nutrients, 17.","DOI":"10.3390\/nu17223552"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Moreira, M.M., Carri\u00e7o, M., Capelas, M.L., Pimenta, N., Santos, T., Ganh\u00e3o-Arranhado, S., M\u00e4kitie, A., and Ravasco, P. (2024). The impact of pre-, pro- and synbiotics supplementation in colorectal cancer treatment: A systematic review. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1395966"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"46","DOI":"10.20517\/mrr.2024.48","article-title":"Synergistic vs. complementary synbiotics: The complexity of discriminating synbiotic concepts using a Lactiplantibacillus plantarum exemplary study","volume":"3","author":"Kleerebezem","year":"2024","journal-title":"Microbiome Res. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Al-Habsi, N., Al-Khalili, M., Haque, S.A., Elias, M., Olqi, N.A., and Al Uraimi, T. (2024). health benefits of prebiotics, probiotics, synbiotics, and postbiotics. Nutrients, 16.","DOI":"10.3390\/nu16223955"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1093\/nutrit\/nuae002","article-title":"The effect of oral synbiotics on the gut microbiota and inflammatory biomarkers in healthy adults: A systematic review and meta-analysis","volume":"83","author":"Cosier","year":"2025","journal-title":"Nutr. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.aninu.2024.05.001","article-title":"Double-side role of short chain fatty acids on host health via the gut-organ axes","volume":"18","author":"Gao","year":"2024","journal-title":"Anim. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Parada Venegas, D., De la Fuente, M.K., Landskron, G., Gonz\u00e1lez, M.J., Quera, R., Dijkstra, G., Harmsen, H.J.M., Faber, K.N., and Hermoso, M.A. (2019). Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01486"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-017-02651-5","article-title":"Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases","volume":"9","author":"Fellows","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3748\/wjg.v17.i12.1519","article-title":"Potential beneficial effects of butyrate in intestinal and extraintestinal diseases","volume":"17","author":"Canani","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12929-018-0483-8","article-title":"Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: Exploring a common ground hypothesis","volume":"25","author":"Yu","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","article-title":"Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer","volume":"15","author":"Johnson","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri.2016.36","article-title":"Development and maintenance of intestinal regulatory T cells","volume":"16","author":"Tanoue","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Kezer, G., Paramithiotis, S., Khwaldia, K., Harahap, I.A., \u010cagalj, M., \u0160imat, V., Smaoui, S., Elfalleh, W., Ozogul, F., and Esatbeyoglu, T. (2025). A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1651965"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/1751-2980.13247","article-title":"Efficacy and safety of probiotics, prebiotics, and synbiotics for the prevention of colorectal cancer and precancerous lesion in high-risk populations: A systematic review and meta-analysis of randomized controlled trials","volume":"25","author":"Kan","year":"2024","journal-title":"J. Dig. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e71146","DOI":"10.1096\/fj.202502118R","article-title":"Microbial therapeutics in cancer: Translating probiotics, prebiotics, synbiotics, and postbiotics from mechanistic insights to clinical applications: A topical review","volume":"39","author":"Tegegne","year":"2025","journal-title":"FASEB J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41430-024-01542-5","article-title":"Efficacy of probiotics or synbiotics supplementation on chemotherapy-induced complications and gut microbiota dysbiosis in gastrointestinal cancer: A systematic review and meta-analysis","volume":"79","author":"Yao","year":"2025","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/j.gastro.2014.12.035","article-title":"Nutrients, foods, and colorectal cancer prevention","volume":"148","author":"Song","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Paduraru, D.N., Palcau, A.C., Dinca, V.G., Ciuc, D.M., and Constantinescu, A. (2025). The role of gut microbiota in colorectal cancer pathogenesis: A comprehensive literature review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262411870"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrgastro.2016.165","article-title":"Diet, microorganisms and their metabolites, and colon cancer","volume":"13","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1126\/science.aar6918","article-title":"The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies","volume":"359","author":"Zitvogel","year":"2018","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Gao, S., Liao, X., He, Y., and Yang, J. (2025). Probiotics\/synbiotics supplementation reduce the infection incidence in patients undergoing resection for colorectal cancer: An umbrella review. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1635409"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"the impact of dietary fiber on gut microbiota in host health and disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.phrs.2012.10.020","article-title":"The influence of diet on the gut microbiota","volume":"69","author":"Scott","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"R\u00edos-Covi\u00e1n, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., de Los Reyes-Gavil\u00e1n, C.G., and Salazar, N. (2016). Intestinal short chain fatty acids and their link with diet and human health. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00185"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0016-5085(82)80339-9","article-title":"Utilization of nutrients by isolated epithelial cells of the rat colon","volume":"83","author":"Roediger","year":"1982","journal-title":"Gastroenterology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.molcel.2012.08.033","article-title":"The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation","volume":"48","author":"Donohoe","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jnutbio.2007.08.002","article-title":"Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon","volume":"19","author":"Waldecker","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0959-437X(99)80026-4","article-title":"Histone acetylation and cancer","volume":"9","author":"Archer","year":"1999","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1053\/gast.1997.v113.pm9247468","article-title":"Short-chain fatty acids promote the migration of colonic epithelial cells in vitro","volume":"113","author":"Wilson","year":"1997","journal-title":"Gastroenterology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jcb.22185","article-title":"Histone deacetylase inhibitors: Potential in cancer therapy","volume":"107","author":"Marks","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1053\/j.gastro.2007.09.008","article-title":"Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors","volume":"133","author":"Fukata","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Malki, A., El Ruz, R.A., Gupta, I., Allouch, A., Vranic, S., and Al Moustafa, A.E. (2020). Molecular mechanisms of colon cancer progression and metastasis: Recent insights and advancements. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010130"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.07.013","article-title":"IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer","volume":"118","author":"Greten","year":"2004","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8063647","DOI":"10.1155\/2018\/8063647","article-title":"Immunomodulatory effects of probiotics on cytokine profiles","volume":"2018","author":"Azad","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1093\/advances\/nmy063","article-title":"Mechanisms of action of probiotics","volume":"10","author":"Gil","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","article-title":"TLR signaling","volume":"19","author":"Kawai","year":"2007","journal-title":"Semin. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes. Dev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-\u03baB signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/gut.47.3.397","article-title":"Butyrate inhibits inflammatory responses through NFkappaB inhibition: Implications for Crohn\u2019s disease","volume":"47","author":"Segain","year":"2000","journal-title":"Gut"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0016-5085(00)70142-9","article-title":"The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line","volume":"118","author":"Inan","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2485S","DOI":"10.1093\/jn\/133.7.2485S","article-title":"Inhibition of histone deacetylase activity by butyrate","volume":"133","author":"Davie","year":"2003","journal-title":"J. Nutr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nutres.2008.02.012","article-title":"Butyrate and trichostatin A attenuate nuclear factor \u03baB activation and tumor necrosis factor \u03b1 secretion and increase prostaglandin E2 secretion in human epithelial cells","volume":"28","author":"Usami","year":"2008","journal-title":"Nutr. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrd2781","article-title":"Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls","volume":"8","author":"Baud","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","article-title":"NF-\u03baB and the link between inflammation and cancer","volume":"246","author":"DiDonato","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cgh.2018.07.012","article-title":"Environmental factors, gut microbiota, and colorectal cancer prevention","volume":"17","author":"Song","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/gut.52.1.94","article-title":"Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway","volume":"52","author":"Ruemmele","year":"2003","journal-title":"Gut"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.tcb.2008.01.007","article-title":"How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?","volume":"18","author":"Chipuk","year":"2008","journal-title":"Trends Cell Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e13265","DOI":"10.1111\/eci.13265","article-title":"Vitamin D and the insulin-like growth factor system: Implications for colorectal neoplasia","volume":"50","author":"Ciulei","year":"2020","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_132","first-page":"711","article-title":"Lys751Gln XPD and Arg399Gln XRCC1 in Romanians. Association with sporadic colorectal cancer risk and different stages of carcinomas","volume":"108","author":"Procopciuc","year":"2013","journal-title":"Chirurgia"},{"key":"ref_133","first-page":"251","article-title":"MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer","volume":"16","author":"Osian","year":"2007","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ccell.2018.03.004","article-title":"The intestinal microbiota in colorectal cancer","volume":"33","author":"Tilg","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.2174\/1381612825666190215121712","article-title":"Oxidative stress and cancer","volume":"24","author":"Klaunig","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nrc3610","article-title":"The microbiome and cancer","volume":"13","author":"Schwabe","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Bischoff, S.C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.D., Serino, M., Tilg, H., Watson, A., and Wells, J.M. (2014). Intestinal permeability\u2014A new target for disease prevention and therapy. BMC Gastroenterol., 14.","DOI":"10.1186\/s12876-014-0189-7"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/beta-catenin signaling in development and disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrc2389","article-title":"Wnt signalling and its impact on development and cancer","volume":"8","author":"Klaus","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: Components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00281-012-0352-6","article-title":"Inflammation and colorectal cancer: Colitis-associated neoplasia","volume":"35","author":"Grivennikov","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","article-title":"Signaling pathways involved in colorectal cancer: Pathogenesis and targeted therapy","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2483780","DOI":"10.1080\/19490976.2025.2483780","article-title":"The impact of gut microbial short-chain fatty acids on colorectal cancer development and prevention","volume":"17","author":"Thulasinathan","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3892\/ijo.2024.5632","article-title":"Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)","volume":"64","author":"Sun","year":"2024","journal-title":"Int. J. Oncol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","article-title":"Inflammation meets cancer, with NF-\u03baB as the matchmaker","volume":"12","author":"Karin","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","article-title":"NF-kappaB and cancer-identifying targets and mechanisms","volume":"18","author":"Naugler","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: Microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/nu3100858","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: How are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Zolfanelli, C., Lauciello, V., Di Ciancia, A., Vagliasindi, A., Varzakas, T., and D\u2019Amore, T. (2026). Short-chain fatty acids as functional postbiotics in colorectal cancer management. Biol. Life Sci. Forum, 56.","DOI":"10.3390\/blsf2026056005"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Dong, Y., Zhang, K., Wei, J., Ding, Y., Wang, X., Hou, H., Wu, J., Liu, T., Wang, B., and Cao, H. (2023). Gut microbiota-derived short-chain fatty acids regulate gastrointestinal tumor immunity: A novel therapeutic strategy?. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1158200"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Porta, C., Paglino, C., and Mosca, A. (2014). Targeting PI3K\/Akt\/mTOR signaling in cancer. Front. Oncol., 4.","DOI":"10.3389\/fonc.2014.00064"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: A nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ccr.2012.11.014","article-title":"Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors","volume":"23","author":"Schwitalla","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1074\/jbc.M611871200","article-title":"Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity","volume":"282","author":"Fang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1038\/s41388-020-1341-1","article-title":"Gut microbiota modulation: A novel strategy for prevention and treatment of colorectal cancer","volume":"39","author":"Fong","year":"2020","journal-title":"Oncogene"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/carcin\/bgp197","article-title":"Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats","volume":"31","author":"Hu","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Uccello, M., Malaguarnera, G., Basile, F., D\u2019agata, V., Malaguarnera, M., Bertino, G., Vacante, M., Drago, F., and Biondi, A. (2012). Potential role of probiotics on colorectal cancer prevention. BMC Surg., 12.","DOI":"10.1186\/1471-2482-12-S1-S35"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Thoda, C., and Touraki, M. (2025). Molecular mechanisms of probiotic action against gastrointestinal cancers. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26167857"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1007\/s12602-024-10405-1","article-title":"Probiotic mixture attenuates colorectal tumorigenesis in murine AOM\/DSS model by suppressing STAT3, inducing apoptotic p53 and modulating gut microbiota","volume":"17","author":"Leung","year":"2025","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Shang, F., Jiang, X., Wang, H., Guo, S., Kang, S., Xu, B., Wang, X., Chen, S., Li, N., and Liu, B. (2024). Bifidobacterium longum suppresses colorectal cancer through the modulation of intestinal microbes and immune function. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1327464"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhang, P., Li, S., Yu, T., Lai, X., and He, Y. (2024). Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM\/DSS in mice. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1382781"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41538-024-00307-5","article-title":"A probiotic Limosilactobacillus fermentum GR-3 mitigates colitis-associated tumorigenesis in mice via modulating gut microbiome","volume":"8","author":"Zhou","year":"2024","journal-title":"npj Sci. Food"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"108319","DOI":"10.1016\/j.fbio.2026.108319","article-title":"Lactobacillus plantarum Zhang-LL alleviates colorectal cancer through the gut microbiome-arachidonic acid metabolism-intratumoral microbiota axis under antibiotic-driven intestinal dysbiosis","volume":"76","author":"Zhu","year":"2026","journal-title":"Food Biosci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcancer.2011.12.005","article-title":"Cancer-related inflammation: Common themes and therapeutic opportunities","volume":"22","author":"Balkwill","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4216722","DOI":"10.1155\/bmri\/4216722","article-title":"Lactobacillus casei\u2019s antitumor potential in colorectal cancer: Exploring mechanisms\u2014A systematic review","volume":"2025","author":"Abdorrashidi","year":"2025","journal-title":"BioMed Res. Int."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Niechcial, A., Schwarzfischer, M., Wawrzyniak, P., Determann, M., P\u00f6hlmann, D., Wawrzyniak, M., Gueguen, E., Walker, M.R., Morsy, Y., and Atrott, K. (2025). Probiotic administration modulates gut microbiota and suppresses tumor growth in murine models of colorectal cancer. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094404"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Ma, F., Sun, M., Song, Y., Wang, A., Jiang, S., Qian, F., Mu, G., and Tuo, Y. (2022). Lactiplantibacillus plantarum-12 alleviates inflammation and colon cancer symptoms in AOM\/DSS-treated mice through modulating the intestinal microbiome and metabolome. Nutrients, 14.","DOI":"10.3390\/nu14091916"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/annonc\/mdu106","article-title":"The efficacy and safety of probiotics in people with cancer: A systematic review","volume":"25","author":"Redman","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41522-025-00818-3","article-title":"Harnessing gut microbiota for colorectal cancer therapy: From clinical insights to therapeutic innovations","volume":"11","author":"Chen","year":"2025","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.18632\/oncotarget.7045","article-title":"The effect of perioperative probiotics treatment for colorectal cancer: Short-term outcomes of a randomized controlled trial","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.ctim.2013.08.018","article-title":"Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy","volume":"21","author":"Mego","year":"2013","journal-title":"Complement. Ther. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6603990","article-title":"Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: A randomised study","volume":"97","author":"Osterlund","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Ding, H., Zhang, C., Yu, L., Tian, F., Chen, W., and Zhai, Q. (J. Future Foods, 2026). Probiotic or synbiotic interventions and chemotherapy-associated diarrhea in cancer patients: A meta-analysis of randomized trials, J. Future Foods, in press.","DOI":"10.1016\/j.jfutfo.2025.12.010"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1016\/j.tjnut.2025.09.005","article-title":"A prebiotic-supplemented formula improves gut microbiota and intestinal inflammatory microenvironment in patients with colorectal adenoma: A double-blind, placebo-controlled trial","volume":"155","author":"Meng","year":"2025","journal-title":"J. Nutr."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clnu.2025.03.025","article-title":"Synbiotics protected radiation-induced tissue damage in rectal cancer patients: A controlled trial","volume":"49","author":"Stene","year":"2025","journal-title":"Clin. Nutr."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MAJ.0b013e31823aace6","article-title":"Preoperative probiotics decrease postoperative infectious complications of colorectal cancer","volume":"343","author":"Zhang","year":"2012","journal-title":"Am. J. Med. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1007\/s00268-015-3071-z","article-title":"A four-probiotics regimen reduces postoperative complications after colorectal surgery: A randomized, double-blind, placebo-controlled study","volume":"39","author":"Kotzampassi","year":"2015","journal-title":"World J. Surg."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Murovec, B., Deutsch, L., and Stres, B. (2024). Predictive modeling of colorectal cancer using exhaustive analysis of microbiome information layers available from public metagenomic data. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1426407"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Negrut, R.L., Cote, A., and Maghiar, A.M. (2023). Exploring the Potential of Oral Microbiome Biomarkers for Colorectal Cancer Diagnosis and Prognosis: A Systematic Review. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061586"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tim.2022.08.010","article-title":"Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer","volume":"31","author":"Wang","year":"2023","journal-title":"Trends Microbiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41522-025-00838-z","article-title":"Fusobacterium in the microbiome: From health to disease across the oral\u2013gut axis and beyond","volume":"11","author":"Li","year":"2025","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"123462","DOI":"10.1016\/j.lfs.2025.123462","article-title":"Oral microbiota in colorectal cancer: Unraveling mechanisms and application potential","volume":"365","author":"Zhang","year":"2025","journal-title":"Life Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrmicro.2016.17","article-title":"The microbial pharmacists within us: A metagenomic view of xenobiotic metabolism","volume":"14","author":"Spanogiannopoulos","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"The Integrative HMP (iHMP) Research Network Consortium (2019). The integrative human microbiome project. Nature, 569, 641\u2013648.","DOI":"10.1038\/s41586-019-1238-8"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/10\/1591\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:14:16Z","timestamp":1779095656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/10\/1591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":190,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["nu18101591"],"URL":"https:\/\/doi.org\/10.3390\/nu18101591","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]}}}