{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:41:46Z","timestamp":1790116906947,"version":"4.0.1"},"reference-count":135,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic inflammation is a well-established risk factor for cancer progression. This review aims to determine how persistent inflammatory signaling reshapes the tissue microenvironment to favor tumor cell proliferation, survival, and progression. It also discusses the role of cytokines such as IL-6 and TGF-\u03b2, reactive oxygen species (ROS), and the transcription factors NF-\u03baB and STAT3 in inflammation and in the tumor microenvironment. Sustained activation of these pathways promotes genomic instability, loss of tumor suppressor gene function, enhanced oncogene expression, and resistance to apoptosis, collectively facilitating malignant transformation and tumor development. The key novelty of this review lies in integrating these interconnected networks with new evidence to clarify how they drive cancer initiation and progression. Furthermore, we discuss the therapeutic potential of plant-derived bioactive compounds, with a particular emphasis on curcumin. Curcumin exhibits significant anti-inflammatory and anticancer effects through inhibition of NF-\u03baB and STAT3 signaling and its downstream targets, thereby attenuating inflammation-driven tumorigenesis. However, its clinical application is limited by poor bioavailability. Finally, this review highlights current strategies to overcome these limitations and future directions for optimizing curcumin-based interventions in inflammation-associated diseases.<\/jats:p>","DOI":"10.3390\/nu18101636","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:06:07Z","timestamp":1779365167000},"page":"1636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Curcumin and Cancer-Related Inflammation"],"prefix":"10.3390","volume":"18","author":[{"given":"Kaitlyn","family":"LeBlanc","sequence":"first","affiliation":[{"name":"Cancer Prevention Laboratory, Southeastern Louisiana University, Hammond, LA 70403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilee","family":"Brewer","sequence":"additional","affiliation":[{"name":"Cancer Prevention Laboratory, Southeastern Louisiana University, Hammond, LA 70403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0310-2765","authenticated-orcid":false,"given":"Sita","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Cancer Prevention Laboratory, Southeastern Louisiana University, Hammond, LA 70403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/MS9.0000000000000424","article-title":"Tumour necrosis factor-alpha levels as predictor factor on clinical response of anthracycline-based neoadjuvant chemotherapy in locally advance breast cancer patients: Experimental research","volume":"85","author":"Adrian","year":"2023","journal-title":"Ann. Med. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zhang, M., Zhang, Y.Y., Chen, Y., Wang, J., Wang, Q., and Lu, H. (2021). TGF-beta Signaling and Resistance to Cancer Therapy. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.786728"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s12672-025-03644-3","article-title":"Role of interleukin-6 in resistance to tumor therapy","volume":"16","author":"Liang","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajpath.2011.10.003","article-title":"Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min\/+) mice","volume":"180","author":"Woo","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"189175","DOI":"10.1016\/j.bbcan.2024.189175","article-title":"ROS: A \u201cbooster\u201d for chronic inflammation and tumor metastasis","volume":"1879","author":"Chen","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-kappaB and STAT3\u2013key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer","volume":"21","author":"Grivennikov","year":"2010","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16059","DOI":"10.1038\/s41598-024-66945-7","article-title":"Curcumin synergistically enhances the efficacy of gemcitabine against gemcitabine-resistant cholangiocarcinoma via the targeting LAT2\/glutamine pathway","volume":"14","author":"Thongpon","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10549-009-0612-x","article-title":"Targeting breast stem cells with the cancer preventive compounds curcumin and piperine","volume":"122","author":"Kakarala","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zoi, V., Galani, V., Lianos, G.D., Voulgaris, S., Kyritsis, A.P., and Alexiou, G.A. (2021). The Role of Curcumin in Cancer Treatment. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091086"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1158\/1078-0432.CCR-08-0024","article-title":"Phase II trial of curcumin in patients with advanced pancreatic cancer","volume":"14","author":"Dhillon","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1002340","DOI":"10.37349\/etat.2025.1002340","article-title":"Synergistic anticancer efficacy of optimized curcumin-piperine loaded magnetic nanoparticles for the treatment of colorectal cancer","volume":"6","author":"Puri","year":"2025","journal-title":"Explor. Target. Antitumor Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.immuni.2019.03.026","article-title":"Targeting Interleukin-6 Signaling in Clinic","volume":"50","author":"Kang","year":"2019","journal-title":"Immunity"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/1873-3468.14220","article-title":"Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer","volume":"596","year":"2022","journal-title":"FEBS Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1007\/s13277-016-5098-7","article-title":"Role of interleukin-6 in cancer progression and therapeutic resistance","volume":"37","author":"Kumari","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Manore, S.G., Doheny, D.L., Wong, G.L., and Lo, H.W. (2022). IL-6\/JAK\/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.866014"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/gutjnl-2019-319200","article-title":"STAT3 activation through IL-6\/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis","volume":"69","author":"Heichler","year":"2020","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/carcin\/bgr075","article-title":"Mesothelin overexpression promotes autocrine IL-6\/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation","volume":"32","author":"Bharadwaj","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jcla.21828","article-title":"Correlations Between Serum IL-6 Levels and Radiation Pneumonitis in Lung Cancer Patients: A Meta-Analysis","volume":"30","author":"Fu","year":"2016","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"152565","DOI":"10.1016\/j.prp.2019.152565","article-title":"Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib","volume":"215","author":"Yang","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cytogfr.2025.01.003","article-title":"Insights into IL-6\/JAK\/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy","volume":"85","author":"Thuya","year":"2025","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in Cancer","volume":"134","author":"Massague","year":"2008","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"a021873","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-beta and the TGF-beta Family: Context-Dependent Roles in Cell and Tissue Physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Saito, A., Horie, M., Micke, P., and Nagase, T. (2018). The Role of TGF-beta Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113611"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Boguslawska, J., Kryst, P., Poletajew, S., and Piekielko-Witkowska, A. (2019). TGF-beta and microRNA Interplay in Genitourinary Cancers. Cells, 8.","DOI":"10.3390\/cells8121619"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1111\/cas.15081","article-title":"Improving function of cytotoxic T-lymphocytes by transforming growth factor-beta inhibitor in oral squamous cell carcinoma","volume":"112","author":"Kondo","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.canlet.2018.01.036","article-title":"Long non-coding RNA XIST promotes TGF-beta-induced epithelial-mesenchymal transition by regulating miR-367\/141-ZEB2 axis in non-small-cell lung cancer","volume":"418","author":"Li","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14065","DOI":"10.18632\/aging.203024","article-title":"TCF-3-mediated transcription of lncRNA HNF1A-AS1 targeting oncostatin M expression inhibits epithelial-mesenchymal transition via TGFbeta signaling in gastroenteropancreatic neuroendocrine neoplasms","volume":"13","author":"Xue","year":"2021","journal-title":"Aging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/sj.bjc.6602141","article-title":"Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer","volume":"91","author":"Aoyagi","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molmed.2017.11.002","article-title":"Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer","volume":"24","author":"Annibaldi","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrd3930","article-title":"Clinical targeting of the TNF and TNFR superfamilies","volume":"12","author":"Croft","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0171-2985(96)80017-9","article-title":"TNF-alpha-induced regulation and signalling in macrophages","volume":"195","author":"Riches","year":"1996","journal-title":"Immunobiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1189\/jlb.0703343","article-title":"LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK\/ERK pathway","volume":"75","author":"Kirchner","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2005.02143.x","article-title":"The intriguing biology of the tumour necrosis factor\/tumour necrosis factor receptor superfamily: Players, rules and the games","volume":"115","author":"Hehlgans","year":"2005","journal-title":"Immunology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80252-6","article-title":"TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex","volume":"4","author":"Hsu","year":"1996","journal-title":"Immunity"},{"key":"ref_37","first-page":"2441","article-title":"Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation","volume":"21","author":"Siakavellas","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/ijc.20333","article-title":"Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling","volume":"111","author":"Aggarwal","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1182\/blood-2015-01-624833","article-title":"Transmembrane TNF-alpha preferentially expressed by leukemia stem cells and blasts is a potent target for antibody therapy","volume":"126","author":"Zhou","year":"2015","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"81110","DOI":"10.18632\/oncotarget.13212","article-title":"Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1158\/0008-5472.CAN-12-3946","article-title":"Targeting transmembrane TNF-alpha suppresses breast cancer growth","volume":"73","author":"Yu","year":"2013","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/stem.2339","article-title":"Tumor Necrosis Factor alpha Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB","volume":"34","author":"Prisco","year":"2016","journal-title":"Stem Cells"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/art.23447","article-title":"Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: Comparison among infliximab, etanercept, and adalimumab","volume":"58","author":"Mitoma","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_44","first-page":"9","article-title":"Defining ROS in Biology and Medicine","volume":"1","author":"Li","year":"2016","journal-title":"React. Oxyg. Species"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1046\/j.1432-1327.2000.01701.x","article-title":"Physiological functions of thioredoxin and thioredoxin reductase","volume":"267","author":"Arner","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.semcancer.2006.10.009","article-title":"The thioredoxin system in cancer","volume":"16","author":"Arner","year":"2006","journal-title":"Semin. Cancer Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature13152","article-title":"NRROS negatively regulates reactive oxygen species during host defence and autoimmunity","volume":"509","author":"Noubade","year":"2014","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jrr\/rrz080","article-title":"Oxidation resistance 1 prevents genome instability through maintenance of G2\/M arrest in gamma-ray-irradiated cells","volume":"61","author":"Matsui","year":"2020","journal-title":"J. Radiat. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"ref_51","first-page":"95","article-title":"Relationship between Optical Redox Status and Reactive Oxygen Species in Cancer Cells","volume":"9","author":"Podsednik","year":"2020","journal-title":"React. Oxyg. Species"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.7150\/jca.54699","article-title":"Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy","volume":"12","author":"Huang","year":"2021","journal-title":"J. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e12505","DOI":"10.1002\/jev2.12505","article-title":"The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress","volume":"13","author":"Ma","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ciccarese, F., and Ciminale, V. (2017). Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells. Front. Oncol., 7.","DOI":"10.3389\/fonc.2017.00117"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS Crosstalk in Inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"uxae108","DOI":"10.1093\/cei\/uxae108","article-title":"Exploring the relation between TGF-beta pathway activity and response to checkpoint inhibition in patients with metastatic melanoma","volume":"219","author":"Amir","year":"2025","journal-title":"Clin. Exp. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1166\/jnn.2015.10834","article-title":"Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells","volume":"15","author":"Vyas","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Shirmohammadi, E., Ebrahimi, S.S., Farshchi, A., and Salimi, M. (2020). The efficacy of etanercept as anti-breast cancer treatment is attenuated by residing macrophages. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07228-y"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00262-015-1684-6","article-title":"Crosstalk of carcinoembryonic antigen and transforming growth factor-beta via their receptors: Comparing human and canine cancer","volume":"64","author":"Fazekas","year":"2015","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100108","DOI":"10.1016\/j.cstres.2025.100108","article-title":"Reactive oxygen species in cancer: Mechanistic insights and therapeutic innovations","volume":"30","author":"Ma","year":"2025","journal-title":"Cell Stress Chaperones"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12672-025-01829-4","article-title":"The heat of the battle: Inflammation\u2019s role in prostate cancer development and inflammation-targeted therapies","volume":"16","author":"Sharma","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3748\/wjg.v8.i3.431","article-title":"Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: Role of reactive oxygen species","volume":"8","author":"Li","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"90","DOI":"10.21037\/atm-24-32","article-title":"Literature review: Nuclear factor kappa B (NF-kappaB) regulation in human cancers mediated by ubiquitin-specific proteases (USPs)","volume":"12","author":"Shen","year":"2024","journal-title":"Ann. Transl. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Daniels, M.A., and Teixeiro, E. (2025). The NF-kappaB signaling network in the life of T cells. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1559494"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Anilkumar, S., and Wright-Jin, E. (2024). NF-kappaB as an Inducible Regulator of Inflammation in the Central Nervous System. Cells, 13.","DOI":"10.20944\/preprints202402.0003.v1"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrd2781","article-title":"Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls","volume":"8","author":"Baud","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Islam, M.T., Chen, F.Z., Chen, H.C., and Wahid, A. (2022). Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel\u2019s activity by suppressing the NF-kB signaling pathway. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.923270"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1582-4934.2011.01388.x","article-title":"Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway","volume":"16","author":"Wang","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"26672","DOI":"10.1038\/s41598-025-12661-9","article-title":"The P4HB\/LGALS3BP\/NF-kB axis promotes the progression of MIA to IAC in lung adenocarcinoma","volume":"15","author":"Mu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_72","unstructured":"Mitrovic Ajtic, O., Suboticki, T., Diklic, M., Dikic, D., Vukotic, M., Dragojevic, T., Zivkovic, E., Antic, D., and Cokic, V. (2022). Regulation of S100As Expression by Inflammatory Cytokines in Chronic Lymphocytic Leukemia. Int. J. Mol. Sci., 23."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ceb.2003.10.005","article-title":"Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery","volume":"15","author":"Burstein","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s13046-019-1258-0","article-title":"ASC-J9(R) increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-kappaB survival signals","volume":"38","author":"Huang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1158\/1535-7163.MCT-07-0186","article-title":"The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN","volume":"6","author":"Sun","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"ref_76","unstructured":"Naeem, M., Aftab, T., and Khan, M.M.A. (2017). Vincristine and Vinblastine Anticancer Catharanthus Alkaloids: Pharmacological Applications and Strategies for Yield Improvement. Catharanthus Roseus: Current Research and Future Prospects, Springer International Publishing."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1124\/mol.105.017400","article-title":"Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation","volume":"69","author":"Aggarwal","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The Essential Medicinal Chemistry of Curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10715762.2023.2298857","article-title":"Recent advances in the antioxidant activity of metal-curcumin complexes: A combined computational and experimental review","volume":"58","author":"Mittal","year":"2024","journal-title":"Free Radic. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.4049\/jimmunol.172.10.5940","article-title":"Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis","volume":"172","author":"Bharti","year":"2004","journal-title":"J. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Hewlings, S.J., and Kalman, D.S. (2017). Curcumin: A Review of Its Effects on Human Health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4318115","DOI":"10.1155\/bmri\/4318115","article-title":"Mechanism of Curcumin in Inhibiting Proliferation of Head and Neck Squamous Cell Carcinoma: A Network Pharmacology and Cellular Experimental Study","volume":"2025","author":"He","year":"2025","journal-title":"BioMed Res. Int."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Sala de Oyanguren, F.J., Rainey, N.E., Moustapha, A., Saric, A., Sureau, F., O\u2019Connor, J.E., and Petit, P.X. (2020). Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Supported by Its Specific Subcellular Localization. Cells, 9.","DOI":"10.3390\/cells9020361"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"911","DOI":"10.31557\/APJCP.2022.23.3.911","article-title":"Antiproliferative Effects of Curcumin Different Types of Breast Cancer","volume":"23","author":"Guneydas","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2174\/1567201814666171019104002","article-title":"Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1alpha and Nuclear p65 (Rel A)","volume":"15","author":"Khan","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3858\/emm.2008.40.6.647","article-title":"Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling","volume":"40","author":"Motta","year":"2008","journal-title":"Exp. Mol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(02)00192-1","article-title":"Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line","volume":"184","author":"Ramachandran","year":"2002","journal-title":"Cancer Lett."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Bracci, L., Fabbri, A., Del Corno, M., and Conti, L. (2021). Dietary Polyphenols: Promising Adjuvants for Colorectal Cancer Therapies. Cancers, 13.","DOI":"10.3390\/cancers13184499"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000011876","article-title":"Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion","volume":"55","author":"Lin","year":"1998","journal-title":"Oncology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.freeradbiomed.2007.06.006","article-title":"Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells","volume":"43","author":"Cao","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s40001-025-02922-8","article-title":"Curcumin as a therapeutic agent in liver cancer: A systematic review of preclinical models and mechanisms","volume":"30","author":"Ma","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1038\/s41598-020-60765-1","article-title":"Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines","volume":"10","author":"Schwarz","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_93","first-page":"4057959","article-title":"Effect of Curcumin-Nanoemulsion Associated with Photodynamic Therapy in Cervical Carcinoma Cell Lines","volume":"2018","author":"Calmon","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Abdull Rahim, U., Mustapa, M., Mohamed Shakrin, N.N.S., Nurdin, A., Mohamad Taridi, N., Yusof, Y.A.M., Mad Nordin, M.F., and Che Roos, N.A. (2024). Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: A systematic review. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0314280"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1007\/s11033-011-1273-5","article-title":"Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways","volume":"39","author":"Zong","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/01635581.2018.1446091","article-title":"Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer","volume":"70","author":"Desai","year":"2018","journal-title":"Nutr. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3835(01)00655-3","article-title":"Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells","volume":"172","author":"Goel","year":"2001","journal-title":"Cancer Lett."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Waghela, B.N., Sharma, A., Dhumale, S., Pandey, S.M., and Pathak, C. (2015). Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117526"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/cncr.21300","article-title":"Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis","volume":"104","author":"Li","year":"2005","journal-title":"Cancer"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/ijc.26132","article-title":"[DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo","volume":"129","author":"Aggarwal","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1158\/1078-0432.CCR-10-0446","article-title":"Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2\/STAT3 signaling pathway","volume":"16","author":"Weissenberger","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.taap.2012.05.012","article-title":"Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells","volume":"262","author":"Cai","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/carcin\/bgs029","article-title":"Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells","volume":"33","author":"Han","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13008-015-0012-z","article-title":"Curcumin and tumor immune-editing: Resurrecting the immune system","volume":"10","author":"Bose","year":"2015","journal-title":"Cell Div."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.intimp.2008.01.008","article-title":"Immunomodulatory effects of curcumin: In-vivo","volume":"8","author":"Varalakshmi","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"15954","DOI":"10.1074\/jbc.M608189200","article-title":"Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction","volume":"282","author":"Bhattacharyya","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1158\/0008-5472.CAN-06-2583","article-title":"Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: Protection by curcumin","volume":"67","author":"Bhattacharyya","year":"2007","journal-title":"Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.2174\/187152012803833035","article-title":"Cancer prevention with promising natural products: Mechanisms of action and molecular targets","volume":"12","author":"Pratheeshkumar","year":"2012","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_109","first-page":"27618","article-title":"A novel imidazo[1,2-a]pyridine derivative and its co-administration with curcumin exert anti-inflammatory effects by modulating the STAT3\/NF-kappaB\/iNOS\/COX-2 signaling pathway in breast and ovarian cancer cell lines","volume":"14","author":"Afshari","year":"2024","journal-title":"Bioimpacts"},{"key":"ref_110","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1007\/s00210-023-02825-7","article-title":"Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: Critical analysis","volume":"397","author":"Khosravi","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wong, S.C., Kamarudin, M.N.A., and Naidu, R. (2021). Anticancer Mechanism of Curcumin on Human Glioblastoma. Nutrients, 13.","DOI":"10.3390\/nu13030950"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/ptr.5149","article-title":"Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: A randomized double-blind placebo-controlled trial","volume":"28","author":"Panahi","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/cncr.32644","article-title":"A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbes","volume":"126","author":"Basak","year":"2020","journal-title":"Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e12458","DOI":"10.1111\/cpr.12458","article-title":"Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells","volume":"51","author":"Man","year":"2018","journal-title":"Cell Prolif."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.18632\/oncotarget.24109","article-title":"Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression","volume":"9","author":"Zou","year":"2018","journal-title":"Oncotarget"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1080\/01635581.2015.1073764","article-title":"Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells","volume":"67","author":"Bojko","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Deng, W., Xiong, X., Lu, M., Huang, S., Luo, Y., Wang, Y., and Ying, Y. (2024). Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12898-z"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e2601007","DOI":"10.4014\/jmb.2601.01007","article-title":"Microbiome Modulation with Lactobacillus rhamnosus GG Potentiates Curcumin\u2019s Efficacy in Reversing Gemcitabine Resistance of Gallbladder Cancer through Gut Microbiota-PI3K\/AKT Axis","volume":"36","author":"Li","year":"2026","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Mahmud, M., Piwoni, A., Filipczak, N., Janicka, M., and Gubernator, J. (2016). Long-Circulating Curcumin-Loaded Liposome Formulations with High Incorporation Efficiency, Stability and Anticancer Activity towards Pancreatic Adenocarcinoma Cell Lines In Vitro. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167787"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e202401106","DOI":"10.1002\/cbdv.202401106","article-title":"Biocompatible PAMAM-PLGA-PCL Nanocarrier for Efficient Curcumin Delivery to Lung Cancer Cells: In Vitro Studies","volume":"21","author":"Jawad","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.2147\/IJN.S200847","article-title":"Hybrid curcumin-phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer","volume":"14","author":"Liu","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Atlan, M., and Neman, J. (2019). Targeted Transdermal Delivery of Curcumin for Breast Cancer Prevention. Int. J. Environ. Res. Public. Health, 16.","DOI":"10.3390\/ijerph16244949"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3835(01)00456-6","article-title":"Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model","volume":"167","author":"Busquets","year":"2001","journal-title":"Cancer Lett."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/ptr.7737","article-title":"Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies","volume":"37","author":"Heidari","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12672-024-01272-x","article-title":"Nanocurcumin in cancer treatment: A comprehensive systematic review","volume":"15","author":"Boroughani","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.2174\/1381612826666201118100045","article-title":"Nanocurcumin: A Double-Edged Sword for Microcancers","volume":"26","author":"Janjua","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Karthikeyan, A., Senthil, N., and Min, T. (2020). Nanocurcumin: A Promising Candidate for Therapeutic Applications. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00487"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Gagliardi, S., Morasso, C., Stivaktakis, P., Pandini, C., Tinelli, V., Tsatsakis, A., Prosperi, D., Hickey, M., Corsi, F., and Cereda, C. (2020). Curcumin Formulations and Trials: What\u2019s New in Neurological Diseases. Molecules, 25.","DOI":"10.3390\/molecules25225389"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpharm.2006.09.025","article-title":"Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats","volume":"330","author":"Maiti","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2008-05-155952","article-title":"Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator","volume":"113","author":"Jiao","year":"2009","journal-title":"Blood"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4142\/jvs.2009.10.4.293","article-title":"Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits","volume":"10","author":"Pavithra","year":"2009","journal-title":"J. Vet. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1055\/s-0032-1328652","article-title":"Curcumin alters the pharmacokinetics of warfarin and clopidogrel in Wistar rats but has no effect on anticoagulation or antiplatelet aggregation","volume":"79","author":"Liu","year":"2013","journal-title":"Planta Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1034\/j.1600-0536.2003.00062.x","article-title":"Contact allergy to tetrahydrocurcumin","volume":"48","author":"Lamb","year":"2003","journal-title":"Contact Dermat."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/10\/1636\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:27:36Z","timestamp":1779366456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/10\/1636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":135,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["nu18101636"],"URL":"https:\/\/doi.org\/10.3390\/nu18101636","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}