{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:21:56Z","timestamp":1785424916047,"version":"3.56.0"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Department of Science and Technology of Zhejiang Province","doi-asserted-by":"publisher","award":["2026C02A1023"],"award-info":[{"award-number":["2026C02A1023"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2026C02A1023"],"award-info":[{"award-number":["2026C02A1023"]}],"id":[{"id":"https:\/\/ror.org\/05yj3y977","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: A high-fat diet (HFD) not only induces metabolic disorders but also causes oxidative damage to the lung tissue, triggering inflammatory responses. However, the detailed mechanisms by which HFD induces pulmonary oxidative stress and inflammation, particularly involving NF-\u03baB\/PPAR-\u03b3 signaling and lung microbiota, remain poorly understood, and effective dietary intervention strategies are still lacking. This study investigated the effects of HFD on lung tissue injury in mice and systematically evaluated the protective effects and potential mechanisms of Torreya grandis seed oil (TGO) and Torreya grandis seed diester oil (TGO-DG). Methods: After 12 weeks of HFD feeding, HFD group mice exhibited a marked increase in body weight (90.36%) compared with the control group, whereas body weight gain was significantly attenuated in the TGO (57.95%) and TGO-DG (55.78%) groups. Results: Biochemical analyses revealed that the levels of malondialdehyde (MDA), nitric oxide (NO), and pro-inflammatory cytokines (TNF-\u03b1, IL-6, IL-1\u03b2) were significantly elevated in the HFD group, indicating pronounced oxidative stress and inflammatory responses in lung tissue. These symptoms were significantly attenuated by TGO and TGO-DG, with TGO-DG showing a more marked effect. Western blot (WB) results showed that both TGO and TGO-DG suppressed IL-6 expression and altered the expression of proteins in the NF-\u03baB and PPAR-\u03b3 signaling pathways, which may contribute to the alleviation of pulmonary inflammation. Lung microbiota analysis revealed that TGO was associated with an increased proportion of Lactobacillus species, which correlated with the restoration of pulmonary microbial homeostasis. Conclusions: Overall, these results suggest that TGO and TGO-DG effectively alleviate HFD-induced oxidative stress and inflammation in lung tissue through regulation of inflammatory signaling pathways and lung microbiota composition. Notably, TGO-DG exhibited superior protective effects, highlighting its potential as a lipid ingredient.<\/jats:p>","DOI":"10.3390\/nu18111671","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:30:33Z","timestamp":1779669033000},"page":"1671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Torreya grandis Diester Oil Attenuates High-Fat Diet-Induced Pulmonary Inflammation with Superior Efficacy to Natural Torreya grandis Oil"],"prefix":"10.3390","volume":"18","author":[{"given":"Lixia","family":"Jia","sequence":"first","affiliation":[{"name":"College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"},{"name":"Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenkai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganglei","family":"Yu","sequence":"additional","affiliation":[{"name":"Dongyang Xiangfei Technology Co., Ltd., Jinhua 322100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwei","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"},{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-6235","authenticated-orcid":false,"given":"Guoxin","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tao","sequence":"additional","affiliation":[{"name":"Zhejiang Forest Resources Monitoring Center, Hangzhou 310020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-0529","authenticated-orcid":false,"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Miao","sequence":"additional","affiliation":[{"name":"College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00134-019-05594-1","article-title":"Obesity in the critically ill: A narrative review","volume":"45","author":"Schetz","year":"2019","journal-title":"Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jiang, M.C., Meng, Z.T., Cheng, Z.Q., Zhan, K., Ma, X.Y., Yang, T.Y., Huang, Y.H., Yan, Q., Gong, X.X., and Zhao, G.Q. 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