{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:09:55Z","timestamp":1780560595450,"version":"3.54.1"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Autoimmune gastritis (AIG), celiac disease (CD), and gastric surgery (GS) often cause iron deficiency anemia (IDA) due to iron malabsorption. In this clinical context, IDA treatment is often challenging. The first-line IDA treatment is oral iron supplementation followed by intravenous (IV) iron administration when ineffective or not tolerated. Ferric carboxymaltose (FCM) showed efficacy in various clinical settings. Prospective data evaluating the efficacy of IV FCM in IDA patients secondary to iron malabsorption are scant. The aim of the current study was to assess the tolerability, efficacy, and QoL impact of IV FCM for the treatment of IDA patients with iron malabsorption. Methods: Study design: single-center, prospective observational study: n = 37 adults with AIG, CD, or GS with IDA receiving IV FCM were consecutively included. Endpoints were (i) safety tolerability, (ii) efficacy on IDA recovery (Hb normalization), and (iii) QoL impact. At baseline (T0) and 12 weeks after treatment (T12), a QoL-SF12 questionnaire was assessed. Complete blood count (CBC) and iron status (ferritin, iron, transferrin, transferrin saturation (TS)) were assessed at T0, 4 weeks (T4), and T12 after treatment. Results: Of the 37 IDA patients, 19 (51.4%) had AIG, 9 (24.3%) CD, and 9 (24.3%) GS; Based on Ganzoni\u2019s formula, 24 (64.9%) patients received a single IV FCM infusion (mean \u00b1 SEM dosage of 975 \u00b1 12 mg); 13 (35.1%) required two IV infusion sessions with a mean \u00b1 SEM cumulative dose of 1400 \u00b1 77 mg. One patient (2.7%) experienced mild adverse events without need for treatment interruption or hospitalization. At T0, anemia was moderate in 7 (18.9%) patients and severe in 1 (2.7%). IDA recovery was achieved in 26 (70.3%) patients at T4 and in 29 (78.4%) at T12. At T4, mean \u00b1 SEM Hb increased from 10.8 \u00b1 0.2 g\/dL to 12.7 \u00b1 0.1 g\/dL, ferritin from 28.5 \u00b1 11.2 ng\/mL to 188.2 \u00b1 25.7 ng\/mL, and TS from 6.7 \u00b1 0.5% to 23.7 \u00b1 1.9% (p &lt; 0.0001). At T12, mean \u00b1 SEM Hb further increased to 13.1 \u00b1 0.2 g\/dL (p &lt; 0.05 vs. T4), ferritin slightly decreased to 125 \u00b1 26.7 ng\/mL, and TS to 22.7 \u00b1 2.8%. At T12, nonsignificant increases in QoL scores relative to baseline were observed. Conclusions: IV FCM is a safe and effective treatment leading to IDA recovery in nearly 80% of patients at T12. Thus, when oral iron treatment is not feasible or has failed, IV FCM treatment might be considered a first-line therapeutic option for IDA consequent to iron malabsorption.<\/jats:p>","DOI":"10.3390\/nu18111807","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:36:28Z","timestamp":1780558588000},"page":"1807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy, Safety, and Hematologic Recovery Following Intravenous Ferric Carboxymaltose in Patients with Iron Malabsorption-Related Iron Deficiency Anemia: A Prospective Clinical Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8395-0047","authenticated-orcid":false,"given":"Silvia","family":"Scalamonti","sequence":"first","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pivetta","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Magnante","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pompili","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8153-1681","authenticated-orcid":false,"given":"Marica","family":"Vavallo","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-5957","authenticated-orcid":false,"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-8639","authenticated-orcid":false,"given":"Edith","family":"Lahner","sequence":"additional","affiliation":[{"name":"Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Teaching Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2011). 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