{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:00:39Z","timestamp":1790625639156,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Obesity is a chronic, multifactorial condition characterized by excessive adipose tissue that adversely affects health and continues to rise worldwide. It is strongly associated with cardiometabolic abnormalities that increase the risk of adverse outcomes, including type 2 diabetes and coronary heart disease. Methods: We conducted a multicenter, clinic-based cross-sectional analysis of electronic health records from 200,022 adults aged \u226520 years, who accessed nutritional and clinical laboratory services at Salud Digna between 1 January 2022 and 31 December 2025. Nutritional status was classified as normal weight or overweight\/obesity using body mass index criteria. Metabolic health was assessed using five components of the National Cholesterol Education Program Adult Treatment Panel III criteria. Individuals were defined as metabolically unhealthy if they met three or more metabolic syndrome criteria. Results: Among participants, 78.17% of males and 79.73% of females were classified as overweight or obese. Metabolic unhealthiness was observed in 50.74% of males and 55.42% of females. The prevalences of metabolically healthy normal weight, metabolically healthy overweight\/obesity, metabolically unhealthy normal weight, and metabolically unhealthy overweight\/obesity were 18.55%, 31.09%, 3.90%, and 44.20%, respectively. Conclusions: These findings highlight a high burden of overweight\/obesity and metabolic abnormalities in a large clinic-based sample of Mexican adults. While not nationally representative, this study provides important insights into the distribution of nutritional and metabolic health profiles in individuals accessing healthcare services, supporting the need for targeted prevention, early detection, and management strategies in clinical settings.<\/jats:p>","DOI":"10.3390\/nu18111827","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:10:42Z","timestamp":1780668642000},"page":"1827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nutritional and Metabolic Health Profiling in a Large Clinic-Based Sample of Mexican Adults: A Cross-Sectional Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-7732","authenticated-orcid":false,"given":"Marco Antonio","family":"Luna-Ruiz-Esparza","sequence":"first","affiliation":[{"name":"Innovation and Research Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-805X","authenticated-orcid":false,"given":"Abraham","family":"Garc\u00eda-Gil","sequence":"additional","affiliation":[{"name":"Innovation and Research Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efren","family":"Encinas-Torres","sequence":"additional","affiliation":[{"name":"Salud Digna, Culiacan 80184, Mexico"},{"name":"Encauza, Culiacan 80200, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"G\u00f3mez-Campa\u00f1a","sequence":"additional","affiliation":[{"name":"Medical Direction, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arely Sarahi","family":"Ramos-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Nutrition Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Yadira","family":"Calva-Espinoza","sequence":"additional","affiliation":[{"name":"Laboratory Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Benitez-Iturrios","sequence":"additional","affiliation":[{"name":"Laboratory Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernando","family":"Hern\u00e1ndez-Lezama","sequence":"additional","affiliation":[{"name":"Faculty of Law, National Autonomous University of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Campos-Romero","sequence":"additional","affiliation":[{"name":"Innovation and Research Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-4223","authenticated-orcid":false,"given":"Jonathan","family":"Alc\u00e1ntar-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Innovation and Research Department, Salud Digna, Culiacan 80184, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"ref_1","unstructured":"World Obesity Federation (2026, February 09). 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