{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:08:08Z","timestamp":1780672088364,"version":"3.54.1"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Despite its beneficial effect on the healing of bone fractures and in the treatment of osteoporosis, there is still a lack of evidence on the impact of clinical outcomes after a total joint arthroplasty (TJA). This review aims to establish the role of vitamin D in clinical outcomes after a total knee arthroplasty (TKA). Methods: In this review, PubMed, Scopus and Web of Science databases were cross-checked by two reviewers independently. The inclusion criteria were original human studies published in English from 2014 to 2024. For identification-relevant studies, the search terms used were as follows: \u201cVitamin D\u201d and \u201ctotal knee arthroplasty\u201d or \u201ctotal knee replacement\u201d or \u201ctotal joint arthroplasty\u201d or \u201ctotal joint replacement\u201d. Case reports, letters and expert consensuses were excluded from the analysis. Finally, 19 studies were included in this review. Results: A literature review shows that vitamin D may have an impact on patients treated for osteoarthritis (OA) of the knee with a significant prevalence of hypovitaminosis in orthopedic patients. The influence was observed for periprosthetic joint infections: PJI patients have significantly lower vitamin D levels than primary ones. Also, a greater incidence of revision knee surgery due to PJIs in the deficient group compared to the non-deficient group at a one-year follow-up was found, of up to a 2-fold increase. This affects the clinical outcome with a lower Knee Society Score (KSS) functional score in the vitamin D-deficient group. Conclusions: The current data suggest that the vitamin D metabolism pathway and its implications in orthopedic patients, especially those treated with TKA surgery, may be a significant factor that improves clinical and functional outcomes. A possible relation between a low preoperative concentration of vitamin D and its impact on the outcomes, such as the length of the hospital stay, implant survival, and risk of complications, is needed to support these findings in multicenter, prospective studies and randomized controlled trials.<\/jats:p>","DOI":"10.3390\/nu18111828","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:10:42Z","timestamp":1780668642000},"page":"1828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Vitamin D Concentration on Postoperative Outcomes and Complications Following Total Knee Arthroplasty: A Scoping Review of the Literature"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0204-7538","authenticated-orcid":false,"given":"Daniel","family":"Jaglarz","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ceynowa Hospital in Wejherowo, Jagalskiego 10, 84-200 Wejherowo, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Strzemecki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ceynowa Hospital in Wejherowo, Jagalskiego 10, 84-200 Wejherowo, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Pankowski","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Traumatology and Spine Surgery, Medical University of Gda\u0144sk, Gda\u0144sk Hospital, Nowe Ogrody 1-6, 80-803 Gdansk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Janowska","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ceynowa Hospital in Wejherowo, Jagalskiego 10, 84-200 Wejherowo, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Sypie\u0144","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopedic Surgery, Sebastian Petrycy Healtcare Facility, 33-200 Dabrowa Tarnowska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Tram\u015b","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Musculoskeletal Trauma, Centre of Postgraduate Medical Education, Adam Gruca Orthopedic and Trauma Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-3596","authenticated-orcid":false,"given":"Rafa\u0142","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Musculoskeletal Trauma, Centre of Postgraduate Medical Education, Adam Gruca Orthopedic and Trauma Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Grzelecki","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Reconstructive Surgery, Centre of Postgraduate Medical Education, Adam Gruca Orthopedic and Trauma Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.arth.2022.10.011","article-title":"Are 20% of Patients Actually Dissatisfied Following Total Knee Arthroplasty? 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Metab."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/11\/1828\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:19:36Z","timestamp":1780669176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/11\/1828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":44,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["nu18111828"],"URL":"https:\/\/doi.org\/10.3390\/nu18111828","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}