{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:01:07Z","timestamp":1781182867303,"version":"3.54.1"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Deportes","award":["2400120016"],"award-info":[{"award-number":["2400120016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Cancer pathophysiology involves metabolic disturbances, and exercise improves muscle metabolism, but little is known about the effect of concurrent high-intensity interval plus resistance training (CTHIIT+RT) on the resting and exercise metabolism of breast cancer survivors with risk factors related to metabolic syndrome (MetS). The purpose of this study was to determine the effects of 8 weeks of CTHIIT+RT on the fat and carbohydrate (CHO) metabolism during rest and progressive exercise post-exercise intervention in breast cancer survivors with histories of high- and low-volume chemotherapy. Methods: An experimental study was conducted in which (n = 21) women breast cancer survivors (age: 58.7 \u00b1 8.7 years) were divided by history of high- (HVchemo, \u22658 to 16 sessions, n = 10) or low-volume (LVchemo, \u22647 chemo sessions, n = 11) chemotherapy. The fat (RFATox) and CHO oxidation during 10 min of resting was measured (i.e., including the area under curve [AUC] points within this time), as well as the fat (ExFATox) and CHO (ExCHOox) oxidation during progressive exercise, before and after 8 weeks of CTHIIT+RT by indirect calorimetry. Additionally, risk factors related to MetS were described from pre- to post-intervention. Results: At rest, the HVchemo group showed significant increases in the AUC of RFATox (\u2206 + 23.7, p &lt; 0.0001), similar to the LVchemo group (\u2206 + 14.0, p &lt; 0.0001). The HVchemo group showed significant increases in the AUC of RCHOox (\u2206 + 109.7, p &lt; 0.0001), similar to the LVchemo group (\u2206 + 107.5, p &lt; 0.0001). During progressive exercise, the ExFATox was increased in the HVchemo group (\u2206 + 0.12 g\/min, p = 0.006), similar to the ExCHOox (\u2206 + 0.52 g\/min, p = 0.013) of this group. The proportion of subjects categorized with MetS were significantly reduced in blood pressure, Glu and triglyceride components. Conclusions: Eight weeks of CTHIIT+RT may promote favorable metabolic and cardiometabolic adaptations in breast cancer survivors regardless of the chemotherapy exposure volume. However, these findings should be interpreted cautiously due to the small sample size and lack of a true non-exercise control group.<\/jats:p>","DOI":"10.3390\/nu18121882","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:14:58Z","timestamp":1781180098000},"page":"1882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Concurrent Training on Resting and Progressive Exercise Metabolism in Breast Cancer Survivors with Metabolic Syndrome Risk Factors"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-9981","authenticated-orcid":false,"given":"Cristian","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-0479","authenticated-orcid":false,"given":"Alejandra","family":"Soto","sequence":"additional","affiliation":[{"name":"Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad Andres Bello, Concepci\u00f3n 4030000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7125-6247","authenticated-orcid":false,"given":"Valeska","family":"Subi\u00e1bre","sequence":"additional","affiliation":[{"name":"Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad Andres Bello, Concepci\u00f3n 4030000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-7453","authenticated-orcid":false,"given":"Paulina","family":"Ibacache-Saavedra","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-9700","authenticated-orcid":false,"given":"Luis","family":"Pe\u00f1ailillo","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3937-1939","authenticated-orcid":false,"given":"Crist\u00f3bal","family":"Dur\u00e1n-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Doctorate in Rehabilitation Science Program, Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-8787","authenticated-orcid":false,"given":"Igor","family":"Cigarroa","sequence":"additional","affiliation":[{"name":"Escuela de Kinesiolog\u00eda, Facultad de Ciencias de la Salud, Universidad Cat\u00f3lica Silva Henr\u00edquez, Santiago 8580000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-3959","authenticated-orcid":false,"given":"C\u00e9zane P.","family":"Reuter","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul 96816-501, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-6947","authenticated-orcid":false,"given":"Anelise R.","family":"Gaya","sequence":"additional","affiliation":[{"name":"School of Physical Education and Physiotherapy, Federal University of Pelotas, Pelotas 96055-630, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-993X","authenticated-orcid":false,"given":"Pedro","family":"Delgado-Floody","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Exercise Applied Physiology Laboratory, Centro de Investigaci\u00f3n en Fisiolog\u00eda y Medicina de Altura (FIMEDALT), Departamento Biom\u00e9dico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1240000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-8162","authenticated-orcid":false,"given":"Emmanuel Gomes","family":"Ciolac","sequence":"additional","affiliation":[{"name":"Exercise and Chronic Disease Research Laboratory, Department of Physical Education, School of Sciences, Sao Paulo State University (UNESP), Bauru 17033-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-4272","authenticated-orcid":false,"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-0788","authenticated-orcid":false,"given":"Gabriel","family":"Rojas-Rojas","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","unstructured":"Institute for Health Metrics and Evaluation (IHME) (2020). 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