{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:56:22Z","timestamp":1781232982696,"version":"3.54.1"},"reference-count":128,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Migraine (MIG) management guidelines support a comprehensive approach combining medication, therapeutic patient education (TPE), behavioral strategies, lifestyle changes, diet, and physical activity (PA). Objective: To present an innovative interdisciplinary outpatient model for individuals with MIG, focusing on PA, sedentary behavior, eating habits (EH), metabolic health, temporomandibular disorders, and postural dysfunctions. Design: A randomized controlled trial will enroll 200 adults with MIG over two years. Inclusion criteria are chronic MIG (\u226515 attacks\/month for \u22653 months) or high-frequency episodic MIG (8\u201314 attacks\/month), physical inactivity, and independent walking ability. Exclusion criteria include contraindications to PA and lack of informed consent. Participants will be randomized to standard care (SC) or an intervention group receiving TPE plus three months of supervised exercise (EXE). All participants will receive an informational brochure with nutritional tips (included in SC) and undergo: (1) neurological examination, (2) validated questionnaires, (3) kinesiological and postural assessment, and (4) gnathological evaluation. The primary outcome is change in monthly MIG frequency at 6 and 12 months; additional outcomes include disability, quality of life, and intensity of MIG, PA levels, sedentary behavior, medication use, EH, functional capabilities, postural parameters, and temporomandibular disorder-related variables. Results: Hypothetically, the intervention may reduce monthly MIG frequency by approximately 15\u201320% relative to baseline. Improvements may also occur in disability, quality of life, medication use, lifestyle behaviors, and psychological and cardiometabolic parameters. Conclusions: This trial will evaluate whether adding supervised EXE and TPE to SC may improve MIG outcomes compared with SC alone, supporting a comprehensive management strategy.<\/jats:p>","DOI":"10.3390\/nu18121893","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:52:08Z","timestamp":1781229128000},"page":"1893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Nutrition and Physical Activity into the EXEMIG\/01 Interdisciplinary Model for Chronic and High-Frequency Migraine"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0429-4996","authenticated-orcid":false,"given":"Roberto","family":"Pippi","sequence":"first","affiliation":[{"name":"Healthy Lifestyle Institute, C.U.R.I.A.Mo. (Centro Universitario di Ricerca Interdipartimentale Attivit\u00e0 Motoria), Department of Medicine and Surgery, University of Perugia, Via G. Bambagioni, 19, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8741-5219","authenticated-orcid":false,"given":"Deborah","family":"Prete","sequence":"additional","affiliation":[{"name":"Healthy Lifestyle Institute, C.U.R.I.A.Mo. (Centro Universitario di Ricerca Interdipartimentale Attivit\u00e0 Motoria), Department of Medicine and Surgery, University of Perugia, Via G. Bambagioni, 19, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-5937","authenticated-orcid":false,"given":"Stefano","family":"Pagano","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Medicine and Surgery, University of Perugia, 06125 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-9135","authenticated-orcid":false,"given":"Chiara","family":"Valenti","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Medicine and Surgery, University of Perugia, 06125 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Master\u2019s Degree Program in Sciences and Techniques of Sport and Preventive and Adapted Physical Activities, Department of Medicine and Surgery, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7425-3840","authenticated-orcid":false,"given":"Sandro","family":"Prati","sequence":"additional","affiliation":[{"name":"Postgraduate School of Orthodontics, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1125-4358","authenticated-orcid":false,"given":"Marco","family":"Alabiso","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Piazzale Gambuli, 1, 06129 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Settembrini","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Piazzale Gambuli, 1, 06129 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-4627","authenticated-orcid":false,"given":"Daniela","family":"Fruttini","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2202-1369","authenticated-orcid":false,"given":"Paola","family":"Sarchielli","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Piazzale Gambuli, 1, 06129 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"03331024241267309","DOI":"10.1177\/03331024241267309","article-title":"Migraine is the most disabling neurological disease among children and adolescents, and second after stroke among adults: A call to action","volume":"44","author":"Peres","year":"2024","journal-title":"Cephalalgia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s40122-024-00690-7","article-title":"The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region","volume":"14","author":"Dong","year":"2025","journal-title":"Pain Ther."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wang, Q., Luo, R., and Wen, Q. 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