{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:13:38Z","timestamp":1784546018597,"version":"3.55.0"},"reference-count":117,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pulses are rich in diverse phenolic compounds, which play a vital role in human health. The biological activity of pulses\u2019 polyphenols is highly dependent on their interaction with the gastrointestinal tract and gut microbiota. Polyphenols from pulses have been proven to be effective in the regulation of gut homeostasis, exerting antioxidant and anti-inflammatory effects, and alleviating various intestinal health problems caused by chronic diseases, thus receiving extensive attention. Furthermore, in view of the prebiotic potential of pulse polyphenols in gut health, they can be enriched by fermentation, germination, and physical-assisted technologies to realize their effective applications. In this review, we systematically summarize and analyze the phenolic compound profiles, which confer extensive gut health benefits, with emphasis on their potential enrichment strategies. A better understanding of polyphenols in pulses may open up new avenues for their application in the development of functional foods.<\/jats:p>","DOI":"10.3390\/nu18121895","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:52:08Z","timestamp":1781229128000},"page":"1895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polyphenols from Pulses: Recent Advances in Gut Health Benefits and Strategies to Elevate Their Concentrations"],"prefix":"10.3390","volume":"18","author":[{"given":"Jiakai","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Haidu College, Qingdao Agricultural University, Qingdao 266000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-7358","authenticated-orcid":false,"given":"Dianzhi","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Charoensiddhi, S., Chanput, W.P., and Sae-Tan, S. (2022). Gut microbiota modulation, anti-diabetic and anti-inflammatory properties of polyphenol extract from mung bean seed coat (Vigna radiata L.). Nutrients, 14.","DOI":"10.3390\/nu14112275"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s10068-023-01495-8","article-title":"Dietary mung bean as promising food for human health: Gut microbiota modulation and insight into factors, regulation, mechanisms and therapeutics\u2014An update","volume":"33","author":"Sehrawat","year":"2024","journal-title":"Food Sci. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103563","DOI":"10.1016\/j.fochx.2026.103563","article-title":"Fermentation-driven function enhancement of faba bean (poly)phenols: Bioactivity augmentation and intestinal flora modulation","volume":"33","author":"Ning","year":"2026","journal-title":"Food Chem. X"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105044","DOI":"10.1016\/j.jff.2022.105044","article-title":"Anti-inflammatory effect of lentil hull (Lens culinaris) extract via MAPK\/NF-\u03baB signaling pathways and effects of digestive products on intestinal barrier and inflammation in caco-2 and Raw264.7 co-culture","volume":"92","author":"Peng","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112634","DOI":"10.1016\/j.foodres.2023.112634","article-title":"Bioaccessibility and transport of lentil hull polyphenols in vitro, and their bioavailability and metabolism in rats","volume":"167","author":"Guo","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhu, L., Li, W., Deng, Z., Li, H., and Zhang, B. (2020). The composition and antioxidant activity of bound phenolics in three legumes, and their metabolism and bioaccessibility of gastrointestinal tract. Foods, 9.","DOI":"10.3390\/foods9121816"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shen, X., Jiang, X., Qian, L., Zhang, A., Zuo, F., and Zhang, D. (2022). Polyphenol extracts from germinated mung beans can improve type 2 diabetes in mice by regulating intestinal microflora and inhibiting inflammation. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.846409"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"138343","DOI":"10.1016\/j.ijbiomac.2024.138343","article-title":"Ameliorative effects of insoluble dietary fiber and its bound polyphenols from adzuki bean seed coat on acute murine colitis induced by DSS: The inflammatory response, intestinal barrier and gut microbiota","volume":"286","author":"Yin","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Guo, F., Tsao, R., Li, C., Wang, X., Zhang, H., Jiang, L., Sun, Y., and Xiong, H. (2021). Green pea (Pisum sativum L.) hull polyphenol extracts ameliorate DSS-induced colitis through Keap1\/Nrf2 pathway and gut microbiota modulation. Foods, 10.","DOI":"10.3390\/foods10112765"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1039\/D3FO04670B","article-title":"Ameliorative effect of bound polyphenols in mung bean coat dietary fiber on DSS-induced ulcerative colitis in mice: The intestinal barrier and intestinal flora","volume":"15","author":"Ao","year":"2024","journal-title":"Food Funct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cj.2016.06.011","article-title":"Nutritional composition and antioxidant activity of twenty mung bean cultivars in China","volume":"4","author":"Shi","year":"2016","journal-title":"Crop J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100850","DOI":"10.1016\/j.fbio.2020.100850","article-title":"The anti-inflammatory and antioxidant properties of chickpea hull phenolic extracts","volume":"40","author":"Mahbub","year":"2021","journal-title":"Food Biosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s11694-020-00399-z","article-title":"Bio-enrichment of phenolic, flavonoids content and antioxidant activity of commonly used pulses by solid-state fermentation","volume":"14","author":"Saharan","year":"2020","journal-title":"J. Food Meas. Charact."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1002\/leg3.37","article-title":"Solid-state fermentation of lentil (Lens culinaris L.) with Aspergillus awamori: Effect on phenolic compounds, mineral content, and their bioavailability","volume":"2","author":"Dhull","year":"2020","journal-title":"Legume Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/87559129.2020.1840581","article-title":"Anticarcinogenic activity of phenolic compounds from sprouted legumes","volume":"38","year":"2022","journal-title":"Food Rev. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110100","DOI":"10.1016\/j.lwt.2020.110100","article-title":"Nutritional composition, enzyme activities and bioactive compounds of mung bean (Vigna radiata L.) germinated under dark and light conditions","volume":"133","year":"2020","journal-title":"LWT"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"139829","DOI":"10.1016\/j.foodchem.2024.139829","article-title":"Ultrasound-assisted germination of red kidney beans: Enhancements in physicochemical and nutritional profiles","volume":"454","author":"Yu","year":"2024","journal-title":"Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1080\/10408398.2022.2105303","article-title":"An update on nutritional profile, phytochemical compounds, health benefits, and potential applications in the food industry of pulses seed coats: A comprehensive review","volume":"63","author":"Hou","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.foodres.2011.02.026","article-title":"Polyphenols content and antioxidant capacity of thirteen faba bean (Vicia faba L.) genotypes cultivated in tunisia","volume":"44","author":"Chaieb","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.foodchem.2016.01.101","article-title":"Phytochemical distribution in hull and cotyledon of adzuki bean (Vigna angularis L.) and mung bean (Vigna radiate L.), and their contribution to antioxidant, anti-inflammatory and anti-diabetic activities","volume":"201","author":"Luo","year":"2016","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100964","DOI":"10.1016\/j.fbio.2021.100964","article-title":"Nutritional components, volatile constituents and antioxidant activities of 6 chickpea species","volume":"41","author":"Zhao","year":"2021","journal-title":"Food Biosci."},{"key":"ref_22","first-page":"199","article-title":"Phenolics content and antioxidant capacity of mung bean (Vigna radiata L.) seed","volume":"28","author":"Orak","year":"2018","journal-title":"Yuz. Y\u0131l Univ. J. Agric. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100705","DOI":"10.1016\/j.fbio.2020.100705","article-title":"Phenolic profiles, antioxidant activities, and antiproliferative activities of different mung bean (Vigna radiata) varieties from sri lanka","volume":"37","author":"Yang","year":"2020","journal-title":"Food Biosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1021\/acs.jafc.4c12023","article-title":"A comprehensive review of the chemical constituents and functional properties of adzuki beans (Vigna angulariz)","volume":"73","author":"Guo","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.7740\/kjcs.2011.56.4.375","article-title":"Determination of phenolic compounds in adzuki bean (Vigna angularis) germplasm","volume":"56","author":"Kim","year":"2011","journal-title":"Korean J. Crop Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jnutbio.2009.11.004","article-title":"Polyphenol-containing azuki bean (Vigna angularis) seed coats attenuate vascular oxidative stress and inflammation in spontaneously hypertensive rats","volume":"22","author":"Mukai","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/1343943X.2023.2206576","article-title":"Variation in antioxidant capacity of the seven azuki bean (Vigna angularis) varieties with different seed coat color","volume":"26","author":"Nagao","year":"2023","journal-title":"Plant Prod. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.foodres.2015.01.018","article-title":"Effect of germination and elicitation on phenolic composition and bioactivity of kidney beans","volume":"70","author":"Frias","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jff.2016.08.030","article-title":"Antioxidant activities and anthocyanins composition of seed coats from twenty-six kidney bean cultivars","volume":"26","author":"Kan","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Alonso, C., Taroncher, M., Castaldo, L., Izzo, L., Rodr\u00edguez-Carrasco, Y., Ritieni, A., and Ruiz, M.-J. (2022). Effect of phenolic extract from red beans (Phaseolus vulgaris L.) on T-2 toxin-induced cytotoxicity in HepG2 cells. Foods, 11.","DOI":"10.3390\/foods11071033"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jff.2017.04.002","article-title":"Antioxidant activity of broad bean seed extract and its phenolic composition","volume":"38","author":"Amarowicz","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Johnson, J.B., Skylas, D.J., Mani, J.S., Xiang, J., Walsh, K.B., and Naiker, M. (2021). Phenolic profiles of ten australian faba bean varieties. Molecules, 26.","DOI":"10.3390\/molecules26154642"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e46920","DOI":"10.1590\/fst.45920","article-title":"Phenolic compounds profile and antioxidant activity of pea (Pisum sativum L.) and black bean (Phaseolus vulgaris L.) sprouts","volume":"42","year":"2022","journal-title":"Food Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100599","DOI":"10.1016\/j.fochx.2023.100599","article-title":"Comprehensive analysis in the nutritional composition, phenolic species and in vitro antioxidant activities of different pea cultivars","volume":"17","author":"Chen","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1080\/01635581.2016.1190019","article-title":"Identification of phenolic compounds from seed coats of differently colored european varieties of pea (Pisum sativum L.) and characterization of their antioxidant and in vitro anticancer activities","volume":"68","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jfca.2011.10.002","article-title":"Antioxidant activity and phenolic content in three lupin species","volume":"25","author":"Siger","year":"2012","journal-title":"J. Food Compos. Anal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/ijfs.14460","article-title":"Lupin seed coat as a promising food ingredient: Physicochemical, nutritional, antioxidant properties, and effect of genotype and environment","volume":"55","author":"Zhong","year":"2020","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.foodres.2018.09.061","article-title":"Characterization of polyphenols in australian sweet lupin (Lupinus angustifolius) seed coat by HPLC-DAD-ESI-MS\/MS","volume":"116","author":"Zhong","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s11694-022-01711-9","article-title":"Lentil seed coat as a source of phenolic compounds: Influence of geographical origin and genotype","volume":"17","author":"Galgano","year":"2023","journal-title":"J. Food Meas. Charact."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ganesan, K., and Xu, B. (2017). Polyphenol-rich lentils and their health promoting effects. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112390"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.foodchem.2014.09.144","article-title":"Phenolic profiles of 20 canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on \u03b1-glucosidase and pancreatic lipase","volume":"172","author":"Zhang","year":"2015","journal-title":"Food Chem."},{"key":"ref_42","first-page":"69","article-title":"Technological properties, antioxidant activity and total phenolic and flavonoid content of pigmented chickpea (Cicer arietinum L.) cultivars","volume":"64","year":"2012","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/compounds3010005","article-title":"Polyphenols in health and disease: Gut microbiota, bioaccessibility, and bioavailability","volume":"3","author":"Sepodes","year":"2023","journal-title":"Compounds"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1021\/acs.jafc.2c00102","article-title":"Polyphenol content of green pea (Pisum sativum L.) hull under in vitro digestion and effects of digestive products on anti-inflammatory activity and intestinal barrier in the caco-2\/Raw264.7 coculture model","volume":"70","author":"Guo","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1007\/s11694-024-02797-z","article-title":"Effect of ultrasound assisted extraction and simulated in vitro gastrointestinal digestion on phenolic compound profile, bio-accessibility, and LC-ESI-QTOF-MS analysis of black beans (Phaseolus vulgaris L.) extract","volume":"18","author":"Mali","year":"2024","journal-title":"J. Food Meas. Charact."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.foodres.2018.09.057","article-title":"Bioaccessibility of defatted lupin seed phenolic compounds in a standardized static in vitro digestion system","volume":"116","author":"Czubinski","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jff.2017.03.040","article-title":"Reprint of \u201cbioaccessibility, in vitro antioxidant and anti-inflammatory activities of phenolics in cooked green lentil (Lens culinaris)\u201d","volume":"38","author":"Zhang","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e28894","DOI":"10.1016\/j.heliyon.2024.e28894","article-title":"Exploring the bioaccessibility and intestinal absorption of major classes of pure phenolic compounds using in vitro simulated gastrointestinal digestion","volume":"10","author":"Pais","year":"2024","journal-title":"Heliyon"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"100602","DOI":"10.1016\/j.foohum.2025.100602","article-title":"How to increase dietary polyphenol bioavailability: Understanding the roles of modulating factors, lifestyle and gut microbiota","volume":"4","author":"Dzah","year":"2025","journal-title":"Food Humanit."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"492","DOI":"10.5958\/0976-0571.2014.00665.1","article-title":"Impact of processing on in vitro bioavailability of phenols and flavonodis and antioxidant activities in faba bean (Vicia faba L.) andazuki bean (Vigna angularis L.)","volume":"37","author":"Luo","year":"2014","journal-title":"Legume Res.-Int. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s11130-022-01006-w","article-title":"Simulated digestion of the pigmented legumes\u2019 (black chickpea (Cicer arietinum L.) and brown lentil (Lens culinaris medikus) phenolics to estimate their bioavailability","volume":"77","author":"Kose","year":"2022","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"133719","DOI":"10.1016\/j.foodchem.2022.133719","article-title":"Catabolism of polyphenols released from mung bean coat and its effects on gut microbiota during in vitro simulated digestion and colonic fermentation","volume":"396","author":"Xie","year":"2022","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/10242422.2019.1614172","article-title":"Enzyme-assisted extraction of biocomponents of lentils (Lens culinaris L.): Effect of process parameters on the recovery of compounds with antioxidant properties","volume":"38","year":"2020","journal-title":"Biocatal. Biotransformation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"144600","DOI":"10.1016\/j.foodchem.2025.144600","article-title":"Unveiling the differences between vitexin and isovitexin: From the perspective of sources, green advanced extraction technologies, biological activities, and safety","volume":"485","author":"Lin","year":"2025","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hou, D., Yousaf, L., Xue, Y., Hu, J., Wu, J., Hu, X., Feng, N., and Shen, Q. (2019). Mung bean (Vigna radiata L.): Bioactive polyphenols, polysaccharides, peptides, and health benefits. Nutrients, 11.","DOI":"10.3390\/nu11061238"},{"key":"ref_56","first-page":"19","article-title":"Nutraceutical evaluation and antioxidant potential of red kidney bean (Phaseolus vulgaris) and chickpea (Cicer arietenum) seed coats","volume":"7","author":"Zaidan","year":"2019","journal-title":"Asian J. Agric. Biol. J. Agric. Biol."},{"key":"ref_57","first-page":"116","article-title":"Occurrence of phenolic compounds in the seed coat and the cotyledon of peas (Pisum sativum L.)","volume":"219","author":"Estrella","year":"2004","journal-title":"Eur. Food Res. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1021\/jf903101k","article-title":"Distribution of nutrients and antinutrients in milled fractions of chickpea and horse gram: Seed coat phenolics and their distinct modes of enzyme inhibition","volume":"58","author":"Sreerama","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/jf104640k","article-title":"Antioxidant activity and phenolic compositions of lentil (Lens culinaris var. Morton) extract and its fractions","volume":"59","author":"Zou","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Galgano, F., Tolve, R., Scarpa, T., Caruso, M.C., Lucini, L., Senizza, B., and Condelli, N. (2021). Extraction kinetics of total polyphenols, flavonoids, and condensed tannins of lentil seed coat: Comparison of solvent and extraction methods. Foods, 10.","DOI":"10.3390\/foods10081810"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2426614","DOI":"10.1080\/19490976.2024.2426614","article-title":"Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds","volume":"16","author":"Alqudah","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"144669","DOI":"10.1016\/j.foodchem.2025.144669","article-title":"Polyphenol metabolism, short-chain fatty acids production, and microbiota changes during in vitro digestion and fermentation of Chilean beans (Phaseolus vulgaris L.)","volume":"486","author":"Nina","year":"2025","journal-title":"Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/09168451.2018.1429886","article-title":"Effect of a combination of inulin and polyphenol-containing adzuki bean extract on intestinal fermentation in vitro and in vivo","volume":"82","author":"Nagata","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1111\/ijfs.15351","article-title":"Interaction of the human intestinal microbiota with the release of bound phenolic compounds in chickpea (Cicer arietinum L.)","volume":"56","year":"2021","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1039\/D2FO01165D","article-title":"Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats","volume":"13","author":"Sun","year":"2022","journal-title":"Food Funct."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e1900626","DOI":"10.1002\/mnfr.201900626","article-title":"Adzuki Bean Water Extract Attenuates Obesity by Modulating M2\/M1 Macrophage Polarization and Gut Microbiota Composition","volume":"63","author":"Lee","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Lee, C.S., Jang, W.-Y., Kim, J.-Y., Lee, M.-H., Mo, S.-J., Kim, Y.-T., Shim, J.-J., and Lee, J.-H. (2025). Combined Prebiotic Extract of Mung Bean, Red Bean, and Fennel Improves Intestinal Barrier Integrity in HT-29 Cells and DSS-Induced Colitis via Gut Microbiota Alteration. Curr. Issues Mol. Biol., 48.","DOI":"10.3390\/cimb48010032"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2100007","DOI":"10.1002\/mnfr.202100007","article-title":"Chickpea Extract Ameliorates Metabolic Syndrome Symptoms via Restoring Intestinal Ecology and Metabolic Profile in Type 2 Diabetic Rats","volume":"65","author":"Li","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jnutbio.2019.01.012","article-title":"Pea polyphenolics and hydrolysis processing alter microbial community structure and early pathogen colonization in mice","volume":"67","author":"Forgie","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_70","unstructured":"Geraldo, R. (2025, January 22\u201325). Anti-inflammatory and metabolic effects of lentil phenolic compounds. Proceedings of the XX International Plant Nutrition Colloquium\u2014Alf\u00e2ndega Porto Congress Centre, Porto, Portugal."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/carcin\/bgaa008","article-title":"Reduction of colitis-associated colon carcinogenesis by a black lentil water extract through inhibition of inflammatory and immunomodulatory cytokines","volume":"41","author":"Mazewski","year":"2020","journal-title":"Carcinogenesis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1021\/acs.jafc.3c02337","article-title":"Green pea (Pisum sativum L.) hull polyphenol extract alleviates NAFLD through VB6\/TLR4\/NF-\u03baB and PPAR pathways","volume":"71","author":"Guo","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/jsfa.70265","article-title":"The ethanol extract derived from mung bean reduced immune suppression, intestinal injury, and disruptions in gut microbiota caused by cyclophosphamide in mice","volume":"106","author":"Liu","year":"2025","journal-title":"J. Sci. Food Agric."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"11955","DOI":"10.1021\/acs.jafc.9b04501","article-title":"Phenolics of green pea (Pisum sativum L.) hulls, their plasma and urinary metabolites, bioavailability, and in vivo antioxidant activities in a rat model","volume":"67","author":"Guo","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11130-023-01075-5","article-title":"In vitro and in vivo Inhibitory Activity of C-glycoside Flavonoid Extracts from Mung Bean Coat on Pancreatic Lipase and \u03b1-glucosidase","volume":"78","author":"Ruan","year":"2023","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"105456","DOI":"10.1016\/j.jff.2023.105456","article-title":"Analysis of the alleviating effect of black bean peel anthocyanins on type 2 diabetes based on gut microbiota and serum metabolome","volume":"102","author":"Sun","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41538-025-00522-8","article-title":"Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis","volume":"9","author":"Feng","year":"2025","journal-title":"npj Sci. Food"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Dami\u00e1n-Medina, K., Milenkovic, D., Salinas-Moreno, Y., Corral-Jara, K.F., Figueroa-Y\u00e1\u00f1ez, L., Marino-Marmolejo, E., and Lugo-Cervantes, E. (2022). Anthocyanin-rich extract from black beans exerts anti-diabetic effects in rats through a multi-genomic mode of action in adipose tissue. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1019259"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.foodres.2014.12.003","article-title":"Phenolic composition changes of processed common beans: Their antioxidant and anti-inflammatory effects in intestinal cancer cells","volume":"76","author":"Estrella","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jff.2016.12.027","article-title":"Anti-inflammatory effects of phenolic-rich cranberry bean (Phaseolus vulgaris L.) extracts and enhanced cellular antioxidant enzyme activities in Caco-2 cells","volume":"38","author":"Chen","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1039\/C8FO00055G","article-title":"Broad bean (Vicia faba L.) pods: A rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties","volume":"9","author":"Mejri","year":"2018","journal-title":"Food Funct."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Margier, M., Georg\u00e9, S., Hafnaoui, N., Remond, D., Nowicki, M., Du Chaffaut, L., Amiot, M.-J., and Reboul, E. (2018). Nutritional Composition and Bioactive Content of Legumes: Characterization of Pulses Frequently Consumed in France and Effect of the Cooking Method. Nutrients, 10.","DOI":"10.3390\/nu10111668"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S0007114519002836","article-title":"Human bioavailability of phenolic compounds found in common beans: The use of high-resolution MS to evaluate inter-individual variability","volume":"123","author":"Mecha","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/10408398.2020.1744512","article-title":"Dietary polyphenol impact on gut health and microbiota","volume":"61","author":"Wan","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1080\/19476337.2021.1965660","article-title":"Polyphenol bioaccessibility and anti-inflammatory activity of mexican common beans (Phaseolus vulgaris L.) with diverse seed colour","volume":"19","author":"Morgan","year":"2021","journal-title":"CyTA-J. Food"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"109024","DOI":"10.1016\/j.lwt.2020.109024","article-title":"Effect of tempe fermentation by three different strains of rhizopus oligosporus on nutritional characteristics of faba beans","volume":"122","author":"Polanowska","year":"2020","journal-title":"LWT"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.foodchem.2014.09.084","article-title":"Fermentation enhances the content of bioactive compounds in kidney bean extracts","volume":"172","author":"Torino","year":"2015","journal-title":"Food Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/1750-3841.15349","article-title":"Co-fermentation of lentils using lactic acid bacteria and Bacillus subtilis natto increases functional and antioxidant components","volume":"86","author":"Chen","year":"2021","journal-title":"J. Food Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/09637486.2014.986068","article-title":"Effect of soaking and fermentation on content of phenolic compounds of soybean (Glycine max cv. Merit) and mung beans (Vigna radiata [L] Wilczek)","volume":"66","author":"Robredo","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Cipollone, M.A., Abraham, A.G., Fontana, A., and Tironi, V.A. (2024). Autochthonous Fermentation as a Means to Improve the Bioaccessibility and Antioxidant Activity of Proteins and Phenolic Compounds of Yellow Pea Flour. Foods, 13.","DOI":"10.20944\/preprints202401.1537.v1"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.foodchem.2012.09.015","article-title":"Antioxidant and antihypertensive properties of liquid and solid state fermented lentils","volume":"136","author":"Torino","year":"2013","journal-title":"Food Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1021\/acsfoodscitech.4c00819","article-title":"In Vitro Antioxidant, Antiglycemic, and Antitumor Potential of Anthocyanin-Rich Extracts from Black Bean Hulls Obtained by Pressurized Liquid Extraction","volume":"5","author":"Kuasnei","year":"2025","journal-title":"ACS Food Sci. Technol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/ijfs.13062","article-title":"Fermentation alters antioxidant capacity and polyphenol distribution in selected edible legumes","volume":"51","author":"Gan","year":"2016","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jff.2014.06.008","article-title":"Enhancement of the antioxidant capacity of chickpeas by solid state fermentation with cordyceps militaris SN-18","volume":"10","author":"Xiao","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Siriparu, P., Panyatip, P., Pota, T., Ratha, J., Yongram, C., Srisongkram, T., Sungthong, B., and Puthongking, P. (2022). Effect of germination and illumination on melatonin and its metabolites, phenolic content, and antioxidant activity in mung bean sprouts. Plants, 11.","DOI":"10.3390\/plants11212990"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Rizvi, Q.U.E.H., Guin\u00e9, R.P.F., Ahmed, N., Sheikh, M.A., Sharma, P., Sheikh, I., Yadav, A.N., and Kumar, K. (2024). Effects of Soaking and Germination Treatments on the Nutritional, Anti-Nutritional, and Bioactive Characteristics of Adzuki Beans (Vigna angularis L.) and Lima Beans (Phaseolus lunatus L.). Foods, 13.","DOI":"10.3390\/foods13091422"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Pencheva, D., Teneva, D., Todorova, Z., Ognyanov, M., Petrova, A., Georgiev, V., Pimpilova, M., and Denev, P. (2026). Germination Triggers Substantial Changes in GABA, Polyphenol, Sugar, and Organic Acid Content of Commonly Consumed Legumes. Plants, 15.","DOI":"10.3390\/plants15020242"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.foodchem.2009.04.051","article-title":"Germination as a process to increase the polyphenol content and antioxidant activity of lupin seeds (Lupinus angustifolius L.)","volume":"117","author":"Estrella","year":"2009","journal-title":"Food Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.17306\/J.AFS.2015.3.25","article-title":"Effect of germination time on proximate analysis, bioactive compounds and antioxidant activity of lentil (Lens culinaris Medik.) sprouts","volume":"14","author":"Fouad","year":"2015","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"114947","DOI":"10.1016\/j.foodres.2024.114947","article-title":"Effects of combined ultrasound and calcium ion pretreatments on polyphenols during mung bean germination: Exploring underlying mechanisms","volume":"195","author":"Yu","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"104974","DOI":"10.1016\/j.ultsonch.2020.104974","article-title":"Ultrasonic assisted phenolic elicitation and antioxidant potential of common bean (Phaseolus vulgaris) sprouts","volume":"64","author":"Ampofo","year":"2020","journal-title":"Ultrason. Sonochemistry"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/ijfs.13345","article-title":"Effects of UV-B on vitamin C, phenolics, flavonoids and their related enzyme activities in mung bean sprouts (Vigna radiata)","volume":"52","author":"Wang","year":"2017","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s00344-020-10125-0","article-title":"Characterization of bean seeds, germination, and phenolic compounds of seedlings by UV-C radiation","volume":"40","author":"Tenango","year":"2021","journal-title":"J. Plant Growth Regul."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Park, Y.R., Kwon, S.-J., Kim, J.H., Duan, S., and Eom, S.H. (2024). Light-induced antioxidant phenolic changes among the sprouts of lentil cultivar. Antioxidants, 13.","DOI":"10.3390\/antiox13040399"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Li, B., Shen, X., Shen, H., Zhou, Y., and Yao, X. (2023). Effect of optimized germination technology on polyphenol content and hypoglycemic activity of mung bean. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1138739"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Kapravelou, G., Mart\u00ednez, R., Perazzoli, G., S\u00e1nchez Gonz\u00e1lez, C., Llopis, J., Cantarero, S., Goua, M., Bermano, G., Prados, J., and Melguizo, C. (2020). Germination Improves the Polyphenolic Profile and Functional Value of Mung Bean (Vigna radiata L.). Antioxidants, 9.","DOI":"10.3390\/antiox9080746"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1021\/jf304443u","article-title":"Effect of Germination on Phytochemical Profiles and Antioxidant Activity of Mung Bean Sprouts (Vigna radiata)","volume":"60","author":"Guo","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.foodchem.2013.07.080","article-title":"Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time","volume":"143","author":"Huang","year":"2014","journal-title":"Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1080\/10942912.2012.654702","article-title":"Effect of soaking and germination on polyphenol content and polyphenol oxidase activity of mung bean (Phaseolus aureus L.) cultivars differing in seed color","volume":"17","author":"Tajoddin","year":"2014","journal-title":"Int. J. Food Prop."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e70103","DOI":"10.1002\/fsn3.70103","article-title":"The Effect of Germination on Antinutritional Components, In Vitro Starch and Protein Digestibility, Content, and Bioaccessibility of Phenolics and Antioxidants of Some Pulses","volume":"13","author":"Sakarya","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"632","DOI":"10.11002\/kjfp.2022.29.4.632","article-title":"Optimization of germination conditions to enhance the antioxidant activity in chickpea (Cicer arietimum L.) using response surface methodology","volume":"29","author":"Kim","year":"2022","journal-title":"Korean J. Food Preserv."},{"key":"ref_113","first-page":"1137","article-title":"The effect of germination on phenolic content and antioxidant activity of chickpea","volume":"11","author":"Tarzi","year":"2012","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3390\/analytica5030026","article-title":"Effects of Different Processing Methods on the Antinutritional Factors Present in Mungbean (Vigna radiata L.)","volume":"5","author":"Pokharel","year":"2024","journal-title":"Analytica"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Chiu, K.-Y. (2021). Changes in microstructure, germination, sprout growth, phytochemical and microbial quality of ultrasonication treated adzuki bean seeds. Agronomy, 11.","DOI":"10.3390\/agronomy11061093"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wang, L., Li, X., Gao, F., Liu, Y., Lang, S., and Wang, C. (2023). Effects of pretreatment with a combination of ultrasound and \u03b3-aminobutyric acid on polyphenol metabolites and metabolic pathways in mung bean sprouts. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1081351"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"100189","DOI":"10.1016\/j.phyplu.2021.100189","article-title":"Influence of UV-B treatment on the accumulation of free phenols and tannins in the legumes of Abrus precatorius L. and Vigna mungo (L.) Hepper","volume":"2","author":"Doss","year":"2022","journal-title":"Phytomedicine Plus"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/12\/1895\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:17:58Z","timestamp":1781756278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/12\/1895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":117,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["nu18121895"],"URL":"https:\/\/doi.org\/10.3390\/nu18121895","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}