{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:27:03Z","timestamp":1785403623292,"version":"3.56.0"},"reference-count":84,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-22-0206"],"award-info":[{"award-number":["APVV-22-0206"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-18-0227"],"award-info":[{"award-number":["APVV-18-0227"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"award":["APVV-22-0206"],"award-info":[{"award-number":["APVV-22-0206"]}],"id":[{"id":"https:\/\/ror.org\/037nx0e70","id-type":"ROR","asserted-by":"publisher"}]},{"award":["APVV-18-0227"],"award-info":[{"award-number":["APVV-18-0227"]}],"id":[{"id":"https:\/\/ror.org\/037nx0e70","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: The aim of the study was to assess the metabolic response of women to a six-week consumption of full-fat sheep milk yogurt, with a focus on cardiovascular risk markers, lipid profile, and subfractions of low-density (LDL) and high-density (HDL) lipoproteins of both atherogenic and non-atherogenic nature. Methods: A total of 55 women were enrolled in the nutritional intervention after the application of inclusion criteria. Blood samples were collected at baseline and after the six-week intervention period. Lipoprotein subfractions were determined in serum using the Lipoprint System LDL\/HDL Subfractions Kit in combination with the Lipoprint\u00ae analyzer. Results: In the group of women over 40 years of age with overweight or obesity, without adjustment for total cholesterol, a significant increase was observed in selected HDL subfractions (intermediate HDL-6, HDL-7 and small HDL-8, HDL-9; p &lt; 0.05), while the small\/large HDL ratio, LDL subfractions, and mean LDL particle size remained unchanged (p &gt; 0.05). A decrease in triglycerides, LDL\/HDL ratio, TG\/HDL ratio, and cardiovascular risk index was recorded, alongside a slight increase in LDL-C and HDL-C levels. After adjustment for total cholesterol (T-C), no significant deterioration in the lipid profile was observed in either the group with normal or elevated T-C levels; in the group with elevated T-C, only the intermediate HDL-7 subfraction increased significantly (p &lt; 0.05). Despite the presence of risk-level values in some parameters already at baseline (VLDL, IDL-A, IDL-B, small HDL), no worsening was observed. Conclusions: Six-week consumption of full-fat sheep milk yogurt did not lead to deterioration of the lipid profile or lipoprotein subfractions. The results suggest a neutral to mildly beneficial effect on selected cardiovascular risk markers.<\/jats:p>","DOI":"10.3390\/nu18121933","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:00:48Z","timestamp":1781535648000},"page":"1933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Ewe\u2019s Yogurt Intake Selectively Modulates HDL Subfractions Without Altering LDL Particle Size in Women: A Six-Week Intervention Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-7311","authenticated-orcid":false,"given":"Martina","family":"Ga\u017earov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-7191","authenticated-orcid":false,"given":"Petra","family":"Len\u00e1rtov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-7868","authenticated-orcid":false,"given":"Jana","family":"Kop\u010dekov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-7161","authenticated-orcid":false,"given":"Marta","family":"Hab\u00e1nov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Civ\u00e1\u0148ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Kijovsk\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"\u0160ubov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Trieda Andreja Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"k2139","DOI":"10.1136\/bmj.k2139","article-title":"Dietary Fat and Cardiometabolic Health: Evidence, Controversies, and Consensus for Guidance","volume":"361","author":"Forouhi","year":"2018","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease. 1. Evidence from Genetic, Epidemiologic, and Clinical Studies. A Consensus Statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-511X-6-25","article-title":"Bovine milk in human nutrition\u2013A review","volume":"6","author":"Haug","year":"2007","journal-title":"Lipids Health Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12937-019-0496-5","article-title":"Comparing the cost of essential nutrients from different food sources in the American diet using NHANES 2011\u20132014","volume":"18","author":"Hess","year":"2019","journal-title":"Nutr. J."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gunstone, F.D., Harwood, J.L., and Harwood, J.L. (2007). Occurrence and characterisation of oils and fats. The Lipid Handbook, CRC Press. [3rd ed.].","DOI":"10.1201\/9781420009675.ch2"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_7","first-page":"e505","article-title":"Recommended Dietary Pattern to Achieve Adherence to the American Heart Association\/American College of Cardiology (AHA\/ACC) Guidelines: A Scientific Statement from the American Heart Association","volume":"134","author":"Carson","year":"2016","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3945\/an.115.011619","article-title":"Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk","volume":"7","author":"Brassard","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"l4137","DOI":"10.1136\/bmj.l4137","article-title":"WHO draft guidelines on dietary saturated and trans fatty acids: Time for a new approach?","volume":"366","author":"Astrup","year":"2019","journal-title":"BMJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/advances\/nmab118","article-title":"Dairy product consumption and cardiovascular health: A systematic review and meta-analysis of prospective cohort studies","volume":"13","author":"Chen","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1093\/advances\/nmy099","article-title":"Milk and dairy product consumption and cardiovascular diseases: An overview of systematic reviews and meta-analyses","volume":"10","author":"Fontecha","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/ajcn\/nqy151","article-title":"Food Groups and Intermediate Disease Markers: A Systematic Review and Network Meta-Analysis of Randomized Trials","volume":"108","author":"Schwingshackl","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/nutrit\/nuu060","article-title":"Effect of Cheese Consumption on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"73","author":"Geleijnse","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jff.2018.07.039","article-title":"Influence of probiotics, prebiotics, synbiotics and bioactive phytochemicals on the formulation of functional yogurt","volume":"48","author":"Fazilah","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1007\/s13197-013-1202-9","article-title":"Proteolytic and ACE-inhibitory activities of probiotic yogurt containing non-viable bacteria as affected by different levels of fat, inulin and starter culture","volume":"52","author":"Shakerian","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.smallrumres.2008.07.009","article-title":"Composition of goat and sheep milk products: An update","volume":"79","author":"Lagriffoul","year":"2008","journal-title":"Small Rumin. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/10942912.2010.498542","article-title":"Fat-derived volatiles of various products of cows\u2019, Ewes\u2019, and Goats\u2019 milk","volume":"15","author":"Vagenas","year":"2012","journal-title":"Int. J. Food Prop."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.foodchem.2016.07.078","article-title":"Fatty acids and fat-soluble vitamins in ewe\u2019s milk predicted by near infrared reflectance spectroscopy. Determination of seasonality","volume":"214","author":"Revilla","year":"2017","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.3168\/jds.2015-10072","article-title":"Physicochemical evaluation of sheep milk yogurts containing different levels of inulin","volume":"99","author":"Balthazar","year":"2016","journal-title":"J. Dairy Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3945\/an.115.011403","article-title":"Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes","volume":"7","author":"Brassard","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.116.151548","article-title":"Whole dairy matrix or single nutrients in assessment of health effects: Current evidence and knowledge gaps","volume":"105","author":"Thorning","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Taormina, V.M., Unger, A.L., and Kraft, J. (2024). Full-fat dairy products and cardiometabolic health outcomes: Does the dairy-fat matrix matter?. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1386257"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/jhh.2012.3","article-title":"Hypertension therapy in the older adults\u2014Do we know the answers to all the questions? The status after publication of the ACCF\/AHA 2011 expert consensus document on hypertension in the elderly","volume":"26","author":"Banach","year":"2012","journal-title":"J. Hum. Hypertens."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.plipres.2012.03.003","article-title":"Dysfunctional HDL: A novel important diagnostic and therapeutic target in cardiovascular disease?","volume":"51","author":"Mikhailidis","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e013479","DOI":"10.1161\/JAHA.119.013479","article-title":"Trajectories of Lipids Profile and Incident Cardiovascular Disease Risk: A Longitudinal Cohort Study","volume":"8","author":"Dayimu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jacc.2004.03.064","article-title":"Plasma level of oxidized low-density lipoprotein is an independent determinant of coronary macrovasomotor and microvasomotor responses induced by bradykinin","volume":"44","author":"Matsumoto","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5245308","DOI":"10.1155\/2020\/5245308","article-title":"Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis","volume":"2020","author":"Khatana","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1194\/jlr.R200004-JLR200","article-title":"Metabolic origins and clinical significance of LDL heterogeneity","volume":"43","author":"Berneis","year":"2002","journal-title":"J. Lipid Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jacl.2012.03.001","article-title":"High-density lipoprotein subclasses and their relationship to cardiovascular disease","volume":"6","author":"Superko","year":"2012","journal-title":"J. Clin. Lipidol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.atherosclerosis.2009.01.044","article-title":"HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC Norfolk prospective population study","volume":"206","author":"Arsenault","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/clinchem\/47.2.266","article-title":"Development of a rapid, quantitative method for LDL subfractionation with use of the Quantimetrix Lipoprint LDL System","volume":"47","author":"Hoefner","year":"2001","journal-title":"Clin. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/v10044-008-0004-6","article-title":"Assessment of the BMI, WHR and W\/Ht in pre- and post-menopausal women","volume":"70","author":"Skrzypczak","year":"2007","journal-title":"Anthropol. Rev."},{"key":"ref_33","unstructured":"World Health Organization (2008). Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation, World Health Organization."},{"key":"ref_34","unstructured":"World Health Organization (2026, April 11). Obesity and Overweight. Available online: https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_35","unstructured":"(2026, April 29). Diet, Anthropometry and Physical Activity Measurement Toolkit. Available online: https:\/\/www.measurement-toolkit.org\/anthropometry\/introduction\/anthropometry."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the national cholesterol education program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)","volume":"285","author":"Cleeman","year":"2001","journal-title":"JAMA"},{"key":"ref_37","first-page":"757","article-title":"Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention","volume":"5","author":"Pallardo","year":"2009","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_38","unstructured":"Laposata, M. (2014). Laboratory Medicine Diagnosis of Disease in Clinical Laboratory 2\/E, McGraw-Hill Education. [3rd ed.]."},{"key":"ref_39","unstructured":"Mu\u00f1iz, N., Nu\u00f1ez, E., Rivera, M., and Ban, M. (2026, January 06). LDL Subfractions Analysis in Pro-atherogenic Dyslipidemia\u2014Quantimetrix, Redondo Beach, CA\u2013#B-099. Available online: https:\/\/quantimetrix.com\/wp-content\/uploads\/Quantimetrix_Lipoprint_poster.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/01.mol.0000236367.42755.c1","article-title":"Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease","volume":"17","author":"Packard","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/jamacardio.2021.5080","article-title":"Apolipoprotein B vs low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol as the primary measure of apolipoprotein B lipoprotein-related risk. The debate is over","volume":"7","author":"Sniderman","year":"2022","journal-title":"JAMA Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Vekic, J., Zeljkovic, A., Cicero, A.F.G., Janez, A., Stoian, A.P., Sonmez, A., and Rizzo, M. (2022). Atherosclerosis development and progression: The role of atherogenic small, dense LDL. Medicina, 58.","DOI":"10.3390\/medicina58020299"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/MOL.0000000000000419","article-title":"LDL particle number and size and cardiovascular risk: Anything new under the sun?","volume":"28","author":"Allaire","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1273042","DOI":"10.1155\/2017\/1273042","article-title":"Small dense low-density lipoprotein as biomarker for atherosclerotic diseases","volume":"2017","author":"Ivanova","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/01.CIR.0000131511.50734.44","article-title":"Atherogenic lipoprotein particles in atherosclerosis","volume":"109","author":"Carmena","year":"2004","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.9734\/jpri\/2021\/v33i47A32997","article-title":"Oxidative Modification of Lipoproteins: A Potential Role of Oxidized Small dense LDL in Enhanced Atherogenicity","volume":"33","author":"Alsaweed","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jamacardio.2019.3780","article-title":"Apolipoprotein B particles and cardiovascular disease: A narrative review","volume":"4","author":"Sniderman","year":"2019","journal-title":"JAMA Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, B.H., Yin, F., Qiao, Y.N., and Guo, S.D. (2022). Triglyceride and triglyceride-rich lipoproteins in atherosclerosis. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.909151"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jacl.2015.03.010","article-title":"Low- and high-density lipoprotein subclasses in subjects with nonalcoholic fatty liver disease","volume":"9","author":"Sonmez","year":"2015","journal-title":"J. Clin. Lipidol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2174\/1570161114666161003093032","article-title":"High-density lipoprotein and low-density lipoprotein subfractions in patients with chronic kidney disease","volume":"15","author":"Banach","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2174\/1570161116666180601083225","article-title":"Cholesterol subfraction analysis in patients with acute coronary syndrome","volume":"17","author":"Kidawa","year":"2019","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bonizzi, A., Piuri, G., Corsi, F., Cazzola, R., and Mazzucchelli, S. (2021). HDL dysfunctionality: Clinical relevance of quality rather than quantity. Biomedicines, 9.","DOI":"10.3390\/biomedicines9070729"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14797\/mdcj-15-1-55","article-title":"High-density lipoprotein subspecies in health and human disease: Focus on type 2 diabetes","volume":"15","author":"Davidson","year":"2019","journal-title":"Methodist DeBakey Cardiovasc. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11883-022-01012-y","article-title":"The role of high-density lipoprotein cholesterol in 2022","volume":"24","author":"Sirtori","year":"2022","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis","volume":"364","author":"Khera","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1038\/s41598-022-15192-9","article-title":"The profile of HDL-C subfractions and their association with cardiovascular risk in the Hungarian general and Roma populations","volume":"12","author":"Piko","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E108","DOI":"10.1016\/j.atherosclerosis.2015.04.378","article-title":"HDL and LDL subfractions and coronary atherosclerosis in adult males","volume":"241","author":"Ezhov","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_58","first-page":"555","article-title":"High density lipoprotein subfractions and paraoxonase 1 in children","volume":"63","author":"Oravec","year":"2016","journal-title":"Acta Biochim. Pol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.2174\/1381612825666190227224246","article-title":"Diabetes-induced alterations in HDL subfractions distribution","volume":"26","author":"Femlak","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e2600","DOI":"10.1097\/MD.0000000000002600","article-title":"Large HDL Subfraction but Not HDL-C Is Closely Linked with Risk Factors, Coronary Severity and Outcomes in a Cohort of Nontreated Patients with Stable Coronary Artery Disease: A Prospective Observational Study","volume":"95","author":"Li","year":"2016","journal-title":"Medicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12944-025-02616-4","article-title":"Full-fat yogurt compared with non-fat yogurt reduces blood triacylglycerol concentrations and lowers the triacylglycerol content in specific lipoprotein subclasses in adults with prediabetes: An exploratory analysis of a randomized-controlled trial","volume":"24","author":"Taormina","year":"2025","journal-title":"Lipids Health Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/ajcn\/nqac224","article-title":"Saturated fat from dairy sources is associated with lower cardiometabolic risk in the Framingham offspring study","volume":"116","author":"Yuan","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Packard, C.J., Boren, J., and Taskinen, M.-R. (2020). Causes and consequences of hypertriglyceridemia. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00252"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41430-017-0042-5","article-title":"Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: A 3-week randomized crossover study","volume":"72","author":"Engel","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/ajcn\/nqab131","article-title":"Impact of low-fat and full-fat dairy foods on fasting lipid profile and blood pressure: Exploratory endpoints of a randomized controlled trial","volume":"114","author":"Schmidt","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Emerenziani, S., Pier Luca Guarino, M., Trillo Asensio, L.M., Altomare, A., Ribolsi, M., Balestrieri, P., and Cicala, M. (2020). Role of Overweight and Obesity in Gastrointestinal Disease. Nutrients, 12.","DOI":"10.3390\/nu12010111"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"924S","DOI":"10.1093\/advances\/nmz069","article-title":"Effects of Full-Fat and Fermented Dairy Products on Cardiometabolic Disease: Food Is More Than the Sum of Its Parts","volume":"10","author":"Astrup","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/nbu.12585","article-title":"Saturated fats, dairy foods and cardiovascular health: No longer a curious paradox?","volume":"47","author":"Givens","year":"2022","journal-title":"Nutr. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Yilmaz, B., Alvanoudi, P., Kalogeropoulou, A., Santa, D., Bulmu\u015f-T\u00fcccar, T., Nikolaou, A., Moreno-Indias, I., Ruiz-Limon, P., Guti\u00e9rrez-Repiso, C., and Hillesheim, E. (2025). Fermented Dairy Product Consumption and Blood Lipid Levels in Healthy Adults: A Systematic Review. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1651134"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacc.2020.05.077","article-title":"Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review","volume":"76","author":"Astrup","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Jakubczyk, A., Kara\u015b, M., Rybczy\u0144ska-Tkaczyk, K., Zieli\u0144ska, E., and Zieli\u0144ski, D. (2020). Current Trends of Bioactive Peptides\u2014New Sources and Therapeutic Effect. Foods, 9.","DOI":"10.3390\/foods9070846"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/1541-4337.12250","article-title":"Sheep Milk: Physicochemical Characteristics and Relevance for Functional Food Development","volume":"16","author":"Balthazar","year":"2017","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3945\/ajcn.113.077735","article-title":"Effect of dairy calcium from cheese and milk on fecal fat excretion, blood lipids, and appetite in young men","volume":"99","author":"Soerensen","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3945\/ajcn.115.107045","article-title":"Potential Role of Milk Fat Globule Membrane in Modulating Lipid Metabolism and Cardiometabolic Risk","volume":"102","author":"Rosqvist","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/CIRCRESAHA.117.309008","article-title":"Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health: A Review of Emerging Biologic Pathways","volume":"122","author":"Mozaffarian","year":"2018","journal-title":"Circ. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11886-020-1263-0","article-title":"Dairy Intake and Risk of Cardiovascular Disease","volume":"22","author":"Bhupathi","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1080\/10408398.2020.1768045","article-title":"Fermented Dairy Foods Rich in Probiotics and Cardiometabolic Risk Factors: A Narrative Review from Prospective Cohort Studies","volume":"61","author":"Companys","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.numecd.2020.12.023","article-title":"The Effect of Probiotic Fermented Milk Products on Blood Lipid Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"31","author":"Ziaei","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.jand.2021.02.029","article-title":"Associations of dairy intake with Circulating biomarkers of inflammation, insulin response, and dyslipidemia among postmenopausal women","volume":"121","author":"Shi","year":"2021","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Machlik, M.L., Hopstock, L.A., Wilsgaard, T., and Hansson, P. (2021). Associations between intake of fermented dairy products and blood lipid concentrations are affected by fat content and dairy matrix\u2014The Troms\u00f8 study: Troms\u00f87. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.773468"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/ajcn\/nqy358","article-title":"Yogurt improves insulin resistance and liver fat in obese women with nonalcoholic fatty liver disease and metabolic syndrome: A randomized controlled trial","volume":"109","author":"Chen","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3945\/ajcn.115.123281","article-title":"Comparison of the DASH (Dietary approaches to stop Hypertension) diet and a higher-fat DASH diet on blood pressure and lipids and lipoproteins: A randomized controlled trial","volume":"103","author":"Chiu","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Astrup, A., Rice Bradley, B.H., Brenna, J.T., Delplanque, B., Ferry, M., and Torres-Gonzalez, M. (2016). Regular-Fat Dairy and Human Health: A Synopsis of Symposia Presented in Europe and North America (2014\u20132015). Nutrients, 8.","DOI":"10.3390\/nu8080463"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11883-018-0724-z","article-title":"Dairy Products, Dairy Fatty Acids, and the Prevention of Cardiometabolic Disease: A Review of Recent Evidence","volume":"20","author":"Yu","year":"2018","journal-title":"Curr. Atheroscler. 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