{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:54:48Z","timestamp":1791233688821,"version":"4.1.0"},"reference-count":101,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Szecsei and Dhar families","award":["809194"],"award-info":[{"award-number":["809194"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Neurodegenerative diseases such as Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD) represent a growing public health concern. Both disorders are driven by mitochondrial dysfunction, oxidative stress, impaired autophagy, neuroinflammation, and neuronal loss. Single-target therapeutics have failed to halt disease progression, highlighting the need for multi-target interventions that address the complex and interconnected nature of neurodegeneration. Natural health products (NHPs) such as curcumin (CUR), coenzyme-Q10 (CoQ10), and Ashwagandha (ASH) possess antioxidant, anti-inflammatory, neuroprotective, and neurotrophic properties that may collectively address this complex pathology. However, poor bioavailability and hydrophobicity have limited clinical translations. Novel formulations, including nanomicellar Ubisol-Q10 (UQ) and water-solubilized ASH (PTS-ASH), have demonstrated enhanced metabolic uptake and neuroprotective efficacy in preclinical models. Moreover, co-administered NHPs, such as CUR + CoQ10 and CoQ10 + ASH, may provide further benefits by diversified targeting of disease pathways. Methods: This review presents an integrative interpretation of a combined UQ + ASH \u201ctonic\u201d in transgenic AD and paraquat-induced PD animal models using previously published qualitative immunohistochemical and functional results. This report constructs a proposed mechanistic model illustrating how these compounds may interact across multiple stages of disease AD and PD progression. Results: Based on comprehensive interpretation of the previous published reports, consistent trends suggest UQ stabilizes mitochondrial energetics and suppresses oxidative damage upstream, whereas ASH promotes downstream repair and synaptic modulation. Combined administration remained as providing balanced neuroprotective and functional outcomes. Conclusions: These interpretations of published reports and proposed mechanistic models aim to improve the translation and support the therapeutic potential of multi-component natural interventions for neurodegenerative diseases and highlight the importance of bioavailability-enhancing formulations in future preclinical and clinical research.<\/jats:p>","DOI":"10.3390\/nu18121986","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:18:43Z","timestamp":1781860723000},"page":"1986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin, Coenzyme-Q10, and Bioactive Compounds in Ashwagandha Extract: Multi-Targeting Potential of Co-Administered Natural Health Compounds as Therapeutic and Preventative Interventions in Alzheimer\u2019s and Parkinson\u2019s Disease Models"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9186-1732","authenticated-orcid":false,"given":"Keanna","family":"Dube","sequence":"first","affiliation":[{"name":"Department of Integrative Biology, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3755-313X","authenticated-orcid":false,"given":"Alex","family":"Stoinescu","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7273-7154","authenticated-orcid":false,"given":"Siyaram","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Eshraghi, M., Adlimoghaddam, A., Mahmoodzadeh, A., Sharifzad, F., Yasavoli-Sharahi, H., Lorzadeh, S., Albensi, B.C., and Ghavami, S. 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