{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:19:24Z","timestamp":1788542364974,"version":"build-2803163510"},"reference-count":90,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Curcumin has been proposed as a nutritional strategy to support exercise recovery through antioxidant and anti-inflammatory actions. However, trials differ in sport context, training status, supplementation timing, dose, formulation, and methodological control. This systematic review evaluated its effects on recovery outcomes in active individuals and athletes, with particular attention to the applicability of the evidence to real-world sport settings. Methods: PubMed, Scopus, Web of Science, SPORTDiscus, and Cochrane Library\/CENTRAL were searched from 2012 to June 2026. Randomized double-blind placebo-controlled trials were eligible when they evaluated oral curcumin, curcuminoids, Curcuma-derived preparations with a specified curcumin dose, or curcumin combined only with bioavailability enhancers. Studies using artificial muscle-damage protocols, clinical populations, non-randomized designs, or combined bioactive interventions were excluded. Methodological quality was assessed using the Physiotherapy Evidence Database (PEDro) scale, supplemented by a Cochrane Risk of Bias 2 (RoB 2) assessment and a Grading of Recommendations Assessment, Development and Evaluation (GRADE) certainty-of-evidence evaluation. Owing to heterogeneity, findings were synthesized narratively by outcome domain, supplementation timing, formulation type, exercise context, and training status. Results: Fifteen trials were included. Favorable effects were reported in 6\/7 studies assessing oxidative stress, 4\/6 assessing muscle damage, 3\/8 assessing inflammation, 3\/7 assessing subjective recovery, soreness, or fatigue, and 4\/8 assessing physical or athletic performance. However, effects varied substantially according to population, exercise context, biomarker selection, timing of assessment, and formulation type. The certainty of evidence was low for oxidative stress and very low for muscle damage, inflammation, subjective recovery\/soreness\/fatigue, and performance. Conclusions: Curcumin supplementation may support selected aspects of exercise recovery, particularly oxidative stress responses. However, these findings should be interpreted cautiously because the evidence derives mostly from small trials with heterogeneous populations, exercise protocols, supplementation regimens, formulations, biomarkers, and assessment time points. Evidence for muscle damage, inflammation, subjective recovery, fatigue, and performance remains inconsistent, and further well-controlled trials in trained and high-performance athletes are needed before practical recommendations can be established.<\/jats:p>","DOI":"10.3390\/nu18121992","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:04:04Z","timestamp":1781874244000},"page":"1992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Curcumin Supplementation on Exercise Recovery, Oxidative Stress, Inflammation, Muscle Damage, and Performance in Exercise and Sport Contexts: A Systematic Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2729-5761","authenticated-orcid":false,"given":"Jes\u00fas","family":"Lloret-Gil","sequence":"first","affiliation":[{"name":"Research Center for High Performance Sport, Catholic University of Murcia (UCAM), Guadalupe, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-9477","authenticated-orcid":false,"given":"Desir\u00e9e","family":"Victoria-Montesinos","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Nutrition, UCAM Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-9029","authenticated-orcid":false,"given":"Francisco Javier","family":"Mart\u00ednez-Noguera","sequence":"additional","affiliation":[{"name":"Research Center for High Performance Sport, Catholic University of Murcia (UCAM), Guadalupe, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an active component of turmeric (Curcuma longa), and its effects on health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and anti-inflammatory properties of curcumin","volume":"Volume 595","author":"Menon","year":"2007","journal-title":"Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jff.2015.01.005","article-title":"Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Sahebkar","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/17425255.2017.1360279","article-title":"Curcumin as a clinically-promising anti-cancer agent: Pharmacokinetics and drug interactions","volume":"13","author":"Adiwidjaja","year":"2017","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.joim.2018.07.001","article-title":"Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers","volume":"16","author":"Jamwal","year":"2018","journal-title":"J. Integr. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bmc.2013.11.006","article-title":"Curcumin glucuronides: Assessing the proliferative activity against human cell lines","volume":"22","author":"Pal","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref_8","first-page":"9417","article-title":"Issues with Human Bioavailability Determinations of Bioactive Curcumin","volume":"12","author":"Stohs","year":"2019","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Stohs, S.J., Chen, C.Y.O., Preuss, H.G., Ray, S.D., Bucci, L.R., Ji, J., and Ruff, K.J. (2019). The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: A comparative study. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-019-2699-x"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00421-015-3170-4","article-title":"Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin","volume":"115","author":"Tanabe","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/physrev.2000.80.3.1055","article-title":"Exercise and the immune system: Regulation, integration, and adaptation","volume":"80","author":"Pedersen","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/BF02376774","article-title":"Exercise and the neutrophil oxidative burst: Biological and experimental variability","volume":"74","author":"Pyne","year":"1996","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1152\/jappl.2001.91.4.1669","article-title":"Cellular adaptation to repeated eccentric exercise-induced muscle damage","volume":"91","author":"Stupka","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1021\/ja809217u","article-title":"Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin","volume":"131","author":"Barry","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/expphysiol.2009.050526","article-title":"Reactive oxygen species are signalling molecules for skeletal muscle adaptation","volume":"95","author":"Powers","year":"2010","journal-title":"Exp. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(99)00242-7","article-title":"Oxidative stress and gene regulation","volume":"28","author":"Allen","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1113\/jphysiol.2013.267419","article-title":"Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: A double-blind, randomised, controlled trial","volume":"592","author":"Paulsen","year":"2014","journal-title":"J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1113\/jphysiol.2013.258061","article-title":"Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men","volume":"591","author":"Gliemann","year":"2013","journal-title":"J. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.freeradbiomed.2007.02.031","article-title":"Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling","volume":"44","author":"Ji","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1055\/s-2005-865634","article-title":"Antioxidant status of interval-trained athletes in various sports","volume":"27","author":"Harbula","year":"2006","journal-title":"Int. J. Sports Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1046\/j.1365-2362.2003.01227.x","article-title":"Biochemical assessments of oxidative stress, erythrocyte membrane fluidity and antioxidant status in professional soccer players and sedentary controls","volume":"33","author":"Cazzola","year":"2003","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1007\/s00394-022-02943-7","article-title":"Effect of curcumin supplementation on exercise-induced muscle damage: A narrative review","volume":"61","author":"Nanavati","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"M\u0103nescu, D.C., Tudor, A., M\u0103nescu, A.M., M\u0103rg\u0103rit, I.R., M\u0103nescu, C.O., Pris\u0103caru, C., P\u0103un, L., and Tudor, V. (2026). Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery. Antioxidants, 15.","DOI":"10.20944\/preprints202603.0975.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2434217","DOI":"10.1080\/15502783.2024.2434217","article-title":"Evaluation of curcumin intake in reducing exercise-induced muscle damage in athletes: A systematic review","volume":"21","author":"Patricia","year":"2024","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/ptr.6912","article-title":"The effect of curcumin supplementation on recovery following exercise-induced muscle damage and delayed-onset muscle soreness: A systematic review and meta-analysis of randomized controlled trials","volume":"35","author":"Fang","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liu, X., Lin, L., and Hu, G. (2024). Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0299135"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/10408398.2020.1749025","article-title":"Effects of curcumin supplementation on sport and physical exercise: A systematic review","volume":"61","author":"Suhett","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-L\u00e1zaro, D., Mielgo-Ayuso, J., Calvo, J.S., Mart\u00ednez, A.C., Garc\u00eda, A.C., and Fernandez-Lazaro, C.I. (2020). Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review. Nutrients, 12.","DOI":"10.3390\/nu12020501"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/02601060231186439","article-title":"The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis","volume":"30","author":"Oxley","year":"2024","journal-title":"Nutr. Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1123\/ijspp.2019-0221","article-title":"Tart Cherry Juice: No Effect on Muscle Function Loss or Muscle Soreness in Professional Soccer Players After a Match","volume":"15","author":"Abbott","year":"2020","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0004-9514(09)70043-1","article-title":"The PEDro scale is a valid measure of the methodological quality of clinical trials: A demographic study","volume":"55","year":"2009","journal-title":"Aust. J. Physiother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_36","unstructured":"GRADEpro GDT (2024). GRADEpro Guideline Development Tool, McMaster University and Evidence Prime."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/ebmed-2017-110668","article-title":"Rating the certainty in evidence in the absence of a single estimate of effect","volume":"22","author":"Murad","year":"2017","journal-title":"Evid. Based Med."},{"key":"ref_38","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., and Page, M.J. (2024). Chapter 14: Completing \u2018Summary of findings\u2019 tables and grading the certainty of the evidence. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. [6.5th ed.]."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1123\/ijspp.2022-0283","article-title":"Curcumin Attenuates Delayed-Onset Muscle Soreness and Muscle Function Deficits Following a Soccer Match in Male Professional Soccer Players","volume":"18","author":"Abbott","year":"2023","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ba\u0144kowski, S., W\u00f3jcik, Z.B., Grabara, M., Ozner, D., Pa\u0142ka, T., Stanek, A., and Sadowska-Kr\u0119pa, E. (2025). Does curcumin supplementation affect inflammation, blood count and serum brain-derived neurotropic factor concentration in amateur long-distance runners?. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0317446"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00421-020-04385-7","article-title":"Effects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: A randomized, double-blind, placebo-controlled trial","volume":"120","author":"Faria","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.scispo.2021.05.002","article-title":"Effect of curcumin supplementation on muscle damage, antioxidant status and inflammatory factors after successive simulated taekwondo competitions","volume":"37","author":"Ghojazadeh","year":"2022","journal-title":"Sci. Sports"},{"key":"ref_43","first-page":"26","article-title":"The Effect of Curcumin and Piperine Supplementation as a Recovery Method after Two Consecutive Futsal Matches","volume":"12","author":"Juniarsyah","year":"2024","journal-title":"Int. J. Hum. Mov. Sports Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/19390211.2021.1936335","article-title":"Short Term, Oral Supplementation with Optimized Curcumin Does Not Impair Performance Improvements Associated with High Intensity Interval Training","volume":"19","author":"Kisiolek","year":"2022","journal-title":"J. Diet. Suppl."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"101099","DOI":"10.1016\/j.imr.2024.101099","article-title":"Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial","volume":"14","author":"Li","year":"2025","journal-title":"Integr. Med. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/19390211.2020.1796885","article-title":"Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation","volume":"18","author":"Mallard","year":"2021","journal-title":"J. Diet. Suppl."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/19390211.2018.1515142","article-title":"Effects of Curcumin on the Oxidative Stress Response to a Dual Stress Challenge in Trained Men","volume":"17","author":"McAllister","year":"2020","journal-title":"J. Diet. Suppl."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/ijpvm.IJPVM_138_20","article-title":"The Effects of Curcumin Supplementation on Muscle Damage, Oxidative Stress, and Inflammatory Markers in Healthy Females with Moderate Physical Activity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"12","author":"Salehi","year":"2021","journal-title":"Int. J. Prev. Med."},{"key":"ref_49","first-page":"e35776","article-title":"Influence of Curcumin Supplementation on Exercise-Induced Oxidative Stress","volume":"8","author":"Bolboli","year":"2016","journal-title":"Asian J. Sports Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3923\/pjn.2013.842.850","article-title":"Effect of temulawak (Curcumin xanthorrhiza Roxb) extract on reduction of MDA (Malondialdehyde) levels of football athletes","volume":"12","author":"Rosidi","year":"2013","journal-title":"Pak. J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1186\/s12970-014-0066-3","article-title":"The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling","volume":"12","author":"Sciberras","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1007\/s00421-024-05429-y","article-title":"Impact of curcumin supplementation on exercise performance and muscle damage after a soccer match: A double-blind placebo-controlled cross-over study","volume":"124","author":"Tanabe","year":"2024","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_53","first-page":"469","article-title":"Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans","volume":"35","author":"Takahashi","year":"2014","journal-title":"Int. J. Sports Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1123\/ijspp.2021-0451","article-title":"Defining Training and Performance Caliber: A Participant Classification Framework","volume":"17","author":"McKay","year":"2022","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1248\/bpb.34.660","article-title":"Innovative preparation of curcumin for improved oral bioavailability","volume":"34","author":"Sasaki","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/mnfr.201300724","article-title":"The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes","volume":"58","author":"Schiborr","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_57","unstructured":"Protocol for Life, B. (2018). CurcuFRESH\u2122 Technical Data Sheet, Protocol for Life Balance."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1021\/jf9024807","article-title":"Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers","volume":"58","author":"Gota","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"530","DOI":"10.5414\/CP204257","article-title":"Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants","volume":"60","author":"Hirose","year":"2022","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref_60","first-page":"92","article-title":"A Pilot Cross-Over Study to Assess the Human Bio Availability of \u201cCureit\u201d A Bio Available Curcumin in Complete Natural Matrix","volume":"3","author":"George","year":"2015","journal-title":"Asian J. Pharm. Technol. Innov."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/np1007262","article-title":"Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation","volume":"74","author":"Cuomo","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00394-018-1766-2","article-title":"Increased bioavailability of curcumin using a novel dispersion technology system (LipiSperse\u00ae)","volume":"58","author":"Briskey","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/sms.13373","article-title":"Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation","volume":"29","author":"Tanabe","year":"2019","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3177\/jnsv.65.82","article-title":"Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men","volume":"65","author":"Tanabe","year":"2019","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbacli.2016.02.003","article-title":"Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin","volume":"5","author":"McFarlin","year":"2016","journal-title":"BBA Clin."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1550-2783-11-31","article-title":"Reduction of delayed onset muscle soreness by a novel curcumin delivery system (meriva): A randomised placebo controlled trial","volume":"11","author":"Drobnic","year":"2014","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"J\u00e4ger, R., Purpura, M., and Kerksick, C.M. (2019). Eight Weeks of a High Dose of Curcumin Supplementation May Attenuate Performance Decrements Following Muscle-Damaging Exercise. Nutrients, 11.","DOI":"10.3390\/nu11071692"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/jmf.2019.4533","article-title":"The Effects of Bioavailable Curcumin (Cureit) on Delayed Onset Muscle Soreness Induced By Eccentric Continuous Exercise: A Randomized, Placebo-Controlled, Double-Blind Clinical Study","volume":"23","author":"Amalraj","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_69","first-page":"147","article-title":"Curcumin and piperine supplementation and recovery following exercise induced muscle damage: A randomized controlled trial","volume":"16","author":"Delecroix","year":"2017","journal-title":"J. Sports Sci. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00421-015-3152-6","article-title":"Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)","volume":"115","author":"Nicol","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/19390211.2021.1875101","article-title":"Ten Days of Curcumin Supplementation Attenuates Subjective Soreness and Maintains Muscular Power Following Plyometric Exercise","volume":"19","author":"Hillman","year":"2022","journal-title":"J. Diet. Suppl."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/19390211.2019.1604604","article-title":"Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage, and Muscle Soreness","volume":"17","author":"Ms","year":"2020","journal-title":"J. Diet. Suppl."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zeng, Z., Centner, C., Gollhofer, A., and K\u00f6nig, D. (2021). Effects of Dietary Strategies on Exercise-Induced Oxidative Stress: A Narrative Review of Human Studies. Antioxidants, 10.","DOI":"10.3390\/antiox10040542"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.ajcnut.2023.03.006","article-title":"The effect of curcumin supplementation on weight loss and anthropometric indices: An umbrella review and updated meta-analyses of randomized controlled trials","volume":"117","author":"Unhapipatpong","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1021\/acsomega.2c07326","article-title":"Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?","volume":"8","author":"Hegde","year":"2023","journal-title":"ACS Omega"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1007\/s10787-025-02038-9","article-title":"Efficacy of curcumin\/turmeric on inflammation and oxidative stress in prediabetes and type 2 diabetes: A systematic review and dose-response meta-analysis","volume":"33","author":"Bahari","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_77","unstructured":"(2010). EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of curcumin (E 100) as a food additive. EFSA J., 8, 1679."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"458592","DOI":"10.1155\/2014\/458592","article-title":"Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects","volume":"2014","author":"Klickovic","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., Narimanyan, M., and Hovhannisyan, A. (2018). Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-017-2062-z"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/WNF.0000000000000344","article-title":"Curcumin as Add-On to Antipsychotic Treatment in Patients with Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"42","author":"Miodownik","year":"2019","journal-title":"Clin. Neuropharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.cgh.2006.03.020","article-title":"Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis","volume":"4","author":"Shoskes","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"283634","DOI":"10.1155\/2015\/283634","article-title":"Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris","volume":"2015","author":"Antiga","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10068-017-0087-1","article-title":"Stability studies of pure and mixture form of curcuminoids by reverse phase-HPLC method under various experimental stress conditions","volume":"26","author":"Peram","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Chen, H.-W., Chen, S.-D., Wu, H.-T., Cheng, C.-H., Chiou, C.-S., and Chen, W.-T. (2024). Improvement in Curcumin\u2019s Stability and Release by Formulation in Flexible Nano-Liposomes. Nanomaterials, 14.","DOI":"10.3390\/nano14221836"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1210\/endrev\/bnae011","article-title":"Relative Energy Deficiency in Sport (REDs): Endocrine Manifestations, Pathophysiology and Treatments","volume":"45","author":"Angelidi","year":"2024","journal-title":"Endocr. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s40001-025-02506-6","article-title":"Polyphenols and post-exercise muscle damage: A comprehensive review of literature","volume":"30","author":"Zhang","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-L\u00e1zaro, D., Arribalzaga, S., Guti\u00e9rrez-Abej\u00f3n, E., Azarbayjani, M.A., Mielgo-Ayuso, J., and Roche, E. (2024). Omega-3 Fatty Acid Supplementation on Post-Exercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performance in Physically Healthy Adults-A Systematic Review of Randomized Controlled Trials. Nutrients, 16.","DOI":"10.3390\/nu16132044"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40798-019-0200-5","article-title":"A Randomized Controlled Trial Investigating the Effects of Undulatory, Staggered, and Linear Load Manipulations in Aerobic Training on Oxygen Supply, Muscle Injury, and Metabolism in Male Recreational Runners","volume":"5","author":"Costa","year":"2019","journal-title":"Sports Med. Open"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: A Review of Its Effects on Human Health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/12\/1992\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:32:56Z","timestamp":1782448376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/12\/1992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":90,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["nu18121992"],"URL":"https:\/\/doi.org\/10.3390\/nu18121992","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]}}}