{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:47:14Z","timestamp":1785422834573,"version":"3.56.0"},"reference-count":59,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2023YFC3503805"],"award-info":[{"award-number":["2023YFC3503805"]}]},{"name":"Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources","award":["2060302"],"award-info":[{"award-number":["2060302"]}]},{"award":["2060302"],"award-info":[{"award-number":["2060302"]}],"id":[{"id":"https:\/\/ror.org\/036h6g940","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science, Education and Industry Major Innovation Pilot Project from Qilu University of Technology","award":["2025ZDZX07"],"award-info":[{"award-number":["2025ZDZX07"]}]},{"award":["2025ZDZX07"],"award-info":[{"award-number":["2025ZDZX07"]}],"id":[{"id":"https:\/\/ror.org\/04y8d6y55","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Acute lung injury (ALI) currently lacks safe and effective therapeutic strategies with low toxicity. Lonicerae japonicae flos, a traditional herb and functional food, contains polyphenols as its principal active components. This study investigated whether Lonicerae japonicae flos polyphenols (LJP) could exert protective effects against lipopolysaccharide (LPS)-induced ALI in mice. Methods: Eighty-four male C57BL\/6J mice were randomly divided into seven groups and treated daily for 7 days with LJP (200, 100, or 50 mg\/kg), liproxstatin-1 (10 mg\/kg), dexamethasone (5 mg\/kg), or saline (control and model groups). Subsequently, another thirty-six mice were used for the fecal microbiota transplantation (FMT) experiment. All groups except the control group received intratracheal instillation of LPS (5 mg\/kg) to induce ALI. Results: LJP treatment significantly ameliorated lung histopathological damage and gut microbiota dysbiosis. Lung proteomics analysis revealed the enrichment of the NF-\u03baB and ferroptosis pathways. Mechanistically, LJP downregulated pro-inflammatory factors (IL-6, TNF-\u03b1, and IL-1\u03b2) by suppressing activation of the TLR4\/MyD88\/NF-\u03baB pathway. Meanwhile, LJP upregulated SOD and GSH levels, thereby suppressing the accumulation of ROS, GSSG, Fe2+, and MDA, which were closely related to the activation of the Nrf2\/HO-1 and Sirt3\/Nrf2\/GPX4 pathways. Furthermore, LJP modulated the gut microbiota and promoted short-chain fatty acid (SCFA) production by elevating the relative abundance of Akkermansia muciniphila and Faecalibaculum. Intriguingly, FMT results confirmed that the LJP-derived gut microbiota markedly alleviated lung tissue injury and intestinal barrier damage in ALI mice. Conclusions: This study demonstrated that LJP could reshape the gut microbiota to enhance the production of SCFAs and inhibit inflammation-related ferroptosis in ALI mice.<\/jats:p>","DOI":"10.3390\/nu18132048","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:11:49Z","timestamp":1782234709000},"page":"2048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lonicerae japonicae flos Polyphenols Attenuate Inflammation-Related Ferroptosis and Gut Microbiota Dysbiosis in LPS-Induced Acute Lung Injury in Mice"],"prefix":"10.3390","volume":"18","author":[{"given":"Yingjian","family":"Guo","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"},{"name":"Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangchuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Dong","sequence":"additional","affiliation":[{"name":"Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-4785","authenticated-orcid":false,"given":"Chuanzhi","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-2483","authenticated-orcid":false,"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"},{"name":"Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40635-020-00350-y","article-title":"Comparison of direct and indirect models of early induced acute lung injury","volume":"8","author":"Chimenti","year":"2020","journal-title":"Intensive Care Med. 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