{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:46:52Z","timestamp":1782906412489,"version":"3.54.5"},"reference-count":12,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Research Program for Agriculture Science and Technology Development","doi-asserted-by":"publisher","award":["RS-2022-RD010294"],"award-info":[{"award-number":["RS-2022-RD010294"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education of Korea","award":["5120200313836"],"award-info":[{"award-number":["5120200313836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Hytallzen\u2122 is a natural combined extract of Artemisia princeps and Thymus vulgaris. The present study evaluated its growth-promoting effects during the rapid growth period in male Sprague\u2013Dawley rats. Methods: Hytallzen\u2122 (150 mg\/kg\/day) was orally administered for 9 weeks beginning at postnatal week 3. Growth-related parameters, including body weight, body length, food intake, serum insulin-like growth factor-1 (IGF-1), and tibia length and weight, were assessed. Results: Hytallzen\u2122 significantly increased body weight, body length, food intake, tibia length, and tibia weight compared with controls. In addition, serum IGF-1 concentration was significantly elevated at week 6 and showed positive correlations with final body weight, body length, tibia length, and tibia weight. Conclusions: These findings suggest that Hytallzen\u2122 is associated with favorable changes in growth-related parameters and serum IGF-1 levels in healthy growing rats, supporting its potential as a growth-supportive material under normal physiological growth conditions.<\/jats:p>","DOI":"10.3390\/nu18132129","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:41:01Z","timestamp":1782902461000},"page":"2129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Hytallzen\u2122 on Growth-Related Parameters in Growing Male Rats"],"prefix":"10.3390","volume":"18","author":[{"given":"Yujin","family":"Kim","sequence":"first","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyoung","family":"Maeng","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5455-9113","authenticated-orcid":false,"given":"Ji Hye","family":"Yoon","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Device Industry, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-2390","authenticated-orcid":false,"given":"Junhyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3666-8247","authenticated-orcid":false,"given":"Sangeun","family":"Im","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-7902","authenticated-orcid":false,"given":"Sungho","family":"Maeng","sequence":"additional","affiliation":[{"name":"College of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4334-9396","authenticated-orcid":false,"given":"Jihwan","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dongduk Women\u2019s University, Seoul 02748, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(12)60149-4","article-title":"Adolescence and the social determinants of health","volume":"379","author":"Viner","year":"2012","journal-title":"Lancet"},{"key":"ref_2","first-page":"39","article-title":"Environmental factors influencing growth and pubertal development","volume":"101","year":"1993","journal-title":"Environ. 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