{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:15:45Z","timestamp":1783340145696,"version":"3.54.6"},"reference-count":50,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Pregnant women with obesity may experience a substantial burden of sleep disruption and obstetric risk, but prospective data integrating non-respiratory sleep symptoms, prescribed nutritional supplement exposure, and routinely collected hematological measures are limited. This single-center prospective pilot study aimed to describe longitudinal changes in anthropometry, non-respiratory sleep symptoms, prescribed nutritional supplement exposure, routine hematological and blood-count-derived inflammatory indices, and obstetric and neonatal outcomes, and to document study-accrual and data completeness metrics for a future controlled cohort. Methods: Seventeen adult women with singleton pregnancies and first-trimester body mass index (BMI) \u2265 30 kg\/m2 reached the sleep unit, and all consented to participate. Protocol-based assessments were performed in the first and third trimesters, whereas routine laboratory and treatment data were extracted from medical records. Nutritional exposure was defined solely by prescription status in routine records; doses, formulations, adherence, dietary intake, and serum micronutrient markers were unavailable. Analyses were endpoint-specific complete-case analyses. Results: Study accrual at the sleep unit occurred from 27 July 2023 to 14 March 2024 (17 participants over 7.6 months; approximately 2.2 participants\/month). The number informed in Obstetrics and the number not reaching the sleep unit were not recorded. Paired anthropometry was available for 15\/17 participants, paired Epworth and Insomnia Severity Index scores for 14\/17, paired restless-legs scores for 13\/17, and delivery outcomes for 16\/17. Median paired changes were 6.0 kg (IQR 1.4\u20137.9) for weight and 2.3 kg\/m2 (IQR 0.5\u20133.1) for BMI. Hemoglobin decreased, and selected blood-count-derived indices varied across routine trimester measurements. Sleep scores showed no clear longitudinal change, although nocturnal awakenings and subclinical insomnia were frequent. Type III polygraphy was attempted in all 17 participants at T1 and was valid in 16; one participant declined a repeat study after a technically invalid recording. Polygraphy was valid in 15 participants at T3; a respiratory event index (REI) \u22655 events\/h was observed in 6\/16 (37.5%) and 8\/15 (53.3%), respectively. Conclusions: This pilot provides feasibility, data completeness, and variability estimates for a larger controlled cohort. The small uncontrolled sample, non-standardized laboratory timing, treatment heterogeneity, and missing upstream referral logs prevent obesity-specific, mechanistic, or clinically actionable conclusions.<\/jats:p>","DOI":"10.3390\/nu18132186","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:43:11Z","timestamp":1783334591000},"page":"2186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Obesity, Non-Respiratory Sleep Symptoms, Prescribed Nutritional Supplements and Routine Hematological Indices During Pregnancy: A Single-Center Prospective Pilot Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-2345","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"L\u00f3pez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Multidisciplinary Sleep and Ventilation Unit J. Ter\u00e1n Santos, University Hospital of Burgos, 09001 Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-7679","authenticated-orcid":false,"given":"Sergio","family":"Galarreta-Aperte","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences of Ceuta, University of Granada, 51001 Ceuta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0045-7871","authenticated-orcid":false,"given":"Piedad","family":"G\u00f3mez-Torres","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences of Ceuta, University of Granada, 51001 Ceuta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-2603","authenticated-orcid":false,"given":"Beatriz","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Area of Human Anatomy and Embryology, Health Sciences, University of Burgos, 09001 Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1749-3212","authenticated-orcid":false,"given":"Natalia","family":"Garc\u00eda-Ruiz","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep and Ventilation Unit J. Ter\u00e1n Santos, University Hospital of Burgos, 09001 Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6669-744X","authenticated-orcid":false,"given":"Francisco de As\u00eds","family":"Membrive-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Sciences, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-1462","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Membrive-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences of Ceuta, University of Granada, 51001 Ceuta, Spain"},{"name":"Institute for Biosanitary Research (ibs.GRANADA), 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-2984","authenticated-orcid":false,"given":"David","family":"Pe\u00f1a-Otero","sequence":"additional","affiliation":[{"name":"Nursing Research Unit, Marqu\u00e9s de Valdecilla Research Institute (IDIVAL), 39008 Santander, Spain"},{"name":"Marqu\u00e9s de Valdecilla University Hospital, Cantabrian Health Service, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","author":"Phelps","year":"2024","journal-title":"Lancet"},{"key":"ref_2","unstructured":"World Health Organization (2026, June 03). 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