{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:58:53Z","timestamp":1785416333134,"version":"3.56.0"},"reference-count":19,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"education Ministry of China","award":["B18053"],"award-info":[{"award-number":["B18053"]}]},{"award":["B18053"],"award-info":[{"award-number":["B18053"]}],"id":[{"id":"https:\/\/ror.org\/01mv9t934","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Micronutrients, including essential minerals and vitamins, together with bioactive molecules such as polyphenols, flavonoids, and milk-derived proteins, are fundamental to human health [...]<\/jats:p>","DOI":"10.3390\/nu18132201","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:53:46Z","timestamp":1783418026000},"page":"2201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Single Nutrients to Networked Health: Micronutrients and Bioactive Molecules in Development, Interaction, and Clinical Translation"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-3086","authenticated-orcid":false,"given":"Jiaqiang","family":"Huang","sequence":"first","affiliation":[{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongdi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in Human Health and Disease","volume":"14","author":"Bao","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wang, S.-S., Li, T., Wei, C.-J., and Cui, L.-Y. (2025). Developmental Regulation of the Murine Selenoproteome Across Embryonic and Postnatal Stages: Implications for Human Nutrition and Health. Nutrients, 17.","DOI":"10.3390\/nu17203200"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.abb.2015.06.024","article-title":"Selenoproteins: Antioxidant Selenoenzymes and Beyond","volume":"595","author":"Steinbrenner","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Liu, C., Chen, K., Xu, Z., Wang, L., Zhu, Y., Yu, Z., Li, T., and Huang, J. (2025). Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Critical Review. Nutrients, 17.","DOI":"10.3390\/nu17152484"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Vulinovic, M.P., Micek, V., Breljak, D., Madunic, I.V., Madunic, J., and Ljubojevic, M. (2026). Overview of the Zinc Functional Interactome Through Health Hallmarks and Medical Conditions. Nutrients, 18.","DOI":"10.3390\/nu18020336"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1039\/c3mt00353a","article-title":"Multiple Impacts of Zinc on Immune Function","volume":"6","author":"Haase","year":"2014","journal-title":"Metallomics"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wang, M., Chen, J., Zhang, Z., Wang, T., Zhao, J., Wang, X., Wang, J., and Zhuang, H. (2025). Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1\u03b1-Driven Glycolysis and Energy Metabolism. Nutrients, 17.","DOI":"10.3390\/nu17172800"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhao, H., Yang, J., Zhang, J., Zhang, Y., Zhu, J., Mei, M., Yu, G., Xian, G., and Zhao, R. (2026). Polyphenols and Neurodegenerative Diseases: Knowledge-Mining Insights, Mechanistic Evidence, and Emerging Nutritional Applications. Nutrients, 18.","DOI":"10.3390\/nu18040602"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"215S","DOI":"10.1093\/ajcn\/81.1.215S","article-title":"Polyphenols: Antioxidants and Beyond","volume":"81","author":"Scalbert","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bcp.2017.03.012","article-title":"Role of the Small Intestine, Colon and Microbiota in Determining the Metabolic Fate of Polyphenols","volume":"139","author":"Williamson","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"172800","DOI":"10.1016\/j.cej.2026.172800","article-title":"Food-Derived Exosomes as a New Generation of Targeted Colonic Delivery Materials: Advantages and Potential","volume":"529","author":"Zhang","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhang, W., Wang, H., Zhao, Y., Wang, P., Wang, R., Sun, Y., Ren, F., and Li, Y. (2025). Dietary Modulation of the Enteric Nervous System: From Molecular Mechanisms to Therapeutic Applications. Nutrients, 17.","DOI":"10.3390\/nu17223519"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/s41564-025-02001-y","article-title":"Iron at the Crossroads of Host-Microbiome Interactions in Health and Disease","volume":"10","author":"Choi","year":"2025","journal-title":"Nat. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/10408398.2011.654142","article-title":"Effect of Processing on Phenolic Antioxidants of Fruits, Vegetables, and Grains-A Review","volume":"55","author":"Nayak","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cofs.2020.03.001","article-title":"Processing Influences on Food Polyphenol Profiles and Biological Activity","volume":"32","author":"Debelo","year":"2020","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1158\/2159-8290.CD-22-0504","article-title":"Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer","volume":"12","author":"Montegut","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41574-025-01141-9","article-title":"Advancing Precision Nutrition: Bridging Mechanistic Insight and Clinical Implementation","volume":"21","author":"Brennan","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-023-03276-9","article-title":"Advancing Nutrition Science to Meet Evolving Global Health Needs","volume":"62","author":"Neufeld","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101528","DOI":"10.1016\/j.tjnut.2026.101528","article-title":"Machine Learning and Artificial Intelligence in Nutrition Research: Analytical Methods, Applications, and Key Considerations","volume":"156","author":"Southey","year":"2026","journal-title":"J. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/13\/2201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:45:55Z","timestamp":1783421155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/13\/2201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":19,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["nu18132201"],"URL":"https:\/\/doi.org\/10.3390\/nu18132201","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]}}}