{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:17:33Z","timestamp":1783588653653,"version":"3.55.0"},"reference-count":41,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Total or partial pancreatectomy is associated with significant metabolic stress and high risk of postoperative malnutrition. Accurate estimation of resting energy expenditure (REE) is essential, as predictive equations may not reflect true energy needs. Methods: A prospective study among patients undergoing total or partial pancreatectomy for pancreatic tumors was conducted. REE was measured by indirect calorimetry (mREE) and compared with the Harris\u2013Benedict and Schofield equations and the weight-based approaches (25 and 30 kcal\/kg). Agreement was assessed using linear regression and Bland\u2013Altman analysis; accuracy indices included \u00b110%, Mean Absolute Percentage Error (MAPE) and Root Mean Square Error (RMSE). Results: In 26 patients (mean age, 66.7 \u00b1 8.7 years; 53.8% male) undergoing pancreatic resection (17 pancreaticoduodenectomies, 8 distal pancreatectomies, 1 total pancreatectomy), 60% were at preoperative malnutrition risk. The median measured REE was 1484 kcal\/day, rising to 1706 kcal\/day after activity adjustment (\u00d71.15) within 14 postoperative days. At 3\u20136 months postoperatively, patients demonstrated significant declines in nutritional status with a median body weight reduction of \u22127.3% and a decrease in BMI of \u22122 kg\/m2. The 30 kcal\/kg method showed the lowest accuracy (MAPE 23.2%, RMSE 416 kcal\/day) and overestimated energy needs. Harris\u2013Benedict underestimated mREE in 61.5% of cases, while the 25 kcal\/kg approach showed more balanced performance. Conclusions: Postoperative energy expenditure in patients undergoing pancreatic resection appeared elevated relative to predictive equations. Predictive equations lack reliability, favoring indirect calorimetry for precision. Sustained weight loss underscores the need for prolonged nutritional surveillance.<\/jats:p>","DOI":"10.3390\/nu18142216","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:40:09Z","timestamp":1783525209000},"page":"2216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimation of Resting Energy Expenditure in Patients Undergoing Total or Partial Pancreatectomy for Pancreatic Tumors"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-1966","authenticated-orcid":false,"given":"Pantelis","family":"Papanastasiou","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Evaggelismos General Hospital, 10676 Athens, Greece"},{"name":"Department of Nutritional Science and Dietetics, School of Health Sciences, University of Peloponnese, 24100 Kalamata, Greece"},{"name":"Laboratory of Hygiene, Social and Preventive Medicine and Medical Statistics, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Bouloubasi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Evaggelismos General Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4142-2392","authenticated-orcid":false,"given":"Dimitrios","family":"Karayiannis","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Evaggelismos General Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Georgolopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Evaggelismos General Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Chasiotis","sequence":"additional","affiliation":[{"name":"2nd Department of Surgery, Evaggelismos General Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Goulis","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokratio General Hospital, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-8068","authenticated-orcid":false,"given":"Maria","family":"Dimitriou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Dietetics, School of Health Sciences, University of Peloponnese, 24100 Kalamata, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/jdi.12799","article-title":"Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes","volume":"9","author":"Niwano","year":"2018","journal-title":"J. Diabetes Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000445018","article-title":"Are There Indications for Total Pancreatectomy in 2016?","volume":"33","author":"Ansorge","year":"2016","journal-title":"Dig. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Furbetta, N., Comandatore, A., Gianardi, D., Palmeri, M., Di Franco, G., Guadagni, S., Caprili, G., Bianchini, M., Fatucchi, L.M., and Picchi, M. (2021). Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature. Nutrients, 13.","DOI":"10.3390\/nu13061765"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Central Editorial Service (2025). Postoperative nutritional support after pancreaticoduodenectomy in adults. Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd.","DOI":"10.1002\/14651858.CD014792.pub2"},{"key":"ref_5","first-page":"59","article-title":"Pancreatic cancer surgery and nutrition management: A review of the current literature","volume":"4","author":"Afaneh","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s11605-007-0187-y","article-title":"Distal Pancreatectomy for Chronic Pancreatitis: Risk Factors for Postoperative Pancreatic Fistula","volume":"11","author":"Schnelldorfer","year":"2007","journal-title":"J. Gastrointest. Surg."},{"key":"ref_7","first-page":"487","article-title":"Nutritional support in pancreatic cancer patients and its effect on nutritional status: An observational regional HPB network study investigating current practice","volume":"32","author":"Wijma","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.clnu.2017.02.013","article-title":"ESPEN guideline: Clinical nutrition in surgery","volume":"36","author":"Weimann","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"428","DOI":"10.26574\/maedica.2025.20.2.428","article-title":"Exocrine Pancreatic Insufficiency: Postoperative Complication Emerging Decades after Surgery?","volume":"20","author":"Pereira","year":"2025","journal-title":"Maedica"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Knapkova, K., Lovecek, M., Tesarikova, J., Gregorik, M., Kolcun, S., Klos, D., and Skalicky, P. (2025). Nutritional Risk Assessment of Patients Undergoing Pancreaticoduodenectomy After Standardization of Preoperative Nutritional Support. Nutrients, 17.","DOI":"10.3390\/nu17172871"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.tem.2020.07.003","article-title":"Endocrine and Metabolic Insights from Pancreatic Surgery","volume":"31","author":"Mezza","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.clnu.2025.08.029","article-title":"ESPEN guideline on clinical nutrition in surgery\u2014Update 2025","volume":"53","author":"Weimann","year":"2025","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3164\/jcbn.10-83","article-title":"Resting energy expenditure in patients undergoing pylorus preserving pancreatoduodenectomies for bile duct cancer or pancreatic tumors","volume":"48","author":"Sasaki","year":"2011","journal-title":"J. Clin. Biochem Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.hpb.2019.05.009","article-title":"Perioperative nutritional management of patients undergoing pancreatoduodenectomy: An international survey among surgeons","volume":"22","author":"Martin","year":"2020","journal-title":"Hpb"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/s41430-021-01063-5","article-title":"Results from a UK-wide survey: The nutritional assessment and management of pancreatic resection patients is highly variable","volume":"76","author":"Russell","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/02601060241290281","article-title":"Personalized nutrition after discharge for pancreatic surgery: A study protocol","volume":"31","author":"Pizzocaro","year":"2025","journal-title":"Nutr. Health"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Delsoglio, M., Achamrah, N., Berger, M.M., and Pichard, C. (2019). Indirect Calorimetry in Clinical Practice. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091387"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/NT.0000000000000092","article-title":"Body Mass Index: Obesity, BMI, and Health: A Critical Review","volume":"50","author":"Nuttall","year":"2015","journal-title":"Nutr. Today"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/jpen.2310","article-title":"Validation of the perioperative nutrition screen for prediction of postoperative outcomes","volume":"46","author":"Williams","year":"2022","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_20","first-page":"213","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"6","author":"Weir","year":"1990","journal-title":"Nutrition"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1073\/pnas.4.12.370","article-title":"A Biometric Study of Human Basal Metabolism","volume":"4","author":"Harris","year":"1918","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum. Nutr. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/jcsm.12080","article-title":"Hypermetabolism: Should cancer types, pathological stages and races be considered in assessing metabolism and could elevated resting energy expenditure be the therapeutic target in patients with advanced cancer?","volume":"6","author":"Ishida","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/jrms.JRMS_844_20","article-title":"Determining the factors affecting energy metabolism and energy requirement in cancer patients","volume":"26","year":"2021","journal-title":"J. Res. Med. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/sj.bjc.6601620","article-title":"Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids","volume":"90","author":"Moses","year":"2004","journal-title":"Br. J. Cancer."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clnesp.2019.11.001","article-title":"Accuracy of predictive equations versus indirect calorimetry for the evaluation of energy expenditure in cancer patients with solid tumors - An integrative systematic review study","volume":"35","author":"Mazzo","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.clnesp.2021.01.019","article-title":"Resting energy expenditure in cancer patients: Agreement between predictive equations and indirect calorimetry","volume":"42","author":"Barcellos","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1445-2197.2011.05970.x","article-title":"Long-term changes in body composition after pancreaticoduodenectomy","volume":"82","author":"Aslani","year":"2012","journal-title":"ANZ J. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11605-017-3618-4","article-title":"Anthropometric Changes in Patients with Pancreatic Cancer Undergoing Preoperative Therapy and Pancreatoduodenectomy","volume":"22","author":"Cloyd","year":"2018","journal-title":"J. Gastrointest. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1177\/0148607114520992","article-title":"Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer","volume":"39","author":"Hashimoto","year":"2015","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.surg.2020.07.056","article-title":"Defining postoperative weight change after pancreatectomy: Factors associated with distinct and dynamic weight trajectories","volume":"168","author":"Trudeau","year":"2020","journal-title":"Surgery"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112204","DOI":"10.4240\/wjgs.v17.i11.112204","article-title":"Pancreatogenic diabetes: Pathophysiology, diagnosis, and management challenges","volume":"17","author":"Wang","year":"2025","journal-title":"World. J. Gastrointest. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s11605-020-04883-1","article-title":"Exocrine Pancreatic Insufficiency After Pancreatectomy for Malignancy: Systematic Review and Optimal Management Recommendations","volume":"25","author":"Moore","year":"2021","journal-title":"J. Gastrointest. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4174\/astr.2022.102.1.20","article-title":"Risk factors deteriorating severe exocrine pancreatic insufficiency measured by stool elastase after pancreatoduodenectomy and the risk factors for weight loss","volume":"102","author":"Cho","year":"2022","journal-title":"Ann. Surg. Treat. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhong, L., Liu, J., Xia, M., Zhang, Y., Liu, S., and Tan, G. (2023). Effect of sarcopenia on survival in patients after pancreatic surgery: A systematic review and meta-analysis. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1315097"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.6026\/973206300220066","article-title":"Sarcopenia with postoperative outcomes in patients undergoing pancreaticoduodenectomy","volume":"22","author":"Jain","year":"2026","journal-title":"Bioinformation"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Phillips, M.E., Robertson, M.D., Bennett-Eastley, K., Rowe, L., Frampton, A.E., and Hart, K.H. (2024). Standard Nutritional Assessment Tools Are Unable to Predict Loss of Muscle Mass in Patients Due to Undergo Pancreatico-Duodenectomy: Highlighting the Need for Detailed Nutritional Assessment. Nutrients, 16.","DOI":"10.3390\/nu16091269"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/01635581.2016.1153667","article-title":"Comparison of Resting Energy Expenditure Between Cancer Subjects and Healthy Controls: A Meta-Analysis","volume":"68","author":"Nguyen","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/ejcn.2016.96","article-title":"Key determinants of energy expenditure in cancer and implications for clinical practice","volume":"70","author":"Purcell","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.ejso.2018.05.001","article-title":"In-hospital length of stay after major surgical oncological procedures","volume":"44","author":"Nazzani","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1007\/s11605-019-04475-8","article-title":"Composite Length of Stay, An Outcome Measure of Postoperative and Readmission Length of Stays in Pancreatoduodenectomy","volume":"24","author":"Williams","year":"2020","journal-title":"J. Gastrointest. Surg."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/14\/2216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:59:19Z","timestamp":1783587559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/14\/2216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":41,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["nu18142216"],"URL":"https:\/\/doi.org\/10.3390\/nu18142216","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]}}}