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Among modifiable risk determinants, atherosclerosis (AS) and hypertension (HTN) are the most critical, interrelated contributors to the onset and progression of CVDs. Nutritional interventions have gained significant global recognition in public health science and clinical practice and are widely regarded as a preventive approach for effective disease management. The goal of the current review is to present evidence from research conducted over the past decade (from 2016 to 2025) supporting the role of nutraceuticals in the management of AS and HTN. This review thoroughly discusses the role of nutraceuticals derived from diverse sources (plants, animals, microorganisms, etc.) from mechanistic aspects to clinical trial endpoints.<\/jats:p>","DOI":"10.3390\/nu18142226","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:40:09Z","timestamp":1783525209000},"page":"2226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nutraceuticals for the Management of Cardiovascular Health: A Mechanistic and Evidence-Based Review Focusing on Atherosclerosis and Hypertension"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4964-446X","authenticated-orcid":false,"given":"Phaniendra","family":"Alugoju","sequence":"first","affiliation":[{"name":"Department of Biophysics, Faculty of Science, Palacky University, 779 00 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-7943","authenticated-orcid":false,"given":"Charanraj","family":"Goud Alladi","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University and University Hospital Olomouc, Hn\u011bvot\u00ednsk\u00e1, 779 00 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-012X","authenticated-orcid":false,"given":"Nyshadham","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-2136","authenticated-orcid":false,"given":"Luxitaa","family":"Goenka","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-6366","authenticated-orcid":false,"given":"Kishoree","family":"Kumaree","sequence":"additional","affiliation":[{"name":"College of Public Health Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-7069","authenticated-orcid":false,"given":"Sudarshan","family":"SJ","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-4694","authenticated-orcid":false,"given":"Krishnaswamy","family":"Duraisamy","sequence":"additional","affiliation":[{"name":"Institute of Fisheries Biotechnology, Tamilnadu Dr. J. 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