{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:16:54Z","timestamp":1783595814207,"version":"3.55.0"},"reference-count":59,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011787","name":"Heilongjiang Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["2024ZX12C09"],"award-info":[{"award-number":["2024ZX12C09"]}],"id":[{"id":"10.13039\/501100011787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Lycopene (LYC), a natural lipid-soluble antioxidant extracted from dietary plants, possesses excellent neuroprotective and metabolic regulatory activities and has shown potential preventive and therapeutic effects on neurodegenerative diseases. However, its precise molecular mechanism against Parkinson\u2019s disease (PD) remains incompletely clarified, which limits its further application. Methods: In this study, a PD mouse model was established, and a series of methods, including molecular docking, untargeted metabolomics, behavioral tests, and histopathological analysis, were used. Results: The results showed that LYC intervention not only improved the motor coordination ability of mice and reduced dopaminergic neuron damage but also reversed the metabolic disorders caused by the disease. Importantly, LYC can significantly increase the expression level of DAT\/SLC6A3 in the midbrain region, and this is evident at both the gene and protein levels. Computational simulations and surface plasmon resonance results show that LYC can form stable complexes with the DAT\/SLC6A3 protein and has a high affinity. Conclusions: This study explored the potential anti-PD effects of LYC from multiple perspectives and observed an association between elevated DAT\/SLC6A3 levels and improved dopamine (DA) homeostasis after LYC intervention. These preliminary findings may offer new experimental clues for further mechanistic study and translational research on PD prevention and treatment.<\/jats:p>","DOI":"10.3390\/nu18142234","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:16:22Z","timestamp":1783592182000},"page":"2234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Effects of Lycopene in Parkinson\u2019s Disease Mice: Potential Modulation of DAT\/SLC6A3-Mediated Dopaminergic Pathway"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9546-8727","authenticated-orcid":false,"given":"Jun","family":"Xia","sequence":"first","affiliation":[{"name":"College of Basic Medical Sciences, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Rui","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Biology and Agriculture, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Xia","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci-Li","family":"Jifu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","article-title":"Disruption of mitochondrial complex I induces progressive parkinsonism","volume":"599","author":"Zampese","year":"2021","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nies, Y.H., Mohamad Najib, N.H., Lim, W.L., Kamaruzzaman, M.A., Yahaya, M.F., and Teoh, S.L. (2021). MicroRNA Dysregulation in Parkinson\u2019s Disease: A Narrative Review. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.660379"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJMra2401857","article-title":"Parkinson\u2019s Disease","volume":"391","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125703","DOI":"10.1016\/j.jns.2025.125703","article-title":"Global, Regional and National Burden of Parkinson\u2019s Disease, 1990\u20132021: Update from the GBD 2021 Study","volume":"480","author":"Yang","year":"2025","journal-title":"J. Neurol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e080952","DOI":"10.1136\/bmj-2024-080952","article-title":"Projections for Prevalence of Parkinson\u2019s Disease and Its Driving Factors in 195 Countries and Territories to 2050","volume":"388","author":"Su","year":"2025","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Picca, A., Guerra, F., Calvani, R., Romano, R., Coelho-J\u00fanior, H.J., Bucci, C., and Marzetti, E. (2021). Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson\u2019s Disease: Roads to Biomarker Discovery. Biomolecules, 11.","DOI":"10.3390\/biom11101508"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13024-024-00774-0","article-title":"Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: Relevance to molecular mechanisms in Pathogenesis of Parkinson\u2019s and other related neurodegenerative diseases","volume":"19","author":"Riaz","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Charli, A., Chang, Y.T., Luo, J., Palanisamy, B., Malovic, E., Riaz, Z., Miller, C., Samidurai, M., Zenitsky, G., and Jin, H. (2025). Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKC\u03b4 and Lamin B1 phosphorylation in neuronal cells: Implications for pathogenesis of age-related neurodegenerative diseases. Front. Cell. Neurosci., 19.","DOI":"10.3389\/fncel.2025.1549265"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41586-024-07796-0","article-title":"Dopamine reuptake and inhibitory mechanisms in human dopamine transporter","volume":"632","author":"Li","year":"2024","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nepal, B., Das, S., Reith, M.E., and Kortagere, S. (2023). Overview of the structure and function of the dopamine transporter and its protein interactions. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1150355"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., and Bisaglia, M. (2023). Oxidative Stress and Neuroinflammation in Parkinson\u2019s Disease: The Role of Dopamine Oxidation Products. Antioxidants, 12.","DOI":"10.3390\/antiox12040955"},{"key":"ref_12","first-page":"925","article-title":"Effectiveness of Continuous Dopaminergic Therapies in Parkinson\u2019s Disease: A Review of L-DOPA Pharmacokinetics\/Pharmacodynamics","volume":"14","author":"Demailly","year":"2024","journal-title":"J. Park. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100274","DOI":"10.1016\/j.mocell.2025.100274","article-title":"Current therapeutic strategies in Parkinson\u2019s disease: Future perspectives","volume":"48","author":"Kim","year":"2025","journal-title":"Mol. Cells"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"di Biase, L., Pecoraro, P.M., Carbone, S.P., Caminiti, M.L., and Di Lazzaro, V. (2023). Levodopa-Induced Dyskinesias in Parkinson\u2019s Disease: An Overview on Pathophysiology, Clinical Manifestations, Therapy Management Strategies and Future Directions. J. Clin. Med., 12.","DOI":"10.3390\/jcm12134427"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00702-021-02427-8","article-title":"Disease-modifying treatment of Parkinson\u2019s disease by phytochemicals: Targeting multiple pathogenic factors","volume":"129","author":"Naoi","year":"2022","journal-title":"J. Neural Transm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1007\/s11033-023-08409-1","article-title":"Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson\u2019s disease: An overview and update on new developments","volume":"50","author":"Zamanian","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"121102","DOI":"10.1016\/j.jep.2025.121102","article-title":"Dendrobium huoshanense attenuates Parkinsonian neurodegeneration via dual antioxidant and anti-inflammatory pathways","volume":"359","author":"Yan","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_18","first-page":"380","article-title":"Effect of lycopene on oxidative stress and behavioral deficits in rotenone induced model of Parkinson\u2019s disease","volume":"29","author":"Liu","year":"2013","journal-title":"Chin. J. Appl. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104730","DOI":"10.1016\/j.phrs.2020.104730","article-title":"Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives","volume":"155","author":"Saini","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2015.05.024","article-title":"Neuroprotective effect of lycopene against MPTP induced experimental Parkinson\u2019s disease in mice","volume":"599","author":"Prema","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kulawik, A., Cielecka-Piontek, J., and Zalewski, P. (2023). The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene. Nutrients, 15.","DOI":"10.20944\/preprints202308.0690.v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.fct.2017.09.050","article-title":"Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2\/NF-\u03baB transcriptional pathway","volume":"109","author":"Zhao","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102975","DOI":"10.1016\/j.tice.2025.102975","article-title":"Lycopene alleviates cognitive dysfunctions in an Alzheimer\u2019s disease rat model via suppressing the oxidative and neuroinflammatory signaling","volume":"96","author":"Hafez","year":"2025","journal-title":"Tissue Cell"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zeng, Q., Ning, F., Gu, S., Zeng, Q., Chen, R., Peng, L., Zou, D., Ma, G., and Wang, Y. (2021). The 10-Repeat 3\u2032-UTR VNTR Polymorphism in the SLC6A3 Gene May Confer Protection Against Parkinson\u2019s Disease: A Meta-analysis. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.757601"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.410410417","article-title":"Immunochemical analysis of dopamine transporter protein in Parkinson\u2019s disease","volume":"41","author":"Miller","year":"1997","journal-title":"Ann. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"eaaw1564","DOI":"10.1126\/scitranslmed.aaw1564","article-title":"Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism","volume":"13","author":"Ng","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wang, X., Chen, X., Liu, G., Cai, H., and Le, W. (2023). The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson\u2019s Disease-Associated Neurodegeneration. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108614"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Xia, N., Cabin, D.E., Fang, F., and Reijo Pera, R.A. (2022). Parkinson\u2019s Disease: Overview of Transcription Factor Regulation, Genetics, and Cellular and Animal Models. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.894620"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2010.02.031","article-title":"Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson\u2019s disease","volume":"1328","author":"Khan","year":"2010","journal-title":"Brain Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1021\/acs.jafc.4c12371","article-title":"Lycopene Protects Corneal Endothelial Cells from Oxidative Stress by Regulating the P62-Autophagy-Keap1\/Nrf2 Pathway","volume":"73","author":"Liu","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1039\/C8FO02460J","article-title":"Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in the liver-brain axis","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103363","DOI":"10.1016\/j.redox.2024.103363","article-title":"Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling","volume":"77","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zheng, L., Zhang, H., and Sun, Y. (2025). Lycopene inhibits ER stress and apoptosis while modulating PI3K\/AKT and enhancing antioxidant and anti-apoptotic proteins. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0339565"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e13834","DOI":"10.1111\/acel.13834","article-title":"Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson\u2019s disease","volume":"22","author":"Yan","year":"2023","journal-title":"Aging Cell"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Maneenet, J., Chotritthirong, Y., Omar, A.M., Choonong, R., Daodee, S., Monthakantirat, O., Khamphukdee, C., Pitiporn, S., Awale, S., and Matsumoto, K. (2024). Nelumbo nucifera Petals Ameliorate Depressive-like Symptom and Cognitive Deficit in Unpredictable Chronic Mild Stress Mouse Model. Nutrients, 17.","DOI":"10.3390\/nu17010094"},{"key":"ref_37","first-page":"E30006","article-title":"The Accelerating Rotating Rod Assay or Rotarod Test: A Method to Test Motor Coordination and Learning in Mice","volume":"196","author":"Bulger","year":"2023","journal-title":"J. Vis. Exp."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0308-8146(96)00177-X","article-title":"Content and isomeric ratio of lycopene in food and human blood plasma","volume":"59","author":"Schierle","year":"1997","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.3390\/cancers3022333","article-title":"Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies","volume":"3","author":"Palozza","year":"2011","journal-title":"Cancers"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41531-023-00586-x","article-title":"Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson\u2019s disease patients","volume":"9","author":"Matarazzo","year":"2023","journal-title":"npj Park. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e210105","DOI":"10.1212\/WNL.0000000000210105","article-title":"Association of Striatal Dopamine Depletion and Brain Metabolism Changes with Motor and Cognitive Deficits in Patients with Parkinson Disease","volume":"103","author":"Yoo","year":"2024","journal-title":"Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e70544","DOI":"10.1111\/cns.70544","article-title":"Identifying Risk Factors and Constructing Predictive Models for Wearing-Off and Dyskinesia in Chinese Patients with Parkinson\u2019s Disease on Long-Term Levodopa Therapy","volume":"31","author":"Zhao","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s40120-026-00898-z","article-title":"Advancing the Treatment of Motor Fluctuations in Parkinson\u2019s Disease with a Next-Generation Levodopa\/Carbidopa Formulation","volume":"15","author":"Stocchi","year":"2026","journal-title":"Neurol. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1007\/s00415-024-12632-6","article-title":"Pharmacotherapy of motor symptoms in early and mid-stage Parkinson\u2019s disease: Guideline \u201cParkinson\u2019s disease\u201d of the German Society of Neurology","volume":"271","author":"Becktepe","year":"2024","journal-title":"J. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jnutbio.2018.01.009","article-title":"Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress","volume":"56","author":"Wang","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5519330","DOI":"10.1155\/2021\/5519330","article-title":"Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with A\u03b2-Induced Alzheimer\u2019s Disease Based on the Wnt\/\u03b2-catenin Pathway","volume":"2021","author":"Ning","year":"2021","journal-title":"Neural Plast."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4314\/jeca.v21i2.28","article-title":"Neuroprotective effects of lycopene on lipopolysaccharide-induced cerebellar damage in rats: Implication for Alzheimer\u2019s disease therapy","volume":"21","author":"Adeyeye","year":"2024","journal-title":"J. Exp. Clin. Anat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3988\/jcn.2022.18.5.529","article-title":"Amino Acid Levels as Potential Biomarkers of Multiple Sclerosis in Elderly Patients: Preliminary Report","volume":"18","author":"Koba","year":"2022","journal-title":"J. Clin. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Socha, E., Ko\u015bli\u0144ski, P., Koba, M., M\u0105dra-Gackowska, K., K\u0119dziora-Kornatowska, K., Gackowski, M., and Daghir-Wojtkowiak, E. (2020). Amino Acid Levels as Potential Biomarker of Elderly Patients with Dementia. Brain Sci., 10.","DOI":"10.3390\/brainsci10120914"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41531-021-00161-2","article-title":"Dynamic control of the dopamine transporter in neurotransmission and homeostasis","volume":"7","author":"Bu","year":"2021","journal-title":"npj Park. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1186\/s12967-024-05535-7","article-title":"Targeting the RUNX3-miR-186-3p-DAT-IGF1R axis as a therapeutic strategy in a Parkinson\u2019s disease model","volume":"22","author":"Huang","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.1038\/s41598-023-35274-6","article-title":"Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson\u2019s disease","volume":"13","author":"Wu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/jnr.24965","article-title":"The dopamine membrane transporter plays an active modulatory role in synaptic dopamine homeostasis","volume":"100","author":"Formisano","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ejn.13357","article-title":"Membrane transporters as mediators of synaptic dopamine dynamics: Implications for disease","volume":"45","author":"Lohr","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chotibut, T., Apple, D.M., Jefferis, R., and Salvatore, M.F. (2012). Dopamine transporter loss in 6-OHDA Parkinson\u2019s model is unmet by parallel reduction in dopamine uptake. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052322"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10863-009-9257-z","article-title":"The role of dopamine oxidation in mitochondrial dysfunction: Implications for Parkinson\u2019s disease","volume":"41","author":"Hastings","year":"2009","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"111431","DOI":"10.1016\/j.celrep.2022.111431","article-title":"Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity","volume":"40","author":"Lycas","year":"2022","journal-title":"Cell Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1046\/j.1460-9568.1999.00764.x","article-title":"Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter","volume":"11","author":"Jaber","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s11064-011-0469-3","article-title":"Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson\u2019s Disease","volume":"36","author":"Kaur","year":"2011","journal-title":"Neurochem. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/14\/2234\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:25:11Z","timestamp":1783592711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/14\/2234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":59,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["nu18142234"],"URL":"https:\/\/doi.org\/10.3390\/nu18142234","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}