{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:18:14Z","timestamp":1791227894068,"version":"4.1.0"},"reference-count":134,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Research, Innovation and Digitization","doi-asserted-by":"publisher","award":["PN-IV-P6-6.1-CoEx-2024-0056"],"award-info":[{"award-number":["PN-IV-P6-6.1-CoEx-2024-0056"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Obesity has reached epidemic proportions, affecting over one billion adults worldwide. While incretin-based pharmacotherapies\u2014GLP-1 receptor agonists (semaglutide) and dual GIP\/GLP-1 agonists (tirzepatide)\u2014have transformed obesity treatment, their use remains limited by high costs, adverse effects, restricted eligibility, and rapid weight regain following discontinuation. Plant-derived bioactive compounds represent a promising complementary approach to address these gaps. Objective: This narrative review synthesizes clinical trial evidence on plant-based interventions for obesity management and examines their potential role as adjunctive strategies before, during, and after incretin-based pharmacotherapy. Methods: A literature search was conducted in PubMed, Scopus, and Web of Science (2012\u20132026), prioritizing randomized controlled trials in adults with overweight or obesity reporting at least one obesity-related metabolic outcome. Sixty-one studies were selected and classified by efficacy tier based on the magnitude and breadth of observed clinical effects. Results: The strongest evidence supports polyphenol-rich dietary patterns, particularly the green-Mediterranean diet, producing significant reductions in body weight, visceral fat, and cardiometabolic risk markers. Specific extracts\u2014including curcumin, bergamot polyphenols, and Lippia citriodora\/Hibiscus sabdariffa combinations\u2014demonstrated clinically meaningful metabolic improvements. Isolated high-dose resveratrol and several single-compound interventions showed limited benefit, largely attributable to poor bioavailability. The most effective compounds acted through multiple pathways, including AMPK activation, gut microbiota modulation, and appetite hormone regulation. Conclusions: Plant-derived bioactive compounds offer a safe, accessible adjunctive strategy for obesity management, particularly relevant for patients ineligible for or discontinuing pharmacotherapy. Future trials should directly evaluate plant-polyphenol combinations alongside GLP-1 receptor agonists.<\/jats:p>","DOI":"10.3390\/nu18142266","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:30:37Z","timestamp":1783701037000},"page":"2266","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond GLP-1 Agonists: Plant-Derived Bioactive Compounds as Adjunctive Strategies for Obesity Management"],"prefix":"10.3390","volume":"18","author":[{"given":"Aurelian","family":"Vasile","sequence":"first","affiliation":[{"name":"Faculty of Agriculture, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4794-1337","authenticated-orcid":false,"given":"Andrei Cristian","family":"Anghel","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, 011464 Bucharest, Romania"},{"name":"National Research-Development Institute for Animal Biology and Nutrition (IBNA), 1 Calea Bucuresti, 077015 Balotesti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1085-7531","authenticated-orcid":false,"given":"Teodor Ioan","family":"Trasca","sequence":"additional","affiliation":[{"name":"Faculty of Animal Production Engineering and Management, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0925-1677","authenticated-orcid":false,"given":"Alina","family":"Ortan","sequence":"additional","affiliation":[{"name":"Faculty of Land Reclamation and Environmental Engineering, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd, District 1, 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/dom.16263","article-title":"An overview of obesity-related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes","volume":"27","author":"Bluher","year":"2025","journal-title":"Diabetes Obes. 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