{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:18:23Z","timestamp":1785406703792,"version":"3.56.0"},"reference-count":74,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Carlos III Institute of Health","doi-asserted-by":"publisher","award":["PI11\/01569"],"award-info":[{"award-number":["PI11\/01569"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PI11\/01569"],"award-info":[{"award-number":["PI11\/01569"]}],"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy and Competitiveness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Alcohol consumption and medication use have increased among older population, potentially increasing the risk of alcohol\u2013drug interactions and adverse outcomes. Biological sex differences may further influence these effects. This study aimed to assess sex-related differences in medication use, comorbidities, and hepatic biomarkers among older adults with risky alcohol consumption. Methods: A cross-sectional, multicenter study was conducted in 455 adults aged \u226565 years. Sociodemographic and clinical characteristics, medication prescriptions, and hepatic biomarkers were collected. Results: Of the participants, 41% were women, with a mean age of 71 years. The median weekly alcohol consumption was 7 standard drink units. Overall, 90% were taking at least one medication, with antihypertensives being the most prescribed (62%). Significant sex differences were observed (p \u2264 0.01): men showed higher use of antidiabetic drugs (24%), anticoagulants (8%), and nitrates (4%), whereas women more frequently used anxiolytics (35%), non-steroidal anti-inflammatory drugs (22%), and antidepressants (18%). Although risky alcohol consumption was more prevalent among men, women had a higher overall medication use. Significant differences were also observed in hepatic biomarkers, with higher gamma-glutamyl transferase levels and a higher prevalence of elevated FIB-4 values among men (p \u2264 0.01). Conclusions: These findings highlight the importance of routinely assessing alcohol consumption and medication use in older adults and support incorporating a sex-specific perspective into clinical practice and future research.<\/jats:p>","DOI":"10.3390\/nu18142346","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:00:52Z","timestamp":1784278852000},"page":"2346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in Older Adults with Risky Alcohol Consumption: Medication Use, Comorbidities, and Hepatic Biomarkers"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-8213","authenticated-orcid":false,"given":"Ingrid","family":"Arteaga","sequence":"first","affiliation":[{"name":"Unitat de Suport a la Recerca Metropolitana Nord (USR MN), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Multidisciplinary and Translational Research Group on Health and Society in Primary Health Care (GREMSAS-TranslAP), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), USR MN, 08303 Matar\u00f3, Spain"},{"name":"Primary Healthcare Center Vall del Tenes, Ger\u00e8ncia d\u2019\u00c0mbit d\u2019Atenci\u00f3 Prim\u00e0ria Metropolitana Nord, Institut Catal\u00e0 de la Salut (ICS), 08186 Lli\u00e7\u00e0 d\u2019Amunt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-9168","authenticated-orcid":false,"given":"Meritxell","family":"Carmona-Cervell\u00f3","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca Metropolitana Nord (USR MN), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Multidisciplinary and Translational Research Group on Health and Society in Primary Health Care (GREMSAS-TranslAP), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), USR MN, 08303 Matar\u00f3, Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-7268","authenticated-orcid":false,"given":"Guillem","family":"Pera","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca Metropolitana Nord (USR MN), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Multidisciplinary and Translational Research Group on Health and Society in Primary Health Care (GREMSAS-TranslAP), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), USR MN, 08303 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8524-6189","authenticated-orcid":false,"given":"Carla","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca Metropolitana Nord (USR MN), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Multidisciplinary and Translational Research Group on Health and Society in Primary Health Care (GREMSAS-TranslAP), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), USR MN, 08303 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5174-7685","authenticated-orcid":false,"given":"Galadriel","family":"Diez-Fadrique","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca Metropolitana Nord (USR MN), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ruiz-Rojano","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca Metropolitana Nord (USR MN), Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Primary Healthcare Center Doctor Guillermo Masriera i Guardiola, Ger\u00e8ncia d\u2019\u00c0mbit d\u2019Atenci\u00f3 Prim\u00e0ria i a la Comunitat Barcelon\u00e8s Nord i Maresme, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Geels, L.M., Vink, J.M., Van Beek, J.H.D.A., Bartels, M., Willemsen, G., and Boomsma, D.I. (2013). Increases in Alcohol Consumption in Women and Elderly Groups: Evidence from an Epidemiological Study. BMC Public Health, 13.","DOI":"10.1186\/1471-2458-13-207"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Britton, A., Ben-Shlomo, Y., Benzeval, M., Kuh, D., and Bell, S. (2015). Life Course Trajectories of Alcohol Consumption in the United Kingdom Using Longitudinal Data from Nine Cohort Studies. BMC Med., 13.","DOI":"10.1186\/s12916-015-0273-z"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/acer.70098","article-title":"Prevalence and Gender-Specific Correlates of Hazardous and Binge Drinking among Swedish and Finnish Older Adults","volume":"49","author":"Jemberie","year":"2025","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s12603-011-0115-4","article-title":"Prevalence of At-Risk Drinking among Older Adults and Associated Sociodemographic and Health-Related Factors","volume":"15","author":"Immonen","year":"2011","journal-title":"J. Health Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/gps.4528","article-title":"Hazardous Drinking in People Aged 50 Years or Older: A Cross-Sectional Picture of Europe, 2011-2013","volume":"32","author":"Brugal","year":"2017","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11606-013-2577-z","article-title":"The Prevalence of Harmful and Hazardous Alcohol Consumption in Older U.S. Adults: Data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES)","volume":"29","author":"Wilson","year":"2014","journal-title":"J. Gen. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1038\/s41598-019-46591-0","article-title":"Changes in Alcohol Consumption and Associated Variables among Older Adults in Spain: A Population-Based Cohort Study","volume":"9","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jand.2014.08.017","article-title":"Patterns of Alcohol Consumption in the Older Population of Spain, 2008\u20132010","volume":"115","year":"2015","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"igae097","DOI":"10.1093\/geroni\/igae097","article-title":"Changes in Alcohol Intake by Educational Level Among Older Men and Women in Spain During the 21st Century","volume":"8","author":"Donat","year":"2024","journal-title":"Innov. Aging"},{"key":"ref_10","unstructured":"National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2005). Helping Patients Who Drink Too Much: A CLINICIAN\u2019S GUIDE."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tevik, K., Bergh, S., Selb\u00e6k, G., Johannessen, A., and Helvik, A.-S. (2021). A Systematic Review of Self-Report Measures Used in Epidemiological Studies to Assess Alcohol Consumption among Older Adults. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0261292"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e2424495","DOI":"10.1001\/jamanetworkopen.2024.24495","article-title":"Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors","volume":"7","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_13","unstructured":"National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2020). Harmful Interactions Mixing Alcohol with Medicines."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/pds.4956","article-title":"Evolution of Polypharmacy in a Spanish Population (2005-2015): A Database Study","volume":"29","year":"2020","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Masnoon, N., Shakib, S., Kalisch-Ellett, L., and Caughey, G.E. (2017). What Is Polypharmacy? A Systematic Review of Definitions. BMC Geriatr., 17.","DOI":"10.1186\/s12877-017-0621-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1111\/jocn.14371","article-title":"Prevalence and Factors Associated with Polypharmacy in the Older People: 2006\u20132014","volume":"27","author":"Martins","year":"2018","journal-title":"J. Clin. Nurs."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Holton, A.E., Gallagher, P., Fahey, T., and Cousins, G. (2017). Concurrent Use of Alcohol Interactive Medications and Alcohol in Older Adults: A Systematic Review of Prevalence and Associated Adverse Outcomes. BMC Geriatr., 17.","DOI":"10.1186\/s12877-017-0532-2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.amjopharm.2007.03.006","article-title":"Risks of Combined Alcohol\/Medication Use in Older Adults","volume":"5","author":"Moore","year":"2007","journal-title":"Am. J. Geriatr. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/pds.721","article-title":"Moderate Alcohol Consumption and Adverse Drug Reactions among Older Adults","volume":"11","author":"Onder","year":"2002","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/cpt1977213343","article-title":"Aging and Ethanol Metabolism","volume":"21","author":"Vestal","year":"1977","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.alcohol.2022.07.005","article-title":"Alcohol and Aging-An Area of Increasing Concern","volume":"107","author":"White","year":"2023","journal-title":"Alcohol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.drugalcdep.2005.01.012","article-title":"Alcohol and Benzodiazepines in Falls: An Epidemiological View","volume":"79","author":"Kurzthaler","year":"2005","journal-title":"Drug Alcohol Depend."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00002018-199411040-00002","article-title":"Comparative Tolerability Profiles of Oral Antidiabetic Agents","volume":"11","author":"Krentz","year":"1994","journal-title":"Drug Saf."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1360-0443.2005.01249.x","article-title":"Gender Differences in Drinking: Why Do They Still Exist?","volume":"100","author":"Holmila","year":"2005","journal-title":"Addiction"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2015.08.023","article-title":"Sex and Gender-Related Differences in Alcohol Use and Its Consequences: Contemporary Knowledge and Future Research Considerations","volume":"156","author":"Erol","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Moore, C.J., Holstege, C.P., and Papin, J.A. (2023). Metabolic Modeling of Sex-Specific Liver Tissue Suggests Mechanism of Differences in Toxicological Responses. PLoS Comput. Biol., 19.","DOI":"10.1101\/2023.02.07.527430"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s12325-019-01201-3","article-title":"Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature","volume":"37","author":"Farkouh","year":"2020","journal-title":"Adv. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tor\u00e1n, P., Montesinos, S., Pach\u00f3n-Camacho, A., Diez-Fadrique, G., Ruiz-Rojano, I., Arteaga, I., Pera, G., Montell\u00e0-Jordana, N., Montero-Al\u00eda, P., and Rodr\u00edguez-P\u00e9rez, C. (2023). Risky Alcohol Consumption in the Elderly: Screening and Brief Intervention from Primary Care. The ALANE Study, a Randomized Clinical Trial. Beverages, 9.","DOI":"10.3390\/beverages9040100"},{"key":"ref_29","unstructured":"Observatorio Espa\u00f1ol de Las Drogas Y Las Adicciones (2021). Monograf\u00eda Alcohol 2021. Consumo Y Consecuencias."},{"key":"ref_30","unstructured":"National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2026, June 25). Aging and Alcohol, Available online: https:\/\/www.niaaa.nih.gov\/alcohols-effects-health\/aging-and-alcohol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0016-5085(88)80022-2","article-title":"Ratio of Serum Aspartate to Alanine Aminotransferase in Chronic Hepatitis. Relationship to Cirrhosis","volume":"95","author":"Williams","year":"1988","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1258\/0004563011901064","article-title":"Biochemical Detection and Monitoring of Alcohol Abuse and Abstinence","volume":"38","author":"Sharpe","year":"2001","journal-title":"Ann. Clin. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.14309\/ajg.0000000000002572","article-title":"ACG Clinical Guideline: Alcohol-Associated Liver Disease","volume":"119","author":"Jophlin","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a Simple Noninvasive Index to Predict Significant Fibrosis in Patients with HIV\/HCV Coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1056\/NEJMra2403308","article-title":"Noninvasive Assessment of Liver Fibrosis","volume":"393","author":"Castera","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neubiorev.2021.11.019","article-title":"Alcohol-Medication Interactions: A Systematic Review and Meta-Analysis of Placebo-Controlled Trials","volume":"132","author":"Traccis","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1108\/DAT-11-2017-0060","article-title":"Prevalence of Alcohol and Medication Use among Elderly Individuals in Spain","volume":"18","year":"2018","journal-title":"Drugs Alcohol Today"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/acer.12815","article-title":"Converging Patterns of Alcohol Use and Related Outcomes Among Females and Males in the United States, 2002 to 2012","volume":"39","author":"White","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Stelander, L.T., H\u00f8ye, A., Bramness, J.G., Wynn, R., and Gr\u00f8nli, O.K. (2022). Sex Differences in At-Risk Drinking and Associated Factors-a Cross-Sectional Study of 8,616 Community-Dwelling Adults 60 Years and Older: The Troms\u00f8 Study, 2015\u20132016. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-02842-w"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"ckad160.399","DOI":"10.1093\/eurpub\/ckad160.399","article-title":"Gender-Specific Differences in at-Risk Alcohol Consumption among Older German Adults","volume":"33","author":"Geigl","year":"2023","journal-title":"Eur. J. Public Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/acer.13365","article-title":"Trends in Alcohol Consumption Among Older Americans: National Health Interview Surveys, 1997 to 2014","volume":"41","author":"Breslow","year":"2017","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJM199106133242403","article-title":"Sensitivity to Triazolam in the Elderly","volume":"324","author":"Greenblatt","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1300\/J074v19n01_03","article-title":"Women, Aging, and Alcohol Use Disorders","volume":"19","author":"Epstein","year":"2007","journal-title":"J. Women Aging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/alcalc\/34.6.894","article-title":"Gender Differences in the Relationship between Alcohol Consumption and Drink Problems Are Largely Accounted for by Body Water","volume":"34","author":"Ely","year":"1999","journal-title":"Alcohol Alcohol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.mayocp.2020.08.020","article-title":"Sex Differences in Alcohol Consumption and Alcohol-Associated Liver Disease","volume":"96","author":"Kezer","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/ueg2.12370","article-title":"Influence of Sex in Alcohol-Related Liver Disease: Pre-Clinical and Clinical Settings","volume":"11","author":"Bizzaro","year":"2023","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_47","first-page":"10","article-title":"Alcohol and Liver Function in Women","volume":"40","author":"Maddur","year":"2020","journal-title":"Alcohol Res."},{"key":"ref_48","unstructured":"(2025, November 20). National Institute on Alcohol Abuse and Alcoholism (NIAAA) Alcohol-Medication Interactions: Potentially Dangerous Mixes, Available online: https:\/\/www.niaaa.nih.gov\/health-professionals-communities\/core-resource-on-alcohol\/alcohol-medication-interactions-potentially-dangerous-mixes."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Cebrino, J., and Portero de la Cruz, S. (2023). Polypharmacy and Associated Factors: A Gender Perspective in the Elderly Spanish Population (2011\u20132020). Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1189644"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Maxwell, C.J., Mondor, L., Kon\u00e9, A.J.P., Hogan, D.B., and Wodchis, W.P. (2021). Sex Differences in Multimorbidity and Polypharmacy Trends: A Repeated Cross-Sectional Study of Older Adults in Ontario, Canada. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0250567"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/JCP.0000000000002083","article-title":"Gender Differences in Psychotropic Medication Use: A Naturalistic Study Among Psychiatric Outpatients in Secondary Care","volume":"46","author":"Liemburg","year":"2026","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Orlando, V., Mucherino, S., Guarino, I., Guerriero, F., Trama, U., and Menditto, E. (2020). Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17113926"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02657051","article-title":"Effects of Single Doses of Alprazolam and Diazepam, Alone and in Combination with Ethanol, on Psychomotor and Cognitive Performance and on Autonomic Nervous System Reactivity in Healthy Volunteers","volume":"39","author":"Linnoila","year":"1990","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3810\/pgm.2013.07.2684","article-title":"Risks, Management, and Monitoring of Combination Opioid, Benzodiazepines, and\/or Alcohol Use","volume":"125","author":"Gudin","year":"2013","journal-title":"Postgrad. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00421011","article-title":"Effect of Two Weeks\u2019 Treatment with Thioridazine, Chlorpromazine, Sulpiride and Bromazepam, Alone or in Combination with Alcohol, on Learning and Memory in Man","volume":"44","author":"Liljequist","year":"1975","journal-title":"Psychopharmacologia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e017453","DOI":"10.1136\/bmjopen-2017-017453","article-title":"Consensus Validation of the POSAMINO (POtentially Serious Alcohol\u2013Medication INteractions in Older Adults) Criteria","volume":"7","author":"Holton","year":"2017","journal-title":"BMJ Open"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Strate, L.L., Singh, P., Boylan, M.R., Piawah, S., Cao, Y., and Chan, A.T. (2016). A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165278"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/j.1572-0241.1999.01517.x","article-title":"The Risk of Acute Major Upper Gastrointestinal Bleeding among Users of Aspirin and Ibuprofen at Various Levels of Alcohol Consumption","volume":"94","author":"Kaufman","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"agag018","DOI":"10.1093\/alcalc\/agag018","article-title":"Alcohol-medication interactions among older people: A narrative review on age-specific evidence","volume":"61","author":"Salis","year":"2026","journal-title":"Alcohol Alcohol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/01.CIR.101.4.398","article-title":"Alcohol Potentiates Orthostatic Hypotension: Implications for Alcohol-Related Syncope","volume":"101","author":"Narkiewicz","year":"2000","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/080370599438374","article-title":"Effects of Propranolol on Cardiovascular and Neurohumoral Actions of Alcohol in Hypertensive Patients","volume":"8","author":"Kawano","year":"1999","journal-title":"Blood Press."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1056\/NEJM198204083061406","article-title":"Ethanol Potentiation of Aspirin-Induced Prolongation of the Bleeding Time","volume":"306","author":"Deykin","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20451253241232563","DOI":"10.1177\/20451253241232563","article-title":"Drug Safety in Older Patients with Alcohol Use Disorder: A Retrospective Cohort Study","volume":"14","author":"Westhoff","year":"2024","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e035212","DOI":"10.1136\/bmjopen-2019-035212","article-title":"Prevalence of Potentially Serious Alcohol\u2013Medication Interactions in Older Adults in a Community Pharmacy Setting: A Cross-Sectional Study","volume":"10","author":"Holton","year":"2020","journal-title":"BMJ Open"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/01.ALC.0000128229.23396.42","article-title":"Differential Effects of Alcohol Drinking Pattern on Liver Enzymes in Men and Women","volume":"28","author":"Stranges","year":"2004","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"101435","DOI":"10.1016\/j.eclinm.2022.101435","article-title":"Association of Gamma-Glutamyltransferase Levels with Total Mortality, Liver-Related and Cardiovascular Outcomes: A Prospective Cohort Study in the UK Biobank","volume":"48","author":"Ho","year":"2022","journal-title":"EClinicalMedicine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3748\/wjg.v16.i11.1377","article-title":"Alcoholic Liver Injury: Influence of Gender and Hormones","volume":"16","author":"Eagon","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1465-3362.2009.00153.x","article-title":"Alcohol as a Risk Factor for Liver Cirrhosis: A Systematic Review and Meta-Analysis","volume":"29","author":"Rehm","year":"2010","journal-title":"Drug Alcohol Rev."},{"key":"ref_69","first-page":"117","article-title":"The de Ritis Ratio: The Test of Time","volume":"34","author":"Botros","year":"2013","journal-title":"Clin. Biochem. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1572-0241.1999.01006.x","article-title":"The Ratio of Aspartate Aminotransferase to Alanine Aminotransferase: Potential Value in Differentiating Nonalcoholic Steatohepatitis from Alcoholic Liver Disease","volume":"94","author":"Sorbi","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gutjnl-2019-319720","article-title":"Recent Advances in Alcohol-Related Liver Disease (ALD): Summary of a Gut Round Table Meeting","volume":"69","author":"Avila","year":"2020","journal-title":"Gut"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/00365513.2025.2559352","article-title":"Age- and Sex-Specific Reference Values for FIB-4 Derived from the Nordic Reference Interval Project (NORIP)","volume":"85","author":"Hamelius","year":"2025","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Minea, H., Singeap, A.-M., Sfarti, C.V., Girleanu, I., Chiriac, S., Muzica, C., Cuciureanu, T., Petrea, O.C., Huiban, L., and Zenovia, S. (2023). The Impact of Alcohol Consumption Pattern on Liver Fibrosis in Asymptomatic Patients. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237405"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/HEP.0000000000000845","article-title":"AASLD Practice Guideline on Blood-Based Noninvasive Liver Disease Assessment of Hepatic Fibrosis and Steatosis","volume":"81","author":"Sterling","year":"2025","journal-title":"Hepatology"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/14\/2346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:19:12Z","timestamp":1784434752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/18\/14\/2346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":74,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["nu18142346"],"URL":"https:\/\/doi.org\/10.3390\/nu18142346","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]}}}